Bipolar disorders and creativity: the roles of ambition, effort-based decision-making, and exploration by Samson Tse, Sheri L. Johnson, Chong Ho Yu, Winnie Yuen, Iris Lo, Luke Clark, Luke Clark, Erin E. Michalak, Erin E. Michalak, Manon Ironside, Kiana Modavi

“…The current work is the first to examine ambition, exploration versus exploitation ratio, and insensitivity to effort/rewards among individuals with and without BD in an Asian cultural context.MethodsWriters and visual artists from Hong Kong who were diagnosed with BD completed a questionnaire to assess lifetime creative accomplishments, a self-rated measure of ambition, and two laboratory-based tasks: the observe-or-bet task to detect exploration versus exploitation tendencies, and an effort discounting task to measure sensitivity to effort required and reward level.ResultsThe sample included 44 participants diagnosed with BD and 69 control participants, with 87 (77%) being female and an average age of 35.1 years (range: 18 to 65). …”
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Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks by Shuai Zhao, Jindan Wu, Xiaomei Liu, Yishan Du, Xiaoqin Wang, Yi Xia, Hao Sun, Haowen Zou, Xumiao Wang, Zhilu Chen, Rui Yan, Hao Tang, Qing Lu, Zhijian Yao

“…This study aimed was to investigate the neurological mechanisms underlying this co-occurrence using a data-driven approach to analyze brain activity patterns. Methods Twenty-nine patients diagnosed with MDD without any comorbid conditions (nSHypo-MDD) were included in the study, along with 29 MDD patients who also had SHypo (SHypo-MDD), 26 patients with SHypo only, and 29 healthy individuals as controls (HCs). …”
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Long-Term Outcomes of Modified Expansive Open-Door Laminoplasty Combined with Short-Level Anterior Cervical Fusion in Multilevel Cervical Spondylotic Myelopathy by Szu-Wei Chen, Kuang-Ting Yeh, Cheng-Huan Peng, Chia-Ming Chang, Hao-Wen Chen, Tzai-Chiu Yu, Ing-Ho Chen, Jen-Hung Wang, Wan-Ting Yang, Wen-Tien Wu

“…This study aimed to assess the long-term efficacy of modified expansive open-door laminoplasty (MEOLP) combined with short-level anterior cervical fusion (ACF) in providing decompression, preserving alignment, and maintaining range of motion (ROM) over a nine-year follow-up. <i>Materials and Methods</i>: A retrospective analysis was conducted on 124 MCSM patients treated with MEOLP combined with ACF between 2011 and 2015. …”
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The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation by Felix Knab, Giambattista Guaitoli, Mohamed Ali Jarboui, Felix von Zweydorf, Fatma Busra Isik, Franziska Klose, Anto Praveen Rajkumar, Thomas Gasser, Thomas Gasser, Christian Johannes Gloeckner

“…With LRRK2 inhibitors entering clinical trials, there is an unmet need for biomarkers that reflect LRRK2-specific pathology and target engagement.MethodsIn this study, we used induced pluripotent stem cells derived from a patient with Parkinson’s disease carrying the LRRK2 G2019S mutation and an isogenic gene-corrected control to generate human dopaminergic neurons. …”
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The effects of the physical procedures in patients with diabetic neuropathy by Grbović Vesna, Stefanović Srđan, Đukić Svetlana, Nurković Jasmin, Zdravković-Petrović Nataša, Parezanović-Ilić Katarina, Divjak Ana, Jurišić-Škevin Aleksandra

“…The aim of our study was to compare the effects of physical therapy (PT) and alpha-lipoic acid (ALA) supplementation on pain reduction and quality of life improvement in the DSP patients. Methods. The study was performed on 60 adult patients with DM type 2 and DSP. …”
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Statistical learning to identify and characterise neurodevelopmental outcomes at 2 years in babies born preterm: model development and validation using population-level data from E... by Sadia Haider, Athanasios Tsanas, G. David Batty, Rebecca M. Reynolds, Heather C. Whalley, Simon R. Cox, Riccardo E. Marioni, Cheryl Battersby, James P. Boardman

