De novo variant in GUCY2D gene causing atypical cone-rod dystrophy in a consanguineous family and literature review by Xin-He Fang, Fa-Yong Ke, Wen-Qing Zou, De-Jun Zhu, Mei-Jiao Ma, Yuan-Yuan Lian, Xue-Li Wu, Rui-Hua Wei, Xun-Lun Sheng

“…AIM: To analyze the pathogenicity and clinical features of patients in a consanguineous cone-rod dystrophy (CRD) family due to heterozygous variants in the GUCY2D gene. METHODS: Whole exome sequencing was used to screen for pathogenic genes and candidate pathogenic variants were obtained by bioinformatics analysis. …”
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Feasibility of relaxation along a fictitious field in the 2nd rotating frame (TRAFF2) mapping in the human myocardium at 3 T by Joao Tourais, Joao Tourais, Joao Tourais, Maša Božić-Iven, Maša Božić-Iven, Maša Božić-Iven, Yidong Zhao, Qian Tao, Iain Pierce, Iain Pierce, Christian Nitsche, Christian Nitsche, George D. Thornton, George D. Thornton, Lothar R. Schad, Lothar R. Schad, Thomas A. Treibel, Thomas A. Treibel, Sebastian Weingärtner, Mehmet Akçakaya, Mehmet Akçakaya

“…PurposeEvaluate the feasibility of quantification of Relaxation Along a Fictitious Field in the 2nd rotating frame (RAFF2) relaxation times in the human myocardium at 3 T.MethodsTRAFF2 mapping was performed using a breath-held ECG-gated acquisition of five images: one without preparation, three preceded by RAFF2 trains of varying duration, and one preceded by a saturation prepulse. …”
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Platelet-rich plasma therapy for knee osteoarthritis: Insights from real-world clinical data in Japan by Yoshitomo Saita, Yohei Kobayashi, Sayuri Uchino, Hirofumi Nishio, Takanori Wakayama, Shin Fukusato, Yasumasa Momoi, Ryosuke Nakajima, Nanako Yamamoto, Shinnosuke Hada, Haruka Kaneko, Muneaki Ishijima

“…The eligibility criteria included chronic knee pain unresponsive to conservative treatment for KOA. Visual Analog Scale (VAS) for knee pain were collected at baseline and 3 and 6 months post-treatment. …”
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Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study by Yin Sun, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Shuqing Wang, Deqi Zhai, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou, Zhao Dong

“…Conclusion Compared to CM − MOH patients, those with MOH exhibit distinct patterns of gray matter volume reduction in regions associated with memory and visual processing, accompanied by significant white matter disruption. …”
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Comparison of low-pressure and standard-pressure pneumoperitoneum laparoscopic cholecystectomy in patients with cardiopulmonary comorbidities: a double blinded randomized clinical... by Feng Tian, Xiaowei Sun, Yang Yu, Ning Zhang, Tao Hong, Lu Liang, Bihui Yao, Lei Song, Changhong Pei, Yu Wang, Wenlong Lu, Qiang Qu, Junchao Guo, Taiping Zhang, Xiaodong He

“…This study aimed to explore the feasibility and pulmonary effects of LPLC in patients with cardiopulmonary comorbidities. Methods This was a multicenter, parallel, double-blind, randomized controlled trial. …”
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Short-term use of ceftriaxone sodium leads to intestinal barrier disruption and ultrastructural changes of kidney in SD rats by Wenli Zou, Yueming Liu, Wei Zhang, Bo Lin, Wei Shen, Yiwen Li, Qiang He, Juan Jin

“…The aim of this study was to evaluate and visualize the impact of antibiotics on colonic mucus and the microbial community, and to assess whether intestinal dysbacteriosis is involved in the pathogenesis and progression of extraintestinal diseases in vivo.Materials and Methods Twenty-one SD rats were randomly assigned into three groups followed by different experimental treatments. …”
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Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study by Marcio Steinbruch, Carlos Nunes, Romualdo Gama, Renato Kaufman, Gustavo Gama, Mendel Suchmacher Neto, Rafael Nigri, Natasha Cytrynbaum, Lisa Brauer Oliveira, Isabelle Bertaina, François Verrière, Mauro Geller

