Expiratory Flow Limitation at Different Exercise Intensities in Coronary Artery Disease by Viviane Castello-Simões, Marlus Karsten, Vinicius Minatel, Rodrigo Polaquini Simões, Ester Silva, Nayara Yamada Tamburús, Ross Arena, Audrey Borghi-Silva, Aparecida Maria Catai

“…All participants underwent two cardiopulmonary exercise tests at a constant workload (moderate and high intensity), and EFL was evaluated at the end of each exercise workload. …”
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A phase I / IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis by Pankit Vachhani, Peter Tan, Anne-Marie Watson, Shang-Ju Wu, Ross Baker, Stanley Cheung, Sung-Eun Lee, Chih-Cheng Chen, Tsai-Yun Chen, Hui-Hua Hsiao, Jae Hoon Lee, Lucia Masarova, Shuh Ying Tan, Jana Baskar, Brett Charlton, Alison Findlay, Dieter Hamprecht, Wolfgang Jarolimek, Joanna Leadbetter, John Miller, Kristen Morgan, Amna Zahoor, Gabriela Hobbs

“…An anti-fibrotic therapy capable of normalising BM microenvironment and function remains a significant gap in the current treatment landscape. …”
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High prevalence but low referral rate of adrenal incidentalomas in a Lebanese tertiary hospital by Isabelle Jambart, Anne-Marie Wakim, Nadine Cheaib, Christelle Lahoud, Maryam Mansour, Carla Bou Issa, Charbel Daoud, Lina Menassa Moussa, Marie-Hélène Gannagé-Yared, Nada El Ghorayeb

“…Studies on their prevalence, characteristics and functional status are lacking in the Middle East.ObjectiveTo determine the prevalence of AI as well as their clinical and radiological characteristics and referral rates to endocrinologists for hormonal testing.MethodsWe prospectively evaluated unselected adult patients who underwent an abdominal computed tomography (CT) between November 2022 and June 2023 at a Lebanese tertiary teaching hospital. …”
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Molecular Screening of SCN1A‐Related Seizures in Children With Febrile Seizures: Diagnostic Yield and Variant Distribution by Jia Wang, Yang‐Yang Wang, Lin‐Yan Hu, Xiu‐Yu Shi, Wen He, Dan Sun, Baoguang Li, Xiaoming Liu, Sanqing Xu, Lijun Du, Chunhui Tang, Li‐Ping Zou

“…Of 106 patients who completed the 1–3‐year follow‐up, 33 experienced progression to DS. …”
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Percepción del funcionamiento familiar por adultos mayores dependientes del alcohol en comunidades terapéuticas internacionales de Holguín by Jorge Manuel Ruiz Diego, Margarita Rodríguez Diéguez, Marcia Ávila Oliva, Liset Rodríguez Martinez, Walter Ricardo Medina

“…The sample comprised 25 patients with the appropriate characteristics to be included in the study. The perception test on family functioning and a deep interview were applied. …”
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CMV Retinitis in the Context of SARS-CoV-2 Infection: A Case Study and Comprehensive Review of Viral Interactions by Emil Robert Stoicescu, Laura Andreea Ghenciu, Roxana Iacob, Adina Iuliana Ardelean, Ecaterina Dăescu, Ovidiu Alin Hațegan, Diana Manolescu, Emanuela Tudorache, Casiana Boru, Mirabela Dima

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Enhancing the effects of nusinersen with cybernic treatment using Hybrid Assistive Limb (HAL) in spinal muscular atrophy: a real-world case series and exploratory cohort analysis by Takashi Nakajima, Toshio Saito, Akihiro Hashiguchi, Taiki Nakabayashi, Kazuki Kodera, Kota Utsumi, Takeshi Kanayama, Haruka Urabe, Satoru Kinoshita

