cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia by Xiangyu Ge, Xingfei Zhu, Wei Liu, Mingsen Li, Zhaotian Zhang, Ming Zou, Mi Deng, Haifeng Cui, Ziqing Chen, Li Wang, Xuebin Hu, Rong Ju, Xiangcheng Tang, Xiaoyan Ding, Lili Gong

“…Here, we show that cGAMP, the endogenous STING agonist, causes iBRB breakdown and retinal degeneration thorough P2RX7-mediated transport into microglia. Methods Extracellular cGAMP and STING pathway were determined in tissue samples from patients with proliferative DR (PDR) and db/db diabetic mice. …”
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Optic neuropathy as an early manifestation of granulomatosis with polyangiitis: a case report and literature review by Yukang Kim, Tonghoon Woo, Sun-Uk Lee, Sun-Uk Lee, Euyhyun Park, Euyhyun Park, Hyun-Jin Shin, Jongmin Sim, Gerard Jounghyun Kim, Ji-Soo Kim, Ji-Soo Kim

“…The final visual outcome was often poor, with significant visual recovery in only eight eyes (8/23, 35%). …”
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Endogenous endophthalmitis due to Klebsiella pneumoniae liver abscess: a retrospective study of clinical course, treatment pattern, and prognosis by Gyu Chul Chung, Dong Sun Kim, Ji Eun Lee, Iksoo Byon, Sung Who Park, Han Jo Kwon, EunAh Kim

“…AIM: To report the demographic and systemic characteristics of patients, clinical progression of endophthalmitis, and the efficacy of various treatment strategies, with a focus on identifying key factors for preserving vision in eyes with endogenous endophthalmitis due to Klebsiella pneumoniae (K. pneumoniae) liver abscess. METHODS: In this single-center, retrospective case series of 18 patients with endogenous endophthalmitis due to K. pneumoniae liver abscess were analyzed. …”
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Clinical and genetic features of CNGA3 achromatopsia in preschool children: novel insights into retinal architecture and therapeutic window for clinical trials by Yanting Lai, Yanting Lai, Aohan Hou, Aohan Hou, Linyan Zhang, Linyan Zhang, Limei Sun, Limei Sun, Miner Yuan, Miner Yuan, Xiaoyan Ding, Xiaoyan Ding

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APENDIC-RADS: an ultrasound reporting system for the diagnosis of acute appendicitis by Marcos Roberto Gomes de Queiroz, Victor Arantes Jabour, José Leão de Souza Junior, Milena Ribeiro Paixão, Paulo Savoia Dias da Silva, Davi Wen Wei Kang, Gaby Cecilia Yupanqui Guerra Barboza, Guilherme Muniz Bourroul, Juliana Maria Haddad de Lamare, Irline Cordeiro de Macedo Pontes, Gabriela Cauper de Carvalho Pereira, Wanessa Rolando Roselli, Marcelo Rocha Corrêa da Silva, Antonio Rahal Junior, Cesar Augusto Passos Braga, Miguel José Francisco Neto

“…This study introduces the Appendix Imaging Reporting and Data System (APENDIC-RADS) to standardize the reporting of appendix ultrasound findings. Methods: This single-center retrospective study included consecutive patients of all ages who underwent abdominal ultrasonography for the investigation of acute appendicitis. …”
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Assessment of printed lung cancer surgery patient education materials in the United StatesCentral MessagePerspective by Woorin Jang, BS, Savanna Kerstiens, MA, Rachel Nordgren, PhD, Anne Dijkstra, MB, Marina DePablo, MPH, DNP, RN, Lauren Gleason, MD, MPH, Darren Bryan, MD, Jessica S. Donington, MD, MSCR, Mark K. Ferguson, MD, Jane L. Holl, MD, MPH, Maria Lucia Madariaga, MD

“…Here we assessed printed lung cancer surgery PEMs for readability, understandability, actionability, and accessibility. Methods: Various lung cancer programs throughout the United States were contacted for their lung cancer surgery PEMs. …”
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Effect of ethnicity and other sociodemographic factors on attendance at ophthalmology appointments following referral from a Diabetic Eye Screening Programme: a retrospective cohor... by James Banks, Adnan Tufail, Ling Zhi Heng, Josef Huemer, Christopher G Owen, Alicja R Rudnicka, Yasir Khan, Abraham Olvera-Barrios, Michael Seltene, Mumina Khatun, Catherine A Egan, Zoe Ockrim, Matilda Pitt, Daisy Williams, Celestine Rutowska

