Evaluation and comparison of large language models’ responses to questions related optic neuritis by Han-Jie He, Han-Jie He, Fang-Fang Zhao, Jia-Jian Liang, Yun Wang, Qian-Qian He, Qian-Qian He, Hongjie Lin, Jingyun Cen, Feifei Chen, Tai-Ping Li, Zhanchi Hu, Jian-Feng Yang, Lan Chen, Carol Y. Cheung, Yih-Chung Tham, Yih-Chung Tham, Yih-Chung Tham, Ling-Ping Cen, Ling-Ping Cen, Ling-Ping Cen, Ling-Ping Cen

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Prevalence of cardiovascular diseases and risk factor assessment in breast cancer survivors exposed to cardiotoxic therapy by Marina V. Vitsenya, Irina V. Barinova, Nana V. Pogosova, Tatevik A. Terteryan, David T. Kuchiev, Yulia V. Khrushcheva, Anna A. Gerasimova, Anastasiya Y. Filatova, Nursiyat M. Ibragimova, Olga O. Frolkova, Fail T. Ageev

“…Aim: To evaluate the frequency of CVDs and their risk factors, and total CVR in BC patients who have undergone cardiotoxic antitumor treatment to determine the need for the development of cardiac rehabilitation programs in this patient category. Methods: This was a single center cross-sectional study performed in 2021 to 2023 in a specialized cardiology clinic in 90 women who had undergone cardiotoxic breast cancer therapy. …”
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CT-SEGMENTED BONE SUV IN MULTIPLE MYELOMA: A COMPARATIVE STUDY OF ¹⁸F-FDG AND ⁶⁸GA-PSMA PET/CT by Alexandre Mercuri Barbosa, Maria Emília Seren Takahashi, Stephan Pinheiro Macedo Souza, Edna Marina Souza, Sérgio Querino Brunetto, Cármino Antonio de Souza, Irene Gyongyver Heidemarie Lorand-Metze, Celso Darío Ramos

“…Materials and Methods: The study included ¹⁸F-FDG and ⁶⁸Ga-PSMA PET/CT images acquired within a 1- to 8-day interval from 15 patients (53% male, mean age 66.7 ± 10.7 years) with symptomatic, biopsy-proven MM. …”
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Prevalence and associated factors of syphilis among female sex workers in East Africa: a systematic review and meta-analysis by Solomon Gedfie, Woldeteklehymanot Kassahun, Abdu Jemal, Muluken Gashaw, Alembante Bazezew, Marye Nigatie, Getinet Kumie, Tadesse Misganaw, Zewdu Tefera, Bewuketu Belete Alemu, Bahriew Mezgebu, Brhanu Kassanew, Ephrem Tamrat, Wagaw Abebe, Agenagnew Ashagre, Assefa Sisay, Yalewayker Gashaw, Melese Abate Reta, Melese Abate Reta

“…Therefore, this review aimed to estimate the pooled prevalence of syphilis and identify the associated factors among female sex workers in the East African region.MethodsThis systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …”
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Comparison of Endoscopic Unilateral Laminectomy for Bilateral Decompression (Endo‐ULBD) and Posterior Lumbar Interbody Fusion (PLIF) in Managing Multi‐Segmental Lumbar Spinal Steno... by Kunpeng Su, Qingyu Yao, Mingzhi Liu, Sheng Chang, Mengxuan Wang, Antao Lin, Guantong Sun, Yichen Jiang, Shengwei Meng, Hao Zhang, Wentao Liu, Hongtao Ge, Zengjie Wu, Zirui Wang, Derong Xu, Chuanli Zhou

“…Furthermore, the text provides detailed technical information regarding the Endo‐ULBD procedure. Methods This retrospective comparative study was conducted from October 2019 to October 2022 and involved 73 patients diagnosed with MS‐LSS. …”
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Variation in Mesopic Retinal Sensitivity Relative to Distance from Geographic Atrophy in Age-Related Macular Degeneration by Souvick Mukherjee, PhD, Emily Vance, MPH, Leon von der Emde, MD, Thilaka Arunachalam, BS, Tharindu De Silva, PhD, Alisa T. Thavikulwat, MD, Christine Orndahl, PhD, Caroline Nyaiburi, MS, Maria Abraham, ScM, Keri Hammel, MS, SriniVas R. Sadda, MD, Emily Y. Chew, MD, Maximilian Pfau, MD, PhD, Wai T. Wong, MD, PhD, Brett G. Jeffrey, PhD, Tiarnán D.L. Keenan, BM BCh, PhD

