Exploring the shared molecular mechanisms of primary hypertension and IgA vasculitis through a case report and combining bioinformatics analysis by Qijiao Wei, Jiayan Feng, Yifei Mu, Qian Shen, Hong Xu, Li Sun, Haimei Liu

“…This study aims to report this unusual case and investigate the biological mechanisms associated with the differentially expressed genes (DEGs) related to PHTN and IgAV through the application of bioinformatics tools.MethodsWe present the case of a boy diagnosed with PHTN and IgAV. …”
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Musical Expertise Reshapes Cross-Domain Semantic Integration: ERP Evidence from Language and Music Processing by Xing Wang, Tao Zeng

“…This event-related potential (ERP) study investigated whether Chinese sentences and musical chord sequences share semantic processing mechanisms and how musical expertise modulates these mechanisms. <b>Methods:</b> This study recruited 46 college students (22 musicians and 24 non-musicians). …”
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The association between vision impairment and multi-site pain in middle-aged and older adults in China: results from the China health and retirement longitudinal study by Tianyi Luo, Cunzi Li, Lan Zhou, Lan Zhou, Yingrui Liu, Hongyan Sun, Ming Ming Yang

“…BackgroundPrevious research on the association between vision impairment (VI) and multi-site pain has been sparse, and no studies have specifically examined this relationship in low- and middle-income countries (LMICs).ObjectiveThis study aims to investigate the relationship between VI and the coexistence of pain in 15 different body sites and multi-site pain among middle-aged and older adults in China using nationally representative survey data.MethodsWe conducted a cross-sectional study using data from the 2020 China Health and Retirement Longitudinal Study (CHARLS), which included 10,240 participants. …”
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[18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging for in vivo prediction of drug resistance in pancreatic cancer by SUN Chenwei, HAI Wangxi, QU Qian, XI Yun

“…Objective·[18F]F-FMISO and [18F]F-FLT are specific PET imaging agents for detecting the hypoxia microenvironment and cell proliferation, respectively. This study aims to visualize and monitor the impact of drug resistance in pancreatic cancer on the hypoxia microenvironment and cell proliferation through [18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging, with the goal of providing a theoretical basis for clinical application.Methods·The CCK-8 assay was conducted to assess drug resistance in the PANC-1/R (PR) pancreatic cancer cell line compared to the parental PANC-1 (P) cell line. …”
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Implantation of a long biological patch in classical carotid endarterectomy for extended atherosclerotic lesions. Long-term outcomes by A. N. Kazantsev, M. A. Chernyavsky, R. A. Vinogradov, V. N. Kravchuk, D. V. Shmatov, A. A. Sorokin, S. V. Artyukhov, V. V. Matusevich, V. A. Porkhanov, G. G. Khubulava

“…Objective: to analyze the in-hospital and long-term outcomes of classical carotid endarterectomy (CEE) in extended atherosclerotic lesions in comparison with the outcomes of this operation in local atherosclerotic plaque (AP). Materials and Methods. This study, which lasted from January 2010 to December 2020, included 148 patients with extended AP and hemodynamically significant internal carotid artery (ICA) stenosis. …”
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Outcomes of Cooled Radiofrequency Ablation of Lumbar Nerves as Treatment for Chronic Low Back Pain by Alaa Abd-Elsayed, Trevor N. Johnson, Kylie K. Ruprecht, Tristan R. Argall, Lukas J. Henjum, Kenneth J. Fiala

“…This study investigates whether patients receiving CRFA for relief of chronic low back pain caused by lumbar facet arthropathy experience a reduction in pain scores, the length of this reduction in pain scores, and the magnitude of this reduction in pain. Methods This study was a retrospective analysis of data extracted from UW-Health Electronic Medical Health records (EMR), encompassing lumbar CRFA procedures performed from 2015 through April of 2024. …”
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Extended-view totally extraperitoneal approach for midline primary and incisional ventral hernia repair: Initial results and experience from a single institution in Vietnam by Van Phu La, Vinh Phuc La, Hai Duong Tong, Minh Dien Tran, Tuan Tu Duong, Vimal Kumar Vasudeavan, Hadinata Prana, Anh Vu Doan

