Unraveling the significance of cuproptosis in hepatocellular carcinoma heterogeneity and tumor microenvironment through integrated single-cell sequencing and machine learning appro... by Wang Liu, Liangjing Xia, Yuan peng, Qiang Cao, Ke Xu, Huiyan Luo, Yongjun Peng, Yanping Zhang

“…A comprehensive understanding of the biological characteristics and molecular mechanisms underlying HCC cell subpopulations is crucial for improving prognostic predictions and refining treatment strategies. Methods Single-cell RNA sequencing data were obtained from the GEO database and processed using the Seurat R package for quality control, including data filtering, batch effect correction, and dimensionality reduction via PCA and UMAP to visualize cell distribution and identify distinct subpopulations. …”
Get full text

Effect of Neuromuscular Exercise Training Combined with Semiconductor Laser Therapy on Patients with Knee Osteoarthritis by LOU Xiaole, TAO Yating, LIN Lin, SONG Xiaodong, WANG Min, JIANG Yong

“…ObjectiveTo observe the effect of neuromuscular exercise (NEMEX训练) training combined with semiconductor laser therapy on patients with knee osteoarthritis (KOA).MethodsA total of sixty patients with knee osteoarthritis were treated in the Rehabilitation Medicine Department of the First Affiliated Hospital of Bengbu Medical University from August 2023 to March 2024 were selected and randomly divided into a control group and an observation group using a random number table method, with 30 patients in each group. …”
Get full text

Enhanced Dermal Delivery of Nanoparticulate Formulation of Cutibacterium acnes Using Sponge Spicules for Atopic Dermatitis Treatment by Jin Y, Zhang C, Jia M, Chen M

“…In this study, a novel nanoparticulate formulation of Cutibacterium acnes (NFCA) was developed with the formulation optimization for the dermal delivery.Materials and Methods: Sponge Haliclona sp. spicules (SHS) were isolated from the explants of sponge Haliclona sp. with our proprietary method. …”
Get full text

Deep Learning-Assisted Diagnostic System: Implant Brand Detection Using Improved IB-YOLOv10 in Periapical Radiographs by Yuan-Jin Lin, Shih-Lun Chen, Ya-Cheng Lu, Xu-Ming Lin, Yi-Cheng Mao, Ming-Yi Chen, Chao-Shun Yang, Tsung-Yi Chen, Kuo-Chen Li, Wei-Chen Tu, Patricia Angela R. Abu, Chiung-An Chen

Get full text

Efficacy of Tuina Versus the Proprioceptive Neuromuscular Facilitation (PNF) Technique in Patients With Nonspecific Chronic Neck Pain: Protocol for a Randomized Controlled Trial by Kaiqi Fan, Aicheng Wang, Hainan Gao, Ting Yu, Xiangyu Zhu

“…However, there is little evidence of the effectiveness of proprioceptive neuromuscular facilitation (PNF), a rehabilitative method involving specific patterns of muscle contraction and stretching, in treating NCNP, either alone or in combination with tuina. …”
Get full text

V. DOMONTOVYCH’S SHORT STORY “THIRST FOR MUSIC” IN THE ASPECT OF INTERDISCURSIVE METHODOLOGY by Alyona R. Tychinina., Nataliia V. Nikoriak

“…It involves the use of biographical, hermeneutical, intertextual, and intermedial research methods. The study is based on the research of M. …”
Get full text

Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial by Yanan Wu, Yaning Yang, Xiaomei Wang, Li Sun, Yunpeng Hei, Yuhua Zou, Zhenhai Ye, Zhi Yu

“…In this study, we investigated the effect of intraoperative esketamine infusion on the incidence of PSD in patients who underwent laparoscopic cholecystectomy. Methods A single-center, double-blinded, placebo-controlled randomized clinical trial was perfomed from May to August 2024 at the People’s Hospital of Ningxia Hui Autonomous Region. …”
Get full text

Antimicrobial activity of copper-nickel coated door handles: a blinded, randomized controlled study in a clinical setting by Idelevich, Evgeny A., Schlattmann, Andreas, Sauerland, Cristina, Gebert, Carsten, Becker, Karsten