“…Functional improvement indicators included the Hammersmith Functional Motor Scale-Expanded (HFMSE) and Revised Upper Limb Module (RULM) scores, and the 2-minute walk test (2MWT), measured 15 months post-nusinersen initiation. …”
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Probiotic Potential of <i>Pediococcus pentosaceus</i> M6 Isolated from Equines and Its Alleviating Effect on DSS-Induced Colitis in Mice by Jialong Cao, Jianqiang Zhang, Hui Wu, Yanan Lin, Xinlan Fang, Siqin Yun, Ming Du, Shaofeng Su, Yuanyi Liu, Na Wang, Tugeqin Bao, Dongyi Bai, Yiping Zhao

“…With the issuance of antibiotic bans, there is an urgent need for healthier and more effective alternatives. In recent years, probiotics have been widely used as microbial feed additives in animal husbandry, playing a crucial role in preventing and treating diarrhea and regulating host immune function. …”
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Causes and MEchanisms foR non-atopic Asthma in Children (CAMERA) study: rationale and protocol by Mary Njoroge, Gabriela Pimentel Pinheiro, Cinthia Vila Nova Santana, Hajar Ali, Stephanie Hobbs, Santiago Mena-Bucheli, Natalia Romero-Sandoval, Steven Robertson, Charlotte E. Rutter, Donna Davoren, Collin Brooks, Jeroen Douwes, Philip J. Cooper, Harriet Mpairwe, Camila A. Figueiredo, Alvaro A. Cruz, Mauricio L. Barreto, Neil Pearce, Lucy Pembrey, the CAMERA study group

“…Methods In each of the four centres, the CAMERA study will enroll 160 participants aged 10–28 years, equally distributed among atopic asthmatics (AA), non-atopic asthmatics (NAA), atopic non-asthmatics and non-atopic non-asthmatics. …”
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New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman by P. A. Gervas, A. Yu. Molokov, A. A. Zarubin, A. A. Ponomareva, N. N. Babyshkina, V. A. Belyavskaya, L. F. Pisareva, E. L. Choynzonov, N. V. Cherdyntseva

“…In this study, we report a 44-year-old tuvinian woman with a family history of breast cancer. …”
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Opposition-based learning techniques in metaheuristics: classification, comparison, and convergence analysis by Rihab Lakbichi, Farouq Zitouni, Saad Harous, Aridj Ferhat, Abdelhadi Limane, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…In recent years, opposition-based learning (OBL) has emerged as a powerful enhancement strategy in metaheuristic algorithms (MAs), gaining significant attention for its potential to accelerate convergence and improve solution quality. …”
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Digital mindfulness-based intervention for people with COPD – a multicentre pilot and feasibility RCT by Hannah Tschenett, Florian Vafai-Tabrizi, Ralf Harun Zwick, Arschang Valipour, Georg-Christian Funk, Urs M. Nater

“…Secondary outcomes included its preliminary effects on the COPD Assessment Test (CAT), Chronic Respiratory Disease Questionnaire (CRQ-SAS), Perceived Stress Scale (PSS-10), and biological stress markers. …”
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New generation of monofocal intraocular lens for cataract surgery in comorbid conditions by A. V. Tereshchenko, I. G. Trifanenkova, Yu. E. Prokofiev, A. M. Ivanov, M. V. Okuneva

“…All patients with the IOL Monofocal+ expressed their satisfaction with the vision they received, which was reflected in the results of the VF test-14 QOL questionnaire.Conclusion. New generation monofocal IOLs showed good functional results in patients with cataracts and the considered comorbid pathology of the eye: primary open-angle glaucoma II a, intermediate stage of the dry form of age-related macular degeneration, non-proliferative diabetic retinopathy. …”
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Quantification of liver fat fraction using T1-weighted mDixon MRI in young patients with ataxia telangiectasia undergoing whole-body MRI: an exploratory study by Soma Kumasaka, Rafal Panek, Renata Neves, Mohnish Suri, Sumit Jagani, Yuka Kumasaka, Yoshito Tsushima, Robert A. Dineen

“…Associations between T1-FF and age, neurological severity and of liver function tests were tested with Spearman correlation. …”
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Principles of effective out-patient diagnostics of diffuse liver diseases by Komova A. G., M. V. Mayevskaya, V. T. Ivashkin

