Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy by Noor Rizvi, Eliseos J. Mucaki, Emily L. Salmini, Monica Zhang, Sabina Trebinjac, Ezra Hahn, Lawrence Paszat, Sharon Nofech-Mozes, Michael T. Hallett, Eileen Rakovitch, Vanessa Dumeaux

“…Conclusions While TP53, PIK3CA, and recurrent copy number alterations represent early events in tumorigenesis, they lack prognostic value in pure DCIS, underscoring the need for alternative biomarkers. …”
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Long-term conservation tillage breaks the plough pan and promotes the development of preferential flow by Jinze Han, Jianye Li, Qiang Chen, Xingyi Zhang

“…Path analysis further confirmed CT governed preferential flow patterns through macroporosity enhancement and pore tortuosity reduction (p < 0.001). …”
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Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT by CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson

“…The initial published protocol omitted to mention death due to peptic ulcer bleeding, noted while planning the statistical analysis after the trial had finished, but before the code was broken. …”
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Ecological drivers of nesting behavior in a subtropical city: An observational study on spotted doves by Yao Sheng, Mengjie Lu, Junpeng Bai, Xiaobin Xie, Long Ma, Wanyou Li, Zhen Zhang, Fang Ming, Xueli Zhang, Ziwei Zhang, Zhifeng Xu, Yuqing Han, Bicai Guan, Luzhang Ruan

“…In conclusion, a nest structure with good permeability is the material basis for the nest reuse in spotted dove, while the relatively low risk of predation in urban habitat and the scarcity of nest site resources due to urbanization increase the tendency of birds to reuse old nests, which is associated with their reproductive success and evolutionary fitness.…”
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A comparative study of anxiety symptoms in Chinese and Rwandan adolescents: a cross-cultural measurement invariance study of the GAD-7 scale by Lisa Cynthia Niwenahisemo, Lisa Cynthia Niwenahisemo, Qi Zhang, Qi Zhang, Wo Wang, Wo Wang, Dan-dan Geng, Dan-dan Geng, He-yan Xu, He-yan Xu, Jin-hui Hu, Jin-hui Hu, Ling-li Ma, Ling-li Ma, Jian-yu Tan, Jian-yu Tan, Yi-ting Kong, Yi-ting Kong, Su Hong, Su Hong, Li Kuang, Li Kuang

“…However, partial scalar invariance suggests that while the GAD-7 effectively detects anxiety symptoms, the severity of reported symptoms may not be directly comparable across cultures due to response patterns and possible linguistic factors. …”
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Probabilistic seasonal dengue forecasting in Vietnam: A modelling study using superensembles. by Felipe J Colón-González, Leonardo Soares Bastos, Barbara Hofmann, Alison Hopkin, Quillon Harpham, Tom Crocker, Rosanna Amato, Iacopo Ferrario, Francesca Moschini, Samuel James, Sajni Malde, Eleanor Ainscoe, Vu Sinh Nam, Dang Quang Tan, Nguyen Duc Khoa, Mark Harrison, Gina Tsarouchi, Darren Lumbroso, Oliver J Brady, Rachel Lowe

“…As a climate-sensitive disease, environmental conditions and past patterns of dengue can be used to make predictions about future outbreak risk. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…We need to move onto ensuring services fit around people rather than trying to fit people into services that can’t meet their needs.’ …”
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Silent Revolution in Research for Sustainability by Bruce Alder

“…<p>Is research ‘fit-for-purpose’ for realizing sustainable development? …”
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Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration by Macsue Jacques, Shanie Landen, Adam P. Sharples, Andrew Garnham, Ralf Schittenhelm, Joel Steele, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, James Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekström, Olof Asplund, Séverine Lamon, Sarah E. Alexander, Cassandra Smith, Carlie Bauer, Mary N. Woessner, Itamar Levinger, Andrew E. Teschendorff, Linn Gillberg, Ida Blom, Jørn Wulff Helge, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Atul S. Deshmukh, Kirsi H. Pietiläinen, Päivi Piirilä, Robert A.E. Seaborne, Marie Klevjer, Anja Bye, Ulrik Wisløff, Bernadette Jones-Freeman, Nir Eynon