“…However, the impact of reducing bacterial contamination through copper-coated surfaces remains controversial. Methods: A pilot study was set up in a blinded, randomized controlled design to elucidate the antimicrobial activity of door handles coated with a copper-nickel alloy. …”
Get full text

Survival outcomes of hybrid total hip replacement following failed proximal femoral nail antirotation: a retrospective study with a median 10-year follow-up by Yannan Chen, Zhifen Lai, Weiguang Yu, Xianshang Zeng, Mingdong Zhao, Guangquan Zhu

“…The primary objective of this study was to evaluate implant longevity, which was assessed using the Kaplan–Meier method, with a particular focus on revision surgeries. …”
Get full text

Partial femoral head replacement: a new innovative surgical technique for precise minimally invasive treatment of association research circulation osseous stage III femoral head ne... by Tianyu Wang, Zhongzheng Wang, Yuchuan Wang, Changhui Li, Yining Lu, Yanbin Zhu, Wei Chen, Xuebin Zhang, Yingze Zhang

“…Conclusions Our preliminary clinical results showed that partial femoral head replacement was a safe and effective method for the treatment of ARCO III femoral head necrosis. …”
Get full text

Clinical efficacy and radiological changes of proximal fibular osteotomy for medial compartment knee osteoarthritis: a systematic review and meta-analysis by Yu Jiang, Jingyuan Li, Liang Zhang, Xiaodong Jia, Tianrui Wang, Xia Zhao, Jinli Chen, Kuishuai Xu

“…Abstract Objective We aimed to analyze the clinical efficacy, safety, and radiological changes of proximal fibular osteotomy (PFO) for medial compartment knee osteoarthritis (MKOA). Methods Since the establishment of the databases, we searched all studies involving proximal fibular osteotomy in PubMed, Proquest, Scopus, and Web of Science. …”
Get full text

Clinical Study on Lumbar Disc Herniation Treated by Sling and Tuina Exercise Technique by Yi DING, Chenchen GUO, LI Li

“…Objective:To explore the clinical effect of sling and tuina exercise technique on lumbar disc herniation(LDH)and the changes of thickness of local core stable muscles including transversus abdominal muscle and multifidus muscle, and to explain the therapeutic advantages of sling and tuina exercise technique for LDH.Methods:A total of 84 LDH patients who were outpatient and admitted to the rehabilitation center of the Second Affiliated Hospital in Shandong University of Traditional Chinese Medicine were collected. …”
Get full text

A COMPARISON OF THE EFFECTS OF BALANCE– PROPRIOCEPTION AND AEROBIC EXERCISES ON FUNCTIONAL STATUS, PAIN, AND BALANCE IN PATIENTS WITH FIBROMYALGIA SYNDROME - A RANDOMIZED CONTROLLE... by Hadi Yavuz, Türker Şahinkaya, Musa Doruk, Mert Zure, Şensu Dinçer, Ayşegül Ketenci, Gökhan Metin

“…This study aimed to compare the effects of aerobic and balance-proprioception exercises on pain, functional status, and balance in female patients with fibromyalgia.Material and Method: Female patients with fibromyalgia syndrome who applied to the university physical medicine and rehabilitation department clinic were evaluated for eligibility. …”
Get full text

Radiomic study on preoperative multi‐modal magnetic resonance images identifies IDH‐mutant TERT promoter‐mutant gliomas by Haoyu Wang, Shuxin Zhang, Xiang Xing, Qiang Yue, Wentao Feng, Siliang Chen, Jun Zhang, Dan Xie, Ni Chen, Yanhui Liu

“…This study aimed to characterize the IDHmut pTERTmut gliomas in multimodal MRI using the radiomic method and establish a precise diagnostic model identifying this group of gliomas. …”
Get full text

Comparison of the effectiveness of subacromial administration of platelet-rich plasma and hyaluronic acid in chronic shoulder pain caused by damage to the tendons of the rotator cu... by V. A. Nesterenko, A. E. Karateev, M. A. Makarov, E. I. Byalik, S. A. Makarov, A. M. Lila