“…This study applies statistical learning to a national database to identify transdomain clusters and their maternal and neonatal predictors. Methods: Latent class analysis (LCA) was used to derive transdomain clusters from parent-reported visual, auditory, neuromotor, and communication impairments in preterm-born children at two years corrected age using the UK National Neonatal Research Database data (N = 27,261). …”
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Blood-brain barrier disruption mediates the association between cerebral small vessel disease and clinical outcome after stroke: a secondary analysis of the Lesion Evolution in Str... by Derrick N. Okine, Derrick N. Okine, Kyle C. Kern, Kyle C. Kern, Kyle C. Kern, Marie Luby, Lawrence L. Latour, Rebecca F. Gottesman

“…WMH were visually graded on baseline FLAIR for presence and severity (minor or moderate-severe). …”
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Layered structural engineering of Bi2O3/PP and WO3/PP composites for γ-ray shielding in high energy range: anisotropic attenuation mechanisms via Monte Carlo simulation and experim... by Xiangjie Duan, Jie Zhao, Shuaida Song, Na Zhou, Jizhuang Fan, Bo Tian, Yunchen Du

“…Herein, FLUKA Monte Carlo simulations capable of visualizing γ-photon transport behaviors are investigated in Bi2O3/PP and WO3/PP multi-layer composites with various layered configurations. …”
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Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…Protein-protein interaction (PPI) networks of these PRGs were constructed using the STRING database and visualized with Cytoscape. Subnetworks were identified using the MCODE plugin. …”
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The clinical features and perfusion density in paracentral acute middle maculopathy by optical coherence tomography angiography study by Zhengfeng Liu, Xuemei Pan, Dan Wang, Yingying Zou, Peipei Liu, Ying Wang, Hongsheng Bi, Xiaofeng Xie

“…Results: The mean age of patients was 48.08 (range 14–72) years. The best corrected visual acuity (BCVA) was from finger count (FC) to 1.0. …”
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Association of blood cadmium levels with all-cause and cause-specific mortality among adults with non-alcoholic fatty liver disease: a prospective cohort study by Congxi Xu, Congxi Xu, Zhi Li, Shirui Hao, Jian Zhang, Jinlong Li, Kuopeng Liang, Xiaojuan Wang, Yi Zhang, Yi Zhang, Guangyuan Zhao, Mengyun Bai, Dengxiang Liu, Jitao Wang

“…This study aimed to evaluate the predictive value of blood cadmium levels for mortality risk in patients with NAFLD.MethodsThis study analyzed data from 13,450 patients with NAFLD in the National Health and Nutrition Examination Survey (NHANES) database, covering the years 1999 to 2018. …”
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Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-... by Caroline J. Stone, Geeta Ahuja, Lais Lopes Almeida Gomes, Joy Poroye, Daniella Forman Faden, Lillian Xie, Rui Feng, Barbara White, Victoria P. Werth

“…Key aims include evaluating the drug’s long-term effectiveness and assessing disease manifestation recurrence. Methods: The phase 2 lenabasum trial enrolled patients with treatment-resistant, skin-predominant DM. …”
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Monitoring Anthropogenically Disturbed Parcels with Soil Erosion Dynamics Change Based on an Improved SegFormer by Zhenqiang Li, Jialin Li, Jie Li, Zhangxuan Li, Kuncheng Jiang, Yuyang Ma, Chuli Hu

“…Currently, traditional methods for change detection, such as field surveys and visual interpretation, suffer from time inefficiencies, complexity, and high resource consumption. …”
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Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled tri... by A. John Rush, Charles R. Conway, Scott T. Aaronson, Mark S. George, Patricio Riva-Posse, David L. Dunner, John Zajecka, Mark T. Bunker, João Quevedo, Rebecca M. Allen, Gustavo Alva, Heather Luing, Ziad Nahas, Lucian Manu, Jeffrey I. Bennett, Brian J. Mickey, Jonathan Becker, Yvette Sheline, Cristina Cusin, James W. Murrough, Kevin Reeves, Peter B. Rosenquist, Ying-Chieh (Lisa) Lee, Shannon Majewski, Jeffrey Way, Bryan Olin, Harold A. Sackeim

