Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study by Linru Fu, Xinyan Liu, Zhao Tian, Zhe Du, Xinyi Wang, Xiuqi Wang, Xiaodong Li, Tao Xu, Zhijing Sun

“…This study aimed to determine the risk factors associated with MTX failure in TEP patients and support personalized treatment strategies. Methods This retrospective study included female patients who were diagnosed with TEP at Peking Union Medical College Hospital (PUMCH) between January 2016 and December 2022. …”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Abstract Background Patients with refractory dry eye disease (DED) often face the threat of diminished visual quality and have limited responses to existing treatments. …”
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Comparison of therapeutic effects of 0.05% Cyclosporine A versus 0.1% Fluorometholone in Chinese patients with mild dry eye unresponsive to artificial tears: a randomized control s... by Huijuan Gao, Lu Zhao, Aoxue Du, Xia Zhang, Mengdi Chai, Lin Liu, Emmanuel Eric Pazo, Ruihua Wei

“…Abstract Background To assess and compare the therapeutic outcomes of 0.05% Cyclosporine A (CsA) ophthalmic solution versus 0.1% Fluorometholone (FML) eyedrops in Chinese patients with mild dry eye disease (DED) unresponsive to conventional artificial tears (AT). Methods A total of 43 patients with mild DED, who have failed to respond to conventional AT therapy for over 3 months, were randomly assigned to receive either 0.05% CsA or 0.1% FML twice daily for 6-months. …”
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Late gadolinium enhancement cardiovascular magnetic resonance with generative artificial intelligence by Omer Burak Demirel, Fahime Ghanbari, Christopher W. Hoeger, Connie W. Tsao, Adele Carty, Long H. Ngo, Patrick Pierce, Scott Johnson, Kathryn Arcand, Jordan Street, Jennifer Rodriguez, Tess E. Wallace, Kelvin Chow, Warren J. Manning, Reza Nezafat

“…In this study, we sought to evaluate a rapid two-dimensional (2D) LGE imaging protocol using a generative artificial intelligence (AI) algorithm with inline reconstruction. Methods: A generative AI-based image enhancement was used to improve the sharpness of 2D LGE images acquired with low spatial resolution in the phase-encode direction. …”
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Comparison of the effects of acupoint application combined with moxibustion in different sequences on alleviating symptoms in patients with knee osteoarthritis based on inheritance... by LI Suqian (李苏茜), TANG Ling (唐玲), E Haiyan (鄂海燕), CHEN Hong (陈宏), DENG Jianhua (邓建华), ZHOU Jie (周洁), LI Ye (李野)

“…Objective To explore the effect of different operating sequences of acupoint application and moxibustion on relieving the pain in patients with knee osteoarthritis. Methods Sixty patients with knee osteoarthritis were randomly divided into group A (n=30) and group B (n=30). …”
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Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis by E. Mormone, L. Savastano, G. Rossi, F. Maruccia, G. Di Maggio, N. P. Sinisi, M. Sandri, M. Copetti, E. De Santis, V. Guerra, G. Biancofiore, C. Cisternino, E. Caradonna, P. Graziano, F. L. Gorgoglione

“…We investigated the clinically beneficial concentration of ex vivo MSCs, derived from BM harvested from the posterior iliac crest and proximal tibia by Marrow Cellution™ Aspiration System, and their phenotypic differences, in comparison to autologous Platelet-Rich Plasma (PRP) treatment prepared with a manual, closed system. Methods A single-center, parallel, randomized controlled study was designed to investigate the efficacy of BMA from the posterior iliac crest compared to BMA from the proximal tibia, against a control group treated with PRP, in knee OA. …”
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The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study by Simin Sajadi, Mohammad Amin Khadembashiri, Gholamreza Raissi, Mohamad Mehdi Khadembashiri, Korosh Mansouri, Homayoun Hadizadeh-Kharazi, Mohammad Taghi Joghataei, Seyed Pezhman Madani, Bijan Forogh, Sina Parsipour

