Standardization of Beef, Pork, Chicken, and Soy Protein Extracts for Patch Testing and Their Accuracy in Diagnosing Adverse Food Reactions in Dogs with Chronic Pruritus by Raniere Gaertner, Vanessa Cunningham Gmyterco, Júlia Só Severo, Camilla Alcalá, Maicon Roberto Paulo, Ruan Daros, Marconi Rodrigues de Farias

“…(1): Background: This study aimed to evaluate the concentrations of four proteins for allergic patch testing (APT) in dogs, assessing sensitivity (SE), specificity (SP), negative predictive value (NPV), positive predictive value (PPV), reactions to adhesives/containers, and the safety of APT with food proteins in dogs. (2) Methods: For evaluation, 43 dogs were screened and divided into two groups: Group 1 consisted of 20 healthy dogs, and Group 2 included 23 dogs with canine atopic dermatitis (AD). …”
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Clinical effect analysis of unilateral percutaneous vertebral cement distribution in the repair of osteoporotic thoracolumbar vertebral compression fractures by Liu Yuntao, Abuduwupuer Haibier, Aiben Kayierhan, Ma Liang, Yimuran Abudukelimu, Alimujiang Aximu, Tuerhongjiang Abudurexiti, Meng Xiangyu

“…Objective This study aimed to investigate the impact of cement distribution on the efficacy of vertebral compression fracture repair to provide effective preventive and therapeutic measures, prevent postoperative vertebral re-fracture, and improve surgical outcomes. Methods A total of 170 patients who underwent unilateral percutaneous vertebroplasty at our hospital from January 2020 to December 2022 were selected. …”
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Association between ABCB1 Gene Polymorphisms and Labor Analgesia in Primiparas by Wei Li, Tianke Xiao, Xuehui Wu, Xinyu Wu, Rui Xiang, Haifeng Liu, Jingyi Wang

“…Background: The present study aimed to explore the association of ATP-binding cassette B1 (ABCB1)/multiple drug resistance 1 (MDR1) gene polymorphisms (rs1128503 and rs1045642) with labor analgesia in primiparas. Methods: The cohort comprised 239 primiparas who received epidural analgesia (0.5 μg/L sufentanil + 0.1% ropivacaine). …”
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Associations between serum lipid profiles and the incidence of chronic obstructive pulmonary disease in the UK Biobank by Mengxia Li, Bingqing Xu, Hao Yu, Yanan Wan, Zheng Zhu, Pengfei Luo, Jian Su, Jinyi Zhou, Xikang Fan

“…Abstract Objective To investigate the relationship between serum lipid levels and the risk of Chronic obstructive pulmonary disease (COPD) in the UK Biobank. Methods We performed this prospective study in 381,938 adults without COPD from UK Biobank. …”
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A Multidisciplinary Approach for the Assessment of the Last Surviving ‘Marrone di Chiusa Pesio’ Chestnut Trees in the Piemonte Region (Italy) by Giovanna Neirotti, Alessandro Tomatis, Federica Germanà, Alessia Imparato, Andrea Valisena, Maria Gabriella Mellano, Paola Ruffa, Dario Donno, Daniela Torello Marinoni, Gabriele Loris Beccaro, Giovanni Gamba

“…A multidisciplinary approach was applied, involving genetic and morphological analyses, Visual Tree Assessment (VTA), and phytochemical and nutritional profiling. …”
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A Multihead Attention Deep Learning Algorithm to Detect Amblyopia Using Fixation Eye Movements by Dipak P. Upadhyaya, MS, Gokce Cakir, MD, Stefano Ramat, PhD, Jeffrey Albert, PhD, Aasef Shaikh, MD, PhD, Satya S. Sahoo, PhD, Fatema Ghasia, MD

“…Subjects: We recruited 40 controls and 95 amblyopic subjects (anisometropic = 32; strabismic = 29; and mixed = 34) at the Cleveland Clinic from 2020 to 2024. Methods: Binocular horizontal and vertical eye positions were recorded using infrared video-oculography during binocular and monocular viewing. …”
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Assessment of enthesitis in patients with psoriasis: Relationships with clinical features, screening questionnaries results, and quality of life: An ultrasound study by Dulović Dragan, Rančić Nemanja, Božić Ksenija, Stamatović Ratko, Mijušković Željko, Pešić Jasna, Kremić Zorana, Vojinović Radiša, Petronijević Milan

