HORNBILL: A First-in-Human Phase I/IIa Study of the Safety, Tolerability, and Early Pharmacodynamics of BI 764524 for Diabetic Macular Ischemia by Quan Dong Nguyen, MD, MSc, Chirag Jhaveri, MD, Maged Habib, MD, Yasir J. Sepah, MBBS, Khaled Nassar, MD, PhD, Bartlomiej Krawczyk, PhD, Gudrun Simons, PhD, Andrea Giani, MD, Elizabeth Pearce, PhD, Martin Gliem, MD, Mohamed Ahmed, MBBCh, MD, Sobha Sivaprasad, DM

“…Participants: Adults with DMI and stable diabetic retinopathy (DR) treated with pan-retinal photocoagulation and without center-involving diabetic macular edema. Methods: Twelve participants received single IVT doses of BI 764524 0.5 mg (n = 3), 1.0 mg (n = 3), or 2.5 mg (n = 6) in the SRD part. …”
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Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Valid... by Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Haowei Lin, Yuxing Lin, Daxin Chen, Shan Lin, Peizhi Jia, Meiling Wang, Ling Zhang, Wei Lin

“…But the precise mechanisms underlying its anti-inflammatory and anti-tumor effects are not fully elucidated. <b>Methods</b>: Use network pharmacology to identify targets and pathways of GQD. …”
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Good Arts, Good Mental Health®: the effectiveness of an Australian health promotion media campaign in promoting community mental wellbeing via the arts by Christina R. Davies, Melanie T. Pescud, Rhonda Clifford, Richard McGrath, Annie Thomson, Mia Jeffrey, Melissa Stoneham, Terri Pikora, Peter Wright, Sonya Girdler, Sonya Girdler, Loretta Baldassar, Stephen Clift

“…The objectives of the campaign (Wave 1) were to increase brand awareness, comprehension, and agreement with the tagline Good Arts, Good Mental Health® and empower the general population to form an intention to engage in the Arts for their mental wellbeing.MethodsThe campaign ran from August to September 2024 (4 weeks), cost AUD$198,965 (23% creative and 77% media/advertising distribution), and targeted the Western Australian (WA) general population aged 18–65 years, all genders, in both metropolitan and regional areas. …”
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A novel nomogram for predicting osteoporosis with low back pain among the patients in Wenshan Zhuang and Miao Autonomous Prefecture of China by Man Jia, Man Jia, Qinzuo Dong, Zeqin Ren, Liwei Xing, Jinjie Li, Xiaomei Wang, Shun Yu, Xiaoyan Wang, Rong Zhao, Rong Zhao

“…However, there are currently no convenient tools available to identify patients with low back pain caused by osteoporosis.MethodsWe consecutively enrolled 769 patients diagnosed with low back pain in our hospital from January 2019 to March 2024. …”
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The clinical course and outcomes following arthroscopic frozen shoulder 360° release by Brandon Ziegenfuss, BSc(Hons), MPH, Kristine Italia, MD, FPOA, Kathir Azhagan Stalin, MBBS, Sarah Whitehouse, PhD, Ashish Gupta, MBBS, MSc, FRACS, FAOrthA, Kenneth Cutbush, MBBS, FRACS, FAOrthA

“…The aim of this study is to evaluate the clinical outcomes following the FS 360° arthroscopic release. Methods: An observational prospective cohort study was conducted assessing patient-reported outcome measures (PROMs) in patients who underwent the 360° arthroscopic release between July 2013 and January 2019. …”
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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008 by Juntong Li, Juntong Li, Sheng Ye, Xiang Li, Xiang Li, Hui Liu, Yue Yang, Xuelei Lu, Heyue Jin, Li Liu, Li Liu

“…ObjectiveThis study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults.MethodsThe study utilized data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. …”
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PSMA response evaluation in follow-up PSMA-PET/CT after stereotactic ablative body radiotherapy (SABR) for oligometastases in prostate cancer by Anna-Lena Zang, Timo Maier, Sandra Freitag-Wolf, Alexander Fabian, Severin Rodler, Jürgen Dunst, David Krug, Ulf Lützen, Olaf Wittenstein

“…PSMA response was evaluated by visual and quantitative assessment of local PSMA uptake pre- and post-SABR. …”
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Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? by Mi-Yeong Kim, Ha-Kyeong Won, Ji-Yoon Oh, Ji-Hyang Lee, Eun-Jung Jo, Sung-Yoon Kang, Ji-Ho Lee, Seung-Eun Lee, Noeul Kang, Young-Chan Kim, Hwa Young Lee, Jin An, Youngsang Yoo, Ji-Su Shim, So-Young Park, Han-Ki Park, Min-Hye Kim, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Sang-Hoon Kim, Byung-Jae Lee, Surinder S. Birring, Woo-Jung Song

“…This study aimed to compare symptom features, such as cough triggers and associated throat sensations, of cough hypersensitivity in patients with asthmatic chronic cough and those with refractory chronic cough (RCC). Methods Patients with chronic cough from the Korean Chronic Cough Registry were prospectively evaluated over 6 months. …”
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Quantitative tremor monitoring before, during and after MR-guided focused ultrasound thalamotomy for essential tremor with MR compatible accelerometers by Thomas Bancel, Mohammed Bashaiweth, Thomas J. Manuel, Benoît Béranger, Cécile Galléa, Mathieu Santin, Mélanie Didier, Eric Bardinet, Pierre Pouget, Mickael Tanter, Stéphane Lehéricy, Marie Vidailhet, David Grabli, Nadya Pyatigorskaya, Carine Karachi, Elodie Hainque, Jean-François Aubry

