Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…This study integrates multi-omics data and machine learning approaches to systematically identify and validate key PANoptosis-related biomarkers in periodontitis.MethodsPeriodontitis-related microarray datasets (GSE16134 and GSE10334) were obtained from the GEO database, and PANoptosis-related genes were retrieved from GeneCards. …”
Get full text

Association of blood cadmium levels with all-cause and cause-specific mortality among adults with non-alcoholic fatty liver disease: a prospective cohort study by Congxi Xu, Congxi Xu, Zhi Li, Shirui Hao, Jian Zhang, Jinlong Li, Kuopeng Liang, Xiaojuan Wang, Yi Zhang, Yi Zhang, Guangyuan Zhao, Mengyun Bai, Dengxiang Liu, Jitao Wang

“…This study aimed to evaluate the predictive value of blood cadmium levels for mortality risk in patients with NAFLD.MethodsThis study analyzed data from 13,450 patients with NAFLD in the National Health and Nutrition Examination Survey (NHANES) database, covering the years 1999 to 2018. …”
Get full text

A pilot study of intraoperative melphalan to prevent recurrent PVR: the IOMPVR study by Carlos A. Moreira-Neto, Jose S Pulido, Luca Bongiovanni de Miranda Gonçalves, Gabriel Nunes Cavalcanti, Acacio Souza Lima, José de Paula Barbosa Neto, Daniel Lavinsky, Talita Virginia Fernandes de Oliveira, Fernando Ejii Ogata, Lucas Zago Ribeiro, Luiz Fernando Teixeira, Flavia Borelli Gomes do Nascimento, Luiz H. Lima, Octaviano Jr. Magalhães, Michel Eid Farah, Maurício Maia

“…We evaluated the safety and efficacy of 5 µg/0.1 ml intravitreal melphalan at the end of pars plana vitrectomy (PPV) before silicone oil (SO) injection in eyes with primary PVR related to rhegmatogenous retinal detachments (RRDs) with a minimal 90-day follow-up period. Methods This prospective, cross-sectional, interventional pilot study was conducted at the Department of Ophthalmology of the Federal University of São Paulo in patients with primary RRD and PVR. …”
Get full text

Quantitative insights into stroke recovery utilizing delayed vessel ratio from color-coded multiphase computed tomography angiography by Yu Lin, Yu Lin, Yu Lin, Xiaoxiao Zhang, Zhen Xing, Xiefeng Yang, Qingwen Tong, Shaomao Lv, Jinan Wang, Jinan Wang, Dairong Cao, Dairong Cao, Dairong Cao, Dairong Cao

“…This research aimed to assess the quantification of cmCTA in AIS patients for characterizing arterial and venous collateral flow, and predicting functional outcomes.MethodsA retrospective study was performed on a consecutive cohort of AIS patients with large vessel occlusion who underwent cmCTA scan and reconstruction. …”
Get full text

Interactive effects of atmospheric oxidative pollutants and heat on circulatory disease mortality by Wenli Wang, Wenli Wang, Yang Chen, Ruoyu Li, Ruoyu Li, Linsheng Yang, Yu Jiang, Yu Jiang, Jianjun Xiang, Jianjun Xiang, Jing Wu, Jing Wu, Jing Li, Jing Li, Baoying Liu, Baoying Liu, Huaying Lin, Chuancheng Wu, Chuancheng Wu

“…This study aims to evaluate the synergistic effects of ozone (O₃), oxidant (Ox), and nitrogen dioxide (NO₂) with temperature and heat waves, and to explore their impact on circulatory disease mortality, providing evidence to support public health interventions.MethodsBased on the mortality, meteorological, and environmental protection data of residents in Fuzhou City from January 1, 2016, to December 31, 2022, we employed a generalized additive model (GAM) and a distributed lag nonlinear model (DLNM) to assess the effects of atmospheric oxidative pollutants interacting with temperature and heat waves on the risk of death from circulatory diseases, where temperature includes the daily maximum temperature and diurnal temperature range (DTR). …”
Get full text

Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study by Xinyu Tong, Huilin He, Shihan Xu, Rui Shen, Zihan Ning, Xiaofeng Zeng, Qian Wang, Dong Xu, Zuo-Xiang He, Xihai Zhao

“…This study aimed to investigate the resting state (RS) functional alternations of SSc patients and the potential influenced factors. Methods Forty-four SSc patients (mean age, 46.3 ± 11.4 years; 40 females) and 19 age and sex comparable healthy volunteers (mean age, 42.6 ± 11.3 years; 16 females) were recruited and underwent RS functional MR imaging (fMRI) and neuropsychological assessments. …”
Get full text

