Reduction in Artemisia Pollen-Specific IgE Levels During House Dust Mite Allergen Immunotherapy in Polysensitized Allergic Rhinitis Patients: A Three-Year Retrospective Study in No... by Sun X, Li X, Gao T, Liu P, Liu N, Jin P, Zhi L

“…Clinical outcomes were also recorded, including Total Nasal Symptom Score (TNSS), Visual Analog Scale (VAS), and medication use.Results:  Over three years, SIgE levels for Der p significantly decreased (p = 0.0001), while Der f showed a slight and significant decrease (p = 0.0334). …”
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Study of anatomy-diagnostic features of leaves of <i>Cynara scolymus</i> L. grown under the conditions of the Kyrgyz Republic by S. C. Chubakova, N. T. Farmanova, N. V. Bobkova, T. A. Mamatov

“…To study the macro and micromorphological characters of C. scolymus leaves for introduction into medical practice.Materials and methods. Dried leaves of artichoke (Cynara scolymus L.), collected in the flowering phase (June) of 2023, in the Osh region of the Kyrgyz Republic, were used as the object of the study. …”
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Features of ankylosing spondylitis at different stages in men and women by I. A. Cherentsova, E. N. Otteva

“…For the calculation of enthesites, the validated index Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) was used; pain intensity in the last week was estimated using a visual analogue scale (VAS). Laboratory examination included the determination of ESR and HLA-B27 antigen. …”
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Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer by Pragya Gupta, Tamas Heffter, Muhammad Zubair, I-Chow Hsu, E. Clif Burdette, Chris J. Diederich

“…This involves the integration with a FDA 510(k) cleared catheter-based ultrasound interstitial applicators and delivery system. Methods: A 3D generalized &#x201C;prostate&#x201D; model was developed to generate temperature and thermal dose profiles for different applicator operating parameters and anticipated perfusion ranges. …”
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Spatiotemporal analysis of rainfall variability using satellite precipitation in watersheds by M.D. Syaifullah, A. Purwandani, M. Kudsy, Tukiyat , S. Tikno, A.E. Sakya, F.H. Widodo, S. Bahri, Muktiyono

“…This study aims to investigate how geomorphological and topographical differences across the Toba-Asahan, Brantas, and Larona-Malili watersheds in Indonesia influence rainfall distribution and trends, in order to support adaptive and sustainable watershed management.METHODS: This study analyzes rainfall variability in three distinct Indonesian watersheds, Toba-Asahan, Brantas, and Larona-Malili, using climate hazards group infrared precipitation with Station version 2 satellite precipitation data. …”
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Hymecromone Administration in Real Clinical Practice: Results of the Prospective Multicentre Observational Study in the Republic of Kazakhstan by A. V. Nersesov, D. A. Kaybullaeva, V. S. Rakhmetova, I. A. Lozinskaya, A. K. Kurmangalieva, V. S. Ayupova, A. B. Orazbaeva, A. K. Kanabaeva, Yu. O. Shulpekova

“…The objectives of the study included collection of clinical characteristics of patients, evaluation of Odeston effects in treatment of biliary pain and changes in the gallbladder emptying, evaluation of compliance to therapy, and treatment effect satisfaction.Materials and methods. The study was conducted from July 2020 to April 2021 at the premises of 60 study sites in 4 cities of the Republic of Kazakhstan. …”
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Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway by Vida Maksimoska, Vida Maksimoska, Qinghong Dan, Neetu Rambharack, Neetu Rambharack, Katalin Szászi, Katalin Szászi, Katalin Szászi, Katalin Szászi

“…The overall objective of the current study was to explore the connection between inflammation-induced keratinocyte mediator release and enhanced migration, and to identify specific RhoA regulators involved.MethodsThe study was done using HaCat cells and primary adult keratinocytes. …”
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Predicting Short-Term Risk of Cardiovascular Events in the Elderly Population: A Retrospective Study in Shanghai, China by Zhu W, Tan S, Zhou Z, Zhao M, Wang Y, Li Q, Zheng Y, Shi J

“…This study aimed to develop a short-term risk prediction model for CVD events among individuals aged ≥ 60 years in Shanghai, China.Methods: Stratified random sampling recruited elderly individuals. …”
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A multicenter, prospective, randomized trial of the efficacy and safety of Alflutop® in an alternating dosing regimen versus the standard one. Communication 2: Evaluation of the ef... by E. P. Sharapova, L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, S. G. Anikin, E. A. Strebkova, A. M. Lila, V. I. Mazurov, N. A. Shostak, E. I. Shmidt, E. P. Ilivanova

