MULTICENTER DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL OF THE SYMPTOM- AND STRUCTURE-MODIFYING EFFECT OF ALFLUTOP IN PATIENTS WITH KNEE OSTEOARTHROSIS. COMMUNICATION 1. EVA... by Lyudmila Ivanovna Alekseeva, E P Sharapova, E A Taskina, N V Chichasova, G R Imametdinova, N A Shostak, N G Pravdyuk, L N Denisov

“…Objective: to evaluate the symptom- and structure-modifying effect of alflutop versus placebo (PL) in patients with knee osteoarthrosis (OA).Subjects and methods. The trial enrolled 90 patients with knee OA (ACR criteria and Kellgren–Lawrence Stages II–III) and pain on walking ≥ 40 mm on a visual analogue scale (VAS) who signed their informed consent. …”
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Impact of Paraspinal Sarcopenia on Clinical Outcomes in Intervertebral Disc Degeneration Patients Following Percutaneous Transforaminal Endoscopic Lumbar Discectomy by Tianci Fang, Zhifang Xue, Quan Zhou, Jiawen Gao, Jian Mi, Huilin Yang, Feng Zhou, Hao Liu, Junxin Zhang

“…To investigate the prognostic value of preoperative paraspinal sarcopenia on long‐term PROMs after PTED, and to identify independent predictors of chronic postoperative low back pain. Methods In this retrospective cohort study, 145 patients who underwent PTED for lumbar disc herniation (2017–2022) were stratified into sarcopenia (n = 52) and non‐sarcopenia (n = 93) groups using sex‐specific psoas muscle index (PMI) thresholds (male: < 6.36 cm2/m2; female: < 3.92 cm2/m2). …”
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Short-term pre-meal whey protein microgel supplementation reduces postprandial glycemia and appetite in adults with overweight: An open-label randomised controlled trial by Ian J. Neeland, Kostas Tsintzas, Bo Ahrén, Robert J. Chilton, Ambra Giorgetti, Alric Mondragon, Rachel Ambiaux, Eugenia Migliavacca, David Philippe, Olivier Aprikian, Odd Erik Johansen

“…We assessed the effects of twice daily consumption of a low-dose non-gelling novel WP formulation (WP microgel [WPM]) on PPG, self-reported appetite, and ad-libitum food consumption. Methods: This was a randomized, prospective, open-label, controlled, single-center crossover study, and adults with BMI 27–35 kg/m2 were randomized to consume either 125 mL of 10 g WPM or control (water) 15 min before breakfast and lunch for four consecutive days. …”
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Emergence and characterization of a ST852 Klebsiella quasipneumoniae clinical isolate coharboring blaNDM-1 and blaKPC-2 in China by Chongmei Tian, Yaping Zhao, Su Dong, Zhixin You, Jingbai Chen, Hongfeng Xu, Yuejuan Fang, Yapei Zhang

“…ObjectivesTo characterize a rare ST852 Klebsiella quasipneumoniae strain co-producing NDM-1 and KPC-2 isolated from a clinical patient.MethodsMinimum inhibitory concentrations (MICs) were measured using a VITEK 2 compact system and broth microdilution. …”
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Restoring coronal pre-arthritic alignment in mobile-bearing unicompartmental knee arthroplasty: mid- to long-term outcomes by Yankun Jiang, Changquan Liu, Qidong Zhang, Guoyuan Sun, Ran Ding, Nianfei Zhang, Cheng Huang, Weiguo Wang, Wanshou Guo

“…This study evaluated whether patients who achieve pre-arthritic alignment following mobile-bearing UKA with the kinematic alignment technique experience superior postoperative knee function compared with those who do not. Methods A retrospective analysis was conducted on 236 knee joints that underwent UKA using kinematic alignment techniques between May 2015 and November 2017. …”
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Intraocular pressure correlation to progressive retinal nerve fiber layer loss in primary open angle glaucoma as measured by standard and modified goldmann applanation tonometers by Sean McCafferty, Manjool Shah, Anupam Laul, Khin Kilgore

“…From the database, 148 eyes, 75 patients met the inclusion criteria of a diagnosis of primary open angle glaucoma (POAG) with at least 5 sequential quality optical coherence tomographer (OCT) measurements. Methods Sequential OCT images were obtained with the spectral domain Zeiss OCT5000. …”
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Analysis of sleep quality and influencing factors in migraine patients with patent foramen ovale by Hu Yijun, Zhang Diwen, Wang Libo, Liu Bo, Ye Hongmei, Zhao Xiongfei