“…This study aimed to evaluate the initial outcomes and institutional experience of the e-TEP technique for midline primary and incisional ventral hernia repair at a tertiary center in Vietnam. Methods: This prospective descriptive study was conducted on 65 patients with midline primary or incisional ventral hernias who underwent e-TEP repair between June 2022 and August 2024. …”
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H‐Shaped Anatomical Titanium Plate: Biomechanical Validation and Clinical Application in the Treatment of Complex Posterior Wall/Column Acetabular Fractures by Qiaoli Zhang, Liang Jin, Xiaorui Hao, Weijie Zheng, Fei Zhou, Shuxin Zhang, Tianfeng Li, Xiaohui Xiong, Yihan He, Xiaojie Chen, Jiexin Huang

“…This study aims to conduct biomechanical testing and clinical evaluation of HTP to assess its stability and efficacy in treating these fractures. Methods In the biomechanical research, posterior column with posterior wall fractures was created on nine acetabular models procured from Sawbones, USA and were allocated to three fixation groups: (1) a single reconstruction plate combined with a single cortical screw (PCS), (2) double parallel reconstruction plates (2P), (3) HTP. …”
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The safe lowest effective power of subthreshold micropulse laser treatment in Chinese patients with acute or chronic central serous chorioretinopathy by Ting Xie, Ting Xie, Wangting Li, Linli Wang, Jiafeng Ning, Zhi Li, Yulei Chen, Xifeng Lin, Shaolin Du, Qingshan Chen

“…PurposeTo assess the safe, lowest effective laser power of subthreshold micropulse laser (SML) for treating acute and chronic central serous chorioretinopathy (CSC) in Chinese patients.MethodsPatients were distinguished with acute or chronic CSC based on focal or diffuse retinal pigment epithelium (RPE) leakage on fundus fluorescein angiography (FFA), with or without widespread RPE decompensation. …”
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Systemic inflammatory and oxidative stress biomarkers as predictors of pain in sequential bilateral phacoemulsification for age-related cataract by Peng Yin, Peng Yin, Liyuan Wang, Yongsheng Hou, Yang Huang, Dawei Sun, Dewang Shao

“…This study investigated whether systemic inflammatory biomarkers and oxidative stress indicators could predict and explain the differential pain experience in sequential bilateral phacoemulsification for age-related cataract.MethodsIn this prospective, single-blinded case-control study, we enrolled 80 patients with age-related cataract undergoing sequential bilateral phacoemulsification. …”
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Sociodemographic factors associated with health-related quality of life in UK healthcare workers: a cross-sectional study by Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Daniel Pan, Joshua Nazareth, Luke Bryant, Carol Rivas, Katherine Woolf, Manish Pareek, The UK-REACH study collaborative group

“…We also examined EQ-5D-5L visual analogue scale (VAS) scores using linear regression. …”
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Effectiveness of Platelet-rich Plasma Therapy and Limberg Flap Reconstruction in the Management of Pilonidal Sinus Disease: A Prospective Observational Study by S Vinith Balaji, K Thinagaran, Reegan Jose, Najeem Fazil, Mohana Vamsi, Arafath Iqbal

“…Aim: To compare the wound healing duration, postoperative pain levels, recurrence rates and postoperative complications between PRP therapy and Limberg flap reconstruction in the management of PSD. Materials and Methods: A prospective observational study was conducted in the Department of General Surgery at SRM Medical College Hospital and Research Institute, Chennai, Tamil Nadu, India from January to December 2024, involving 62 patients. …”
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ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Contro... by Thomas M Deutsch, Léa L Volmer, Manuel Feisst, Laura Bodenbeck, Kathrin Hassdenteufel, Lara Tretschock, Christiane Breit, Stefan Stefanovic, Armin Bauer, Carolin Anders, Lina Weinert, Tobias Engler, Andreas D Hartkopf, Nico Pfeifer, Pascal Escher, Marc Mausch, Oliver Heinze, Marc Suetterlin, Sara Y Brucker, Andreas Schneeweiss, Markus Wallwiener

“…Additionally, it assessed the impact of a patient-reported outcome–based intervention across various therapy settings. MethodsPatients with breast cancer were eligible to participate in the study before neoadjuvant, adjuvant, postneoadjuvant, or palliative systemic therapy against breast cancer was initiated at the Heidelberg, Mannheim, and Tuebingen, Germany, university hospitals. …”
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Effect of Floating Needle Perfusion Therapy combined with Joint Mobilization on Shoulder Pain of Hemiplegia after Stroke by Xin WANG, Hu LI, Xiuyan LU

