Multidimensional outcome after endovascular or microsurgical occlusion of ruptured intracranial aneurysms – Comparative analysis of a prospective Swiss multicenter study by Vincens Kälin, Martin N. Stienen, Olivia Zindel-Geisseler, Noemi Dannecker, Yannick Rothacher, Ladina Schlosser, Julia Velz, Martina Sebök, Noemi Eggenberger, Adrien May, Philippe Bijlenga, Ursula Guerra-Lopez, Rodolfo Maduri, Daniele Starnoni, Valérie Beaud, Alessio Chiappini, Thomas Robert, Sara Bonasia, Stefania Rossi, Johannes Goldberg, Christian Fung, David Bervini, Klemens Gutbrod, Nicolai Maldaner, Severin Früh, Marc Schwind, Anna-Maria Zeitlberger, Isabel C. Hostettler, Oliver Bozinov, Peter Brugger, Menno R. Germans, Luca Regli

“…Research question: Are there significant differences in multidimensional outcomes between clipping and coiling treatments for alert aSAH patients when treatment selection is individualized? Material and methods: Within the prospective MoCA-DCI study (ClinicalTrials.gov identifier: NCT03032471), patients with a GCS of 13–15 72h post-aSAH in six neurovascular centers underwent neuropsychological (Montreal Cognitive Assessment; MoCA), neurological (National Institutes of Health Stroke Scale; NIHSS), headache (visual analog scale; VAS), disability (modified Rankin Scale; mRS) and health-related quality of life (EuroQol Five Dimensions; EQ5D) assessments within 72h, 14 days and three months after aSAH. …”
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Epidemiological trends and forecasting of tuberculosis burden in the Gulf Cooperation Council countries: Evidence from global burden of disease 1990–2021 by Akashanand, Shailesh Kumar Samal, Shilpa Gaidhane, Diptismita Jena, R. Roopashree, Mandeep Kaur, Deepak Nathiya, Aryantika Sharma, G.V. Siva Prasad, Aashna Sinha, Lara Jain, Vaibhav Jaiswal, Muhammed Shabil, Ganesh Bushi, Sanjit Sah, Ghaya Alqurainees, Jawaher Alotaibi, Maha A. Alshiekheid, Amal A. Sabour, Nawal A. Al Kaabi, Hayam A. Alrasheed, Muhammad A. Halwani, Zainab H. Almansour, Fatimah S. Aljebaly, Mubarak Alfaresi, Ali A. Rabaan

“…Understanding trends in TB burden in these countries is essential for guiding public health strategies. Methods: We analyzed TB trends in GCC countries from 1990 to 2021 using data from the Global Burden of Disease (GBD) study. …”
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The impact of aripiprazole on neurocognitive function in individuals at clinical high risk for psychosis: A comparison with olanzapine and non-antipsychotic treatment by JiaHui Zeng, Andrea Raballo, JiaYi Ye, YuQing Gao, WenJun Su, YanYan Wei, XiaoChen Tang, LiHua Xu, YeGang Hu, Dan Zhang, HuiRu Cui, YingYing Tang, XiaoHua Liu, HaiChun Liu, Tao Chen, ChunBo Li, JiJun Wang, TianHong Zhang

“…This study investigates the association between aripiprazole and olanzapine use and cognitive and clinical outcomes in CHR individuals, compared to those receiving no antipsychotic treatment. Methods A retrospective analysis was conducted on 127 participants from the Shanghai At Risk for Psychosis (SHARP) cohort, categorized into three groups: aripiprazole, olanzapine, and no antipsychotic treatment. …”
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Treatment effects of human amnion-derived mesenchymal stem cells for skin lesions and metastatic pulmonary calcification in calciphylaxis patients – case series and literature revi... by Shijiu Lu, Ming Zeng, Fan Li, Chun Ouyang, Jingjing Wu, Jiaying Hu, Yanggang Yuan, Hongqing Cui, Yi Xu, Wei Liu, Ling Zhang, Yan Lu, Zhonglan Su, Xiaoxue Ye, Cui Li, Anning Bian, Chunyan Jiang, Yugui Cui, Xiang Ma, Song Ning, Xiaolin Lv, Ling Wang, Jiahui Yang, Xiuqin Wang, Ningxia Liang, Changying Xing, Jiayin Liu, Lianju Qin, Ningning Wang

