Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

“…Therefore, this study aims to clarify the mechanism of RosA in the treatment of LUAD by integrating bioinformatics, network pharmacology and in vivo experiments, and to explore the potential of the active ingredients of traditional Chinese medicine in treating LUAD. Methods Firstly, the network pharmacology was used to screen the RosA targets, and LUAD-related differential expressed genes (DEGs) were acquired from the GEO database. …”
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Effect of different administration methods of esketamine on postoperative depression in patients undergoing heart valve replacement by LI Zongxiao, MA Xin, MA Wenru, NIU Zejun

“…Objective To investigate the impact of single or continuous administration of subanesthetic doses of eske-tamine during anesthesia on postoperative depression in patients undergoing heart valve replacement. Methods A total of 256 patients who underwent heart valve replacement in our hospital from August 2023 to August 2024 were enrolled, and according to the use of esketamine during surgery, the patients were divided into control group (group C), single-dose group (group S-S), and continuous-dose group (group C-S). …”
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Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…We used ‘realist evaluation’ methods to look at different models of paramedics in general practice (we call this ‘paramedic working in general practice’). …”
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Abrasion resistant characteristics of UHPC based on high-speed underwater method: Efficiency, process, evaluation, and mechanisms by Xuan Qiu, Jihui Zhao, Zhong Li

“…The wear characteristics of UHPC under high-speed water flow conditions were investigated using a 3D visualization quantitative method. Additionally, the abrasion mechanism of UHPC was analyzed using nanoindentation testing, SEM, and MIP techniques. …”
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Double ARA-Sumudu decomposition method for the solution of linear fractional partial integro-differential equations by Jagdish Nanaware, Akshaykumar Dongardive

“…By leveraging the double ARA-Sumudu transform, a decomposition method is constructed using the definition of the Caputo fractional derivative. …”
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Neck shape optimization of resonator-type sound absorbers using adjoint lattice Boltzmann method by Kimiya Takeuchi, Kazuya Kusano

“…In this study, we attempted to improve the sound absorption characteristics of a Helmholtz resonator using an unsteady adjoint method based on the lattice Boltzmann equation. The adjoint-based shape optimization created a concave shape on the upper side and a convex shape on the lower side of the resonator neck, alleviating noise to a greater extent compared with straight and serrated neck shapes. …”
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Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N by Julius Bogomolovas, Ju Chen

“…Abstract Protein kinases play crucial roles in regulating cellular processes, making real-time visualization of their activity essential for understanding signaling dynamics. …”
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A Novel, Sport-Specific EMG-Based Method to Evaluate Movement Efficiency in Karate Punching by László Csákvári, Bence Kopper, Tamás Horváth

“…Background: This study aimed to develop a method to analyze the kinetic and kinematic characteristics of the traditional karate Gyaku Tsuki (reverse punch), focusing on the activation sequence of lower and upper extremities and trunk muscles during execution. …”
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PFRNet: A Small Object Detection Method Based on Parallel Feature Extraction and Attention Mechanism by Hai Lin, Ji Wang, Jingguo Li

“…To address the challenge of detecting small objects in aerial and satellite remote sensing images with low-resolution, we propose a high-precision object detection method based on PFRNet. PFRNet incorporates parallel feature extraction branches and a progressive feature refinement mechanism, significantly enhancing the model’s ability to perceive detailed features. …”
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Knowledge Graph-Augmented ERNIE-CNN Method for Risk Assessment in Secondary Power System Operations by Xiang Huang, Ping Li, Ye Wang, Xuchao Ren, Zhenbing Zhao, Gang Li

“…With the increasing complexity of modern power systems, traditional risk assessment methods relying on expert experience and historical data face challenges in accuracy and adaptability. …”
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Research on Multi-Scale Point Cloud Completion Method Based on Local Neighborhood Dynamic Fusion by Yalun Liu, Jiantao Sun, Ling Zhao

“…Experimental results show that LNDM-Net reduces the average Chamfer Distance (CD) by 5.78% on PCN and 4.54% on ShapeNet compared to SOTA. The visualization of completion results demonstrates the superior performance of our method in both point cloud completion accuracy and local detail preservation. …”
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A Method for En Face OCT Imaging of Subretinal Fluid in Age-Related Macular Degeneration by Fatimah Mohammad, Justin Wanek, Ruth Zelkha, Jennifer I. Lim, Judy Chen, Mahnaz Shahidi