“…Background/aims To examine the association between sociodemographic characteristics and attendance at Hospital Eye Service (HES) referrals from the Diabetic Eye Screening Programme (DESP), in a large, ethnically diverse urban population.Methods Retrospective cohort study (4 January 2016–12 August 2019) of people with diabetic retinopathy (DR) referred from an English DESP to a tertiary referral eye hospital. …”
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Automated fiber quantification analysis identifies tract-specific microstructural alterations in brain in intermittent exotropia by Jianlin Guo, Leqing Zhou, Ying Wang, Di Hu, Yanqiu Lv, Huiying Kang, Li Li, Yun Peng

“…This study aimed at examining the characteristics of brain microstructure along major fiber tracts in IXT patients using an automated fiber quantification analysis. Methods: A total of 25 patients with IXT as well as 25 healthy participants matched for age and gender finished the diffusion tensor imaging scanning and the ophthalmic examination. …”
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The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational... by Cheryl Xi-Zi Chong, Frederick H. Koh, Hui-Lin Tan, Sharmini Su Sivarajah, Jia-Lin Ng, Leonard Ming-Li Ho, Darius Kang-Lie Aw, Wen-Hsin Koo, Shuting Han, Si-Lin Koo, Connie Siew-Poh Yip, Fu-Qiang Wang, Fung-Joon Foo, Winson Jianhong Tan

“…The aim of this study was to assess whether TNT (TNT-RAPIDO) is associated with increased difficulty of total mesorectal excision (TME) compared with long-course chemoradiotherapy (LCRT) and upfront surgery. Methods Twelve laparoscopic videos of low anterior resection with TME for rectal cancer were prospectively collected from January 2020 to October 2021, with 4 videos in each arm. …”
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Articular cartilage degeneration and aberrant osteocyte perilacunar/canalicular remodeling in subchondral bone of patients with developmental dysplasia of the hip by Teng Ye, Jiren Yan, Tianyou Kan, Guoming Xie, Zhichang Zhang, Wenjing Yin, Bizeng Zhao, Zhifeng Yu, Linyang Chu

“…Ploton silver staining was used to visualize lacunocanalicular network and picrosirius red staining was to visualize collagen fiber orientation in subchondral bone. …”
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Relationship between the length of macular Bruch's membrane on fundus photograph and myopia occurrence in pre-myopia children aged 3–6 years: A 3-year longitudinal study by Xuejing Mi, Yuxin Fang, Jianing Pu, Wei Chen, Zhen Zhou, Mengmeng Qin, Ranran Zhang, Dan Wang, Yanyan Yang, Chuzhi Peng, Shimeng Bian, Mingrui Jin, Huaying Xu, Yonghong Jiao

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Ten-year outcomes of repeat keratoplasty for optical indications by Victoria Grace Dimacali, Hon Shing Ong, Hon Shing Ong, Hon Shing Ong, Hon Shing Ong, Stephanie Shuang Lang, Hla Myint Htoon, Hla Myint Htoon, Howard Cajucom-Uy, Hui Chen Charmaine Chai, Hui Chen Charmaine Chai, Marcus Ang, Marcus Ang, Anshu Arundhati, Anshu Arundhati, Anshu Arundhati, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta

“…AimTo analyze the clinical outcomes of repeat keratoplasties following a failed primary optical keratoplasty in an Asian population.MethodsIn this prospective cohort study, clinical data of consecutive patients who had repeat keratoplasty at Singapore National Eye Centre from 2007 to 2020 were recorded from our ongoing Singapore Corneal Transplant Registry.ResultsA total of 284 first regrafts (181 Descemet stripping automated endothelial keratoplasty (EK), 63 penetrating keratoplasty (PK), 21 Descemet membrane endothelial keratoplasty, and 19 deep anterior lamellar keratoplasty (DALK)) were analyzed. …”
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Management and Microbiological Characteristics of Membrane Formation on a Hydrophilic Acrylic Intraocular Lens: A Clinical Case Series and Material Comparative Study of Different I... by Xiaodi Qiu, Yang Wu, Yongxiang Jiang, Yinghong Ji, Xiangjia Zhu, Jin Yang, Yi Lu