“…Background Calciphylaxis, also termed calcific uremic arteriolopathy (CUA) in patients with end-stage kidney disease (ESKD), is a rare and fatal condition characterized by cutaneous ischemic necrosis.Methods Three patients with calciphylaxis and metastatic pulmonary calcification (MPC) were treated with human amnion-derived mesenchymal stem cells (hAMSCs). …”
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Efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel... by José Antonio Pinto, Alex Fonollosa, Ester Carreño, Maria Isabel Rodriguez, David Diaz-Valle, Diana Peiteado, Luis Rodriguez-Rodriguez, Miguel Cordero-Coma, Marta Tejera Santana, Lidia Cocho, Ana Belen Rivas, Amanda Lopez-Picado, Valentina Calamia, Felix M Francisco Hernandez, Angel Garcia-Aparicio, Javier Garcia-Gonzalez, Jose Juan Mondejar, Leticia Lojo-Oliveira, Llucí Martínez-Costa, Santiago Munoz, Beatriz Rodriguez-Lozano, Esperanza Pato, Elena Molina, Luis Alberto Tebar, Mara Albert Fort, Mayte Ariño Gutierrez, Pedro Arriola Villalobos, Joseba Artaraz Beobide, Antonio Atanes Sandoval, Jose Manuel Sanchez, Francisco Blázquez, Pablo Borges Deniz, Lara Borrego Sanz, Gabriela Bustamante Sanchez-Arnedo, Bruno Casco Silva, Ricardo Cuiña Sardiña, Almudena De Pablo Cabrera, Maria Del Mar Esteban Ortega, Patricia Fernandez Puente, Dalifer Dayanira Nuñez, Javier Garcia Bella, Sara Garcia Carazo, Luis Garcia Onrubia, Jose Maria Morales, Jose Antonio Fernandez, Vanesa Hernandez Hernandez, Inés Hernanz Rodriguez, Jose Maria Cantalapiedra, Ventura Hidalgo Barrero, Maria De Jovani Casano, Sara López Sierra, Virginia Lozano Lopez, Alfredo Madrid Garcia, Rosalia Mendez Fernandez, Pilar Nozal Aranda, Eugenio Perez Blazquez, Chamaida Plasencia Rodriguez, Sheila Recuero Diaz, Ignacio Robles Barrena, Esther Rodriguez Almaraz, Fayna Maria Gonzalez, Guadalupe Rodriguez Martinez, Fredeswinda Isabel Bueno, Ioana Ruiz Arruza, Beatriz Sanchez Marugan, Olga Sanchez Pernaute, Armelle Schlinker Giraud, Alvaro Seijas Lopez, Patricia Simon Alonso, Elia Valls Pascual

“…However, a direct comparison between these two treatment strategies has not been carried out yet.Methods and analysis The Combination THerapy with mEthotrexate and adalImumAb for uveitis (CoTHEIA) study is a phase III, multicentre, prospective, randomised, single-blinded with masked outcome assessment, parallel three arms with 1:1:1 allocation, active-controlled, superiority study design, comparing the efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis. …”
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Polymorphous corneal dystrophy subtype 3 and keratoconus aggravation after corneal refractive surgery in a three-generation family carrying both ZEB1 and ZNF469 pathogenic variant by Qinghong Lin, Qinghong Lin, Qinghong Lin, Qinghong Lin, Qinghong Lin, Qinghong Lin, Xuejun Wang, Xuejun Wang, Xuejun Wang, Xuejun Wang, Xuejun Wang, Xiaoliao Peng, Xiaoliao Peng, Xiaoliao Peng, Xiaoliao Peng, Xiaoliao Peng, Xiaosong Han, Xiaosong Han, Xiaosong Han, Xiaosong Han, Xiaosong Han, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Ling Sun, Ling Sun, Ling Sun, Ling Sun, Ling Sun, Yan Wang, Shengtao Liu, Shengtao Liu, Shengtao Liu, Shengtao Liu, Shengtao Liu, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou

“…BackgroundThis study reports a three-generation Chinese family with polymorphous corneal dystrophy subtype 3 (PPCD3) and keratoconus (KC) aggravation induced by corneal refractive surgery, specifically small incision lenticule extraction (SMILE), in the context of genetic variations.MethodsThe history of illnesses and blood samples of all family members were collected. …”
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The feasibility and efficacy of the Position Acute Tone External system score in evaluating hemorrhoid severity and guiding clinical treatment by Sun Songpeng, Wan Weiping, Li Tianyu, Wu Yao, Wang Jianguo, Xu Fangfang, Zhang Zhiyun, Tian Ying, Lin Mei, Cao Qiaorong, Wang Zhanjun, Li Xinjian, Yang Tianqing, Liao Riyu, Xieyida Kuerban, Ni Hong, Huo Xingxiao, Jia Shan, Long Junhong, Zhang Shuxin

“…[Objectives] To analyze the feasibility and efficacy of the Position Acute Tone External (PATE) system score in evaluating hemorrhoid severity and guiding clinical treatment. [Methods] This cross-sectional study conducted a questionnaire survey among patients with hemorrhoids in outpatient/ward settings at six anorectal centers from November 2021 to November 2022. …”
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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…As a response to high intraocular pressure, the clinical and molecular glaucoma biomarkers indicate the biological state of the visual system. Classical and uncovering novel biomarkers of glaucoma development and progression, follow-up, and monitoring the response to treatment are key objectives to improve vision outcomes. …”
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Application of platelet-rich plasma therapy combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis (富血小板血浆联合5E康复护理模式在膝骨性关节炎患者中的应用)... by AN Linjing (安林静), ZHAO Chen (赵晨), CHANG Yueyuan (常月圆), PAN Yaying (潘亚英), CHEN Yanqi (程艳琪), ZHANG Bing (张兵), CHEN Weinan (陈炜楠), GAO Bei (高蓓), NIU Jing (牛静), ZHANG Ting (张婷)

“…Objective To explore the clinical effect of platelet-rich plasma therapy (PRP) combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis. Methods Totally 80 patients with knee osteoarthritis admitted to the orthopedics department of the hospital from March 2021 to March 2023 were selected as subjects. …”
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Evaluation of the effectiveness of Tofacitinib in rheumatoid arthritis in real clinical practice: The relationship between pain relief in the first 4 weeks and disease activity aft... by A. E. Karateev, E. Yu. Pogozheva, V. N. Amirjanova, E. S. Filatova, A. M. Lila, V. I. Mazurov, R. R. Samigullina, A. M. Dadalova, A. Yu. Dyo, D. S. Chakieva, A. A. Baranov, N. A. Lapkina, E. N. Koltsova, N. A. Kiryukhina, I. N. Shchendrigin, T. G. Rasevich, A. F. Davydova, I. V. Semizarova, I. A. Shafieva, I. B. Bashkova, D. A. Bobrikova, D. A. Murtazalieva, I. N. Kushnir, E. V. Kalinina, T. S. Salnikova, I. M. Marusenko, O. V. Semagina, I. B. Vinogradova, D. G. Krechikova, M. Yu. Semchenkova, E. L. Nasonov