“…The aims of this study were to establish the prevalence of US signs of en-thesitis, compare it with screening questionnaires results, and estimate possible connections of US verified enthesitis with quality of life (QOL) of patients with psoriasis without PsA diagnosis. Methods. A cross-sectional study was performed on 67 patients with psoriasis who were without systemic therapy. …”
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TOTAL HIP ARTHROPLASTY IN PATIENTS WITH JUVENILE ARTHRITIS by D. V. Ivanov, S. A. Makarov, D. E. Karateev, V. P. Pavlov, M. A. Makarov, A. L. Logunov, I. P. Nikishina, T. A. Shelepina, V. N. Amirdzhanova

“…Prolonged hip arthritis in juvenile arthritis (JA) is a cause of serious joint destruction, leading to severe pain and functional disorders.Objective: to assess the results of total hip arthroplasty (THA) in patients with JA. Subjects and methods. The investigation enrolled 20 women and 2 men. …”
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Efficacy of fosaprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery: a multicenter, randomized, double-blind study by Yingjun Zhang, Xiaolin Luo, Qisen Fan, Sha Zhou, Yinqian Kang, Zhongqiao Mo, Jierong Luo, Bin Zheng, Lan Lan, Jingdun Xie

“…Abstract Purpose This study aims to investigate whether adding fosaprepitant to palonosetron and dexamethasone is effective in preventing postoperative nausea and vomiting (PONV) in high-risk patients undergoing gynecologic surgery. Methods Eligible patients undergoing gynecological surgery were randomized into two groups (1:1). …”
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Mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH): protocol for a prospective, randomised, open-label, blinded-endpoint phase IIb trial by Jesse Dawson, David J Werring, Nikola Sprigg, Christine Roffe, Zhe Kang Law, Kailash Krishnan, Philip Bath, Rob A Dineen, Diane Havard, Timothy J England, Mary Joan Macleod, Stefan Pszczolkowski, Jennifer Craig, Amanda Buck, David W Hewson, Lisa Woodhouse, Fergus Doubal, Emma Grace, Keenan Wells

“…We aim to assess the feasibility of a phase II randomised, controlled trial of mannitol in patients with ICH with, or at risk of, cerebral oedema to inform a definitive trial.Methods The mannitol for cerebral oedema after acute intracerebral haemorrhage trial (MACE-ICH) aims to include 45 ICH participants from 10 UK sites with estimated largest diameter of haematoma volume >2 cm, presenting within 72 hours of onset with, or at risk of, cerebral oedema (limited Glasgow Coma Scale (GCS)<9, including motor and visual components only, and National Institutes of Health Stroke Scale>8) with or without mass effect. …”
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Arthroscopic Pectoralis Minor Release and Infraclavicular Brachial Plexus Decompression for Neurogenic Thoracic Outlet Syndrome by Eric R. Wagner, MD, MS, FAOA, Thomas J. McQuillan, MD, Oluwakorede Omole, MD, Sameer R. Khawaja, BS, Kevin R. Cuneo, BS, Zaamin B. Hussain, MD, EdM, Hayden L. Cooke, BS, Krishna N. Chopra, MA, Michael B. Gottschalk, MD, FAOA, Robert L. Bowers, DO, PhD

“…The purpose of this study was to analyze clinical outcomes of this technique compared with historically published outcomes for open first rib resection (FRR) and/or scalenectomy. Methods:. All patients who underwent endoscopic surgical decompression for nTOS of infraclavicular etiology were retrospectively reviewed at a single institution. …”
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Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects by Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama

“…Previous studies indicated that achieving a maximum concentration (Cmax) of 3-HB in plasma at 0.28 mM could initiate ketone metabolism in the brain; we hypothesized that attaining this Cmax would improve brain health.MethodsWe aimed to demonstrate the efficacy of an optimized single oral dose of 3-HB on cognitive function and mood through two clinical studies: a pharmacokinetic study and an efficacy study. …”
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Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study by Roberto Bonanni, Angela Falvino, Antonio Matticari, Anna Maria Rinaldi, Giovanna D’Arcangelo, Giovanna D’Arcangelo, Pierangelo Cifelli, Riccardo Iundusi, Elena Gasbarra, Virginia Tancredi, Virginia Tancredi, Ida Cariati, Umberto Tarantino

“…This study aimed to evaluate the targeting of ERRs in myoblasts isolated from the skeletal muscle of inactive women by assessing the metabolic and expression changes associated with its activation.MethodsTwenty women undergoing hip arthroplasty for coxarthrosis were enrolled and divided into an active group (n = 10) and an inactive group (n = 10) based on self-reported physical activity. …”
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A study on the status of myopia and pre-myopia among primary school students in different regions of Shaanxi Province, China by Dong Wei, Dong Wei, Li Yangbing, Liu Chengfei, Liu Chengfei, Zhang Ye, Zhang Ye, Wang Zihao, Wang Zihao, Li Yanying, Li Yanying, He Xiaokang, He Xiaokang, Fu Kunlin, Du Zhaojiang