Long-term safety and effectiveness of canakinumab in patients with monogenic autoinflammatory diseases: results from the interim analysis of the RELIANCE registry by Tilmann Kallinich, Juergen Rech, Ivan Foeldvari, Norbert Blank, Frank Weller-Heinemann, Gerd Horneff, Ioana Andreica, Joerg Henes, Jasmin B Kuemmerle-Deschner, Florian Meier, Frank Dressler, Michael Borte, Markus Hufnagel, Birgit Kortus-Götze, Prasad T Oommen, Tobias Krickau, Aleš Janda, Catharina Schuetz, Michael Fiene, Julia Weber-Arden

“…Objective Interim analysis of the RELIANCE registry, an on-going, non-interventional, open-label, multicentre, prospective study evaluating the long-term safety, dosing regimens and effectiveness of canakinumab in patients with cryopyrin-associated periodic syndromes (CAPS), familial Mediterranean fever (FMF), tumour-necrosis factor receptor-associated periodic syndrome (TRAPS) or mevalonate-kinase deficiency (MKD)/hyperimmunoglobulin-D syndrome (HIDS).Methods From September 2017 for patients with CAPS, and June 2018 for patients with FMF, TRAPS or MKD/HIDS, the registry enrolled paediatric (aged ≥2 years) and adult patients (aged ≥18 years) receiving canakinumab as part of their routine medical care. …”
Get full text

Repeat expansions in RFC1 gene in refractory chronic cough by Barnaby Hirons, Peter S.P. Cho, Katie Rhatigan, Joe Shaw, Riccardo Curro, Bianca Rugginini, Natalia Dominik, Richard D. Turner, Ewan Mackay, James H. Hull, Hisham Abubakar-Waziri, Harini Kesavan, Caroline J. Jolley, Robert D. Hadden, Andrea Cortese, Surinder S. Birring

“…The prevalence and identifying clinical characteristics of RFC1 repeat-expansion disorders in patients with RCC are unknown. Methods Consecutive patients with RCC underwent RFC1 genotyping, cough severity visual analogue scale (VAS) and cough-specific health status assessment (Leicester Cough Questionnaire (LCQ)). …”
Get full text

Relationship between high-resolution computed tomography quantitative imaging analysis and physiological and clinical features in antisynthetase syndrome-related interstitial lung... by Donald P Tashkin, Rohit Aggarwal, Chester V Oddis, Grace Kim, Fereidoun Abtin, Daniela Markovic, Christina Charles-Schoeman, Galina Marder, Jonathan Goldin, Paul F Dellaripa, Swamy Venuturupalli, Gary Matt Hunninghake, Tracy J Doyle, Siamak Moghadam-Kia, Sangmee Sharon Bae, Cato Chan, Daniel Sullivan, Jeremy Falk

“…Objectives To explore the association between the extent of CT abnormalities by quantitative imaging analysis (QIA) and clinical/physiological disease parameters in patients with antisynthetase syndrome associated interstitial lung disease (ARS-ILD).Methods We analysed 20 patients with antisynthetase antibodies and active ILD enrolled in the Abatacept in Myositis-Associated Interstitial Lung Disease study. …”
Get full text

Effects of 2 different flap techniques on clinical outcomes after epulis excision by SUN Wentao, DONG Jiachen, SUN Mengjun, LIAO Yue, SONG Zhongchen

“…Objective·To evaluate the effects of normally positioned flap (NPF) and coronally advanced flap (CAF) techniques on clinical results after epulis excision.Methods·A total of 55 patients with epulis who visited the Department of Periodontology, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine from August 2022 to December 2023 were included. …”
Get full text

Effect of Midsole Compliance on Oxygen Consumption and Perception of Effort and Comfort during running by Kai Biedermann, Gian-Andri Baumann, Christina M. Spengler, Fernando G. Beltrami

“…This study aimed to address these issues by comparing three current AFT models with similar resilience but varying compliance: Nike AlphaFly 2 (NAF), Nike VaporFly 3 (NVF), and On Cloudboom Echo 3 (CBE), with the NAF being the most compliant shoe, and thus the one with the highest level of energy return (11.1J) compared with both the NVF (6.5 J) CBE (6.0 J). Methods Sixteen well-trained runners (age 31 ± 5 years, height 178 ± 9 cm, body mass 66 ± 10 kg, body fat 14 ± 4%, V̇O2peak 59 ± 4 ml･kg-1･min-1) performed, on different days, sub-maximal running for 6 min at 16 km·h-1 (80 ± 7% V̇O2peak) on a treadmill and a 400-m track. …”
Get full text

Application of strut-septum complex stent in nasal tip refinement of secondary unilateral cleft rhinoplasty by DONG Zhe, LI Qiaoqiao, YANG Jiegang, FU Yuchuan, LI Jian

