Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats by Brandon M. Roberts, Alyssa V. Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa N. Varanoske, Alyssa M. Kelley, Maximus C. Leiss, Alexander L. Kolb, Julie M. Hughes, Marshall A. Naimo, Ryan E. Tomlinson, Jeffery S. Staab

“…The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6 weeks of aerobic exercise. Methods Nine‐week‐old male Wistar rats (n = 80) were randomized to either exercise (EX) or no‐exercise control (CON) conditions and treated with naproxen, ibuprofen (IBU), flurbiprofen (FLU) or placebo (PLA). …”
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Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry by Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

“…We hypothesized that the Everyday Cognition Scale (ECog), a subjective change measure, predicts longitudinal change in cognition in the Brain Health Registry (BHR), an online registry for neuroscience research. Methods This study included BHR participants aged 55 + who completed both the baseline ECog and repeated administrations of the CANTAB® Paired Associates Learning (PAL) visual learning and memory test. …”
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Two different unilateral percutaneous vertebroplasty approaches for acute osteoporotic vertebral compression fractures: clinical and radiological outcomes by Anquan Huang, Haijun Liu, Yubo Liu, Jun Shen, Guoqing Zhu, Yefeng Wang, Shiming Li, Tianming Zou, Chenxi Gu, Bin Lv

“…Abstract Objective To investigate whether the unilateral posterosuperior approach PVP is superior to the traditional unilateral transpedicular approach in the treatment of acute osteoporotic vertebral compression fractures (OVCFs). Methods A retrospective study was conducted on 167 patients with single-segment acute OVCFs admitted to our hospital from September 2019 to March 2022. …”
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Mental fatigue and sleep restriction effects on perceptual-cognitive performance in trained beach volleyball athletes by Bruno Teixeira Barbosa, Bruno Teixeira Barbosa, Bruno Teixeira Barbosa, Dalton de Lima-Junior, Alexandre Moreira, Fábio Yuzo Nakamura, Gilmário Ricarte Batista, Gilmário Ricarte Batista, Heloiana Faro, Leonardo de Sousa Fortes, Leonardo de Sousa Fortes

“…This study aimed to analyze the effects of MF and SR on perceptual-cognitive performance in beach volleyball athletes.MethodsFourteen volunteers participated (12 men; 17.9 ± 1.2 years; 182.0 ± 7.7 cm; 72.3 ± 8.4 kg) and were randomly submitted to four experimental conditions: (a) Control (CT), (b) MF, (c) SR, and (d) SR + MF. …”
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Socio‐economic status and adherence to HIV preventive and therapeutic interventions: exploring the mediating role of food insecurity among men who have sex with men and transgender... by Paula M. Luz, Thiago S. Torres, Victor C. Matos, Giovanna G. Costa, Brenda Hoagland, Cristina Pimenta, Marcos Benedetti, Beatriz Grinsztejn, Valdilea G. Veloso

“…We explored whether food insecurity mediated the association of socio‐economic status on adherence to ART/PrEP. Methods Adult men who have sex with men (MSM) and transgender and non‐binary persons (TGNB) living in Brazil (May−September/2021) voluntarily participated in a cross‐sectional online study advertised on dating apps and social media. …”
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Effect of acupoint application combined with moxibustion in the treatment of postoperative constipation in patients with thoracolumbar compression fracture (艾灸联合穴位贴敷治疗胸腰椎压缩性骨折患者术后便... by WANG Tingting (王亭亭), LIU Fei (柳菲), NIE Shanshan (聂珊珊), YANG Qiujing (杨秋景), YANG Yang (杨杨)

“…Objective To observe the therapeutic effect of acupoint application therapy combined with moxibustion on postoperative constipation in patients with thoracolumbar compression fracture. Methods Totally 100 patients with constipation after surgery for thoracolumbar compression fracture were randomly divided into two groups. …”
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Transitional and CD21− PD-1+ B cells are associated with remission in early rheumatoid arthritis by Sarah McGrath, Boel Sundbeck, Katrin Thorarinsdottir, Charlotte A. Jonsson, Alessandro Camponeschi, Monica Leu Agelii, Anna-Karin H. Ekwall, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Michael Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev-Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald van Vollenhoven, Anna Rudin, Inga-Lill Mårtensson, Inger Gjertsson