“…ObjectiveThis cross-sectional study aimed to investigate the geographic disparities in myopia and pre-myopia prevalence among elementary school students across three distinct regions of Shaanxi Province (southern Hanzhong, Guanzhong, and northern Yulin) to inform region-specific myopia control strategies.MethodsFrom March to May 2024, we employed multistage cluster sampling to recruit 8,207 eligible students (2,724 southern Shaanxi, 2,761 Guanzhong, 2,722 northern Shaanxi) from 12 randomly selected primary schools. …”
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Neurotropic effects of distilled water real exposed to Kyokushin Karate katas. Neurotropic Resonance: Biophotonic Information Transfer through Kyokushin Karate-Exposed Water by Valeriy Babelyuk, Igor Popovych, Olga Smoleńska, Anna Michalska, Radosław Muszkieta, Magdalena Hagner-Derengowska, Yuriy Dobrovolsky, Galyna Dubkova, Tetyana Korolyshyn, Walery Zukow

“…This report presents data on neurotropic effects of water actually exposed to KKK. Material and methods. The study involved five male participants (aged 26-60 years, right-handed, without clinical diagnoses). …”
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Evaluation of the efficiency and safety of magnet therapy for osteoarthritis. Results of the multicenter blind placebo-controlled study COSMO (Clinical Evaluation of Current Magnet... by A. E. Karateev, E. Yu. Pogozheva, M. L. Sukhareva, A. M. Lila, A. V. Ivanov, I. P. Osnovina, O. V. Shchashkova, S. V. Borisova, N. Е. Larinsky, Yu. A. Israelyan, S. А. Afoshin, T. P. Bondarenko, E. А. Repchanskaya, L. A. Chernyavskaya, S. P. Pupina, T. V. Darmova

“…Objective: to determine the efficiency and safety of Mt for knee OA.Subjects and methods. A study group consisted of 231 patients with knee OA (77.9% were women; mean age,61.9+12.2 years; body mass index, 30.6+5.8 kg/m2; median disease duration, 5.0 [2, 0; 10.0] years). …”
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Efficacy of sensorimotor training combined with core strength training for low back pain in adult idiopathic scoliosis: a study protocol for a randomized controlled trial by Tongtong Zhang, Xin Li, Xuan Zhou, Nan Chen, Qing Du, Hong Yu, Xiaoqing Zhu, Qimeng Fan, Juping Liang, Zhengquan Chen, Xiangyue Zhou

“…This randomied controlled trial protocol aims to determine whether the combination of SoMT and CST can significantly reduce LBP, and improve scoliosis-related outcomes and overall functional status in adult idiopathic scoliosis (AdIS) patients.Methods and analysis A total of 300 AdIS patients will be recruited from the outpatient clinic and randomly assigned to one of three groups: CST group, SoMT group or the combined therapy group, using stratified block randomization based on the severity of scoliosis curve. …”
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The relationship between vitamin D levels and Alzheimer’s disease risk: insights from a centenarian study of Chinese women by Yupeng Li, Xujie Wang, Mei Yu, Fei Wang, Dong Song, Musong Liu, Xu Liang, Hongzhou Liu, Jiangbo Liu, Shihui Fu, Shihui Fu, Xuhui Liu

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Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optica... by Yan-Mei Shi, Xiao Xie, Wen-Qi Wang, Xiao-Meng Yuan, Zhi-Ping Zhang, Hong-Yan Wang, Jie Meng, Ze-Hao Kong, Xia Jing, Ting-Ting Liu

“…AIM: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques. METHODS: In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. …”
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Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trialResearch in context by Byron L. Lam, Vitaliy Zak, Victor H. Gonzalez, Ninel Z. Gregori, Sai H. Chavala, Subrata Batabyal, Michael Carlson, Sanghoon Kim, Ananta Ayyagari, Jean Chang, Hayley Lane, Nozhat Choudry, John Koester, Mark Von Tress, Jody Piltz-Seymour, Najam A. Sharif, Stephen H. Tsang, Vinit B. Mahajan, David S. Boyer, Allen C. Ho, Samuel B. Barone, Samarendra K. Mohanty

“…Optogenetics is a promising approach to restoring vision by photosensitizing spared healthy retinal neurons. Methods: The STARLIGHT phase 2 open-label study (NCT05417126) was conducted over 48-weeks at two US sites to assess the safety and efficacy of MCO-010 administered via a single intravitreal injection in the worse-seeing eye of SD patients. …”
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