Challenges in developing a digital pathology consultation network: insights from the MELCAYA experience by Dario Di Gangi, Roberta Gugliotta, Filippo Ugolini, Anna Szumera-Ciećkiewicz, Llucia Alos, Natalia Castrejón, Stephan Forchhammer, Barbara Valeri, Nicolas Macagno, Sule Ozturk Sari, Ozge Hurdogan, Sokol Sina, Sylvie Fraitag, Valerio Gaetano Vellone, Chiara Trambaiolo, Rita Alaggio, Sabrina Rossi, Giovanni Arcuri, Daniela Massi, Claudio Conti

“…Results: A total of 144 WSIs (46.3 %) exhibited technical defects, classified as critical, major, or minor based on their impact on WSI quality and visualization. Of these, 101 (70.1 %) showed analytical defects, while the remaining 43 (29.9 %) presented pre-analytical issues. …”
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Co-Designing a Web-Based and Tablet App to Evaluate Clinical Outcomes of Early Psychosis Service Users in a Learning Health Care Network: User-Centered Design Workshop and Pilot St... by Kathleen E Burch, Valerie L Tryon, Katherine M Pierce, Laura M Tully, Sabrina Ereshefsky, Mark Savill, Leigh Smith, Adam B Wilcox, Christopher Komei Hakusui, Viviana E Padilla, Amanda P McNamara, Merissa Kado-Walton, Andrew J Padovani, Chelyah Miller, Madison J Miles, Nitasha Sharma, Khanh Linh H Nguyen, Yi Zhang, Tara A Niendam

“…MethodsOur UCD approach included incorporation of user feedback, prototyping, iterative design, and continuous evaluation. …”
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Radiolabeling and Preliminary In Vivo Evaluation of the Candidate CCR2 Targeting PET Radioligand [¹¹C]AZD2423 by Kenneth Dahl, Peter Johnström, Miklós Tóth, Martin Bolin, Katarina Varnäs, Ryuji Nakao, Akihiro Takano, Yasir Khani Meynaq, Malken Bayrakdarian, Zsolt Cselényi, Christer Halldin, Lars Farde, Magnus Schou

“…The aims of the current positron emission tomography (PET) study were as follows: (i) to develop an efficient synthetic method for labeling AZD2423 with carbon-11 (¹¹C, t_1/2 = 20.4 min) and (ii) to evaluate its potential to visualize CCR2 binding in the non-human primate (NHP) brain. …”
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Hyperspectral imaging-driven deep learning approach: Asymptomatic stage detection and severity grading of tomato yellow leaf curl disease by Junzhi Chen, Wenshan Zhong, Xuejun Yue, Ziyu Ding, Mengdan Du, Xuantian Li, Biao Chen, Haifeng Li, ZiFu He, Xiaoman She, Yafei Tang

“…The prolonged asymptomatic infection period and non-distinct early symptoms of TYLCD impose limitations on traditional detection methods, whereas hyperspectral imaging technology, capable of capturing rich spectral and spatial features, provides a technical foundation for early lesion identification and dynamic disease progression monitoring. …”
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Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker by Yankun Chen, Junzhi Liu, Yubin Jia, Jiaxing Yang, Yan Jin, Yun Liu, Benfu Zhong, Qiang Zhao

“…Utilizing a single-cell dataset of neuroblastoma samples, cells were categorized and labeled based on UMAP analysis. Feature map visualization was employed to display the expression level and allocation of specific genes across various cell populations. …”
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Comparison of endoscopic and microscopic microvascular decompression for treating primary trigeminal neuralgia by Lei Li, Lei Li, Dongqi Shao, Xialin Zheng, Yuanbo Pan, Tao Sun, Huadong Tang, Hongjie Zhai, Xiaohui Dong, Jing Sun, Mengtian Fang, Feiyun Lou, Zhiquan Jiang, Zhiquan Jiang

“…ObjectiveTo compare the intraoperative outcome and postoperative efficacy of endoscopic and microscopic microvascular decompression (MVD) under neuroelectrophysiological monitoring in the treatment of primary trigeminal neuralgia (PTN).MethodsThis retrospective study included 131 patients with PTN who were admitted to our hospital between January 2019 and October 2022. …”
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Antitumor effect of a new human epidermal growth factor receptor inhibitor by O. I. Kit, I. P. Kodonidi, E. M. Frantsiyants, I. V. Kaplieva, A. A. Glushko, L. K. Trepitaki, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, I. V. Neskubina, O. V. Bykadorova, E. V. Serdyukova

