Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies by Xingyao Chen, Xingyao Chen, Xingyao Chen, Nuo Chen, Nuo Chen, Nuo Chen, Peng Lai, Peng Lai, Yiqi Sun, Jie Yu, Ming Xin, Deliang Zhu, Fanrong Liang, Fanrong Liang, Fanrong Liang, Qian Song, Shirui Cheng, Shirui Cheng, Shirui Cheng, Zhengjie Li, Zhengjie Li, Zhengjie Li, Zhengjie Li

“…In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.MethodsA systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. …”
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Greater neural pattern similarity to the native language is associated with better novel word learning by Yuan Feng, Yuan Feng, Yuan Feng, Yuan Feng, Aqian Li, Aqian Li, Aqian Li, Aqian Li, Jing Qu, Jing Qu, Jing Qu, Jing Qu, Huiling Li, Huiling Li, Huiling Li, Huiling Li, Xiaoyu Liu, Xiaoyu Liu, Xiaoyu Liu, Xiaoyu Liu, Jingxian Zhang, Jingxian Zhang, Jingxian Zhang, Jingxian Zhang, Jiayi Yang, Jiayi Yang, Jiayi Yang, Jiayi Yang, Leilei Mei, Leilei Mei, Leilei Mei, Leilei Mei

“…Nevertheless, it is still unclear how the utilization of the L1 neural strategies affects visual word learning in a new language.MethodsTo address this question, the present study scanned native Chinese speakers while performing implicit reading tasks before 9-day form-meaning learning in Experiment 1 and before 12-day comprehensive word learning in Experiment 2. …”
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Squalomix: shark and ray genome analysis consortium and its data sharing platform [version 2; peer review: 2 approved] by John Rozewicki, Kazuaki Yamaguchi, Osamu Nishimura, Ryo Misawa, Takashi Asahida, Mitsumasa Koyanagi, Akihisa Terakita, Filipe Castro, André Machado, Milton Tan, Salvatore D'Aniello, Shotaro Hirase, Akane Kawaguchi, Chiharu Tanegashima, Akinori Teramura, Masaru Yagura, Taiki Niwa, Kaori Tatsumi, Yuta Ohishi, Susumu Hyodo, Mitsutaka Kadota, Itsuki Kiyatake, Keiichi Sato, Kazuyuki Yamada, Kiyonori Nishida, Yasuko Semba, Shinya Yamauchi, Sho Tanaka, Tatsuya Sakamoto, Norio Miyamoto, Atsushi Toyoda, Rui Matsumoto, Iker Irisarri, Atsuko Yamaguchi, Tazro Ohta, Kiyomi Murakumo, Junna Kawasaki, Masayuki Horie, Yoshinobu Uno, Shigehiro Kuraku

“…Their peculiar body fluid composition has also hindered the establishment of methods to perform routine cell culturing required for their karyotyping. …”
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Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase by Yukari Nishikawa, Kosuke Yamaguchi, Ma’arif Athok Shofiudin, Momone Mimura, Miyako Takata, Shu Mihara, Takeru Kawakami, Ayumu Doi, Risa Matsuda, Hiroyuki Kato, Ryo Okamoto, Kengo Mukuda, Naoki Kinoshita, Kensaku Okada, Tsuyoshi Kitaura, Masaki Nakamoto, Hisashi Noma, Yusuke Endo, Akira Yamasaki, Hiroki Chikumi

“…This study analyzed alterations in natural killer (NK) cell-associated immunity dynamics in mild and moderate COVID-19 cases during the Omicron phase of the COVID-19 pandemic.MethodsWe conducted a retrospective observational cohort study of patients aged ≥16 with confirmed SARS-CoV-2 infection who were hospitalized at Tottori University Hospital between January 2022 and May 2022. …”
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Patient-reported outcome tools of acupuncture clinical trials in mainland China: a cross-sectional study by Feng Cao, Feng Cao, Yue Dong, Zhi-Qiang Li, Zhi-Qiang Li, Xue-Feng Wang, Xue-Feng Wang, Cheng-Yuan Su, Cheng-Yuan Su, Jia-Xuan Lv, Zhong-Yu Shi, Ming-Hong Du, Xin-Yue Zhang, Hong-Guo Rong, Hong-Guo Rong, Hong-Guo Rong, Yu-Tong Fei, Yu-Tong Fei, Yu-Tong Fei

“…This study aims to evaluate the characteristics and application of PRO measurements in acupuncture clinical trials in mainland China, further exploring and developing patient-reported outcomes (PROs) that are in line with the characteristics of acupuncture treatment.MethodsThis cross-sectional study analyzed acupuncture clinical trials in mainland China (2010–2022). …”
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Elevated septal native T1 time in cardiac magnetic resonance imaging suggesting myocardial fibrosis in young kidney transplant recipients by Tim Alexander Ubenauf, Jeannine von der Born, Rizky I. Sugianto, Carl Grabitz, Elena Lehmann, Nima Memaran, Nele Kanzelmeyer, Jan Falk, Nigar Babazade, Samir Sarikouch, Diane Miriam Renz, Bernhard Magnus Wilhelm Schmidt, Anette Melk