“…Objective To evaluate the clinical efficacy of costal cartilage septal-columellar composite grafts in refining nasal tip aesthetics for secondary unilateral cleft lip nasal deformities, and to provide a reference for clinical treatment. Methods This study has been approved by the institutional medical ethics committee and informed consent was obtained from the patients. …”
Get full text

Clinico-epidemiological characteristics of cerebral venous sinus thrombosis in Kenya: a retrospective case series by Taby Siika, Jaskirat Sokhi, Juzar Hooker, Sheila Waa, Anne Mwirigi, Jasmit Shah, Jasmit Shah, Dilraj Singh Sokhi, Dilraj Singh Sokhi

“…We describe here the largest cohort of CVST from the region with novel findings that may be relevant to everyday clinical practice.MethodsWe conducted a retrospective cross-sectional study of patients diagnosed with CVST from 2010 to 2022 at our tertiary regional neurology referral center in Nairobi, Kenya.ResultsWe identified 122 cases: 67.2% (82/122) were female, 80.3% (98/122) were Black African, and the median (interquartile range) age was 36.8 (31.5–45.7) years. …”
Get full text

Efficacy and safety of traditional Chinese medicine for post-COVID-19 syndrome: a systematic review and meta-analysis by Yiting Wang, Xiao Li, Huaizheng Hui, Dianxing Yang

“…This study aimed to evaluate the clinical efficacy and safety of Chinese herbal medicine (CHM) in treating post-COVID-19 syndrome through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods Five electronic databases (PubMed, Embase, Web of Science, Cochrane Library and CNKI) were systematically searched up to March 15, 2025. …”
Get full text

LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway by Zhang Y, Liu J, Zhang D, Qian H

“…However, its specific molecular mechanism has not been clarified to explore the underlying macular mechanism of LCZXL enema effect on UC, based on Jagged-1/Notch1 signaling pathway and the macrophage polarization.Methods: After modeling of UC mice, the experiment was conducted in two parts: Experiment I: Control, Model, Mesalazine, Low dose of LCZXL (LCZXL-L), High dose of LCZXL (LCZXL-H); Weight and Disease Activity Index (DAI) scores were recorded on days 1, 3, 5, 7, 9, 11, and 13. …”
Get full text

Therapeutic efficacy of home-based neuromuscular electrical stimulation on early postoperative functional recovery following arthroscopic rotator cuff repair: a double-blind random... by Rui-song Wang, Jian-ning Sun, Qun-ya Zheng, Liang Chen, Peng Chen

“…This study aimed to evaluate the clinical efficacy of home-based NMES intervention for promoting early functional recovery after ARCR. Methods A total of 63 ARCR patients were randomized into the NMES group (n = 32) and MENS (Micro-current electrical nerve stimulation) group (n = 31), both receiving a 6-week home-based intervention (5 sessions weekly, 30 min per session) following surgery. …”
Get full text

Effect of Locoregional Vs General Anesthesia on Incidence of Delayed Neurocognitive Recovery in Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial by Xie S, Zhao X, Zhao Z, Gui M, Cao X, Shen X, Luo J, Chen X, Xia Y, Yu B

“…We conducted a randomized controlled trial to examine whether continuous femoral nerve block plus sacral plexus block reduces the rate of delayed neurocognitive recovery in patients undergoing hip surgery.Methods: This is a single-centre, randomized controlled trial. …”
Get full text

Improved alignment accuracy but similar early clinical outcomes with NAVIO imageless robotic-assisted vs. conventional total knee arthroplasty: a meta-analysis by Changjiao Sun, Qi Ma, Xiaofei Zhang, Huimin Li, Xin Yang, Xu Cai

“…Abstract Background This meta-analysis aimed to compare the radiological and clinical outcomes in patients who underwent total knee arthroplasty (TKA) using either NAVIO-assisted TKA or conventional TKA. Methods In accordance with the Preferred Reporting Items for Systematic Reviews and meta-analysis criteria, a systematic review was carried out. …”
Get full text

Effect of Yao medicine collapse stains combined with wax therapy in the treatment of chronic lumbar muscle strain (瑶药塌渍联合蜡疗治疗慢性腰肌劳损效果观察) by WEI Yingfen (韦英芬), HE Xinghong (何星宏)

“…Objective To investigate the effect of Yao medicine collapse stains combined with wax therapy in the treatment of chronic lumbar muscle strain. Methods A total of 138 patients with chronic lumbar muscle strain were selected as the study objects and randomly divided into observation group and control group, with 69 cases in each group. …”
Get full text

MORPHOLOGICAL CONDITION OF THE MUCOUS DURING THE PERIOD OF PHYSIOLOGICAL CHANGE OF THE CANINES OF THE UPPER JAW by M. Cholovskyi

“…Stratified squamous epithelium with expressive differentiation into basal, prickly granular and stratum corneum was visualized along the entire length. The formation of acanthotic epithelial cords took place in almost all cases. …”
Get full text