“…The dynamics of animal weight, dynamics of tumor node volume were evaluated, the tumor growth inhibition index (TGII) was calculated.Results. Tumor visualization time and animal weight did not statistically significantly differ between the groups during the whole study. …”
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A novel three-dimensional navigation technology for ultrasound-guided transcarotid artery revascularization by William R. Warner, MEM, Kirthi S. Bellamkonda, MD, MSc, Richard J. Powell, MD, Roberta M. diFlorio-Alexander, MD, MS, Keith D. Paulsen, PhD, Xiaoyao Fan, PhD

“…In this study, an innovative fluoroscopy-sparing technique was evaluated to guide stent placement precisely in the carotid artery using real-time navigated ultrasound (US) fused with preoperative computed tomography (CT) imaging. Methods: The endovascular navigation approach combined a clinical US unit and optical tracking system to visualize and localize two-dimensional ultrasound images in three-dimensional (3D) space. …”
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The Role of the Educational Programs in the Improving of Confidence in Vaccination against Pneumococcal Infection among Population by N I Briko, V A Korshunov, A Ya Mindlina, R V Polibin, A V Shamis, A G Saltykova

“…Statistical processing was performed using IBM SPSS Statistics v.20.0, data visualization – Microsoft Excel 2016. Results. The proportion of students who have a positive attitude towards vaccination increased by 16% – from 41.0±5.6% to 57.0±6.0%, p<0.05. …”
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Percutaneous Lapidus Procedure for the Management of Primary Hallux Valgus Deformity – A Retrospective Cohort Analysis by Alasdair John Henry Barrie MBChB MSc FRCS, James Ryeburn BSc, Alastair S.E. Younger MB ChB, ChM, FRCSC, Andrea Veljkovic MD, MPH, BComm, FRCSC, Kevin Wing MD, FRCSC, Murray J. Penner MD, FRCSC, Oliver Gagne MD, FRCSC

“…Our technique entails percutaneous preparation of the first tarsometatarsal joint using a Shannon burr for debridement, arthroscopy for visualization, and fixation with three full thread 4 mm non-variable pitch headless chamfered cannulated screws, preserving subchondral bone for stability. …”
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Distribution Patterns and Driving Factors of Highly Educated Talent in China from a Heterogeneity Perspective: An Examination Based on Prefectural Administrative Regions by Wu Rongwei, Wang Yuanxin, Zhang Qin, Zhou Liang

“…We employed the Gini coefficient and visualization methods to depict the spatiotemporal patterns of talent distribution at college, undergraduate, and graduate education levels in Chinese prefecture-level administrative regions. …”
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Application of augmented reality technology in the surgery of skull base tumor and cerebrovascular disease by GUO Yi⁃ding, ZHAO Ben⁃qi, ZHANG Pei⁃hai, LIU Yong, CHEN Gang, YANG Xue⁃jun, GUO Yi

“…Postoperatively symptoms such as eye pain, ptosis, and double visian were completely relieved and the mRS was 0 after 6 months. 3) Basilar artery apex aneurysm clipping: based on preoperative simulation, we opted for the orbito⁃zygomatic approach during surgery to provide full exposure of the aneurysm neck and direct visualization of the bilateral P1 segment of posterior cerebral artery (PCA), offering better safety compared to the subtemporal approach. …”
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Deep learning model for diagnosis of thyroid nodules with size less than 1 cm: A multicenter, retrospective study by Na Feng, Shanshan Zhao, Kai Wang, Peizhe Chen, Yunpeng Wang, Yuan Gao, Zhengping Wang, Yidan Lu, Chen Chen, Jincao Yao, Zhikai Lei, Dong Xu

“…Furthermore, feature heatmap visualization showed that TNT-Net could extract richer and more energetic malignant nodule patterns. …”
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Extended Trochanteric Osteotomy Increases the Risk of Tapered Splined Stem Subsidence in Revision Total Hip Arthroplasty by Josef E. Jolissaint, MD, Samuel Rodriguez, MD, Leonardo Albertini Sanchez, BA, Travis R. Weiner, BS, Elizabeth B. Gausden, MD, MPH, Jason L. Blevins, MD, Peter Sculco, MD, Jose Rodriguez, MD, FAOA

