Optimizing Corticosteroid Sinonasal Irrigation Outcomes Through 3D Printing: A Randomized Pilot Clinical Trial by Zachary T. Root, Thomas J. Lepley, Kanghyun Kim, Aspen R. Schneller, Songzhu Zhao, Raymond Wen, Veronica L. Formanek, Sarah M. Sussman, Joseph S. Lee, Ahmad Odeh, Lai Wei, Kathleen M. Kelly, Bradley A. Otto, Kai Zhao

“…Setting Tertiary medical center from November 2021 to July 2023. Methods Sixty‐two patients with CRS were randomized into either control (CG), backfill (BG), or model (MG) groups; daily 2 mg mometasone irrigations were then performed for 2 months with either standard head‐forward and natural side‐tilt position (CG), a head tilt of 90° to the side with fluid entering the lower nostril (BG), or in an optimized position as determined by a patient‐specific 3D printed irrigation model (MG), respectively. …”
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Longitudinal Assessment of Structural and Functional Changes in Rod-cone Dystrophy: A 10-year Follow-up Study by Alexis Ceecee Britten-Jones, BOptom (Hons), PhD, Chi D. Luu, BOrth (Hons), PhD, Jasleen K. Jolly, MSc, DPhil, Carla J. Abbott, BOptom, PhD, Penelope J. Allen, MBBS, FRANZCO, Tina Lamey, PhD, Terri McLaren, BSc, Jennifer A. Thompson, PhD, John De Roach, PhD, Thomas L. Edwards, PhD, FRANZCO, Lauren N. Ayton, BOptom, PhD

“…Participants: Individuals initially diagnosed with retinitis pigmentosa who underwent baseline assessment between 2010 and 2013. Methods: Baseline and follow-up assessments included best-corrected visual acuity (VA), Goldmann visual field (GVF) perimetry, spectral-domain OCT imaging, electroretinogram, and panel-based genetic testing. …”
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Energy-Efficient Office Renovation by Minyoung KWON

“…For the empirical studies, a multidisciplinary methodology was applied to prioritise the important aspects of office renovations. The various methods for data collection and analyses included examining energy use and the quality of indoor climate after renovation, and investigating the impact of design factors on user satisfaction with thermal, visual, and psychological comfort. …”
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Building evidences in Public Health Emergency Preparedness (“BePHEP” Project)—a systematic review by Michelangelo Mercogliano, Gloria Spatari, Chiara Noviello, Francesca Di Serafino, Maria Elisabetta Mormile, Giuseppa Granvillano, Annalisa Iagnemma, Riccardo Mimmo, Irene Schenone, Eleonora Raso, Andrea Sanna, Enrica Frasson, Veronica Gallinoro, Marcello Di Pumpo, Duha Shellah, Caterina Rizzo, Nunzio Zotti

“…This systematic review aims to evaluate strategies and interventions implemented in LMICs to prevent and manage infectious diseases outbreaks during humanitarian crises from 2018 to 2023. Methods A comprehensive literature search was conducted across Scopus, PubMed, and Web of Science, adhering to the PRISMA guideline and the SPIDER framework to identify relevant studies. …”
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Comparative study of chitosan-based liquid dressing and recombinant human epidermal growth factor on acute limb skin wound healing: A randomized controlled trial by Dunyong Tan, Jiawei Guo, Xiaoqiang Chen, Jianquan Liu, Siyao Yang, Daping Wang, Wencui Li

“…However, its efficacy and safety are yet to be sufficiently verified in patients. Methods: This randomized controlled trial enrolled 40 patients suffering from acute skin wounds in the limbs from 12/2022 to 12/2023. …”
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Impacts of Traditional Warm-Up and Post-Activation Potentiation on Muscle Endurance During the Back Squat: Response of Blood Lactate, Perceived Effort, and Time Under Tension by Taianda M. Amorim, Alexandre V. Gurgel, Viviane Faleiro, Thiago T. Guimarães, Estêvão R. Monteiro, Felipe G. Teixeira, Bruno Jotta, Tiago C. Figueiredo, Raquel C. Castiglione, Silvio R. Marques-Neto

“…This randomized crossover study compared the acute effects of traditional and PAP-based warm-ups on local muscular endurance (LME) during free weight back squats in resistance-trained men. Methods: Twelve trained males (age: 41.3 ± 5.7 years; one repetition maximum squat: 129.3 ± 14.3 kg) completed three randomized squat sessions: mobility with LME (M + LME), traditional warm-up with LME (T + LME), and PAP with LME (PAP + LME). …”
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Effect of Traditional Chinese Formula Dingkun Pill on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial by Xuesong Ding, Shiyang Zhu, Yan Deng, Xiao Ma, Jingwen Gan, Yanfang Wang, Aijun Sun

