Sodium butyrate and sodium propionate inhibit breast cancer cell migration and invasion through regulation of epithelial-to-mesenchymal transition and suppression of MEK/ERK signal... by Dania Mahmoud Kharazi, Louna Karam, Charbel El Boustany, José-Noel Ibrahim

“…ObjectiveThis study aims to investigate the roles played by NaB and NaP in breast carcinogenesis by elucidating their potential anti-metastatic effects in the context of tumor migration, invasion, and EMT regulation in two distinct breast cancer cell lines, MCF-7 and MDA-MB-231.MethodsThe cytotoxic effect of both compounds on 3D spheroid formation was evaluated using a hanging drop assay. …”
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Effect of esketamine on postoperative delirium in general anesthesia patients undergoing elective surgery: a meta-analysis of randomized controlled trials by Wenhui Zhang, Di Wang, Siru Li, Yutao Chen, Congjie Bi

“…The objective was to investigate the effects of esketamine on postoperative delirium in patients with general anesthesia. Methods The databases of PubMed, Embase, Cochrane Library and the Chinese National Knowledge Infrastructure were searched for all available randomised controlled trials on the effects of esketamine induction on postoperative delirium in patients undergoing elective general anesthesia from inception until April 21, 2024. …”
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Efficiency of local hyaluronic acid injections in subacromial impingement syndrome by V. A. Nesterenko, A. E. Karateev, E. I. Byalik, M. A. Makarov, S. A. Makarov, V. E. Byalik, M. R. Nurmukhametov, I. A. Fedotov

“…One of the treatments for SIS is the local injection of hyaluronic acid (HA) preparations.Objective: to evaluate the efficiency of subacromial injection of HA in chronic shoulder pain associated with SIS.Subjects and methods. A study group consisted of 31 patients (48.4% of women and 51.6% of men; mean age 53.8±15.2 years) with chronic shoulder pain (>3 months) that had occurred after rotator tendon injury confirmed by ultrasound and/or magnetic resonance imaging. …”
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Clinical Results of All-Inside Lateral Ankle Ligament Complex Repair were Comparable to Open Brostrom Procedure in High-Demand Patients with Chronic Ankle Instability: Randomized C... by Sung Hyun Lee MD, PhD, Gyeong Hun Lim MD

“…This study aimed to compare the clinical and radiological outcomes of arthroscopic repair and open repair of the lateral ligament complex (LLC) in patients with CAI. Methods: We prospectively randomized 64 patients who underwent ligament repair surgery for CAI into two groups: arthroscopic LLC repair (group A, 33 patients) and open modified Broström-Gould procedure (group O, 31 patients). …”
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Retinal optical coherence tomography changes as biomarkers for Parkinsonism duration and severity in the Kashmiri population by Irtiqa Mohammad, Sabia Rashid, Bashir A. Sanie, Shubana Ashraf, Adnan F. Raina

“…AIMS AND OBJECTIVES: To evaluate retinal morphological changes using optical coherence tomography (OCT) in patients with PD and atypical parkinsonian syndromes and to correlate these changes with disease duration and severity. METHODS: This cross-sectional study included 50 parkinsonian patients (37 idiopathic PD, 5 multiple system atrophy [MSA], 4 corticobasal degeneration [CBD], 4 progressive supranuclear palsy [PSP]) and 50 age-matched healthy controls. …”
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Results of Autograft vs Allograft with Bone Marrow Aspirate Concentrate in Lateral Column Lengthening for Reconstruction of Progressive Collapsing Flatfoot Deformity by Daran Huang MBBS, Eric Wei Liang Cher MD, MRCS, MMed (Ortho), FRCSEd (Ortho), Wenxian Png MBBS, MRCS, MMed (Ortho), FRCSEd (Ortho), Inderjeet Rikhraj Singh MBBS, FRCSEd (Ortho), FAMS