“…Local injections of platelet-rich plasma (PRP) and hyaluronic acid (HLA) are considered an effective method for treating chronic shoulder pain (CSP) associated with damage to the tendons of the rotator cuff muscles (RCM).The aim of the study is to compare the effectiveness and safety of local therapy of PRP and HLA in patients with CSP caused by damage to the tendons of the RCM muscles.Materials and methods. …”
Get full text

The effect of lumbar multifidus muscle degeneration on upper lumbar disc herniation by Bingwen Wang, Lifei Xu, Peng Teng, Lin Nie, Lin Nie, Hongwei Yue

“…PurposeThis study aimed to investigate the effect of lumbar multifidus muscle (MF) degeneration on upper lumbar disc herniation (ULDH).MethodsThis study used 3.0T magnetic resonance imaging (MRI) T2 axial weighted images to retrospectively analyze 93 ULDH patients and 111 healthy participants. …”
Get full text

EFFICIENCY OF TREATMENT OF HARD TISSUES DEFECTS OF LATERAL TEETH WITH DIRECT AND INDIRECT RESTORATIONS MADE OF COMPOSITE MATERIALS: COMPARATIVE CLINICAL EVALUATION by N.I. Mykyievych

“…The patients were divided into two groups according to the method of treatment. The I (basic) group included 42 patients, who underwent 76 indirect restorations for reconstructing the defects of teeth crowns. …”
Get full text

VALIDATION OF A RUSSIAN-LANGUAGE VERSION OF THE VEINES-QOL/SYM QUESTIONNAIRE IN PATIENTS WITH RHEUMATIC DISEASES AND LOWER EXTREMITY CHRONIC VENOUS DISEASES by M. A. Satybaldyeva, N. V. Seredavkina, S. I. Glukhova, I. N. Gorskikh, T. M. Reshetnyak, E. L. Nasonov

“…Objective: to assess the psychometric properties (reliability, sensitivity, and validity) of a Russian-language version of the VEINES-QOL/Sym questionnaire in patients with rheumatic diseases and lower extremity chronic venous diseases.Subjects and methods. The investigation enrolled 89 patients (66 (74%) women and 23 (26%) men) (their mean age was 46.3±13.4 years) with rheumatic diseases. …”
Get full text

Negative Correlation Between Fractional Anisotropy on Diffusion Tensor Imaging and Neck Disability Index in Cervical Spondylotic Radiculopathy After Percutaneous Cervical Nucleopla... by Fan N, Li T, Lu X, Ma X, Yang L, Du P, Zang L, Yuan S

“…Ning Fan,1,* Tusheng Li,1,* Xuanyu Lu,1,* Xinyu Ma,2 Lihui Yang,1 Peng Du,1 Lei Zang,1 Shuo Yuan1 1Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, People’s Republic of China; 2Department of Orthopedics, Civil Aviation General Hospital, Beijing, 100123, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Zang, Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email zanglei@ccmu.edu.cn Shuo Yuan, Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email happyshuohappy@163.comPurpose: This study aimed to examine the correlation between diffusion tensor imaging (DTI) parameters (fractional anisotropy, FA; apparent diffusion coefficient, ADC) and clinical outcomes (neck disability index, NDI; visual analog scale, VAS) in cervical spondylotic radiculopathy (CSR) patients following percutaneous cervical nucleoplasty (PCN), respectively.Methods: This is a cross-sectional study. …”
Get full text

Therapeutic Effect of Core Stability Training Combined with Extracorporeal Shock Wave on Lumbar Disc Herniation by Shuo LI, Lishuang LIU, Jinna ZHOU, Qiaoyun XIANG, Tingting LUAN, Wenwen WANG

“…The Combined group was given core stability training and extracorporeal shock wave therapy, and the method was the same as above. The pain degree was evaluated by visual analogue score (VAS) before treatment, 3 months of treatment and 6 months after treatment. …”
Get full text