Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Exploring family physicians’ mental health referrals via centralized referral systems in Quebec, Canada: a qualitative descriptive study by Jessica Spagnolo, Marie Beauséjour, Marie-Josée Fleury, Jean-François Clément, Claire Gamache, Lyne Couture, Carine Sauvé, Shane Knight, Christine Gilbert, Richard Fleet, Helen-Maria Vasiliadis

“…Methods: A qualitative descriptive study with 20 participants working in the healthcare sector was conducted. …”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…Objective: to evaluate the efficacy and safety of glycosaminoglycan-peptide complex (GPC, Rumalon) used in patients with knee osteoarthritis (OA) and comorbidities (hypertension and/or type 2 diabetes mellitus (T2DM).Patients and methods: A 10-month multicenter (13 centers from 10 subjects of the Russian Federation) prospective study included 179 patients with Stages II–III primary tibiofemoral knee OA and comorbidity, a walking pain intensity of ≥40 mm on a visual analogue scale (VAS), and a need for nonsteroidal anti-inflammatory drugs (for at least 30 days in the previous 3 months). …”
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Machine Learning Model Based on Prognostic Nutritional Index for Predicting Long‐Term Outcomes in Patients With HCC Undergoing Ablation by Nan Zhang, Ke Lin, Bin Qiao, Liwei Yan, Dongdong Jin, Daopeng Yang, Yue Yang, Xiaohua Xie, Xiaoyan Xie, Bowen Zhuang

“…ABSTRACT Aims To develop multiple machine learning (ML) models based on the prognostic nutritional index (PNI) and determine the optimal model for predicting long‐term survival outcomes in hepatocellular carcinoma (HCC) patients after local ablation. Methods From January 2009 to December 2019, we analyzed data from 848 primary HCC patients who underwent local ablation. …”
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Does the number of drain tubes influence the formation of postoperative spinal epidural hematoma following biportal endoscopic unilateral laminotomy for bilateral decompression (BE... by Zhuolin Zhong, Jingjing Ying, Shaohua Zhang, Kaili Cai, Xiaowei Jing, Zhengyu Xu, Lejian Jiang, Tianxin Wu, Guojun Wei, Qingfeng Hu

“…The objective of this study is to investigate the potential impact of the number of drain tubes on POSEH following biportal endoscopic unilateral laminotomy for bilateral decompression (BE-ULBD) in patients of two-level adjacent lumbar spinal stenosis. Methods A prospective randomized study was conducted involving 89 patients with two-level adjacent lumbar spinal stenosis who underwent BE-ULBD. …”
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Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysis by Charbel El-Kefraoui, Ghadeer Olleik, Marc-Aurele Chay, Araz Kouyoumdjian, Philip Nguyen-Powanda, Fateme Rajabiyazdi, Uyen Do, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Agnihotram V. Ramanakumar, Marc-Olivier Martel, Gabriele Baldini, Liane Feldman, Julio F Fiore Jr

“…We propose a systematic review and meta-analysis to assess the extent to which opioid analgesia impact postoperative pain intensity and adverse events in comparison to opioid-free analgesia in patients discharged after surgery.Methods and analysis Major electronic databases (MEDLINE, Embase, Cochrane Library, Scopus, AMED, BIOSIS, CINAHL and PsycINFO) will be searched for multi-dose randomised-trials examining the comparative effectiveness of opioid versus opioid-free analgesia after surgical discharge. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…Introduction Myopia and its complications can lead to irreversible visual impairment and even blindness, making this a worldwide public health concern for the 21st century. …”
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Hyperuricemia predicts adverse clinical outcomes after arthroscopic microfracture of osteochondral lesions of the talus by Yuanqiang Li, Zhenyu Wang, Guo Zheng, Lin Ma, Xin Xin Li, Yan Liang, Xinyu Xie, Xiaolin Zhang, Chengsong Yuan, Wan Chen