“…The purpose of this study is to compare the results of graft choice on bony union, subsequent clinical outcomes and complication rates after LCL osteotomy. Methods: This was a retrospective study of 34 patients who underwent Evan’s LCL divided into 2 cohorts dependent on the type of graft used for the opening osteotomy (Group A used tricortical autograft harvested from the iliac crest, n = 24; Group B used tricortical allograft soaked in the patient’s own bone marrow aspirate concentrate, n = 10). …”
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Dynamic changes in autophagosome formation and lipid droplet accumulation during spermiogenesis in mice by YANG Yixuan, QIAN Xiaojing, LIU Zhenghui, HAN Daishu, CHEN Yongmei

“…Objective To investigate the temporal and spatial relationship between autophagosome formation during spermatid deformation and lipid droplet distribution in seminiferous tubules, thereby providing insights into the energy sources underlying spermiogenesis. Methods Healthy adult wild-type male mice were used in this study. …”
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A novel opioid/pramipexole combination treatment for the management of acute pain: a pilot study by Cara Girardi, Joseph Duronio, Ryan Patton, Kevin O’Brien, Stefan Clemens, Kori L. Brewer

“…Our objective was to test if adjunct treatment with a D3R agonist can lead to a reduction in opioid use while maintaining effective analgesia.Patients and methodsThis study was set up as a double-blinded, placebo-controlled randomized trial. …”
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Spreading New Light on Attention Restoration Theory: An Environmental Posner Paradigm by Alessandro Piedimonte, Gianluca Lanzo, Francesco Campaci, Valeria Volpino, Elisa Carlino

“…To capture both behavioral and neural responses, the study collected reaction times (RTs) as a measure of task performance, alongside electrophysiological data (event-related potentials, ERPs: P1, N1, P2, N2, and P3) to explore underlying attentional processes. <b>Methods</b>: Participants completed a visuospatial task in which visual cues anticipated the appearance of a target stimulus, while background images depicting either natural or urban environments remained visible throughout. …”
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Clinical and radiographic evaluation of non-surgical therapy with and without ozone gel application in controlled type 2 diabetic patients with periodontitis: a randomized controll... by Abeer Abubaker Barahim, Nesma Shemais, Arwa Mousa, Mona Darhous

“…Abstract Background The current study aimed to assess the clinical and radiographic outcomes of the effect of subgingival application of ozonated gel as an adjunct to scaling and root planing (SRP) in diabetic patients with stage III periodontitis. Methods Twenty-four patients with type II diabetes mellitus (DM) were randomized into two groups, with 12 patients in each group. …”
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STUDY FOR THE INFLUENCE OF NEW DIAZINONE-4 DERIVATIVES AND THEIR ACYCLIC PREDECESSORS ON THE DYNAMICS OF WEIGHT AD MASS COEFFICIENTS OF RATS’ ORGANS by A. V. Voronkov, S. A. Luzhnova, Suda Billel, S. A. Osychenko

“…The purpose of the work is an estimation of the influence of 30-day administration course of PYATd1, PYATs2, PYATs4, PYATd12, PYATs3, PYATd8 on a general condition, weight dynamics and mass coefficients of the rats’ organs. Materials and methods. The studies used 120 both gender Wistar rats weighed 190-210 g. …”
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PXseg: automatic tooth segmentation, numbering and abnormal morphology detection based on CBCT and panoramic radiographs by Raokaijuan Wang, Fangyuan Cheng, Guangsheng Dai, Jiayu Zhang, Chengmin Fan, Jinghong Yu, Juan Li, Fulin Jiang

“…Abstract Objective PXseg, a novel approach for tooth segmentation, numbering and abnormal morphology detection in panoramic X-ray (PX), was designed and promoted through optimizing annotation and applying pre-training. Methods Derived from multicenter, ctPXs generated from cone beam computed tomography (CBCT) with accurate 3D labels were utilized for pre-training, while conventional PXs (cPXs) with 2D labels were input for training. …”
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Outcomes According to Remnant Ligament Tissue Quality after Arthroscopic All-Inside Anterior Talofibular Ligament Repair for Chronic Ankle Instability by Sung Hyun Lee MD, PhD, Gyeong Hun Lim MD