“…To study prevalence of diffuse liver diseases in the Russian Federation by the example of large industrial city with application of screening tests. Material and methods. Overall 5000 Moscow inhabitants age 18 to 75 years, chosen randomly within the «the liver check up» project, have been included in prospective population study. …”
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Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with plasma from Plasmodium falciparum endemic areas of Africa. by Saidou Balam, Kazutoyo Miura, Imen Ayadi, Drissa Konaté, Nathan C Incandela, Valentina Agnolon, Merepen A Guindo, Seidina A S Diakité, Sope Olugbile, Issa Nebie, Sonia M Herrera, Carole Long, Andrey V Kajava, Mahamadou Diakité, Giampietro Corradin, Socrates Herrera, Myriam Arevalo Herrera

“…<h4>Methods</h4>rPvs48/45 was produced in Chinese hamster ovary cell lines and tested by ELISA for cross-reactivity with plasma from Burkina Faso, Tanzania, Mali, and Nigeria. …”
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Transcranial Doppler sonography follow-up study in mild vascular cognitive impairment. by Mariagiovanna Cantone, Manuela Pennisi, Giuseppe Lanza, Raffaele Ferri, Francesco Fisicaro, Francesco Cappellani, Emanuele David, Vito Nicosia, Klizia Cortese, Giovanni Pennisi, Valentina Puglisi, Rita Bella

“…<h4>Methods</h4>From the original cohort of 161 patients, 127 with VCI (mean age 73.6 ± 7.1; 67 males) were re-evaluated after 5.0 ± 1.8 years. Namely, the Montreal Cognitive Assessment (MoCA), the 17-items Hamilton Depression Rating Scale (HDRS), and the Stroop Color-Word Interference Test (StroopT) were administered to screen for global cognitive status, to quantify depressive symptoms, and to explore executive functions, respectively. …”
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Patterns and Associated Factors of Congenital Anomalies Among Neonates in 14 Yemeni Governorates 2021–2023: A Case: Control Study by Hiam Al-Atnah, Anas Al-Qubati, Amir Addin Al-Hashedi, Muath Al-Saidy, Saleh Al-Shawish, Moamer M. Badi, Najeeb Al-Qubati, Yasser Ghaleb, Maha Al-Muntaser

“…Background: Long-term disability and a reduced quality of life are often associated with congenital anomalies (CAs), which present as structural, functional, or metabolic defects. This study provides a comprehensive view of neonatal congenital anomalies in 14 Yemeni governorates, a significant but often overlooked public health concern. …”
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Biochemical algorithms of early diagnostic of metabolic remodeling and cardiac hypertrophy in patients with diabetic mellitus and chronic heart failure cause by ischemic heart dise... by O. P. Donetskaya, N. V. Shuldeshova, V. A. Tulupova, G. V. Sukoyan

“…The aims of study – a development of biochemical algorithms of early diagnostic of severity of CHF in patients with DM and IHD and analyze interrelationships between plasma redox-potential, as a marker of progressive of tissues metabolic remodeling and cardiac hypertrophy and markers of progressive of DM, neurohumoral markers of severity of CHF, and frequency of heart rhythm disturbances.Materials and methods. 172 patients, male / female (45–65 years), with diagnosis of DM (metabolic decompensation of carbohydrate metabolism, HbА1c – 7.4 ± 1.9 %) during 3–15 years, accompanied with IHD and symptoms of CHF I–IV NYHA functional class (FC). …”
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Exploring perceptions of dignity among older adults living in nursing homes: a qualitative study by Kejimu Sunzi, Hui Luo, Lina Yin, Yadi Li, Xin Zhou, Cheng Lei

“…Between June and December 2023, we conducted semi-structured interviews with 35 nursing-home residents in western China (aged 65–92 years; length of stay 1 to &gt; 7 years). Purposive maximum-variation sampling captured diversity in age, gender, functional status, and socioeconomic background. …”
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