“…Adult patients with a symptomatic CVD of the lower limbs (C0-C3 grade; 20-60 mm on a 100 mm visual analog scale (VAS)) were included. The primary endpoint was the change (from baseline to last postbaseline value) of the intensity of the lower-limb symptoms on VAS. …”
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A space-gamified approach to examine muscle contraction behaviour in children and adolescents with spastic cerebral palsy: feasibility, acceptability and repeatbility by Jule Heieis, Jule Heieis, Jule Heieis, Ibrahim Duran, Ibrahim Duran, Eckhard Schönau, Eckhard Schönau, Christoph Fritzsche, Bettina Götz, Laura Kehe, Moritz Meier, Karoline Spiess, Wilhelm Bloch, Jörn Rittweger, Jörn Rittweger

“…We therefore examined feasibility and acceptability of a muscle testing protocol that is based on the muscle examinations of astronauts and in bed-rest studies in children and adolescents with CP (clinical trial registry number DRKS00031107).MethodsTwelve participants, aged between 8 and 18 years, with CP and age-matched able-bodied counterparts (Ctrl) have been included to the study. …”
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A predictive model for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis by Rui Huang, Rui Huang, Dan Wu, Dan Wu, Ling Wang, Ling Wang, Ping Liu, Ping Liu, Xiaoru Zhu, Xiaoru Zhu, Leqiu Huang, Leqiu Huang, Mengmeng Chen, Mengmeng Chen, Xin Lv, Xin Lv

“…The outcome of this study carries important clinical value for early diagnosis and treatment of EBV-HLH.MethodsA retrospective analysis was conducted on 60 patients diagnosed with EBV-HLH and 221 patients diagnosed with EBV-IM at our hospital between November 2018 and January 2024. …”
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A Study of Multimodality Imaging Features of Brown Tumor or Osteitis Fibrosa Cystica by Dhruv Patel, Abhijeet Ashok Salunke, Nandlal Bharwani, Ritesh Suthar, Umank Tripathi, M. Varun, Dipesh Dave, Keval Patel, Vikas Warikoo, Jebin Aron, Rahul Shah, Shashank J. Pandya

“…We performed paired t-tests on the blood investigation values and Visual Analog Scale (VAS) scores for all patients. …”
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The potential for dementia prevention in Brazil: a population attributable fraction calculation for 14 modifiable risk factorsResearch in context by Claudia K. Suemoto, Wyllians V. Borelli, Ismael L. Calandri, Laiss Bertola, Raphael M. Castilhos, Paulo Caramelli, Ricardo Nitrini, Sonia M.D. Brucki, Jerson Laks, Naaheed Mukadam, Gill Livingston, Cleusa P. Ferri

“…The three risk factors with the highest PAFs were less education (9.5%, 95% CI = 8.9–10.1), untreated visual loss (9.2%, 95% CI = 8.6–9.8), and midlife depression (6.3%, 95% CI = 5.8–6.8). …”
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Five-Year Follow-Up of a Slowly Resorbable Biosynthetic P4HB Mesh (Phasix) in VHWG Grade 3 Incisional Hernia Repair by L. M. Van den Dop, MD, M. M. J. Van Rooijen, MD, PhD, T. Tollens, MD, L. N. Jørgensen, MD, PhD, T. S. De Vries-Reilingh, MD, PhD, G. Piessen, MD, PhD, F. Köckerling, MD, PhD, M. Miserez, MD, PhD, M. Dean, MD, F. Berrevoet, MD, PhD, B. Dousset, MD, PhD, H. L. Van Westreenen, MD, PhD, F. Gossetti, MD, PhD, G. W. M. Tetteroo, MD, PhD, A. Koch, MD, PhD, M. F. Boomsma, MD, PhD, J. F. Lange, MD, PhD, J. Jeekel, MD, PhD