“…Minimal sex differences were observed, while modality-specific analysis highlighted distinct pathways for aerobic and resistance exercise, contrasting with muscle disuse patterns. …”
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Influence of Playing Position on the Match Running Performance of Elite U19 Soccer Players in a 1-4-3-3 System by Yiannis Michailidis, Andreas Stafylidis, Lazaros Vardakis, Angelos E. Kyranoudis, Vasilios Mittas, Vasileios Bilis, Athanasios Mandroukas, Ioannis Metaxas, Thomas I. Metaxas

“…This information should be utilized by fitness coaches to tailor physical loads based on playing position. …”
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Sex differences in the impact of social determinants of health on substance use disorder treatment outcomes by C. Leonardo Jimenez Chavez, MacKenzie R. Peltier, Sherry A. McKee

“…Results Both SDOH and clinical severity indicators were significantly associated with poorer treatment outcomes, with distinct patterns by sex. Women showed more consistent risk for poor treatment outcomes across predictors, including unemployment, psychiatric comorbidities, and polysubstance use, while lack of prior treatment history was the strongest predictor of substance use at discharge and dropout for men. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…It is likely that there is no one size fits all and that support for those with additional social and care needs may need to be able to respond flexibly to bespoke and complex life situations. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…EFA supported a two-factor model as providing the best fit [χ2/degrees of freedom (df) = 1.7, root-mean-square error of approximation (RMSEA) = 0.053, Comparative Fit Index (CFI) = 0.91] compared to a one- or three-factor model. …”
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Characteristics of patients prescribed SGLT-2i and/or GLP-1RA among cardiology clinics in the US: insights from the COORDINATE-diabetes trial by Adam J Nelson, Lisa A. Kaltenbach, Hussein R. Al-Khalidi, Monica Leyva, Laura Webb, Darren K. McGuire, Rodica Pop-Busui, Matthew A Cavender, Vanita R. Aroda, Melissa L. Magwire, Caroline R. Richardson, Ildiko Lingvay, Julienne K. Kirk, Ambarish Pandey, Tanya Gaynor, Jonathan Pak, Alana Washington, Cagri Senyucel, Renato D. Lopes, Jennifer B. Green, Christopher B. Granger, Neha J Pagidipati

“…Understanding the prescribing patterns of these agents by cardiologists may aid in implementation efforts. …”
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Exploring voluntary sector specialist services for victim-survivors of sexual violence in England: the PROSPER co-production study by Caroline Bradbury-Jones, Sarah Damery, Kirsten Fruin, Clare Gunby, Jenny Harlock, Lucy Hebberts, Louise Isham, Anne-Marie Jones, Fay Maxted, Amelia Mighty, Priti Parmar, Laura Patterson, Jason Schaub, Fee Scott, Harriet Smailes, Debs Smith, Julie Taylor

“…Investigate referral patterns and pathways, and how voluntary sector specialist services fit with each other and link to the wider network of services for victim-survivors. …”
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Intelligent Environmental Health Risk Assessment System for the Elderly in Cold Regions Based on Artificial Intelligence Integrated Development Environment by Tianheng ZHANG, Yao FU, Jian GAO, Huanran XUE

“…The research addresses the unique challenges faced by the elderly in cold regions, where prolonged low temperatures significantly impact cardiovascular health and outdoor activity patterns, creating special health management challenges for this vulnerable population. …”
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Designing an educational model based on identity development with an Iranian-Islamic approach for primary school students. by Ali Oladhamzehzadeh, masoumeh oladiyan, Mahmoud Safari

“…Islam has made the base of nature as the basis of its identity for humans; in the sense that man defines his identity in harmony with what is naturally entrusted to him; in Islam, according to the principle of nature, a human being is born in the beginning, while he actually has no understanding, no imagination, no recognition, and no human tendency; at the same time, he comes into the world with existential dimensions in addition to animal dimensions, which are the basis of second understanding. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Comparing agreement in the data, we found sources agreed on ‘non-use’, but suitable informant over- and under-reporting of ‘use’ compared with hospital records did not follow a consistent pattern. Comparing SIR ‘hospital use’ over the 3-month periods pre-baseline and pre-6-month follow-up were identical at both assessments. …”
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Presenting a model for the establishment and maintenance of expert human resources in the government organizations of Sistan and Baluchestan province by Majid Reza Dahmardeh, Vahid pourshahabi, Amin Reza Kamalian, Habibollah Salaerzehi

“…All these coefficients are higher than 0.7 and show the reliability of the measurement tool.Divergent validity is a measure of the fit of measurement patterns and is checked through the HTMT coefficient. …”
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