“…Purpose: To investigate the correlation of serum uric acid levels with the clinical outcomes of arthroscopic microfracture in osteochondral lesions of the talus (OLTs) and determine the cut-off point for predicting outcomes. Methods: A total of 134 OLTs patients who underwent arthroscopic microfracture from November 2008 to June 2019 were included: 42 in the hyperuricemia group (≥ 420 μmol/L) and 92 in the non-hyperuricemia group (< 420 μmol/L). …”
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Low density of intratumoral M1-macrophage infiltration may correlate with worse prognosis in low-grade early-stage uterine endometrioid carcinoma by Michiko Nagamine, Hiroshi Ogi, Maki Hirai, Ikoi Omatsu, Sanzo Moriwaki, Saya Shibata, Satoru Yasukawa, Kaori Yoriki, Motohiro Kojima, Taisuke Mori, Kyoko Itoh, Eiichi Konishi

“…Our objective was to explore the differences in tumor immune microenvironment (TIME) between recurrent and cured low-grade early-stage endometrioid carcinoma cases. Methods: We retrospectively examined the TIME in recurrent (n = 11) and non-recurrent (cured, n = 10) cases of low-grade, early-stage endometrioid carcinoma. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…However, their impact on procedural outcomes, especially with the use of dual-layer micromesh stents, is not fully understood. Methods This prospective, multi-center observational study included 1965 patients with asymptomatic or symptomatic carotid artery stenosis treated with the Roadsaver dual-layer micromesh stent. …”
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Characterisation of combined abiotic and biotic stresses effects on lettuce plants via a multi-analysis approach by Roberta Bulgari, Roberta Bulgari, Jouhaina Riahi, Riccardo Cecire, Riccardo Cecire, Luisella Celi, Mery Malandrino, Gica Stefanescu Miralles, Gica Stefanescu Miralles, Lorenzo Comba, Luca Alfarano, Luca Alfarano, Massimo Pugliese, Massimo Pugliese

“…These findings pave the way to the development of proactive, reliable, and effective methods for stress detection in lettuce cultivation, also including non-destructive optical approaches.…”
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Deep anterior chamber depth may be a risk factor for axial length growth in children by Huijie Cao, Huijie Cao, Yongguo Xiang, Yongguo Xiang, Hong Cheng, Hong Cheng, Kexin Sun, Kexin Sun, Shijie Zheng, Shijie Zheng, Miaomiao Du, Miaomiao Du, Ning Gao, Ning Gao, Tong Zhang, Xin Yang, Jiuyi Xia, Wenjuan Wan, Wenjuan Wan, Ke Hu, Ke Hu

“…ObjectiveTo investigate and evaluate the progression of myopia and associated factors of axial length (AL) growth among children in Chongqing.MethodsThis six-month prospective study was conducted on students in grades 1 to 8 at a school in Chongqing, China. …”
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Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study by S. Berkani, S. Tuffet, A. Rousseau, N. Rincheval, E. Maheu, B. Combes, A. Saraux, B. Fautrel, L. Gossec, F. Berenbaum, J. Sellam, A. Courties

“…Objectives: To compare the burden of established chronic rheumatoid arthritis (RA) and erosive hand osteoarthritis (EHOA), in terms of pain, functional impairment, comorbidities, and cardiometabolic diseases (CMD). Methods: This study included EHOA patients from the inclusion visit of the DIGICOD cohort and RA patients from the 10th year visit of the ESPOIR cohort. …”
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A pilot study to explore utility of electronic informed consent in a low- income setting; the case of a Controlled human infection study in Blantyre, Malawi [version 2; peer review... by Clara Ngoliwa, Joel Gondwe, Chikondi Chakwiya, Anthony E. Chirwa, Pemphero Liwonde, Evaristar Kudowa, Vitumbiko Nkhoma, Linda Chantunga, Modesta Reuben, Edward Mangani, Tiferanji Sochera, Neema Toto, Lumbani Makhaza, Dingase Dula, Stephen B. Gordon, Ben Morton, Tarsizio Chikaonda, Marc Y.R. Henrion, Edna Nsomba

“…Objectives We aimed to explore the utility of electronic consent (e-consent) in an ongoing human infection study in Blantyre, Malawi. Methods The approved paper consent forms were digitized using Open Data Kit (ODK). …”
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Effect of laser acupuncture on pain, range of motion, and function in patellofemoral pain syndrome: a randomised controlled trial by Nesma M. Allam, Hadeel Alsirhani, Maani Batel Alruwaili, Dalal Mabkhout Dosh, Huriyyah Mislat Alruwaili, Wessal Hisham Almazyad, Rokaia A. Toson, Doaa Ayoub Elimy, Doaa Ayoub Elimy, Mohamed El-Sherbiny, Ateya Megahed Ibrahim, Ateya Megahed Ibrahim, Hasnaa Ali Ebrahim, Nermine Nosseir, Mohamed A. Eladl, Zeinab A. Ali