“…However, long-term outcomes after resorption are scarce. Methods:. Patients with VHWG grade 3 incisional midline hernia, who participated in the Phasix trial (Clinilcaltrials.gov: NCT02720042) were included by means of physical examination and computed tomography (CT). …”
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Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort by Matteo Tonietto, Oscar Sotolongo-Grau, Núria Roé-Vellvé, Santiago Bullich, Juan Pablo Tartari, Ángela Sanabria, Ainhoa García-Sánchez, Edilio Borroni, Christopher Galli, Esther Pérez-Martínez, Joan Castell-Conesa, Isabel Roca, Lluís Tárraga, Agustín Ruiz, Andrew W. Stephens, Mercè Boada, Gregory Klein, Marta Marquié, on behalf of the FACEHBI study group, on behalf of the AMYPAD consortium

“…In this work, we aimed to compare the in-vivo uptake of tau tracers [18F]PI-2620 and [18F]RO948 in the early stages of the AD continuum. Methods Data from the TAU-PET FACEHBI clinical trial (EUDRA-CT 2021–000473-83) were analyzed. …”
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Unravelling Metazoan and Fish Community Patterns in Yujiang River, China: Insights from Beta Diversity Partitioning and Co-Occurrence Network by Yusen Li, Dapeng Wang, Yuying Huang, Jun Shi, Weijun Wu, Chang Yuan, Shiqiong Nong, Chuanbo Guo, Wenjian Chen, Lei Zhou

“…However, traditional survey methods often fail to comprehensively capture species diversity, particularly for low-abundance taxa. …”
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Association between remnant cholesterol (RC) and endometriosis: a cross-sectional study based on NHANES data by Zeru Chen, Ruixuan Li, Jiajie Guo, Xiaorong Ye, Yang Zhou, Mingzhu Cao

“…Consequently, looking into and clarifying the connection between RC and EMs was the primary goal of this study. Methods Following the screening of participants from the NHANES dataset spanning 2001 to 2006, a total of 1,840 individuals were incorporated into this research. …”
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Venous Sinus Stenting Using a Ledge‐Reducing Catheter, 0.088‐in. Catheter‐Extender With an External Single Point of Control: Technique and Multicenter Clinical Experience by Oded Goren, Fabio Settecase, George Luh, Tareq Kass‐Hout, Rami Morsi, Coleman O. Martin, Ahmad K. Almekkawi, Nicholas A. Telischak, Matthew D. Alexander, Michael G. Abraham, Sivani Lingam, Ramesh Grandhi, M. Shazam Hussain, Tudor G. Jovin, Priyank Khandelwal, Thanh T. Nguyen, Piers Klein, Joey D. English, Mohamad K. Abdalkader

“…In this study, we describe the MS technique for VSS and our multicenter clinical experience. Methods We retrospectively reviewed consecutive patients who underwent VSS with the MS from 2022 to 2023 for intracranial hypertension and/or pulsatile tinnitus at 13 sites. …”
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Examining the evolution and impact of OTC vending machines in Global Healthcare Systems by Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sahab Alkhoujah, Faris El-Dahiyat, Ammar Ali Saleh Jaber, Sa'ed H. Zyoud

“…Data analysis included bibliometric indicators such as publication counts, citation trends, and co-authorship networks, which were visualized using VOSviewer software (version 1.6.20) to highlight key research themes and collaboration patterns. …”
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Epidemiological trends of hepatitis C incidence and death in Mainland China between 2004 and 2018 and its predictions to 2030 by Guo Tian, Yang Zheng, Yinghua He, Can Chen, Xiaobao Zhang, Yuxia Du, Shigui Yang, Tianan Jiang, Lanjuan Li

“…Temporal-spatial scanning analysis was conducted to visualize the grading of hepatitis C incidence in mainland China. …”
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Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…Scanning and transmission electron microscopy were employed to visualize ultrastructural details of the endometrial tissue, while hematoxylin and eosin staining facilitated the examination of tissue morphology and cellular composition. …”
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Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations by Harjot Uppal, MBA, George Abdelmalek, MD, Neil Patel, MD, Daniel Coban, MD, Stuart Changoor, MD, Nikhil Sahai, MD, Kumar Sinha, MD, Ki Hwang, MD, Arash Emami, MD

“…Functional outcomes were measured using the Visual Analog Scale for neck and arm pain (VAS-neck, VAS-arm) and the Neck Disability Index (NDI), with attention to timelines for returning to full-time work. …”
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