Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized tri... by Liudmila I. Alekseeva, Natalia G. Kashevarova, Elena A. Taskina, Ekaterina A. Strebkova, Tatiana A. Korotkova, Evgenia P. Sharapova, Natalya M. Savushkina, Aleksander M. Lila, Nadezhda A. Shostak, Irina I. Nesterovich, Viktoriia A. Dedkova, Vasiliy B. Vasilyuk, Natalia V. Egorova, Marina A. Leontyeva, Svetlana P. Yakupova, Irina B. Vinogradova, Valentina N. Sorotskaya, Larisa I. Shirokova, Alla V. Rudakova

“…Current strategies for treating osteoarthritis (OA) are based on a multimodal approach that includes pharmacological and non-pharmacological methods. Undenatured chicken collagen type II (NK2) is considered safe and effective for maintaining joint health and can be used alone and combined with drugs for OA treatment. …”
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Management of choroidal/ciliary body metastasis in the era of targeted cancer therapy by Moses O. Evbuomwan, Rupak Bhuyan, Uwajachukwumma A. Uzomah, Farzad Jamshidi, Carryn Anderson, H. Culver Boldt, H. Culver Boldt, Elaine Binkley, Elaine Binkley

“…The difference between final visual acuity in these groups was not visually significant p=0.48.ConclusionPatients with choroidal/ciliary body metastasis treated with either EBR or systemic therapy can have good visual outcomes. …”
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Fundus Autofluorescence and Optical Coherence Tomography Characteristics in Different Stages of Central Serous Chorioretinopathy by Mary Ho, Stephanie H. W. Kwok, Andrew C. Y. Mak, Frank H. P. Lai, Danny S. C. Ng, Li Jia Chen, Lawrence P. Iu, Alvin L. Young, Marten Brelen

“…Photoreceptor layer (IS/OS) height acts as a good and objective predictor of visual outcomes in CSC patients.…”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…The outcomes of those potential risk factors were visualized by different statistical analyses.Results: In total, 3871 hF patients were enrolled. …”
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Facing depression: evaluating the efficacy of the EmpkinS-EKSpression reappraisal training augmented with facial expressions – protocol of a randomized controlled trial by Marie Keinert, Lena Schindler-Gmelch, Lydia Helene Rupp, Misha Sadeghi, Klara Capito, Malin Hager, Farnaz Rahimi, Robert Richer, Bernhard Egger, Bjoern M. Eskofier, Matthias Berking

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Cinical, morphological and functional comparisons in acute period of ischemic hemispheric stroke by A. A. Kuznetsov

“…Statistical analysis was made with program Statistica 6.0 with the use of nonparametric methods (Mann-Whitney criterion), correlation analysis (Spearman’s rank correlation coefficient). …”
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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…Searching for new treatment methods and regimens for OA is relevant.Objective: to evaluate the efficiency and safety of therapy with a symptomatic sustained-release drug (Alflutop) in combination with intra-articular hyaluronic acid (HA) injection versus monotherapy with HA in patients with knee OA in routine clinical practice.Patients and methods. …”
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Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications by Mikkel Schou Andersen, Aaraby Yoheswaran Nielsen, Martin Wirenfeldt, Jeanette Krogh Petersen, Morten Winkler Møller, Christopher L. Powell, Anavaleria Castro, Grayson Herrgott, Tiit Mathiesen, Charlotte Aaberg Poulsen, Birgitte Brinkmann Olsen, Henning Bünsow Boldt, Christian Bonde Pedersen, Bo Halle, Frantz Rom Poulsen

“…All 3D models had similar copy number variation profiles, visually. Genome-wide DNA methylation level patterns were similar between pairs of 3D models and primary tumors. …”
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Comparison of clinical efficacy between da Vinci® robotic surgery and laparoscopic surgery for rectal cancer: a report of 550 cases by Zhang Cheng, Ma Rui, Duan Fuxiao, Gao Guangrong, Li Da

“…There are no significant differences in other perioperative outcomes and long-term survival, indicating that both methods are safe and effective.…”
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Epidemiological Characteristics and Trends in the Incidence of Newly Diagnosed Pulmonary Tuberculosis in China from 2016 to 2022 by Caihong Xu, Yaxin Wen, Dongmei Hu, Yuhong Li, Yanlin Zhao

“…Descriptive epidemiological methods were used to analyze the population distribution, and temporal and spatial distribution (also known as the three-dimensional distribution in epidemiology). …”
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Prognostic value of tumor-infiltrating T-lymphocytes density in the therapeutic response to initial platinum-based chemotherapy in patients with non-small cell lung cancer by Novaković-Lacković Lora, Latinović-Tadić Ljilja, Stanetić Mirko, Lacković Marko