“…To report a case series of membrane formation on intraocular lenses (IOLs) after uneventful phacoemulsification and to evaluate the material characteristics and biofilm formation on different IOLs. Methods. Ten eyes implanted with the same type of IOLs were found to have membranes on their IOLs after uneventful phacoemulsification from May 2015 to May 2016. …”
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Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis by Vincenzo Rania, Cristina Vocca, Gianmarco Marcianò, Maria Cristina Caroleo, Lucia Muraca, Emanuele Toraldo, Francesca Greco, Caterina Palleria, Gian Pietro Emerenziani, Luca Gallelli

“…In this setting, intra-articular injections of hyaluronic acid (HA) represent a relevant and diffused therapeutic option. <b>Materials and Methods</b>: A prospective observational study was performed from October 2024 to May 2025 in 70 patients with knee OA. …”
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Early detection of human Mpox: A comparative study by using machine learning and deep learning models with ensemble approach by Madhumita Pal, Francesco Branda, Adel Qlayel Alkhedaide, Ashish K Sarangi, Himansu Bhusan Samal, Lizaranee Tripathy, Binapani Barik, Salah M El-Bahy, Alok Patel, Ranjan K Mohapatra, Lawrence Sena Tuglo, Mona Youssef

“…Objective This study aims to enhance the early diagnosis of Mpox through machine learning (ML) and deep learning (DL) models, integrating an ensemble approach to improve classification accuracy. Methods We used the Mpox Skin Lesion Dataset v2.0, comprising six skin lesion categories, including chickenpox, cowpox, Mpox, measles, hand-foot-mouth disease, and healthy skin. …”
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Phenotypic and molecular characterization of the response to two soil-borne viruses in durum wheat landraces for the identification of new sources of resistance by Monica Marra, Raul Pirona, Laura Miozzi, Daniele Marian, Cinzia Montemurro, Aldo Ceriotti, Gian Paolo Accotto, Elena Baldoni

“…These viruses are transmitted through a soil-inhabiting vector, the plasmodiophoromycota Polymyxa graminis Led. There are very few methods available to eradicate P. graminis, whose resting spores survive in infested soil for decades, but they are either too expensive or not environmentally friendly. …”
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Neurovascular Decoupling Is Associated With Lobar Intracerebral Hemorrhages and White Matter Hyperintensities by Suzanne E. van Dijk, Nadieh Drenth, Anne Hafkemeijer, Gerda Labadie, Marie‐Noëlle W. Witjes‐Ané, Frank Baas, Jeroen P. Vreijling, Gerard J. Blauw, Serge A. R. B. Rombouts, Jeroen van der Grond, Sanneke van Rooden

“…Therefore, understanding the relationship between neurovascular coupling and established vascular risk factors for AD is essential to gain deeper insights into the vascular mechanisms underlying AD. Methods This cross‐sectional observational study investigated the association between neurovascular coupling and vascular risk factors for AD, specifically small vessel disease magnetic resonance imaging markers, cardiovascular risk factors, and the apolipoprotein E genotype. …”
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Global bibliometric analysis of traditional Chinese medicine regulating gut microbiota in the treatment of diabetes from 2004 to 2024 by Jieling Liang, Xiaojuan Lin, Xin Liao, Xi Chen, Ying Zhou, Lin Zhang, Yunyun Qin, Haoru Meng, Zhongwen Feng

“…This study aims to meticulously examine current research trajectories and focal areas from 2004 to 2024, providing a foundational framework for future inquiries.MethodsA comprehensive search of documents published between 2004 and 2024 was conducted using the Web of Science database. …”
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An approach to the meso-scale epidemiological behavior of Plasmodiophora brassicae from cruciferous crops under tropical conditions; Supplementary material by Andres F. Quintero-Mercado, Juan Camilo Garcia-Peña, Andrea Botero-Ramirez, Celsa Garcia, Joaquín Guillermo Ramírez-Gil

“…The different epidemiological analysis approaches used suggest that P. brassicae presents a high risk in areas with host presence and conducive edaphoclimatic characteristics, indicating the need to carry out epidemiological surveillance, reduce the dispersion of infested soil, and implement P. brassicae exclusion methods.…”
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PriBeL: A primary betel leaf dataset from field and controlled environmentMendeley Data by Gauri Mane, Raghav Bhise, Rutuja Kadam, Gagandeep Kaur, Devika Verma, Rupali Chopade, Gitanjali Shinde, Ghanshyam G. Tejani, Seyed Jalaleddin Mousavirad

“…Essentially, visual identification of plant health is vital for research in agriculture and medicinal plants for important crops, both in terms of economics and pharmacology, such as betel leaves. …”
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