“…Objective:To observe the effect of floating needle perfusion therapy combined with joint mobilization on shoulder pain of hemiplegia after stroke. Methods: A total of 90 hemiplegia patients with shoulder pain after stroke in the department of rehabilitation medicine of Shandong Provincial Third Hospital from February to December 2019, which were divided into the control group, the floating needle group and the comprehensive group according to the random number table, with 30 cases in each group. …”
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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…ObjectiveThis randomized controlled trial examines the specific and combined effects of brief SS and TS interventions on older adults’ physical and mental health and pain intensity levels, among individuals living in nursing homes. MethodsA total of 96 patients aged 65-99 years from a nursing home were randomly assigned to 3 groups: SS, TS, and combined SS+TS interventions, each delivered as four 20-minute sessions. …”
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Influence of the duration of psoriatic arthritis on the achievement of remission and minimal disease activity during therapy with genetically engineered biologic drugs. Data from t... by E. Yu. Loginova, T. V. Korotaeva, E. E. Gubar, Yu. L. Korsakova, M. V. Sedunova, I. N. Pristavskiy, I. N. Kushnir, I. F. Umnova, S. S. Kudishina, E. L. Nasonov

“…To study the frequency and timing of the onset of remission and minimal disease activity after the administration of genetically engineered biologic drugs (GEBD) in patients with early and long-term psoriatic arthritis observed within the framework of the All-Russian register of patients with psoriatic arthritis.Material and methods. The study included 140 patients with psoriatic arthritis (77 men, 63 women) who met the CASPAR criteria, who took part in the All-Russian register and were followed up every 6 months. …”
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ARCHITECTONICS OF THE SILENCE IN VERCORS’ NOVEL “THE SILENCE OF THE SEA” by Tatyana A. Pakhareva

“…The combination of the structural-semiotic, contextual, and holistic methods during the story analysis allowed us to come to the conclusion that compositionally the “silence of the sea”, which corresponds to the “surface/depth” structure, is implemented in Vercors’ story in a similar way to L. …”
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Impact of Posterior Quadratus Lumborum Block on Acute Pain Relief and Chronic Pain Prevention in Breast Cancer Surgery by Min Wang, Shu-Jie Niu, Jin Wu, Yi-Wei Zhong, Zi-Yun Lu, Qun Fu, Bing-Bing Li

“…The aim of this research was to evaluate whether ESPB and QLB2 can relieve acute and chronic pain following breast cancer surgery. Methods A total of 120 female patients undergoing breast cancer surgery were randomly assigned to receive either ESPB, posterior QLB, or no intervention. …”
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Effectiveness of Digital Health Interventions for Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis by Miaoqing Zhuang, Intan Idiana Hassan, Wan Muhamad Amir W Ahmad, Azidah Abdul Kadir, Xiaodong Liu, Furong Li, Yinuo Gao, Yang Guan, Shuting Song

“…ObjectiveThis systematic review and meta-analysis assesses the clinical effectiveness of smartphone apps, wearable monitors, and web-delivered platforms in four COPD management areas: (1) quality of life (measured by the COPD Assessment Test [CAT] and St George’s Respiratory Questionnaire), (2) self-efficacy (assessed by the General Self-Efficacy Scale), (3) functional capacity (evaluated via the 6-minute walk test and Modified Medical Research Council Dyspnea Scale), and (4) health care use (indicated by hospital and emergency department visits). MethodsA systematic review was conducted using predefined search terms in PubMed, Embase, Cochrane, and Web of Science up to January 26, 2025, to identify randomized trials on digital health interventions for COPD. …”
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Evaluation of clinical efficacy of pelvic ultrasound monitoring combined with scale scoring in the treatment of interstitial cystitis by intravesical instillation regimen combined... by Lin Liu, Liang Xue, Jiahe Zhou, Bingzheng Dong, Yang Li, Zhigang Li, Yang Dong, Conghui Han

“…This study aimed to evaluate the clinical efficacy of a treatment regimen combining intravesical instillation of heparin and alkalized lidocaine, hydrodistention, and transurethral fulguration, using pelvic ultrasound monitoring and symptom scales to assess patient outcomes. Methods From June 2016 to June 2023, patients who were diagnosed as interstitial cystitis in urology department of the xuzhou central hospital were selected. …”
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