“…To assess the density of CD4+ and CD8+ T-lymphocytes, the number of lymphocytes was determined at ×200 magnification (1.1 mm2). Three visual fields with the densest lymphocyte infiltrate were selected for counting, and the values of all individual fields were added up. …”
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Overloaded Vertebral Body Following Consecutive Three‐Level Hybrid Surgery Comparing with Anterior Cervical Discectomy and Fusion by Shi‐hao Chen, Ya‐ling Li, Hao Liu, Ting‐kui Wu, Kang‐kang Huang, Ming‐he Yao, Bei‐yu Wang

“…Clinical outcomes were evaluated using visual analog scale (VAS) scores for neck and arm pain, Japanese Orthopedic Association (JOA) scores, and neck disability index (NDI) scores. …”
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Clinical Characteristics, Risk Factors, and Predictors of Nonobese Fatty Liver Disease: A Cross-Sectional Study by Zhang X, Wang S, Xu S, Min R, Ling Y, Sun S, Gong R

“…Correlation between non-obese fatty liver and high blood lipids, hypertension, hyperuricemia, diabetes, thyroid dysfunction were analyzed using the Pearson and Spearman methods. ROC curve was used to evaluate the diagnostic effect of the indicator.Results: Compared with the normal group, age, proportion of males, ALT, AST, GGT, ALP, TG, TC, BUN, Cr, UA, TSHI, TT4RI, FT3/FT4, TSH, FT3, FBG, SBP, DBP and BMI in the disease group were significantly higher. …”
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Machine Learning–Based Prediction of Early Complications Following Surgery for Intestinal Obstruction: Multicenter Retrospective Study by Pinjie Huang, Jirong Yang, Dizhou Zhao, Taojia Ran, Yuheng Luo, Dong Yang, Xueqin Zheng, Shaoli Zhou, Chaojin Chen

“…Overall, 7 machine learning methods were used to establish prediction models, with their performance appraised via the area under the receiver operating characteristic curve (AUROC), accuracy, sensitivity, specificity, and F1-score. …”
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A Novel Unilateral Bi/Multi‐Portal Endoscopic Transforaminal Interbody Fusion Utilizing Uniaxial Spinal Endoscope Instead of Arthroscope: Technical Note and Preliminary Clinical Re... by Liyu Yang, Long Zhou, Min Qiu, Feng Liang, Liqing Yang, Qin Fu, Gen Ba

“…Based on the previous findings, we utilized uniaxial spinal endoscopy as the primary operating method, with the assistance of multi‐portal endoscopic techniques (UME‐TLIF), to perform transforaminal lumbar interbody fusion. …”
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A Mobile App (Joint Effort) to Support Cannabis Use Self-Management and Reinforce the Use of Protective Behavioral Strategies: Development Process and Usability Testing by José Côté, Patricia Auger, Gabrielle Chicoine, Jinghui Cheng, Sylvie Cossette, Guillaume Fontaine, Christine Genest, Shalini Lal, Judith Lapierre, M Gabrielle Pagé, Marc-André Maheu-Cadotte, Geneviève Rouleau, Billy Vinette, Didier Jutras-Aswad

“…ObjectiveThis study aims to describe the development process and usability testing of Joint Effort, a CU self-management mobile app prototype centered on promoting the use of PBSs among young adults with any past 30-day CU. MethodsIntervention mapping (IM) and a co-design approach were used. …”
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Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections by Hao Xing, Junlin Pan, Huan Liu, Yanan Wang, Zhengqi Chang

“…ObjectiveThis study aims to investigate the mechanism by which Negative Pressure Wound Therapy (NPWT) regulates local immune responses in spinal infection through Piezo1-mediated mechanical stress, and elucidate its potential role in the treatment of spinal infections.MethodsFrom July 2021 to April 2022, a total of 7 patients with spinal infection treated with NPWT at our department were included in the study. …”
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Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring by Bing Li, Yong Wang, Charles R. Owens, Touka Banaee, Charleen T. Chu, Kayvon Jabbari, Anna D. Lee, Neil J. Khatter, Alan G. Palestine, An-Jey A. Su, Christene A. Huang, Kia M. Washington

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ECG‐based epileptic seizure prediction: Challenges of current data‐driven models by Sotirios Kalousios, Jens Müller, Hongliu Yang, Matthias Eberlein, Ortrud Uckermann, Gabriele Schackert, Witold H. Polanski, Georg Leonhardt

“…Abstract Objective Up to a third of patients with epilepsy fail to achieve satisfactory seizure control. A reliable method of predicting seizures would alleviate psychological and physical impact. …”
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Sociodemographic and Socioeconomic Determinants for the Usage of Digital Patient Portals in Hospitals: Systematic Review and Meta-Analysis on the Digital Divide by Nina Goldberg, Christin Herrmann, Paola Di Gion, Volker Hautsch, Klara Hefter, Georg Langebartels, Holger Pfaff, Lena Ansmann, Ute Karbach, Florian Wurster

“…Data on sociodemographic and socioeconomic factors and statistical outcomes were extracted, and study quality was assessed using the Mixed Methods Appraisal tool. Results were visualized using forest and funnel plots to assess heterogeneity and publication bias. …”
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