“…This study aims to evaluate the safety and efficacy of allogeneic ADMSC in treating knee OA. Methods This triple-blind, interventional clinical trial included 20 patients with idiopathic knee OA, meeting the American College of Rheumatology (ACR) criteria. …”
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An evaluation of novel AMP2-coated electrospun composite scaffolds for intraoral bone regeneration: a proof-of-concept in vivo study by Blaire V. Slavin, Shangtao Wu, Savanah R. Sturm, Kevin K. Hwang, Ricky Almada, Nicholas A. Mirsky, Vasudev Vivekanand Nayak, Vasudev Vivekanand Nayak, Lukasz Witek, Lukasz Witek, Lukasz Witek, Paulo G. Coelho, Paulo G. Coelho, Paulo G. Coelho

“…Further, it sought to determine if OsteoAdapt would remain within the defect without a membrane in place, as this is not feasible with the particulate xenograft currently used in clinical practice.MethodsFour-walled mandibular defects were created in each adult beagle dog (n = 4 defects per dog; n = 4 dogs for a total of 16 defects). …”
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Electronic Pillbox-enabled Self-administered Therapy Versus Standard Directly Observed Therapy for Tuberculosis Medication Adherence and Treatment Outcomes in Ethiopia: a Multicent... by Dr Tsegahun Manyazewal, Dr. Yimtubezinash Woldeamanuel, Mr. Tewodros Getinet, Ms Alison Hoover, Dr Kidist Bobosha, Mr Oumer Fuad, Dr. Belete Getahun, Prof. Abebaw Fekadu, Dr. David Holland, Prof. Vincent Marconi

“…This study aimed to evaluate the effectiveness of pillbox-enabled self-administered therapy (SAT) compared to standard DOT on adherence to tuberculosis medication and treatment outcomes. Methods: In this multicenter, randomized controlled trial, adults diagnosed with new or previously treated, bacteriologically-confirmed, drug-sensitive pulmonary tuberculosis and eligible to commence anti-tuberculosis therapy were enrolled from 10 healthcare facilities across Ethiopia. …”
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Building a pre-surgical multiparametric-MRI-based morphologic, qualitative, semiquantitative, first and high-order radiomic predictive treatment response model for undifferentiated... by Raul F. Valenzuela, Elvis Duran-Sierra, Mathew Antony, Behrang Amini, Sam Lo, Keila E. Torres, Robert S. Benjamin, Jingfei Ma, Ken-Pin Hwang, R. Jason Stafford, Dejka Araujo, Andrew J. Bishop, Ravin Ratan, Wei-Lien Wang, Jossue Espinoza, Pia V. Valenzuela, Chengyue Wu, John E. Madewell, William A. Murphy, Colleen M. Costelloe

“…Lesions were visually classified on CE-SWI into one of 6 morphology patterns. …”
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10-YEARS ANALYSIS OF CRYOBAG FRACTURE IN A LARGE INVENTORY OF CELLULAR THERAPY PRODUCTS: RATES AND RISK FACTORS by AR Belisário, LT Mendonça, RK Andrade, MC Martins, LA Costa, KL Prata

“…This study aimed to investigate the incidence and determinants of cryobag fractures within a large inventory of cellular therapy products in Brazil. Methods: This retrospective cohort study included cryobags from individuals referred for hematopoietic stem cell transplantation or immunotherapy. …”
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Metabolism-associated marker gene-based predictive model for prognosis, targeted therapy, and immune landscape in ovarian cancer: an integrative analysis of single-cell and bulk RN... by Lele Ling, Bingrong Li, Boliang Ke, Yinjie Hu, Kaiyong Zhang, Siwen Li, Te Liu, Peng Liu, Bimeng Zhang

“…Thus, it is of utmost significance to identify potent prognostic biomarkers and delve into the exploration of novel therapeutic drugs and targets, in pursuit of advancing the treatment of OC. Methods Single-cell RNA sequencing (scRNA-seq) data related to OC were analyzed using AUCell scores to identify subpopulations at the single-cell level. …”
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A time-stratified case-crossover study on association between short-term exposure to air pollutants and myocardial infarction mortality in Shenzhen by Ziyang ZOU, Ruijun XU, Ziquan LYU, Zhen ZHANG, Jiaxin CHEN, Meilin LI, Xiaoqian GUO, Suli HUANG