“…The purpose of the study is to report a method for en face imaging of subretinal fluid (SRF) due to age-related macular degeneration (AMD) based on spectral domain optical coherence tomography (SDOCT). …”
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A Discrete Fourier Transform-Based Signal Processing Method for an Eddy Current Detection Sensor by Songhua Huang, Maocheng Hong, Ge Lin, Bo Tang, Shaobin Shen

“…Our experimental results demonstrate that the digital method yields smoother signal waveforms and superior 3D defect imaging for nuclear power plant tubes, enhancing result interpretability. …”
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Design, Simulation and Experimental Validation of a Pneumatic Actuation Method for Automating Manual Pipetting Devices by Valentin Ciupe, Erwin-Christian Lovasz, Robert Kristof, Melania-Olivia Sandu, Carmen Sticlaru

“…This study provides a set of designs, simulations and experiments for developing an actuating method for manual pipettes. The goal is to enable robotic manipulation and automatic pipetting, while using manual pipetting devices. …”
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Communication skills for medical/dental students at the University of Pretoria: Lessons learnt from a two-year study using a forum theatre method by C. Krüger, J.J. Blitz-Lindeque, G.E. Pickworth, A.J. Munro, M. Lotriet

“…Background: This study describes the lessons learnt from using a novel method for teaching communication skills to second-year medical/dental students. …”
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A Single Needle Tip Position Approach ‘The Middle Trunk’ Block-for Supraclavicular Block: An Anatomic Cadaveric Study by Sandeep Diwan, S Shivaprakash, Rasika Timane, Pallavi Pai, Anju Gupta

“…We hypothesized that a single injection of dye at the level of the middle trunk (MT) would result in diffusion in the superior and inferior trunks. Methods: After ethics approval, ultrasound-guided injections were performed with a needle tip positioned within fatty connective tissue at the level of the MT bilaterally in 6 soft-embalmed cadavers. …”
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A New Method for Assessing the Rate of Biodegradation of Magnesium Alloy-Based Products in an In Vivo Experiment by Kwang Seon Shin, Alexey Drobyshev, Nikolai Redko, Kantemir Kunizhev, Aleksander Komissarov, Viacheslav Bazhenov, Zaira Gurganchova, Andrey Miterev, Yaroslav Skakunov, Dmitry Lezhnev, Oleg O. Yanushevich

“…A systematic review of research articles identified CT as the most effective method, offering high accuracy and detailed three-dimensional imaging capabilities, though it has limitations such as cost and radiation exposure. …”
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Formation and peculiarities of advertising campaign by Yu.O. Golovchuk, L.V. Dibchuk

“…Brands combine powerful messages based on a well-researched idea and effective delivery methods that impact their audience. However, with the ever-changing paradigm of media consumption, control over how the message is delivered has shifted from marketing experts to consumers. …”
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Comparative analysis of centrally mediated and inflammatory pain experiences amongst patients diagnosed with rheumatoid arthritis: A multimethods study by Zoe Rutter‐Locher, Tom Esterine, Ruth Williams, Leonie S. Taams, Kirsty Bannister, Bruce W. Kirkham, Heidi Lempp

“…In this study, we aimed to explore the pain experiences of patients with rheumatoid arthritis (RA), differentiating between those predominantly exhibiting features of peripheral inflammatory versus centrally mediated pain. Methods Through a multimethods approach we (i) quantitatively analysed the differences in pain descriptors between patients diagnosed with RA experiencing peripheral inflammatory and centrally mediated pain, utilising the Short Form‐McGill Pain Questionnaire which includes the pain visual analogue scale (VAS) and (ii) qualitatively explored their subjective pain experiences grounded in the biopsychosocial model, commonly applied in chronic pain. …”
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CHANGE OF PRECIPITATION REGIME IN THE NORTH CAUCASUS REGION UNDER ARTIFICIAL REGULATION OF PRECIPITATION by S. Gekkieva

“…This article presents the results of a statistical assessment of the redistribution of precipitation using the historical regression method. The method is based on the use of data from long-term observations of atmospheric precipitation in protected and adjacent areas of equal size. …”
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