“…Participants: Individuals with GA from AMD in ≥1 eye. Methods: Mesopic retinal sensitivity was assessed longitudinally with a fundus-guided microperimetry device at baseline, month 3, and every 6 months thereafter, using a custom T-shaped test pattern centered on the fovea. …”
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Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT by Spencer S. Burt, BA, Aaron S. Coyner, PhD, Elizabeth V. Roti, BS, Yakub Bayhaqi, PhD, John Jackson, MD, Mani K. Woodward, MS, Shuibin Ni, PhD, Susan R. Ostmo, MS, Guangru Liang, BS, Yali Jia, PhD, David Huang, MD, Michael F. Chiang, MD, Benjamin K. Young, MD, Yifan Jian, PhD, John Peter Campbell, MD

“…Participants: Thirty-three infants with ROP in the Oregon Health & Science University neonatal intensive care unit. Methods: OCT B-scans were collected using an investigational ultrawidefield OCT. …”
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Clinical effect of external application of Rutongyu medicine film in the treatment of hyperplasia of mammary gland (乳痛愈药膜治疗乳腺增生病临床疗效观察) by HAN Jianping (韩建萍), LI Ying (李影), HOU Pengxiao (候朋晓), ZHANG Ning (张宁), REN Yaxing (任亚星), LIU Haihan (刘海涵), DAI Wei (代巍), ZHANG Chunyan (张春艳), YUE Yuzi (岳玉姿), LI Yiliang (李以良), TANG Ling (唐玲)

“…Objective To observe the clinical effect of external application of Rutongyu medicine film in the treatment of hyperplasia of mammary gland. Methods Totally 96 patients with hyperplasia of mammary gland were randomly divided into the treatment group (n=48) and control group (n=48). …”
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Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial by Zhi-Xiu Lin, Tin Muk Ho, Yan-Fang Xian, Kam Leung Chan, Qing-Qing Xu, Cho Wing Lo, Justin Che Yuen Wu, Kam Lun Hon, Sin Bond Leung, Chon Pin Chia, Chi Him Sum, Tak Yee Chow, Pui Kuan Cheong, Jessica Yuet Ling Ching, Hongwei Zhang, Ka Chun Leung, Wai Ling Lin

“…Purpose To evaluate the efficacy and safety of YPV on AR patients with the lung and spleen Qi deficiency type using a randomized, double-blind, placebo-controlled clinical trial (RCT). Study design and methods Between April 2022 and June 2023, a total of 58 participants were recruited and randomly allocated to receive either YPV (n = 29) or placebo (n = 29) for 8 consecutive weeks. …”
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Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs by Zhongyu Ma, Jiawen Hao, Zhaohui Yang, Miao Zhang, Ruixue Zhang, Jizhao Xin, Bo Bao, Xuewei Yin, Xuewei Yin, Hongsheng Bi, Hongsheng Bi, Hongsheng Bi, Dadong Guo, Dadong Guo, Dadong Guo, Dadong Guo

“…This study aimed to investigate the process of thiamine changes in choroidal tissue of guinea pigs with negative lens-induced myopia (LIM).MethodsThe right eyes of guinea pigs in the LIM group wore −6.0D lenses to model experimental myopia. …”
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Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…This study aims to investigate these mechanisms using single-cell RNA sequencing data. Methods: Single-cell RNA sequencing data from HCC patients were obtained from the GEO database. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…The main objective of this prospective study was to explore the effects of neoadjuvant relugolix on health-related quality of life in prostate cancer patients immediately prior to stereotactic body radiation therapy (SBRT).MethodsPatients treated at Georgetown between January 2021 and September 2023 with neoadjuvant relugolix per an institutional protocol were included in the study (IRB 12-1775). …”
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Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled tri... by A. John Rush, Charles R. Conway, Scott T. Aaronson, Mark S. George, Patricio Riva-Posse, David L. Dunner, John Zajecka, Mark T. Bunker, João Quevedo, Rebecca M. Allen, Gustavo Alva, Heather Luing, Ziad Nahas, Lucian Manu, Jeffrey I. Bennett, Brian J. Mickey, Jonathan Becker, Yvette Sheline, Cristina Cusin, James W. Murrough, Kevin Reeves, Peter B. Rosenquist, Ying-Chieh (Lisa) Lee, Shannon Majewski, Jeffrey Way, Bryan Olin, Harold A. Sackeim

“…Objective: Compare the effects of adjunctive versus sham vagus nerve stimulation (VNS) on QoL and function in markedly treatment-resistant depression (TRD). Methods: In this multicenter, double-blind, sham-controlled trial, 493 adults with TRD and ≥4 adequate but unsuccessful antidepressant treatment trials (current episode) were randomized to active (n = 249) or sham (n = 244) VNS (plus treatment as usual) over a 12-month observation period. …”
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Use of technetium-99m-pyrophosphate single-photon emission computed tomography/computed tomography in monitoring therapeutic changes of RNA interference therapeutics in patients wi... by Yi-Hsin Hung, An-Li Yu, Yi-Chieh Chen, Cheng-Hsuan Tsai, Mao-Yuan Su, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ming-Jen Lee, Ping-Huei Tseng, Chia-Hua Hsu, Sung-Tsang Hsieh, Chi-Lun Ko, Kon-Ping Lin, Wen-Chung Yu, Mei-Fang Cheng, Chi-Chao Chao, Yen-Hung Lin