“…This study aimed to explore cardiac function and structure with focus on myocardial fibrosis and associated risk factors in KTx recipients. Methods: Forty-six KTx recipients (mean age 16.0 ± 3.5 years) and 46 age- and sex-matched healthy controls were examined with non-contrast CMR imaging. …”
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Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…This study aimed to improve the protective immunity of a previously developed growth-deficient strain—a double auxotroph for D-glutamate and D-alanine—by engineering the inducible expression of type 1 fimbriae. <b>Methods</b>: P<i>_tetA</i>-driven expression of the <i>fim</i> operon was achieved by λ-Red mutagenesis. …”
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Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study by Fang Zhong, Shiyu Zhang, Chengxi Zheng, Dilihumaer Zhayier, Shuting Liu, Qinyu You, Hongming Huang, Bin Zhu, Jin Tian, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu, Xin Zheng, Baoju Wang, Zhihang Peng, Zhihang Peng, Zhihang Peng

“…Glucocorticoids (GCs) can be used as anti-inflammatory agents for SFTS, but no standardized protocols have been proposed.MethodsA total of 901 patients with SFTS diagnosed at two hospitals between July 2017 and October 2023 were included in this retrospective cohort study. …”
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Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis by Huan Jin, Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Lin Shen, Chen Ma, Zixian Wang, Lingfeng Zeng, Bo Shuai

“…This study systematically evaluated the synergistic effect of traditional Chinese medicine (TCM) compounds combined with conventional Western medicine (such as bisphosphonates and calcium) compared to Western medicine alone in the treatment of OP through a meta-analysis.MethodsBased on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Measurement Tool for Systematic Review Assessment guidelines, databases such as PubMed and Embase were systematically searched (as of March 2025), and 13 randomized controlled trials (RCTs), involving a total of 2,403 patients, were included.ResultsThe integrated Chinese and Western medicine group showed significantly higher lumbar and femoral neck Bone mineral density (BMD) growth rates than the control group, alongside reduced pain visual analogue scale (VAS) scores. …”
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Impact of Teleworking on Work‐Related and Home‐Related Stress at During the First Global Lockdown–The International COVISTRESS Study by Sébastien Couarraze, Guillaume Decormeille, Louis Delamarre, Fouad Marhar, Karen Gbaglo, Raimundo Avilès Dorlhiac, Mickael Berthon, Andy Su‐I Liu, Samuel Antunes, Bruno Pereira, Julien S Baker, Morteza Charkhabi, Ukadike C Ugbolue, Reza Bagheri, José J. Gil‐Cosano, Marek Zak, The COVISTRESS Network, Maëlys Clinchamps, Frédéric Dutheil

“…Objectives Our aim was to measure the impact of teleworking on work‐related and home‐related during the COVID‐19 pandemic. Methods The international study was conducted using an online questionnaire to collect demographic and stress‐related data from individuals worldwide during the 2020 pandemic year. …”
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How could 20-minute neighbourhoods impact health and health inequalities? A policy scoping review by Roxana Pollack, Jonathan R Olsen, Alison Heppenstall, Andreas Hoehn, Jennifer Boyd, Vicki Ponce Hardy, Jennifer Littlejohn, Amy Stevenson, Richard Mitchell, Petra Meier, Jonathan Stokes

“…This scoping review aimed to identify proposed and evidenced pathways to health (inequality) outcomes from international policy plans. Methods We first identified relevant academic literature, searching Scopus, (Ovid) Medline and Embase databases. …”
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Evaluation of the therapeutic effect of repeated photodynamic therapy-assisted SRP treatments on class II furcation by Yikuan Wu, Haoyu Li, Yixiang Wang, Beiying Zhang, Chunsheng Bi, Xiaojun Li

“…Objective: This study aims to evaluate whether repeated photodynamic therapy (PDT) ad-junctive to periodontal scaling and root planing (SRP) provides additional short-term clinical benefits for teeth with class II furcation involvement (FI). Materials and methods: This single-center randomized controlled trial enrolled 27 patients (85 Class II FI sites), randomly allocated to receive either scaling and root planing (SRP) with adjunctive photodynamic therapy (PDT) at baseline, 1, and 2 weeks (Group A) or SRP alone (Group B). …”
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Comparison of two portable metabolic systems for measuring energy expenditure at rest and during exercise in untrained women by Feng Gao, Feng Gao, Feng Gao, Yujing Chan-Yu, Yujing Chan-Yu, Zhi Li, Zhi Li, Yongfu Liu, Yongfu Liu, Fei Liu, Fei Liu, Di Liu, Wenjun Yu, Wenjun Yu, Weiwei Chen, Junhua Wang, Junhua Wang, Junhua Wang, Shenglong Le, Shenglong Le, Shenglong Le