“…This study aims to evaluate the outcomes of the arthroscopic all-inside anterior talofibular ligament (ATFL) repair, according to the quality of remnant ligament. Methods: A retrospective analysis was conducted on consecutive CAI patients who underwent arthroscopic ATFL repair, with a follow-up period of at least two years. …”
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MiR-145 encapsulated small extracellular vesicles inhibit colorectal cancer progression by downregulating fascin actin-bundling protein 1 expression by Yanxia Chen, Meijuan He, Lei Cui, Jianguo Zhang, Hanpeng Huang, Zhimin Tao

“…Abstract Background Drug degradation poses a significant challenge in the pursuit of effective gene therapies for cancers. Methods Here we have developed a bioactive nanosized composite that utilizes human umbilical cord mesenchymal stem cells (hucMSCs) derived small extracellular vesicles (sEVs), to carry tumor suppressor miR-145 alongside erbium-doped rare earth nanoparticles (ErNPs). …”
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Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients by Neslihan Eskut, Ali Murat Koc, Asli Koskderelioglu, Ismail Dilek, Mustafa Agah Tekindal

“…Objective To measure the cranial volume differences from 15 different parts in the follow-up of relapsing-remitting multiple sclerosis (RRMS) patients and correlate them with clinical parameters. Methods Forty-seven patients with RRMS were included in the study. …”
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Detection of hypertension from pharyngeal images using deep learning algorithm in primary care settings in Japan by Takeo Nakayama, Yusuke Tsugawa, Hiroshi Yoshihara, Memori Fukuda, Sho Okiyama

“…Background The early detection of hypertension using simple visual images in a way that does not require physical interaction or additional devices may improve quality of care in the era of telemedicine. …”
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Features of Progress and Treatment of Postprimary Refractory Glaucoma in a Patient with Progressive Mesodermal Iris Atrophy by A. D. Chuprov, L. I. Popova, V. I. Lapochkin, A. V. Lapochkin, D. V. Lapochkin, L. V. Demakova

“…To optimize the approaches to the treatment of secondary decompensated refractory glaucoma on the basis of the clinical case analysis. Patient and methods. A case of bilateral progressivemezodermal atrophy of the iris and the cornea on 49 years old patient, who appealed to the Kirov clinical Ophthalmology hospital in February 2015 year with repeatedly operated decompensated refractory glaucoma. …”
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Color-vision abnormalities among patients undergoing tuberculosis treatment by Emerson M. Cruz, MD, Frances G. Puentespina, MD, Karlo Paolo L. Alejo, MD

“…Objective: This study determined the incidence of and risk factors for color-vision abnormalities among Filipino patients undergoing directly observed treatment short-course (DOTS) for tuberculosis. Methods: A prospective single-cohort study involving newly diagnosed patients with category-1 tuberculosis, recruited from DOTS health centers in Manila, was conducted. …”
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High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study. by Julius Mulindwa, Joyce Namulondo, Anna Kitibwa, Jacent Nassuuna, Oscar Asanya Nyangiri, Magambo Phillip Kimuda, Alex Boobo, Barbara Nerima, Fred Busingye, Rowel Candia, Annet Namukuta, Ronald Ssenyonga, Noah Ukumu, Paul Ajal, Moses Adriko, Harry Noyes, Claudia J de Dood, Paul L A M Corstjens, Govert J van Dam, Alison M Elliott, Enock Matovu, TrypanoGEN+ Research group

“…It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease.<h4>Methods</h4>We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. …”
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Data Insights on the Risks of Local Heat and Massage in Gouty Arthritis Treatment by Shivam Mehra, Kamal Mehra, Nindiya Kapoor Mehra, Sachin Yashwant Kale, Bharat Veer Manchanda

“…This study aims to compare the effects of hot fomentation versus cold fomentation in patients experiencing acute gout flares, assessing pain reduction, swelling, joint mobility, and overall patient satisfaction. Materials and Methods: A randomized controlled trial was conducted with 2,400 patients diagnosed with acute gouty arthritis, divided into two equal groups: Group A received hot fomentation (38°C–42°C) and Group B received cold fomentation (5°C–10°C). …”
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