“…In this study, we sought to identify B-cell subset(s) at diagnosis that might be associated with Clinical Disease Activity Index (CDAI) remission at 24-week follow-up. Methods Seventy early RA patients from the NORD-STAR trial, recruited from two Swedish sites, and 28 matched healthy controls, were included in this spin-off study. …”
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Exploration of the molecular mechanism of melatonin against polycystic ovary syndrome based on a network pharmacology approach and experimental validation by Ran Cheng, Ran Cheng, Ran Cheng, Ying Zhu, Sheng-kai Wang, Chun-Xiao Zong, Hong-Li Zhao, Hong-Li Zhao, Hong-Li Zhao, Qin Zhang, Qin Zhang, Qin Zhang

“…This study integrated network pharmacology, molecular docking, molecular dynamics simulations, and laboratory confirmation to explore the pharmacological mechanisms of melatonin in PCOS.MethodsFirst, we conducted animal studies to evaluate the therapeutic efficacy of melatonin by administering it to circadian disruption-induced PCOS-like rats. …”
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Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity: a study protocol for a randomized intervention, multi-centre, double-blinded trial... by Ann Hellström, Mariya Petrishka-Lozenska, Aldina Pivodic, Anders K. Nilsson, Ulrika Sjöbom, Ingrid Hansen Pupp, David Ley, Lotta Gränse, Hanna Maria Öhnell, Gunnar Jakobsson, Karin Sävman, Lois E. H. Smith, Pia Lundgren, the DROPROP collaboration group

“…Our current study aims to assess the efficacy and safety of timely administered dexamethasone eye drops to reduce the need for laser or anti-VEGF ROP treatment in preterm infants. Methods In a randomized prospective interventional, multi-centre, double-blinded trial, we plan to include 100 infants with severe ROP born before gestational age 30 weeks in Sweden. …”
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Dietary antioxidants and flavonoids are inversely associated with prostate cancer risk and mortality: evidence from NHANES and machine learning by Yanyang Jin, Dong-shan Lv, Li-po Zhou, Li Xiao, Guang-quan Tong, Abdallah Karim, Shuai Xue, Hongyang Tian, Cheng-cai Wang, Kun Feng, Ding-ming Song, You-liang Guan

“…Although flavonoids and antioxidants show promise in experimental models, evidence from population-based studies remains limited.ObjectivesThis research aimed to investigate the relationship between the consumption of antioxidants and flavonoids in the diet and the risk and survival of PCa, as well as to assess the potential of machine learning models in identifying significant dietary factors.MethodsData from 2,629 male participants aged ≥40 years from National Health and Nutrition Examination Survey (NHANES) 2007–2010 were analyzed. …”
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Evaluation of hpv risk groups among women enrolled in the mulher cervical cancer screening study in Mozambique by Cristina Mendes de Oliveira, Ricardina Rangeiro, Nafissa Osman, Ellen Baker, Andrea Neves, Arlete A. N. Mariano, Guilhermina Tivir, Joseph P. Thomas, Jennifer Carns, Viviane Andrade, Carla Carrilho, Eliane C. S. Monteiro, Hannah Hoover, Edson Chivambo, Marcos Chissano, Elizabeth Chiao, Hira Atif, Philip E. Castle, Rebecca Richards-Kortum, Eva Lathrop, Kathleen M. Schmeler, Cesaltina Lorenzoni, Mila P. Salcedo

“…We describe the prevalence of high-risk HPV risk groups detected in women who participated in the MULHER Study, a prospective trial of Mozambican women undergoing cervical cancer screening with HPV testing. Methods From January 2020 to January 2023, 9,014 women aged 30–49 years in Maputo City and Gaza Province, Mozambique underwent cervical cancer screening. …”
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Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis by Zhi-Ming Ouyang, Yao-Wei Zou, Ye Lu, Jie Pan, Tao Wu, Pei-Wen Jia, Hu-Wei Zheng, Yun Su, Le-Feng Chen, Jian-Zi Lin, Kui-Min Yang, Pei-Yu Lin, Jin-Yuan Han, Jian-Da Ma, Lie Dai

“…We aimed to investigate its impact on disease characteristics in RA patients. Methods This cross-sectional study included natural post-menopausal RA patients from an observational RA cohort recruited between January 2015 and October 2023. …”
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Deciphering the anticoccidial mechanism of Qinghao Changshan formula through network pharmacology and molecular docking by Dong Tian, Hui Fu, Hongxia Tao, Miaolan Li, Qinghua Zhang, Weidong Deng

“…Overlapping targets were visualized using Venn diagrams, and protein–protein interaction (PPI) networks were constructed using STRING and Cytoscape. …”
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Cervical Spine Pain and the Impact on the Quality of Life of Patients with Multiple Sclerosis by Martyna Odzimek, Hubert Lipiński, Małgorzata Błaszczyk, Patrycja Strózik, Julia Zegarek, Piotr Dubiński, Agata Michalska, Justyna Klusek, Marek Żak, Waldemar Brola

