Synthesis and preliminary biological evaluation of a novel PET tracer for α-synuclein PET imaging by WANG Ce, PAN Donghui, TAN Siyi, WANG Lizhen, WANG Xinyu, YAN Junjie, CHEN Chongyang, XU Yuping, ZOU Lianghua

“…The development of PET tracers to visualize aggregated α-synuclein is useful for early diagnosis and treatment of PD.PurposeThis study aims to design and synthetize a novel PET tracer, i.e., 18F-YM, for for alpha-synuclein PET imaging, and conduct preliminary biological evaluation.MethodsFirstly, based on benzothiazole scaffolds, 2-((3-fluorobenzyl)thio)-6-(3-[fluorine-18] propoxy)benzo[d]thiazole, a small molecule compound, denoted as 18F-YM, was prepared as PET tracer and labeled using Cu(II) mediated radiofluorination methods. …”
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Survival of retinoblastoma patients: a cohort study by two Russian medical centers by S. V. Saakyan, O. A. Ivanova, S. S. Tadevosyan, A. Yu. Tsygankov, L. V. Olkhova, T. L. Ushakova, V. G. Polyakov

“…To evaluate the overall, disease-specific, event-free, relapse-free survival of retinoblastoma (RB) patients and cumulative probability of eye survival in such patients.Material and methods. The study included 223 children with RB (126 male, 97 female). …”
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Clinical Characteristics and Influencing Factors of Postoperative Pain in Patients Undergoing Gastric Endoscopic Submucosal Dissection by Fen Deng, Liru Pan, Lei Tao, Xiaoyu Qiu, Bing Li, Jing Hao, Huihui Li, Zhenzhen Zhang, Weiwei Ding, Yingying Wang, Bo Ning

“…Pain severity was assessed using a visual analogue scale, with a score ≥ 4 defined as postoperative pain. …”
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Clinical experience with the interleukin-1β blocker canakinumab in patients with chronic tophaceous gout: abolishment of arthritis and prevention of exacerbations when allopurinol... by M. S. Eliseev, O. V. Zhelyabina, M. V. Mukagova, E. L. Nasonov

“…The use of canakinumab in patients with severe gout, who are resistant to therapy with NSAIDs, colchicine, and GCs, is an effective method to treat arthritis and to prevent acute arthritis attacks during allopurinol therapy. …”
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Electroacupuncture Prevent and Treat Perioperative Cognitive Impairment in Elderly Patients Undergoing Hip Surgery: A Protocol for a Randomized Controlled Trial by Fang Q, Xie J, Zheng S, Hou Y, Wu M, Chen Y, Yang Y, Wang G, Li J

“…And the secondary outcome measures are the Confusion Assessment Method (CAM), Visual Analog Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), neuron-specific enolase (NSE), superoxide dismutase (SOD), central nervous system-specific protein (s100-β) in serum. …”
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Study protocol for key interventions to improve the follow-up adherence postcervical precancerous lesion treatment in Ethiopia: a pragmatic randomised controlled trial by Adamu Addissie, Eva Johanna Kantelhardt, Eric Sven Kroeber, Sefonias Getachew, Muluken Gizaw, Abel Shita, Alemnew Destaw, Eyerusalem Getachew, Miresa Midaksa, Sophie Rossner

“…Our study will include women aged 30–49 who are HIV-negative and those over 25 who are HIV-positive, and who have been treated for suspicious cervical lesions after a positive visual inspection with acetic acid (VIA) screening, as per Ethiopian Ministry of Health guidelines for cervical cancer screening eligibility. …”
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Effects of virtual reality-based interventions on cognitive function, emotional state, and quality of life in patients with mild cognitive impairment: a meta-analysis by Xiaohan Li, Yuting Zhang, Lifeng Tang, Lifeng Tang, Lin Ye, Min Tang

“…Publication bias was assessed using funnel plots and Egger’s regression test. A “trim and fill” method was employed to adjust for any detected publication bias. …”
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Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial by Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Edoardo Sessa, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto

“…Pilates has been suggested as an ideal PA to manage physical, cognitive, and psychological symptoms of MS and a useful method to maintain and improve balance and gait. …”
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The state of the biogeometric profile of the posture of young athletes specializing in hand-to-hand combat as a prerequisite for the development of corrective and preventive measur... by Vitalii Kashuba, Аndrii Radchenko, Yuri Radchenko, Ilia Vako, Vitaly Usychenko

“…The problems identified during the study were solved using generally accepted methods: theoretical analysis of scientific literature on the chosen research topic; the Torso program was used to determine the types of posture, visual screening of the state of the biogeometric profile of the posture of young athletes specializing in hand-to-hand combat included a focus on the tribal system and the use of a method for comparing individual posture on a photogram and methods of mathematical statistics. …”
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Small fiber damage in patients with chemo-induced polyneuropathy by O. A. Tikhonova, D. S. Druzhinin, O. P. Tuchina, A. V. Vinogradova, S. A. Doktorova, M. I. Dolgaleva, A. M. Tynterova

“…Skin biopsy is a validated method for determining intraepidermal nerve fiber density and can be considered for the diagnosis of distal sensory neuropathy, especially small fiber neuropathy. …”
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Stroke awareness among cardiovascular disease patients Nível de conhecimento sobre acidente vascular cerebral entre pacientes de uma clínica cardiológica by Rodolfo de Souza Coelho, Wladimir Magalhães de Freitas, Geniberto Paiva Campos, Ricardo Afonso Teixeira