“…Basic demographic data were collected using a self-designed questionnaire， headache severity was assessed with the Visual Analogue Scale （VAS）， and sleep quality was invaluated using the Pittsburgh Sleep Quality Index （PSQI）. …”
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Factors associated with knee pain at early stages of osteoarthritis by A. R. Khalmetova, Lila A. M., E. A. Taskina, L. I. Alekseeva, N. M. Savushkina, N. G. Kashevarova, E. A. Strebkova, O. G. Alekseeva

“…Objective: To investigate key risk factors associated with knee pain in early-stage osteoarthritis (OA).Material and methods. The study included 109 women aged 35–75 years with knee pain lasting no more than one year and minimal radiographic changes (Kellgren–Lawrence grades 0–II). …”
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Identification of Ferroptosis -Related Genes in MAFLD/MASH and HQHF Validation by Liu S, Zhang L, Xu J, Zhao Q, Shang D, Liu X, Zhang Q, Liu M, Zhao W

“…This study aims to identify differentially expressed genes (DEGs) associated with MAFLD/MASH and explore their potential link to ferroptosis, a form of regulated cell death.Methods: We conducted differential expression analysis using two datasets from the GEO database. …”
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Correlation analysis between facial feature-based traditional Chinese medicine inspection of spirit classification and Beck Depression Inventory score by Shan Lu, Xubo Shang, Dong Yang, Junfeng Yan, Xiaoye Wang

“…Objective: To determine the correlation between traditional Chinese medicine (TCM) inspection of spirit classification and the severity grade of depression based on facial features, offering insights for intelligent intergrated TCM and western medicine diagnosis of depression. Methods: Using the Audio-Visual Emotion Challenge and Workshop (AVEC 2014) public dataset on depression, which conclude 150 interview videos, the samples were classified according to the TCM inspection of spirit classification: Deshen (得神, presence of spirit), Shaoshen (少神, insufficiency of spirit), and Shenluan (神乱, confusion of spirit). …”
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External application of Xiaoding ointment in the treatment of swelling around arteriovenous fistula sites in patients with hemodialysis (消定膏对血液透析动静脉内瘘患者肿胀的临床疗效评价)... by XU Xia (徐霞), CHENG Lijun (程立军), LI Xiao (李潇), LI Xiaoping (李晓萍), ZHUANG Hua (庄华), ZHANG Lianhe (张莲荷)

“…Objective To observe the clinical effect of the external use of Xiaoding ointment in the treatment of swelling around arteriovenous fistula sites in patients with hemodialysis. Methods A total of 112 patients with swelling around arteriovenous fistula sites during hemodialysis treatment were randomly divided into the experimental group and the control group according to the random number table, with 56 cases in each group. …”
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A MULTICENTER, BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY OF THE SYMPTOM- AND STRUCTURE-MODIFYING EFFET OF ALFLUTOP IN PATIENTS WITH KNEE OSTEOARTHRITIS. REPORT 2: THE ASSESSMENT... by L. I. Alekseeva, E. P. Sharapova, E. A. Taskina, N. V. Chichasova, G. R. Imametdinova, N. A. Shostak, N. G. Pravdyuk, L. N. Denisov

“…To evaluate the symptom- and structure-modifying effect of Alflutop compared to placebo (PL) in patients with knee osteoarthritis (OA). Material and methods. The study included 90 patients with knee OA (according to the criteria of the Russian Association of Rheumatologists) at the stage 2–3 (according to the Kellgren-Lawrence scale); pain score when walk- ing ≥ 40 mm (assessed using the visual analog scale). …”
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TiMON: a real-time integrated monitor for improving the placement and wear of emergency tourniquets by John Quan Nguyen, Avery Goss, Helen Keshishian, Francis Berchard, Jonathan Parks, Conor Evans

“…Here, we present the results of two studies in which the TiMON was tested among a group of soldiers participating in the Army Expeditionary Warrior Experiments (AEWE) as well as in a group of untrained civilians from Massachusetts General Hospital. Methods In the first study, 30 soldiers with prior tourniqueting experience were asked to apply a TiMON equipped CAT tourniquet onto a leg mannequin with (unblinded) and without (blinded) assistance from the TiMON’s output. …”
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Acupuncture as an Adjunctive Therapy to Etoricoxib for Patients with Acute Gouty Arthritis: Protocol for a Multicenter Randomized Controlled Trial by Wang YR, Liu CZ, Cong Y, Xi YW, Xu YY, Li B, Zhou Y, Tu JF, Fu YM, Chen W, Wang LQ, Shi GX

