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  1. 761

    Analysis of prenatal diagnosis and pregnancy outcomes for rare autosomal trisomies detected by non-invasive prenatal testing in 33,079 cases by Xu Yan, Kai Ding, Xin Zhang, Shuai Zhang, Haiying Peng, Ying Zhang

    Published 2025-02-01
    “…Of these 60 valid outcomes, 50 (83.33%) resulted in full-term births, while 10 (16.67%) experienced adverse pregnancy outcomes. …”
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  2. 762

    LLM-based collaborative programming: impact on students’ computational thinking and self-efficacy by Yi-Miao Yan, Chuang-Qi Chen, Yang-Bang Hu, Xin-Dong Ye

    Published 2025-02-01
    “…To explore the effectiveness of integrating LLMs into collaborative programming, we conducted a quasi-experiment involving 82 sixth- and seventh-grade students, who were randomly assigned to either an experimental group or a control group. …”
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  3. 763
  4. 764

    Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study by Ruicong Ma, Jinyi Ren, Xianmei Chen, Xia Li, Ying Zhao, Yanchun Ding

    Published 2025-02-01
    “…In the logistic regression model, PIV was positively related to CHD [Q4 vs. Q1, OR = 1.23 (1.03–1.48, P < 0.001)]. Restricted cubic spline indicated a positive non-linear relationship (P for overall <0.001, P for non-linear = 0.009). …”
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  8. 768

    Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort stud... by Xin Liu, Kaihua Zhao, Ziyan Zhang, Meiyan Liu, Hongwu Chu, Xiao Zou

    Published 2024-12-01
    “…HER2-low status was validated as an independent low-risk factor for RFS both pre-PSM (HR 0.354, 95% CI 0.178–0.706, p = 0.003) and post-PSM (HR 0.405, 95% CI 0.1850.886, p = 0.024). …”
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  9. 769
  10. 770

    The protective role of carotenoids in chronic obstructive pulmonary disease: A systematic review and Meta-analysis of observational studies by Jing Sui, Wenbin Shen, Yanni Zhang, Jiarui Liang, Hui Xia, Guiju Sun

    Published 2025-02-01
    “…The odds ratio (OR) between carotenoids consumption and COPD risk was 0.69 (95 % CI: 0.59–0.80, p < 0.001), which indicates a significant protective effect. …”
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  11. 771

    Evaluation of enzymatic hydrolysis of palm kernel meal in largemouth bass (Micropterus salmoides) by Tao Ding, Hao Wang, Xiaofang Liang, Jie Yang, Yaping Zhu, Min Xue

    Published 2025-04-01
    “…The control diet, labeled as SBM, was formulated to contain approximately 46 % crude protein and 13 % crude lipids. Experimental diets substituted 5 % soybean meal and 3 % wheat flour with 5 % palm kernel meal or enzymatic hydrolysis of palm kernel meal, and 3 % cotton protein concentrate (CPC) labeled as PKM and EPKM. …”
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  12. 772
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  16. 776

    Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases by Wei Guo, Bolun Zhou, Lizhou Dou, Lei Guo, Yong Li, Jianjun Qin, Zhen Wang, Qilin Huai, Xuemin Xue, Yin Li, Jianming Ying, Qi Xue, Shugeng Gao, Jie He

    Published 2025-01-01
    “…Furthermore, stromal cells in the tumor microenvironment, including MMP3+IL24+ fibroblasts, APLN+ endothelial cells, and CXCL12+ pericytes, were implicated in ESCC metastasis through angiogenesis, collagen production, and inflammatory responses. Exhausted CD8+ T cells in a cycling status were notably prevalent in metastatic lymph nodes, indicating their potential role in facilitating metastasis. …”
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  17. 777

    NOS2 as a prognostic biomarker for early-onset colorectal cancer based on public data and clinical validation analysis by Chaoqun Xing, Lipeng Zhao, Weiwei Zou, Xie Peng, Xiao-Liang Xing, Jie Li

    Published 2025-02-01
    “…Sensitivity analysis of chemotherapy drugs showed that NOS2 was significantly correlated with several chemotherapy drugs, such as MG.132_1862, BMS.754807_2171, and GEN.317_1926. Clinical validation analysis showed that the expression of NOS2 and its related genes CXCL1 and CXCL2 were significantly decreased in EOCRC patients. …”
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    Central Nervous System-related Conditions and Associated Healthcare Resource Use Among Japanese nmCRPC Patients Based on Retrospective Claims Data by Dianne A. Ledesma, Jonathan L. Chua, Susan S.H. Tang, Xiu W. Lim

    Published 2023-10-01
    “…**Results:** A total of 455 patients (average age, 78.5 years), were included. The 3 most common concomitant CNS-related conditions were pain (~60% of events), insomnia (~30%), and headache (2%-3%). …”
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