“…PURPOSE: To compare the knowledge of stroke among a community-based sample and patients treated in a cardiologic clinic. METHOD: We applied a questionnaire during one morning to people who were walking in a park (Pa) and spontaneously stopped at a health tent and during one week to patients of a cardiologic clinic (Ca). …”
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Discrepancies in CDE and Measured Phaco Tip Energy: Comparison of Energy Produced in Longitudinal and Torsional Ultrasound Using Calorimetry by Ricks RG, Cardenas IA, Jensen JL, Nelson TK, Olson RJ, Pettey JH

“…We propose that a discrepancy may exist between the CDE reported by the surgical machine and the actual energy delivered to the eye.Methods: About 50 mL of distilled water were degassed and placed in an isobaric calorimeter. …”
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Effect of remifentanil general anesthesia combined with thoracic paravertebral nerve block on the prognosis of elderly patients undergoing retroperitoneal laparoscopic radical neph... by LIU Haozhong, GAO Jinghao, QI Xiaomei, MA Wenru, XU Hao, WANG Pei, WANG Peng

“…Objective To investigate the effect of remifentanil general anesthesia combined with thoracic paravertebral nerve block (TPVB) on the prognosis of elderly patients undergoing retroperitoneal laparoscopic radical nephrectomy. MethodsA total of 90 elderly patients who underwent retroperitoneal laparoscopic radical nephrectomy in our hospital from October 2024 to January 2025 were enrolled and divided into general anesthesia group (group C) and general anesthesia+TPVB group (group T) using the simple randomization method. …”
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Surgical treatment of isolated soft tissue gunshot shrapnel injuries by combining primary delayed sutures with platelet-rich autoplasma injections into mine-explosive wounds by S. M. Zavhorodnii, O. I. Kotenko, M. B. Danyliuk, M. A. Kubrak

“…Aim: to assess the treatment effectiveness in patients with soft tissue gunshot shrapnel injuries by applying primary delayed sutures in combination with platelet-rich autoplasma injections into wounds. Materials and methods. The study included 60 (100.0 %) patients with soft tissue gunshot shrapnel wounds. …”
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Ultrasensitive bionic photonic-electronic skin with wide red-shift mechanochromic response by Tianqi Wang, Lei Chen, Haogeng Liu, Haoran Zhu, Zijie Zeng, Yixin Lu, Ping Zhang, Yaofei Chen, Yue Huang, Gui-Shi Liu, Yunhan Luo, Zhe Chen

“…The PC layer containing in-plane-spaced and interplane-packed nanoparticle arrays was fabricated via a fast, facile, combined method of “Marangoni self-assembly”, “plasma etching”, and “adhesive PDMS transfer”. …”
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Abnormalities of insular functional connectivity in patients with musculoskeletal pain: A meta-analysis of resting-state fMRI studies by Peng Lai, Xingyao Chen, Jiacheng Liu, Zilei Tian, Yangke Mao, Chenyang Jia, Siting Ma, Deliang Zhu, Ming Xin, Fang Zeng, Shirui Cheng

“…Meta-regression analysis showed that revealed a negative association between the Visual Analog Scale (VAS) score and the reduction in FC between the INS and the left precuneus. …”
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Anterior segment characteristics and spatial variations of different crystalline lens diseases by Jianxia Fang, Ce Shi, Xinyu Ma, Siting Sheng, Jingwei Xu, Sha Zhu, Yixuan Feng, Yu Zhang, Lirui Liu, Huiling Zhao, Zhe Xu, Wen Xu

“…Methods: We examined 98 eyes (19 normal, 25 cataracts, 27 LS, 27 MSP) using AS optical coherence tomography (AS-OCT), ultrasound biomicroscopy (UBM), and IOLMaster700. …”
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Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy by Hongyan Li, Rong Gan, Jiadi Liu, Duling Xu, Qiyue Zhang, Haidong Tian, Huijun Guo, Haijun Wang, Zhimin Wang, Xianwu Zeng

“…Thus, the ANGPT2-specific peptides were successfully designed, and the PEGylated liposome modified with ANGPT2-specific peptide served as part of a potent delivery method for integrative glioma-targeted imaging and therapy.…”
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Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson’s disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a... by Dongning Su, Zhijin Zhang, Zhe Zhang, Rui Yan, Wanlin Zhu, Ning Wei, Yue Suo, Xinyao Liu, Ying Jiang, Lingyan Ma, Huiqing Zhao, Zhan Wang, Xuemei Wang, Huizi Ma, Xin Liu, Chaodong Wang, Zhirong Wan, Fangfei Li, Yuan Li, Joyce S. T. Lam, Junhong Zhou, Ning Zhang, Tao Wu, Jing Jing, Tao Feng

“…Abstract Background Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson’s disease (PD) and can be effectively visualized using 7T MRI. This study was aimed to develop and validate the optimal DNH assessment method as a biomarker for PD, idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson-plus syndromes, and to explore the nigral iron deposition patterns in these diseases. …”
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Patellofemoral Pain Syndrome: Focused Vibrations Plus Kinesiotaping with Insights into Radiological Influences—An Observational Study by Gabriele Santilli, Milvia Martino, Patrizia Pacini, Francesco Agostini, Andrea Bernetti, Luca Giuliani, Giovanni Del Gaudio, Massimiliano Mangone, Vincenzo Colonna, Mario Vetrano, Maria Chiara Vulpiani, Giulia Stella, Antonello Ciccarelli, Samanta Taurone, Antonio Franchitto, Carlo Ottonello, Vito Cantisani, Marco Paoloni, Pietro Fiore, Francesca Gimigliano

“…Background: This observational study investigates the efficacy of combining local muscle vibration (LMV) therapy and kinesiotaping using the McConnell method (KMcCM) in patients with patellofemoral pain syndrome (PFPS). …”
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