“…The primary outcome is the change in pain intensity (Visual Analogue Scale) after the 30-minute acupuncture treatment from baseline. …”
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Work related musculoskeletal stress among residents of internal medicine on cardiological wards in their daily working practice – a kinematic and ergonomic analysis by Fabian Holzgreve, Corinna Rittinghausen, Ingo Hermanns, Britta Weber, Rolf Ellegast, Julia Bille, Doerthe Brueggmann, Stefanie Mache, David A. Groneberg, Daniela Ohlendorf

“…The aim of this study is to provide a comprehensive kinematic and ergonomic analysis of an average working day of a resident physician in internal medicine on a cardiological ward. Methods The kinematic data of 17 resident physicians (9f/8m) of internal medicine, working in 3 different cardiological wards in a hospital of maximum care was collected on an average workday using the CUELA measurement system. …”
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Automated analysis of retinal microcirculation in type 1 diabetes mellitus by Yu. N. Yusef, M. H. Durzhinskaya, V. G. Pavlov, D. V. Petrachkov, I. B. Gurevich, V. V. Yashina, A. T. Tleubaev, V. V. Fadeyev, I. V. Poluboyarinova, A. E. Goldsmid, R. А. Karamullina, D. V. Lipatov, M. V. Budzinskaya

“…Automatic analysis of optical coherence tomogram angiograms (OCT-A) was carried out with specially developed software that provides the ability to estimate quantitative vascular parameters.AIM: The purpose of the study was to assess diagnostic accuracy of clinical parameters and imaging biomarkers in type 1 diabetes using a new algorithm for OCT-A analysis.MATERIALS AND METHODS: The study involved 186 people (365 eyes) with type 1 diabetes. …”
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Yachting tourism in the Krasnodar Territory and new Russian regions: problems and prospects by Liudmila A. Ovcharenko, Elena A. Panina, Evgeniy S. Franchenko

“…The purpose of the article is to identify problems and substantiate the prospects for the development of yacht tourism in the Krasnodar Territory and in new Russian territories within the Azov-Black Sea coast, due to the implementation of new investment projects for yacht infrastructure. Materials and Methods. The study is based on data from yacht clubs and companies specializing in servicing, renting yachts, selling yacht equipment and small boats, organizing yacht cruises: "Storm crew", "International Yacht Training Worldwide", "Mediterranean Yacht Charter". …”
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Development a nomogram for predicting HELLP syndrome in women complicated with gestational hypertension by Ying Jiang, Lu-Jiao Chen, Hui-Hui Hu, Neng Jin, Shi-Rui Lv, Chen Fang, Chun-Mei Zhu, Meng-Meng Yang, Dong Xu, Qiong Luo

“…This study aimed to develop a clinically accessible prediction model for assessing the risk of HELLP syndrome progression in patients with hypertensive disorders of pregnancy (HDP) and find effective factors that may predict the progression of HELLP within 3 days. Methods We used electronic data from Women’s Hospital, Zhejiang University School of Medicine, between January 1,2014 and December 31,2023. …”
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Efficiency of drug therapy for coxitis in patients with ankylosing spondylitis according to the data of a 12-month prospective follow-up by A. V. Petrov, V. A. Beloglazov, Yu. O. Shevnina, A. A. Petrov

“…However, the influence of these treatments on the time course of HJ structural changes has not been currently studied.Objective: to estimate the time course of HJ changes clinical, X-ray, and ultrasonographic examination was performed in AS patients receiving various drugs: NSAIDs, SSZ, and adalimumab (ADA) during 12 months.Subjects and methods. Seventy-eight AS patients who had clinical, ultrasonographic, and radiological signs of HJ inflammation were followed up. …”
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Comparison of Biportal Endoscopic Technique and Conventional Unilateral Laminectomy for Bilateral Decompression (ULBD) for Multi‐Level Degenerative Lumbar Spinal Stenosis in Elderl... by Chenhao Dou, Qingsong Yu, Wei Zhang, Lei Ma, Xianzhong Meng

“…ABSTRACT Objective The object of this retrospective study was to compare the clinical, radiological, and spinal stability outcomes of biportal endoscopic Unilateral Laminectomy for Bilateral Decompression (BE‐ULBD) and traditional Unilateral Laminectomy for Bilateral Decompression (ULBD) for multi‐segmental lumbar spinal stenosis in elderly patients with osteoporosis. Methods We retrospectively identified 41 and 47 patients who underwent BE‐ULBD and ULBD, respectively, who were diagnosed with multi‐level lumbar stenosis and underwent double‐segmental surgery in elderly patients. …”
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