“…BackgroundPatellofemoral pain syndrome (PFPS) is a knee disorder characterised by pain behind or surrounding the patella that predominantly affects adolescents.ObjectivesThis study aimed to evaluate the impact of laser acupuncture (LA) on pain, range of motion (ROM), and function in patients diagnosed with PFPS.Materials and methodsSixty participants, predominantly young women aged 18–25 years, were randomly distributed into two equal groups: Group A (LA group), which received laser acupuncture (LA) applied to six knee acupoints at 4 J for 80 s/point, in conjunction with an exercise programme; and Group B (Sham LA group), which received LA with the device deactivated, along with an exercise programme including stretching and strengthening exercises. …”
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Scleral Buckling for Primary Retinal Detachment: Outcomes of Scleral Tunnels versus Scleral Sutures by Matthew R. Starr, Edwin H. Ryan, Anthony Obeid, Claire Ryan, Xinxiao Gao, Malika L. Madhava, Sean M. Maloney, Adam Z. Adika, Krishi V. Peddada, Kareem Sioufi, Luv G. Patel, Michael J. Ammar, Nora J. Forbes, Antonio Capone Jr., Geoffrey G. Emerson, Daniel P. Joseph, Dean Eliott, Carl D. Regillo, Jason Hsu, Omesh P. Gupta, Yoshihiro Yonekawa, for the Primary Retinal Detachment Outcomes (PRO) Study Group

“…Abstract Purpose: There are primarily two techniques for affixing the scleral buckle (SB) to the sclera in the repair of rhegmatogenous retinal detachment (RRD): scleral tunnels or scleral sutures. Methods: This retrospective study examined all patients with primary RRD who were treated with primary SB or SB combined with vitrectomy from January 1, 2015 through December 31, 2015 across six sites. …”
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Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial by SoYoung Ahn, Parivash Jamrasi, Byunggul Lim, Ji-won Seo, Xinxing Li, Shu Jiang, Yunho Sung, Seo Hyun Ahn, Chaeyoung Shin, Dongjin Noh, Bora Jin, Seonjoo Lee, Ki Won Lee, Jin Soo Kim, Young Tae Koo, Wook Song

“…Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial. Methods: In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). …”
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Clinical manifestation and management of severe blepharokeratoconjunctivitis combined with corneal perforation by Xu Li, Ping Hou, Xiao-Lin Qi, Su-Xia Li, Wei-Yun Shi, Hua Gao, Ting Zhang

“…AIM: To investigate the clinical signs of blepharokeratoconjunctivitis (BKC) and evaluate the efficacy of penetrating keratoplasty (PKP) for the disease. METHODS: Sixteen patients (16 eyes) with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively analyzed. …”
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Nitrogen dioxide exposure attenuates or even reverses the association between physical activity and fasting plasma glucose levels in non-diabetic elderly Chinese adults by Chen Zhang, Qingsi Wu, Xuqiu Cheng, Ziwei Tian, Junzhe Li, Qiang Liu, Yan Zhang, Xianwei Guo, Guimei Chen, Huaibiao Li, Changliu Liang, Bing Hu, Dongmei Zhang, Chunmei Liang, Jie Sheng, Fangbiao Tao, Jun Wang, Yuyou Yao, Linsheng Yang

“…This study aimed to examine whether long-term exposure to NO2 attenuates the association between PA and FPG levels in non-diabetic older adults. Methods A total of 2600 non-diabetic elderly Chinese adults were included in this cross-sectional study. …”
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Development and validation of an early diagnosis model for severe mycoplasma pneumonia in children based on interpretable machine learning by Si Xie, Mo Wu, Yu Shang, Wenbin Tuo, Jun Wang, Qinzhen Cai, Chunhui Yuan, Cong Yao, Yun Xiang

“…Therefore, there is an urgent need to establish an early warning model for SMPP to improve the prognosis of pediatric pneumonia. Methods The study comprised 597 SMPP patients aged between 1 month and 18 years. …”
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