“…The WHODAS 2.0 (P = 0.304) and EQ-5D visual analog scale (P = 0.125) failed to reveal between-group differences. …”
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Validating the SONG-PKD Pain Instrument, a Core Outcome Measure for Pain in ADPKD by Rosanna Cazzolli, Angela Ju, Patrizia Natale, Armando Teixeira-Pinto, Martin Howell, Allison Jaure, Ronald D. Perrone, Eva Burnette, Niek F. Casteleijn, Arlene Chapman, Jonathan C. Craig, Sarah Eastty, Ron T. Gansevoort, Tess Harris, Marie C. Hogan, Shigeo Horie, Bertrand Knebelmann, Richard Lee, Karine Manera, Reem A. Mustafa, Richard Sandford, Gopala K. Rangan, Bénédicte Sautenet, Andrea K. Viecelli, Yeoungjee Cho

“…There was a high convergence of SONG-PKD Pain with the Brief Pain Inventory-Short Form (BPI-SF; 0.84, 95% CI: 0.80–0.87) and a visual analog scale (VAS; 0.84, 95% CI: 0.81–0.87). …”
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The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses by Dustyn Barnette, Amy L. Inselman, Pravin Kaldhone, Grace S. Lee, Kelly Davis, Sumit Sarkar, Pritpal Malhi, J. Edward Fisher, Joseph P. Hanig, Richard D. Beger, E. Ellen Jones

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a dynamic approach capable of generating 2D ion images to visualize the distribution of an analyte of interest across a tissue section.MethodsGiven the importance of lipid metabolism and neurotransmitters in the developing central nervous system, this study incorporates MALDI MSI to assess lipid distributions across mouse gestational day (GD) 18 fetuses, with and without observable NTDs following maternal exposure on GD 8 to morphine (400 mg/kg BW) or the NTD positive control valproic acid (VPA) (500 mg/kg BW).ResultsAnalysis of whole-body mouse fetuses revealed differential lipid distributions localized mainly in the brain and spinal cord, which included several phosphatidylcholine (PC) species such as PCs 34:1, 34:0, and 36:2 localized to the cortex or hippocampus and lyso PC 16:0 across all brain regions. …”
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Modeling the distribution of the invasive snail Physella acuta in China: Implications for ecological and economic impact by Yingxuan Yin, Anyuan Xu, Xiaowen Pan, Qing He, Aoxun Wu, Linya Huang, Yinjuan Wu, Xuerong Li

“…Gaining insight into their geographical spread in China under current and future climate scenarios is crucial for effective monitoring and control strategies against this invasive species. Methods: Global distribution data of P. acuta were collected and screened using “ENMtool”; environmental variables were screened based on contribution of environmental variables, jackknife test and variable correlation analysis using MaxEnt 3.4.1 and GraphPad Prism 8; “kuenm” package in R 4.0.4 software was used to calculate and adjust model parameters; the optimized MaxEnt model was used to predict the potential distribution range of P. acuta in China under different climate scenarios; ArcGIS 10.7 was used to process and visualize the results. …”
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Key motor and non-motor features in early dementia with Lewy bodies by Anna Planas-Ballvé, Anna Planas-Ballvé, José Rios, Lourdes Ispierto, Mireia Gea, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vilas, Dolores Vilas

“…ObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. …”
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Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Exploring family physicians’ mental health referrals via centralized referral systems in Quebec, Canada: a qualitative descriptive study by Jessica Spagnolo, Marie Beauséjour, Marie-Josée Fleury, Jean-François Clément, Claire Gamache, Lyne Couture, Carine Sauvé, Shane Knight, Christine Gilbert, Richard Fleet, Helen-Maria Vasiliadis

“…Methods: A qualitative descriptive study with 20 participants working in the healthcare sector was conducted. …”
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