“…An extended trochanteric osteotomy is an excellent technique to gain direct visualization of the femoral canal. However, it is not without its associated morbidity and postoperative complications, specifically stem subsidence. …”
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Algorithm for the provision of comprehensive psychotherapeutic support to women experiencing neuropsychiatric symptoms during rehabilitation following the treatment of malignant ne... by D. V. Blinov, A. G. Solopova, E. E. Achkasov, E. S. Akarachkova, O. V. Kotova, S. A. Akavova, V. N. Galkin, G. K. Bykovshchenko, L. N. Sandzhieva, D. I. Korabelnikov, T. A. Blbulyan, D. A. Petrenko, A. Yu. Vlasina

“…Chronic pain syndrome, distress, anxiety and depression, decreased self-esteem, sexual dysfunction and social maladjustment reduce quality of life (QoL) and require psychotherapeutic support.Objective: to create an algorithm for the provision of comprehensive psychotherapeutic support during rehabilitation following the treatment of reproductive system MNs and to evaluate its effect on QoL indicators in women with neuropsychiatric disorders.Material and methods. The algorithm for the provision of comprehensive psychotherapeutic support included clinical interview, cognitive behavioral therapy, visualization, audio therapy, art therapy, group and individual psychotherapy, family psychotherapy, image therapy. …”
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Quantification of rehabilitation for patients with Parkinson’s disease and related disorders using wearable devices; a proof of concept by Hikaru Kamo, Hikaru Kamo, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Koichi Nagaki, Koichi Nagaki, Koichi Nagaki, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori

“…Each rehabilitation session was quantified and visualized using radar charts.DiscussionThis study offers insight into the quantification and visualization of rehabilitation effects in patients with progressive neurodegenerative diseases presenting with parkinsonism. …”
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A single-institution experience with intraoperative in vivo confocal laser endomicroscopy for brain tumors in 50 patients by Yuan Xu, Thomas J. On, Irakliy Abramov, Oscar Alcantar-Garibay, Joelle N. Hartke, Jennifer M. Eschbacher, Kivanc Yangi, Michael T. Lawton, Kris A. Smith, Randall W. Porter, Mark C. Preul

“…We evaluated the feasibility and diagnostic capability of the first clinically approved CLE system for intraoperative in vivo imaging of brain tumors.MethodsA total of 50 patients who were to undergo brain tumor surgery were prospectively enrolled. …”
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Efficacy and Safety of Biologics Targeting Type 2 Inflammation in COPD: A Systematic Review and Network Meta-Analysis by Li S, Yi B, Wang H, Xu X, Yu L

“…Following data extraction, we conducted a network meta-analysis using R software to indirectly compare the efficacy and safety profiles of the five included biologic agents, incorporating visualization of the analytical results.Results: In COPD patients with elevated eosinophil levels (peripheral blood eosinophil count ≥ 200 cells/μL), dupilumab demonstrated significant therapeutic efficacy by: (1) reducing the annualized rate of acute exacerbations (versus placebo: − 0.44; 95% CI − 0.77 to − 0.10), (2) decreasing SGRQ total scores (versus placebo: − 3.41; 95% CI − 6.00 to − 0.82), and (3) increasing pre-bronchodilator FEV1 (versus placebo: 0.06 L; 95% CI 0.00 to 0.12). …”
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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…The 2−∆∆Ct Livak and Schmittgen method was used to compare the expression of genes in treated and untreated samples. …”
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Comparative microbial metagenomic analysis of drinking water plants and wastewater treatment plants in Istanbul by Mehmet Demirci, Cankut Çubuk, Ferhat Dasdemir, Abdulkerim Suat Saribas, Esra Billur Balcıoglu, Dogukan Ozbey, Dogu Yorulmaz, Tugba Olmez Hanci, Safak Basa, Bekir Sami Kocazeybek, Bekir Sami Kocazeybek

“…Kraken2 tools and R scripts were used for statistical analysis and data visualization.ResultsThe microbial metagenomic analysis identified 71 phyla, 113 classes, 217 orders, 480 families, and 1,282 genera across all samples. …”
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