“…Therefore, this trial aimed to assess the efficacy and safety of DKP in patients with PD. Methods: Our study was a multicenter, prospective, randomized, double-blind, placebo-controlled study. …”
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Sub‐Acromioclavicular Decompression Increases the Risk of Postoperative Shoulder Stiffness after Arthroscopic Rotator Cuff Repair by Cheng Li, Zhiling Wang, Maslah Idiris Ali, Yi Long, Ymuhanmode Alike, Min Zhou, Dedong Cui, Zhenze Zheng, Ke Meng, Jingyi Hou, Rui Yang

“…This study is aim to evaluate the impact of additional sub‐acromioclavicular (SAC) decompression during arthroscopic rotator cuff repair on the postoperative shoulder stiffness (POSS) in patients. Methods This retrospective study examined digital data from patients with full‐thickness rotator cuff tears who underwent arthroscopic rotator cuff repair at a local institution. …”
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Gadoxetic acid-enhanced MRI for identifying cholangiocyte phenotype hepatocellular carcinoma by interpretable machine learning: individual application of SHAP by Wei Liu, Zhiping Cai, Yifan Chen, Xingqun Guan, Jieying Feng, Haixiong Chen, Baoliang Guo, Fusheng OuYang, Chun Luo, Rong Zhang, Xinjie Chen, Xiaohong Li, Cuiru Zhou, Shaomin Yang, Ziwei Liu, Qiugen Hu

“…This study aims to develop and validate an optimal machine learning model to predict cholangiocyte phenotype HCC based on T1 mapping gadoxetic acid-enhanced MRI and to implement individual applications via the Shapley Additive explanation (SHAP). Methods We included 180 patients with histologically confirmed HCC from two institutions. …”
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Post-exertional malaise in Long COVID: subjective reporting versus objective assessment by Barbara Stussman, Nathan Camarillo, Gayle McCrossin, Marybeth Stockman, Gina Norato, C. Stephenie Vetter, Alenka Ferrufino, Ashade Adedamola, Nicholas Grayson, Avindra Nath, Leighton Chan, Brian Walitt, Lisa M. K. Chin

“…Secondarily, Long COVID symptom responses to exercise were compared to those of ME/CFS and healthy volunteers.MethodsData from three registered clinical trials comprised four cohorts in this study: Long COVID Questionnaire Cohort (QC; n = 244), Long COVID Exercise Cohort (EC; n = 34), ME/CFS cohort (n = 9), and healthy volunteers (HV; n = 9). …”
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EFFICIENCY OF DYNAMIC ELECTRONEUROSTIMULATION IN KNEE OSTEOARTHRITIS: RESULTS OF A MULTICENTER RANDOMIZED STUDY by O. M. Lesnyak, E. Yu. Kadochnikova, L. I. Alekseeva, I. G. Dydykina, O. B. Ershova, E. M. Zaitseva, T. A. Korotkova, T. A. Popova, M. L. Sukhareva, E. A. Taskina, V. N. Khodyrev, E. P. Sharapova, A. G. Solodovnikov, A. A. Vlasov

“…Dynamic electroneurostimulation (DENS) is a type of percutaneous electroneurostimulation with a differentiation approach to choosing exposure areas and to optimizing electrocutaneous therapeutic action on the reflexogenic areas and acupuncture points for analgesia and for the treatment of functional disorders.Objective: to study the clinical efficiency and safety of therapy using a DiaDENS-PC apparatus in the treatment of knee osteoarthritis (OA).Subjects and methods. A multicenter randomized double-blind placebo-controlled study was conducted in 132 knee OA patients with pain value above 40 mm on visual analogue scale (VAS) and Lequesne’s index of 4–12. …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…This systematic review and meta-analysis examines the effects of TS on EIMD and muscle pain in athletes. Methods: PubMed, Scopus, and Web of Science were systematically searched for randomized controlled trials (RCTs) on TS in athletic populations until March 2025. …”
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Circulating DNA methylation level of CXCR5 correlates with inflammation in patients with rheumatoid arthritis by Yiming Shi, Cen Chang, Lingxia Xu, Ping Jiang, Kai Wei, Jianan Zhao, Linshuai Xu, Yehua Jin, Runrun Zhang, Huijuan Wang, Yi Qian, Yingying Qin, Qin Ding, Ting Jiang, Shicheng Guo, Rongsheng Wang, Dongyi He

“…Abstract Objectives To assess the differences in circulating DNA methylation levels of CXCR5 between rheumatoid arthritis (RA) and osteoarthritis (OA) and healthy controls (HC), and the correlation of methylation changes with clinical characteristics of RA patients. Methods Peripheral blood samples were collected from 239 RA patients, 30 patients with OA, and 29 HC. …”
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Implementing a Common Data Model in Ophthalmology: Mapping Structured Electronic Health Record Ophthalmic Examination Data to Standard Vocabularies by Justin C. Quon, MD, Christopher P. Long, MD, William Halfpenny, MBBS, MEng, Amy Chuang, MS, Cindy X. Cai, MD, MS, Sally L. Baxter, MD, MSc, Vamsi Daketi, MS, Amanda Schmitz, BS, Neil Bahroos, MS, Benjamin Y. Xu, MD, PhD, Brian C. Toy, MD