“…Currently, clinical examination is used to identify therapeutic efficacy during treatment, but MRgFUS surgery could benefit from real-time, rater-independent quantitative monitoring of tremor, such as accelerometry data.Methods Fourteen patients with medically refractory essential tremor underwent MRgFUS thalamotomy. …”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

“…IntroductionThis study investigates the preferences of cataract patients in East China regarding intraocular lenses (IOLs).MethodsA Discrete Choice Experiment (DCE) was conducted using a questionnaire that included various IOLs attributes. …”
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Interrelationships of stress, burnout, anxiety, depression, quality of life and suicidality among Chinese residents under Standardized Residency Training: a network analysis by Zejun Li, Min Wu, Xiaoyu Zhang, Kewen Yan, Xin Wang, Huixue Xu, Peizhen Li, Yueheng Liu, Qijian Deng, Xueyi Li, Qianjin Wang, Manyun Li, Yunfei Wang, Yuzhu Hao, Li He, Yi-Yuan Tang, Tieqiao Liu, Pu Peng, Qiuxia Wu

“…This study aims to investigate the symptom network of stress, burnout, anxiety, depression (SBAD) and adverse personal outcomes in this cohort.Methods From October 2020 to April 2022, 994 physicians were recruited across China through snowball sampling. …”
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Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors by Yi Duan, Wen Chen, Jian Xu, Xiaoyu Zhang, Xiaozhen Zhang, Tingbo Liang, Xueli Bai, Mengyi Lao, Hanshen Yang, Muchun Li, Honggang Ying, Lihong He, Kang Sun, Chengxiang Guo, Haitao Jiang

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HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma by Xu Chen, Hai Huang, Qiong Wang, Qiang-Hua Zhou, Kai-Wen Li, Hai-Xia He, Sheng-Meng Peng, Shi-Rong Peng, Ze-An Li, Yi-Ran Tao, Wen-Li Cai, Ran-Yi Liu

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Apatinib plus camrelizumab (anti-PD1 therapy, SHR-1210) for advanced osteosarcoma (APFAO) progressing after chemotherapy: a single-arm, open-label, phase 2 trial by Xin Sun, Yuan Li, Jie Xu, Wei Guo, Yi Huang, Lu Xie, Jin Gu, Kuisheng Liu, Bingxin Zheng, Tingting Ren, Xiaodong Tang, Taiqiang Yan, Rongli Yang, Kunkun Sun, Danhua Shen

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Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind c... by Una Martin, Timothy Barrett, Susan Mollan, Karen E Morrison, Ruth Evans, Isabelle Meunier, Rajat Gupta, Andrew Peet, Martin Wilson, Sulev Koks, Wojciech Młynarski, Patrick Yu-Wai-Man, Agathe Roubertie, Darren Barton, Dewi Astuti, Renuka P Dias, Lucinda Billingham, Kun Hu, Malgorzata Zatyka, Archana Kulkarni, Benjamin Wright, Kristian Brock, Victoria Homer, Rebecca Malpass, Heather Rose, Christophe Orssaud, Zsuzsanna Nagy, Tracy Lynch, Sabrina Cronier, Amandip Malhi, Pooja Takhar, Amy Lamb, Gema Esteban-Bueno

“…To date, there have been no multicentre randomised controlled trials investigating the efficacy of treatments for neurodegeneration in patients with Wolfram syndrome.Methods and analysis TREATWOLFRAM is an international, multicentre, double-blind, placebo-controlled, randomised clinical trial designed to investigate whether 36-month treatment with up to 40 mg/kg/day of sodium valproate will slow the rate of loss of visual acuity as a biomarker for neurodegeneration in patients with Wolfram syndrome. …”
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Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial by Kristine Godziuk, Mary Forhan, Flavio T. Vieira, Joao F. Mota, Jason Werle, John A. Batsis, Lorenzo M. Donini, Mario Siervo, Carla M. Prado

“…We investigated the feasibility and efficacy of a multimodal behavioural intervention compared to usual care to enhance physical function and muscle mass in this population. Methods The POMELO (Prevention Of MusclE Loss in Osteoarthritis) study is a two‐arm pilot randomized controlled trial; NCT05026385. …”
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The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…Our goal is to relieve the acute postoperative pain and promote fast recovery and rapid discharge for ARCR patients.Patients and Methods: Ninety-six patients who underwent ARCR from December 2023 to March 2024 were enrolled in this double-blinded, randomized control trial (Registration number, ChiCTR2300078507). …”
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Comparison of the efficacy and safety of various anti-inflammatory drugs in urate-lowering therapy initiation in patients with gout (preliminary data) by M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina

“…Non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and glucocorticoids (GC) are used to prevent arthritis attacks in gout, but data on their comparative effectiveness is lacking.Objective: to compare the efficacy and safety of various anti-inflammatory drugs at the start of treatment in patients with gout.Patients and methods. Of the 108 patients with gout, observed in the V.A. …”
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User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…ObjectiveThis study aimed to clarify how a digital behavioral intervention for people with chronic pain can be developed through a user-centered approach to address the needs and preferences of the target population. MethodsThis study used a multimethod approach involving end users, namely, patients with chronic pain and therapists, to develop prototypes for a digital behavioral intervention across 3 phases. …”
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Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity by Linrong He, Xiaoming Shu, Xia Liu, Yongpeng Ge, Sizhao Li, Xin Lu, Guochun Wang

“…To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods. Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE), and 20 healthy controls (HCs) by chemiluminescent immunometric assay. …”
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