“…We aimed to investigate alterations in technetium-99 m (99mTc)-pyrophosphate (PYP) single-photon emission computed tomography/computed tomography (SPECT/CT) outcomes in patients receiving patisiran or vutrisiran. Methods: We retrospectively identified individuals with hereditary ATTR-CA who received patisiran or vutrisiran. …”
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Diabetic Retinopathy Assessment through Multitask Learning Approach on Heterogeneous Fundus Image Datasets by Hongkang Wu, MS, Kai Jin, MD, PhD, Yiyang Jing, MD, Wenyue Shen, MD, Yih Chung Tham, PhD, Xiangji Pan, PhD, Victor Koh, MD, PhD, Andrzej Grzybowski, MD, PhD, Juan Ye, MD, PhD

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Anti-VEGF drugs compared with laser photocoagulation for the treatment of proliferative diabetic retinopathy: a systematic review and individual participant data meta-analysis by Mark Simmonds, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Matthew Walton, Rob Hodgson, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, João Pereira Figueira, Sobha Sivaprasad, John G Lawrenson, Tunde Peto, David Steel

“…Key outcomes were best corrected visual acuity, diabetic macular oedema and vitreous haemorrhage. …”
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Toripalimab plus axitinib in patients with metastatic mucosal melanoma: 3-year survival update and biomarker analysis by Xuan Wang, Jie Dai, Li Zhou, Hui Feng, Jun Guo, Xue Bai, Lu Si, Bixia Tang, Chuanliang Cui, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Xiaowen Wu, Xiongwen Tang, Keith T Flaherty

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Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration by Ben Yi Tew, Gerald C. Gooden, Pei-An Lo, Pei-An Lo, Dimitrios Pollalis, Dimitrios Pollalis, Brandon Ebright, Brandon Ebright, Alex J. Kalfa, Alejandra Gonzalez-Calle, Alejandra Gonzalez-Calle, Biju Thomas, Biju Thomas, David N. Buckley, Thomas Simon, Zeyi Yang, Ege Iseri, Ege Iseri, Cody L. Dunton, Vadim Backman, Stan Louie, Stan Louie, Gianluca Lazzi, Gianluca Lazzi, Gianluca Lazzi, Mark S. Humayun, Mark S. Humayun, Bodour Salhia

“…With promising results, there is a need for detailed molecular characterization of the therapeutic effects of TES.MethodsControlled, non-invasive TES was delivered using a custom contact lens electrode to the retinas of Royal College of Surgeons (RCS) rats, a model of retinal degeneration. …”
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Synergistic effects of 1-MCP and H₂S co-treatment on sugar and energy metabolisms in postharvest strawberry fruit by Xingyue Wang, Xingyue Wang, Tian Qiu, JingJing Jiang, Kaili Shi, Zhikang Liu, Zhikang Liu, YanYan Wang, Qingyuan Song, Chen Zhang, Tingyu Wu, Dan Chen, Xiaohui Yang, Fang Liu, Qing Gong, Wei Lan, Li Wang

“…However, little knowledge was available for the effect of the combined treatment of 1-MCP and H2S on the quality maintenance of postharvest strawberry fruit.MethodsThe synergistic effects of 1.0 μL L−1 1-MCP and 0.8 mmol L−1 sodium hydrosulfide (NaHS, H2S donor) combined treatment on the sugar and energy metabolisms of strawberry fruit during cold storage at 4 ± 0.5°C with a relative humidity of 80–85% for 15 d were studied.ResultsThe results showed that the combined treatment effectively suppressed the increase of decay rate, decay index, and weight loss rate while maintaining the firmness and visual quality of strawberry fruit compared to the 1-MCP or H2S treatment. …”
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A CECT-Based Radiomics Nomogram Predicts the Overall Survival of Patients with Hepatocellular Carcinoma After Surgical Resection by Peng Zhang, Yue Shi, Maoting Zhou, Qi Mao, Yunyun Tao, Lin Yang, Xiaoming Zhang

“…<b>Objective</b>: The primary objective of this study was to develop and validate a predictive nomogram that integrates radiomic features derived from contrast-enhanced computed tomography (CECT) images with clinical variables to predict overall survival (OS) in patients with hepatocellular carcinoma (HCC) after surgical resection. <b>Methods</b>: This retrospective study analyzed the preoperative enhanced CT images and clinical data of 202 patients with HCC who underwent surgical resection at the Affiliated Hospital of North Sichuan Medical College (Institution 1) from June 2017 to June 2021 and at Nanchong Central Hospital (Institution 2) from June 2020 to June 2022. …”
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