“…Subjects: Not applicable. Methods: Source eye examination data elements from the default Cerner Model Experience EHR and a local implementation of the Cerner Millennium EHR were extracted, classified into one of 8 subject categories, and mapped to the semantically closest standard concept in the OMOP CDM. …”
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Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV by Joanah Madzime, Joanah Madzime, Marcin Jankiewicz, Marcin Jankiewicz, Marcin Jankiewicz, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Peter Torre, Barbara Laughton, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes

“…Investigating the functional connectivity (FC) within the CAS and between the CAS and non-auditory regions may reveal the influence of HIV on regions involved in auditory function.MethodsWithin a Bayesian statistical framework, we used resting-state functional magnetic resonance imaging to map FC in the CAS as well as between CAS regions and non-auditory regions of 11-year-old CPHIV. …”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…As group therapy has proven to be a valuable and effective treatment option for managing anxiety and depression, the aim of this study was to determine its effects on patients with CHD and anxious–depressive symptoms. <i>Methods</i>: We used non-pharmacological psychological group intervention, of six weekly sessions of 90 min each, administered by trained personnel, in adult patients with CHD. …”
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Partial volume effect correction impairs the diagnostic utility of [18F]-THK-5351 PET in nonfluent-agrammatic variant primary progressive aphasia by Patrick J. Sommer, Sebastian Schuster, Oliver Goldhardt, Nobuyuki Okamura, Felix Mueller-Sarnowski, Maximilian Scheifele, Florian Eckenweber, Annika Kreuzer, Maria Griessl, Peter Bartenstein, Thomas Wegehaupt, Lucas Wolski, Josef Priller, Axel Rominger, Leonie Beyer, Timo Grimmer, Matthias Brendel

“…The aim of this study was to challenge partial volume effect correction (PVEC) in patients with nonfluent-agrammatic variant primary progressive aphasia (nfv-PPA) imaged with [18F]-THK-5351 PET a marker of reactive neuroinflammatory astrogliosis as well as tau-binding. Methods: Patients with nfv-PPA (n = 20) were imaged with [18F]-THK-5351 PET accompanied by structural magnetic resonance tomography imaging (MRI). …”
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Efficacy of Kegan Liyan oral liquid vs. Lianhuaqingwen capsules for patients with mild COVID-19: a double-blinded, randomized, controlled, non-inferiority trial by Yuewei Li, Yihe Chi, Mengting Zhu, Feiting Fan, Zhongyang Deng, Jingmin Xiao, Shaohan Jin, Luoqi Lin, Xiaochun Chen, Ruhong Xu, Long Fan, Xuhua Yu, Ziyao Liang, Jingyu Quan, Shangzhao Li, Xinying Peng, Yuanbin Chen, Yuanbin Chen, Yuanbin Chen, Lin Lin, Lin Lin, Lin Lin, Lei Wu, Lei Wu, Lei Wu

“…This trial aims to assess whether KGLY is non-inferior to LHQW in treating mild COVID-19.MethodsA total of 127 participants (63 in KGLY group and 64 in LHQW group) were randomly allocated to receive either KGLY therapy or LHQW therapy in a 1:1 ratio. …”
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Deep Learning to Predict the Future Growth of Geographic Atrophy from Fundus Autofluorescence by Anish Salvi, MS, Julia Cluceru, PhD, Simon S. Gao, PhD, Christina Rabe, PhD, Courtney Schiffman, PhD, Qi Yang, PhD, Aaron Y. Lee, MD, MSCI, Pearse A. Keane, MD, FRCOphth, Srinivas R. Sadda, MD, Frank G. Holz, MD, Daniela Ferrara, MD, PhD, Neha Anegondi, MTech

“…Purpose: The region of growth (ROG) of geographic atrophy (GA) throughout the macular area has an impact on visual outcomes. Here, we developed multiple deep learning models to predict the 1-year ROG of GA lesions using fundus autofluorescence (FAF) images. …”
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Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study by Jaesub Park, Jaesub Park, Woo Jung Kim, Woo Jung Kim, Han Wool Jung, Han Wool Jung, Jae-Jin Kim, Jae-Jin Kim, Jin Young Park, Jin Young Park, Jin Young Park

“…This study aimed to explore the relationship between regional EEG abnormalities and amyloid deposition in patients with mild cognitive impairment (MCI).MethodsWe recruited 24 older adults with MCI from a community center for dementia prevention, and 21 participants were included in the final analysis. …”
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