“…From this point of view, therapy seems to be relevant when the latter involves drugs that have both symptom- and structure-modifying properties and have a high safety profile.Objective: to compare the safety of alternating and standard treatment regimens with Alflutop® in patients with knee OA.Patients and methods. 130 patients were enrolled in the trial who had Kellgren-Lawrence Grade II–III primary tibiofemoral knee OA with pain intensity on walking ≥40 mm on a visual analogue scale and who needed to take nonsteroidal anti-inflammatory drugs (≥30 days in the previous 3 months). …”
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Exploring Ocular Fundus Changes and Biochemical Correlations in Pregnancy-Induced Hypertension: Two Year Observational Study in Tertiary Care Center, India by A. M. Raja, G Seema

“…Each participant received a thorough ocular examination, which included visual acuity testing, anterior segment assessment, and fundus examination. …”
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Septal panniculitis as manifestation of COVID-19: own data by O. N. Egorova, R. G. Goloeva, D. I. Abdulganieva

“…Objective: to study the clinical and laboratory features of erythema nodosum (EN) in a cohort of patients with COVID-19 referred to a rheumatological center.Patients and methods. During 2020–2021 years 21 patients (18 women and 3 men, mean age 43.2±11.4 years) with EN and polyarthralgia/arthritis were examined. …”
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Evaluation of enhanced recovery after surgery combined with percutaneous acupoint electrical stimulation in perioperative nursing of patients with gastric cancer (快速康复护理联合经皮穴位电刺激在胃... by HUANG Yanying (黄艳颖), LI Wenjuan (李文娟)

“…Objective To investigate the effect of enhanced recovery after surgery combined with percutaneous acupoint electrical stimulation in perioperative nursing of patients with gastric cancer. Methods Totally 52 patients undergoing surgery for gastric cancer were randomly divided into the control group and study group, with 26 cases in each group. …”
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Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors by Yi Duan, Wen Chen, Jian Xu, Xiaoyu Zhang, Xiaozhen Zhang, Tingbo Liang, Xueli Bai, Mengyi Lao, Hanshen Yang, Muchun Li, Honggang Ying, Lihong He, Kang Sun, Chengxiang Guo, Haitao Jiang

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HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma by Xu Chen, Hai Huang, Qiong Wang, Qiang-Hua Zhou, Kai-Wen Li, Hai-Xia He, Sheng-Meng Peng, Shi-Rong Peng, Ze-An Li, Yi-Ran Tao, Wen-Li Cai, Ran-Yi Liu

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Apatinib plus camrelizumab (anti-PD1 therapy, SHR-1210) for advanced osteosarcoma (APFAO) progressing after chemotherapy: a single-arm, open-label, phase 2 trial by Xin Sun, Yuan Li, Jie Xu, Wei Guo, Yi Huang, Lu Xie, Jin Gu, Kuisheng Liu, Bingxin Zheng, Tingting Ren, Xiaodong Tang, Taiqiang Yan, Rongli Yang, Kunkun Sun, Danhua Shen

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Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial by Kristine Godziuk, Mary Forhan, Flavio T. Vieira, Joao F. Mota, Jason Werle, John A. Batsis, Lorenzo M. Donini, Mario Siervo, Carla M. Prado

“…We investigated the feasibility and efficacy of a multimodal behavioural intervention compared to usual care to enhance physical function and muscle mass in this population. Methods The POMELO (Prevention Of MusclE Loss in Osteoarthritis) study is a two‐arm pilot randomized controlled trial; NCT05026385. …”
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The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…Our goal is to relieve the acute postoperative pain and promote fast recovery and rapid discharge for ARCR patients.Patients and Methods: Ninety-six patients who underwent ARCR from December 2023 to March 2024 were enrolled in this double-blinded, randomized control trial (Registration number, ChiCTR2300078507). …”
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Comparison of the efficacy and safety of various anti-inflammatory drugs in urate-lowering therapy initiation in patients with gout (preliminary data) by M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina

“…Non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and glucocorticoids (GC) are used to prevent arthritis attacks in gout, but data on their comparative effectiveness is lacking.Objective: to compare the efficacy and safety of various anti-inflammatory drugs at the start of treatment in patients with gout.Patients and methods. Of the 108 patients with gout, observed in the V.A. …”
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User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…ObjectiveThis study aimed to clarify how a digital behavioral intervention for people with chronic pain can be developed through a user-centered approach to address the needs and preferences of the target population. MethodsThis study used a multimethod approach involving end users, namely, patients with chronic pain and therapists, to develop prototypes for a digital behavioral intervention across 3 phases. …”
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Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity by Linrong He, Xiaoming Shu, Xia Liu, Yongpeng Ge, Sizhao Li, Xin Lu, Guochun Wang

“…To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods. Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE), and 20 healthy controls (HCs) by chemiluminescent immunometric assay. …”
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