“…<i>Background and Objectives</i>: The main aim of this study was to evaluate the impact of cervical pain on the quality of life of patients with multiple sclerosis in comparison with a group of healthy people (without diseases of the Central Nervous System). <i>Materials and Methods</i>: Data were collected at the Specialist Hospital St. …”
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CLP-Net: an advanced artificial intelligence technique for localizing standard planes of cleft lip and palate by three-dimensional ultrasound in the first trimester by Guangzhi He, Zhou Li, Zhiyuan Zhu, Tong Han, Yan Cao, Chaoyu Chen, Yuhao Huang, Haoran Dou, Lianying Liang, Fangmei Zhang, Jin Peng, Tao Tan, Hongmei Liu, Xin Yang, Dong Ni

“…Therefore, this study aims to develop and validate the first artificial intelligence (AI)-based model (CLP-Net) for fully automated multi-plane localization in three-dimensional(3D) ultrasound during the first trimester. Methods This retrospective study included 418 (394 normal, 24 CLP) 3D ultrasound from 288 pregnant woman between July 2022 to October 2024 from Shenzhen Guangming District People’s Hospital during the 11–13+ 6 weeks of pregnancy. 320 normal volumes were used for training and validation, while 74 normal and 24 CLP volumes were used for testing. …”
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Integrating clinical trial landscapes and bibliometric analysis: unveiling the impact of PD-1/PD-L1 inhibitors on renal cell carcinoma research and therapeutic trajectories summary by Yuanbin Huang, Yuanbin Huang, Xinmiao Ma, Hengxing Zhu, Chen Shen, Ke Hu, Yang Yu, Aoyu Yang, Zhuo Liu, Chuanyang Liu, Wenrui Shi, Wei Wang, Xueyan Xia, Jiawen Wang, Xiancheng Li

“…Thus, we aim to assess the global scientific outcomes of studies focusing on PD-1/PD-L1 in RCC from 2005 to 2024 and to identify emerging research trends.MethodsData were collected from the Web of Science Core Collection using a predefined search strategy. …”
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Insights into De Quervain’s Tenosynovitis as an Unintended Consequence of Problematic Smartphone Usage: A Cross-sectional Observational Study by Aswin Sugumaran, Dilip Kumar Naidu, Madhan Raju, Sabari Vaasan Lakshmikanthan, S Karthikeyan, Kevin Dhas, Vamsi Krishna, Praveen Raja

“…Materials and Methods: A cross-sectional observational study was conducted at the Department of Orthopaedics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India, from July 2024 to September 2024, with 300 participants aged 20-50 years. …”
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The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study on <i>Streptococcus mutans</i> and <i>... by Ronit Vogt Sionov, Ahmad Siag, Emma Theresa Mersini, Natalya M. Kogan, Tatiana Alkhazov, Igor Koman, Praveen Rowlo, Vitaly Gutkin, Menachem Gross, Doron Steinberg

“…<b>Objective</b>: The aim of this study was to develop a sustained-release device of CBD that can provide an antibacterial effect against the Gram-positive bacteria <i>Streptococcus mutans</i> and <i>Staphylococcus aureus</i> for extended periods of time. <b>Methods</b>: CBD was incorporated into the biodegradable PURASORB 5010 or PURASORB 7510 DL-lactide/glycolide polymers using either dimethylsulfoxide (DMSO) or acetone as the solvent, and the dried polymer scaffolds were exposed daily to a fresh culture of bacteria. …”
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Pseudomonas oryzihabitans D1-104/3 and P. gessardii C31-106/3 differentially modulate the antioxidative response of duckweed (Lemna minor L.) to salt stress by Tatjana Popržen, Dragana Antonić Reljin, Branka Uzelac, Marija Milovančević, Danijela Paunović, Milana Trifunović-Momčilov, Marija Marković, Martin Raspor, Ivan Nikolić, Slaviša Stanković, Olga Radulović

“…Fluorescence microscopy was used to visualize bacterial presence on duckweeds.ResultsFluorescence microscope revealed that Pseudomonas bacteria colonized all duckweed surfaces. …”
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The value of home-centered dressing change model in wound healing after low simple anal fistulectomy—a cross-sectional study by Zhang Linhan, Jia Shize, Wei Kaikai, Wan Xingyang, Ren Donglin, Lin Hongcheng, Liu Zhimin

“…[Objectives] To investigate the value of home-centered dressing change model in wound healing after low simple anal fistulectomy. [Methods] Total of the sixty-four patients with low simple anal fistula who underwent fistulectomy at the Department of Anorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University from June 2022 to December 2022 were included as the study subjects. …”
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