“…However, it is not clear how pain reduction is associated with achieving low activity in rheumatoid arthritis (RA).The aim of the study was to assess the relationship between the early clinical response to tofacitinib and a decrease in rheumatoid arthritis activity after 3 and 6 months.Material and methods. The study group consisted of 88 RA patients (age – 53±11.5 years; 79.3% of women) who received basic anti-inflammatory drugs (59.5% – methotrexate, 19.8% – leflunomide) and who were prescribed TOFA in a dose 10 mg/day. …”
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The TESS Ten Thousand Catalog: 10,001 Uniformly Vetted and Validated Eclipsing Binary Stars Detected in Full-frame Image Data by Machine Learning and Analyzed by Citizen Scientists by Veselin B. Kostov, Brian P. Powell, Aline U. Fornear, Marco Z. Di Fraia, Robert Gagliano, Thomas L. Jacobs, Julien S. de Lambilly, Hugo A. Durantini Luca, Steven R. Majewski, Mark Omohundro, Jerome Orosz, Saul A. Rappaport, Ryan Salik, Donald Short, William Welsh, Svetoslav Alexandrov, Cledison Marcos da Silva, Erika Dunning, Gerd Gühne, Marc Huten, Michiharu Hyogo, Davide Iannone, Sam Lee, Christian Magliano, Manya Sharma, Allan Tarr, John Yablonsky, Sovan Acharya, Fred Adams, Thomas Barclay, Benjamin T. Montet, Susan Mullally, Greg Olmschenk, Andrej Prša, Elisa Quintana, Robert Wilson, Hasret Balcioglu, Ethan Kruse, The Eclipsing Binary Patrol Collaboration

“…Of these, we have performed an in-depth analysis on ∼60,000 targets using automated methods and manual inspection by citizen scientists. …”
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Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled cl... by Yange Wei, Yange Wei, Shanyuan He, Peng Luo, Hanshuo Su, Yuanle Chen, Shisen Qin, Zhongguo Zhang, Rongxun Liu, Dongshuai Wei, Juan Wang, Fei Wang, Fei Wang, Chuansheng Wang

“…This study aims to examine the synergistic efficacy of tDCS and MT on cognitive impairments in individuals with schizophrenia and to elucidate the potential mechanisms involved in this process.MethodsThe study is designed as a randomized, double-blind, sham-controlled trial. …”
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Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer in rats by Hui Guo, Hui Guo, Zihan Xu, Zihan Xu, Lili Zhu, Meng Zhu, Meng Zhu, Weijin Zhang, Weijin Zhang, Man Gong, Mengyun Liu, Mengyun Liu, Mengmeng Wang, Mengmeng Wang, Erping Xu, Liping Dai, Liping Dai

“…However, the pharmacological basis of this herb for treating peptic ulcer, also an inflammatory condition in the GI tract, remains insufficiently understood.PurposeThe aim of this study is to investigate the ameliorating effects of a standardized aqueous extract of AT (ATAE) on experimental gastric ulcer (GU) in rats and explore whether the human GU-associated molecules/signaling pathways obtained using bioinformatics have a role to play in the drug’s efficacy for molecular mechanism elucidation.MethodsUltra-performance liquid chromatography (UPLC) and UPLC coupled to tandem mass spectrometry (UPLC-MS) were used for standardization of ATAE. …”
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Comparison of Deep Learning and Clinician Performance for Detecting Referable Glaucoma from Fundus Photographs in a Safety Net Population by Van Nguyen, MD, Sreenidhi Iyengar, Haroon Rasheed, MD, Galo Apolo, Zhiwei Li, Aniket Kumar, Hong Nguyen, Austin Bohner, MD, Kyle Bolo, MD, Rahul Dhodapkar, MD, Jiun Do, MD, PhD, Andrew T. Duong, MD, Jeffrey Gluckstein, MD, Kendra Hong, MD, Lucas L. Humayun, Alanna James, MD, Junhui Lee, MD, Kent Nguyen, OD, Brandon J. Wong, MD, Jose-Luis Ambite, PhD, Carl Kesselman, PhD, Lauren P. Daskivich, MD, Michael Pazzani, PhD, Benjamin Y. Xu, MD, PhD