“…This study aimed to compare EE measurements obtained using the COSMED K5 (K5) and CORTEX METAMAX 3B (M3B) during the resting state and submaximal-intensity exercise in women without self-reported regular exercise training.MethodsTwenty women aged 21.4 ± 1.5 years completed two measurements, including resting in a seated position and cycling on a simple upright ergometer at 30 W, 40 W, 50 W, and 60 W. …”
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Agarwood Chromone Alleviates Gastric Ulcers by Inhibiting the NF-κB and Caspase Pathways Based on Network Pharmacology and Molecular Docking by Canhong Wang, Yulan Wu, Bao Gong, Junyu Mou, Xiaoling Cheng, Ling Zhang, Jianhe Wei

“…<b>Objectives:</b> This study aimed to investigate the ameliorative effect of agarwood chromone on gastric ulcers and its mechanism. <b>Methods:</b> Network pharmacology was used to predict the disease spectrum and key therapeutic targets of 2-(2-phenylethyl)chromone (CHR1) and 2-(2-(4-methoxyphenyI)ethyl)chromone (CHR2). …”
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The oncolytic avian reovirus p17 protein suppresses invadopodia formation via disruption of TKs5 complexes and oncogenic signaling pathways by Chao-Yu Hsu, Jyun-Yi Li, Jyun-Yi Li, Wei-Ru Huang, Wei-Ru Huang, Tsai-Ling Liao, Tsai-Ling Liao, Hsiao-Wei Wen, Chi-Young Wang, Chi-Young Wang, Lon-Fye Lye, Brent L. Nielsen, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu

“…Cancer cell migration and invadopodia formation are essential processes in metastasis, and targeting these mechanisms could be beneficial in limiting cancer progression.MethodsThis study investigated the effects of ARV p17 protein on cancer cell migration and invadopodia formation in HeLa and A549 cell lines. …”
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Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up s... by Alemayehu Worku, Yemane Berhane, Luke C Mullany, Charles A Nelson, Lian V Folger, Anne CC Lee, Maria Andersson, Parul Christian, Krysten North, Yoseph Yemane Berhane, Nebiyou Fasil, Sitota Tsegaye, Kalkidan Yibeltal, Fred Van Dyk, Sara Cherkerzian, Firehiwot Workneh, Workagegnhu Tarekegn Kidane, Theresa I Chin, Sarah K G Jensen, Mulatu Melese, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Stephen Pihl, Winko W An, Sonya V Troller-Renfree, Moriah E Thomason, Terrie Inder, P Ellen Grant

“…This study will examine the effects of prenatal nutrition and infection management interventions on long-term growth and neurodevelopmental outcomes of offspring.Methods The Enhancing Nutrition and Antenatal Infection Treatment (‘ENAT’) study (ISRCTN15116516) was a pragmatic, open-label, 2×2 factorial, randomised clinical effectiveness study implemented in 12 rural health centres in Amhara, Ethiopia. …”
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Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China by Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Yun Chang, Yun Chang, Yun Chang, Yun Chang, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao

“…This study explored the dose–response relationship between AIP and physical dysfunction.MethodsData from 11,369 CHARLS participants (aged ≥45 years) in 2015 and 2018 were analyzed using univariate and multivariate logistic regression, adjusting for demographics and lifestyle factors. …”
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Predicting diabetic retinopathy stages using a simple nerve conduction measuring device, DPNCheck®: a retrospective observational study by Mayu Sakai, Mayu Sakai, Mayu Sakai, Takehiro Kato, Takehiro Kato, Takuma Ishihara, Ken Takao, Ken Takao, Tokuyuki Hirose, Tokuyuki Hirose, Sodai Kubota, Sodai Kubota, Saki Kubota-Okamoto, Saki Kubota-Okamoto, Toshinori Imaizumi, Toshinori Imaizumi, Yoshihiro Takahashi, Yoshihiro Takahashi, Masami Mizuno, Masami Mizuno, Takuo Hirota, Takuo Hirota, Yukio Horikawa, Yukio Horikawa, Hirokazu Sakaguchi, Hirokazu Sakaguchi, Shin Tsunekawa, Daisuke Yabe, Daisuke Yabe, Daisuke Yabe

“…In contrast, DPNCheck® is a simpler alternative that quantifies neuropathy severity through the severity of the estimated modified Baba classification (eMBC).Materials and methodsUsing electronic medical records (EHRs), we identified individuals with diabetes who underwent DPNCheck® and subsequent ophthalmologic assessment for DR. …”
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Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model by Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang

“…However, the precise mechanism by which AD antagonizes lung cancer progression warrants further elucidation. Methods To this end, we established a co‐morbidity model using 5xFAD transgenic mice induced with the carcinogen urethane. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…BN models may be a useful method to identify clusters of symptoms that predict PsA with reasonable accuracy. …”
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