“…ObjectiveTo quantitatively assess the association between air pollutants and myocardial infarction mortality in residents. MethodsBased on the mortality surveillance system of Shenzhen Center for Disease Control and Prevention, we conducted a time-stratified case-crossover study of 10089 permanent residents who died from myocardial infarction in Shenzhen between 2013 and 2022. …”
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Clinical Evidence of Acupoint Stimulation for Primary Dysmenorrhea: A Systematic Review and Updated Meta-Analysis by Wang Y, Liu L, Wu X, Wu Y, Qin R, Wang M, Zhou B, Sun J, Song Y, Zhang M, Li M, Yu L

“…This systematic review aims to evaluate efficacy and safety of both invasive and noninvasive acupoint stimulation for PD through analysis of randomized controlled trials (RCTs).Methods: The PROSPERO registration number is CRD42024586857. …”
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Modified minimally invasive chevron osteotomy versus traditional incision chevron osteotomy by Run Tang, Jie Yang, Xiao Jun Liang, Yi Li, JunHu Wang, MiaoLuo Jin, Yang Du, Tong Lu, YiXiang Hao

“…Abstract Purpose This study aimed to compare modified minimally invasive chevron osteotomy (MIC group) and traditional incision chevron osteotomy (TIC group) for correction of mild to moderate hallux valgus deformity. Methods This retrospective study enrolled 42 patients (60 feet) with mild to moderate hallux valgus deformities who were treated with modified MIC osteotomy or TIC osteotomy between January 2020 and June 2021. …”
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Relationship between vitamin D and osteoarthritis by Natalia G. Kashevarova, Liudmila I. Alekseeva, Elena A. Taskina, Ekaterina A. Strebkova, Evgenia P. Sharapova, Natalya M. Savushkina, Kirill M. Mikhaylov, Svetlana I. Glukhova, Olga G. Alekseeva, Danil M. Kudinsky, Nikolay V. Demin, Elena Yu. Samarkina, Aleksander M. Lila

“…To evaluate the relationship of vitamin D levels with clinical and instrumental parameters in OA in a cross-sectional study. Materials and methods. The study included 171 patients aged 40–75 with confirmed knee OA according to the American College of Rheumatology (ACR) classification, stage I–III (according to Kellgren and Lawrence). …”
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Diversity analysis of fruit traits of 105 peach germplasm resources in Xinjiang by LI Dan, BAI Lixia, TANG Zhuoyue, YANG Kanghui, YANG Lu, CHENG Ping

“…Batsch] germplasm resources and screen excellent peach germplasm resources. [Methods] A total of 105 peach germplasm resources were used as experimental materials, and 22 descriptive traits were observed by visual observation. …”
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In Search of Al Wehdat Camp by Nama’a Abdullah Qudah

“…Through my interdisciplinary research methodology, encompassing methods from the fields of architecture, anthropology, and the visual arts, I conceptualized my research methodology as Taq’otat, or a set of spatio-temporal intersections with both the camp’s spaces and its inhabitants. …”
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A meta-analysis of randomized controlled trials: evaluating the efficacy of isokinetic muscle strengthening training in improving knee osteoarthritis outcomes by Wanqin Guo, Jingyang Gao, Dawazhuoma, Xiuling Mi, Ciwang, Bianba

“…We aimed to utilize a meta-analysis to evaluate the efficacy of isokinetic muscle strengthening training (IMST) as a rehabilitation treatment for KOA in lowland areas. Methods The study conducted a comprehensive search of the CNKI, WanFang Data, VIP Database, PubMed, Ovid MEDLINE (1946–), Cochrane Library, Embase, and CBM databases. …”
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The impact of sarcopenia on the efficacy of posterior surgical treatment for degenerative lumbar scoliosis by Juyi Lai, Xinbei Li, Huangsheng Tan, Hualong Feng, Zhi Ming Lan, Zhitao Sun, Jian Wang, Yuanfei Fu, Shenghua He

“…Abstract Purpose This study aimed to investigate the impact of sarcopenia on the clinical outcomes of patients undergoing posterior surgical treatment for degenerative lumbar scoliosis. Methods A retrospective analysis was conducted on clinical data from 76 patients with degenerative lumbar scoliosis, who meet the selection criteria between January 2019 and December 2023. …”
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