“…Participants: A total of 6116 patients from the Los Angeles County (LAC) Department of Health Services (DHS) were included. Methods: Fundus photographs and patient-level labels of referable glaucoma (cup-to-disc ratio ≥0.6) provided by 21 certified optometrists. …”
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Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias—the cross-sectional diagnostic test accuracy study... by Stefanie Hahner, Philipp Hartrampf, Felix Beuschlein, Matthias Miederer, Konstanze Miehle, Wiebke Schlötelburg, Carmina Teresa Fuß, Thomas Pfluger, Christian Fottner, Anke Tönjes, Ken Herrmann, Holger Amthauer, Martin Reincke, Mathias Schreckenberger, Osama Sabri, Johanna Werner, Miriam Reuter, Stefan Kircher, Wiebke Arlt, Martin Fassnacht, Andreas Konrad Buck, Hans-Helge Müller, Andreas Schirbel, Christian Furth, Knut Mai, Marcus Quinkler, Frank Weber, Henning Dralle, Benjamin Sandner, Thomas Lincke, Regine Kluge, Nada Rayes, Matthias Weber, Martina Gräsl, Wolfgang Saeger, Joachim Reibetanz

“…We proposed that combined molecular imaging with [18F]Fluorodeoxyglucose-positron emission tomography (FDG PET) and [123I]Iodometomidate-single photon emission tomography (IMTO SPECT) improves non-invasive classification of ACA. Methods: This cross-sectional, multicentre diagnostic study included patients (≥30 years) with non-functioning indeterminate adrenal masses (>3 cm or increase >1 cm, Hounsfield units [HU] ≥10 on unenhanced computed tomography [CT]) scheduled for surgery. …”
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An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape by Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen

“…BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the IMGT database to illustrate the amino acid polymorphism present within germline sequences of IGHV genes. …”
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Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial by Yanyan Zhao, Changdong Guan, Yang Wang, Zening Jin, Bo Yu, Guosheng Fu, Yundai Chen, Lijun Guo, Xinkai Qu, Yaojun Zhang, Kefei Dou, Yongjian Wu, Weixian Yang, Shengxian Tu, Javier Escaned, William F. Fearon, Shubin Qiao, David J. Cohen, Harlan M. Krumholz, Bo Xu, Lei Song, On behalf of FAVOR III China Study Group, Ting Gao

“…This study aimed to assess the cost-effectiveness of QFR-guided PCI from the perspective of the current Chinese healthcare system. Methods:. This study is a pre-specified analysis of the FAVOR III China trial, which included 3825 patients randomized between December 25, 2018, and January 19, 2020, from 26 centers in China. …”
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Efficacy and safety of rapid dose escalation of methotrexate in rheumatoid arthritis. Results of the multicenter “METEOR” study by V. N. Amirjanova, E. Yu. Polishchuk, O. N. Anoshenkova, I. B. Vinogradova, E. V. Zonova, L. V. Ivanova, R. R. Samigullina, T. S. Salnikova, E. L. Shakhramanova, E. I. Shmidt, S. P. Yakupova, A. M. Lila, E. L. Nasonov

“…Rompharm Company S.R.L) in patients with rheumatoid arthritis (RA) with high disease activity and rapid dose escalation, to assess their quality of life (QoL) in real clinical practice.Material and methods. The study included 105 patients, mostly women, with a reliable diagnosis of RA with high disease activity (DAS-28 (Disease Activity Score 28) ≥5.1) aged 18 years and older and ineffectiveness of previous oral MTX therapy for at least 6 months or who had not received MTX. …”
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Evaluating the Elements of Vitality in Jahānshahr Walkway, Karaj City, Iran by Mina Heydari Tamrabadi, Habibollah Fasihi, Tajaddin Karami

“…This research aimed to evaluate the vitality components of Jahānshahr Walkway, a major thoroughfare that played a significant social, economic, and cultural role in the bustling and lively part of Karaj City, Iran. Materials & Methods:The study focused on Jahānshahr Walkway located in the northeastern region of Karaj, Iran. …”
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Application of acupuncture therapy in relieving the anxiety among patients undergoing glaucoma surgery (针灸疗法缓解青光眼手术患者焦虑的效果观察) by LI Gonghui (李贡辉), (毛珍), MA Di (马迪), HUANG Chukai (黄楚开), TAN Ronghui (谭容慧)

“…Objective To investigate the effect of acupuncture therapy in relieving the anxiety of patients undergoing glaucoma surgery. Methods Totally 95 glaucoma patients undergoing trabeculectomy were randomly divided into two groups: control group with 47 cases and observation group with 48 cases. …”
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