Defining the relationship between clinician-rated ECOG performance status and patient-reported health-related quality of life scores in men with metastatic hormone-naïve prostate c... by Ikenna I. Nnabugwu, Eric N. Obikeze, Chinwe A. Nnabugwu, Solomon K. Anyimba, Okwudili C. Amu, Okezie M. Mbadiwe, Kevin S. N. Echetabu, Ijeoma L. Okoronkwo

“…The aim of this study is to define the relationship between clinician-rated ECOG-PS and the patient-reported HRQoL in men with metastatic hormone-naïve prostate cancer (mPCa). Methods An analytical cross-sectional study recruiting patients presenting with mPCa in Enugu, southeast Nigeria. …”
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Development of Rifampicin Eye Drops for the Treatment of Exudative Age-Related Macular Degeneration by Valory Anne S. Vailoces, Andrew J. Tolentino, Jose Fernando Arevalo, Ron A. Adelman, Robert Bhisitkul, Diana V. Do, Quan Dong Nguyen, Michael J. Tolentino, Masaki Tanito, Hiroaki Serizawa

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Shear bond strength to sound and caries-affected dentin of sim-plified “etch-and-rinse” and “self-etch” adhesives and the hybrid layer micromorphology by Drobac Milan, Stojanac Igor, Ramić Bojana, Premović Milica, Petrović Ljubomir

“…The purpose of study was to compare shear bond strength (SBS) of currently available adhesive systems to sound dentin (SD) and caries-affected dentin (CAD) and elucidate the hybrid layer micromorphology. Methods. Sixty extracted human molars with coronal carious lesions formed the experimental sample while additional sixty extracted intact human molars (impacted third molars) served as controls. …”
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Early peripapillary neurovascular injury and its relevant systemic factors in type 2 diabetic patients without retinopathy: An OCTA based study by Haochen Jin, Kaiyue Wang, Changhong Ren, Shan He, Yuan Gao, Xiaofang Liang, Xuxiang Zhang

“…Purpose: To determine the ability of peripapillary neurovascular units (NVU) to detect early changes in the retinal microvasculature and microstructure, and to explore systemic factors linked to the peripapillary NVU injury in type 2 diabetic patients without clinically detectable retinopathy (NDR). Methods: Fifty-two NDR patients (mean age 51.08 ± 9.60 years; 24 females; diabetes duration 8.74 ± 6.71 years) and 42 age- and sex-matched healthy controls (mean age 50.24 ± 7.97 years; 20 females) were recruited for this prospective, cross-sectional study. …”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…In this work, we first explain the great potential of CYFIP2 malignant progression from a broader perspective (pan-cancer) and confirm its oncogenic value in pancreatic cancer. Methods The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) database, CELL and GEO databases were utilized to explore the distribution of the CYFIP2 gene in human cancers. …”
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MYOCARDIAL PERFUSION AND NEUROTROPIC SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY FEATURES IN PATIENTS WITH PRIMARY PULMONARY HYPERTENSION by A. A. Ansheles, E. G. Kuznetsova, T. V. Martynyuk, V. B. Sergienko

“…To compare cardiac 123I-MIBG and 99m Tc-MIBI single-photon emission computed tomography (SPECT) data in patients with primary pulmonary hypertension (PPH).Material and methods. The study included 22 patients with confirmed diagnosis of PPH, with clinical status assessment, Holter ECG monitoring and rest cardiac ultrasound (US) data. …”
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Myofascial trigger points therapy increases neck mobility and reduces headache pain in migraine patients – pilot study by Maciej Olesiejuk, Małgorzata Chalimoniuk, Tomasz Sacewicz

“…Design A case series employing a repeated-measures design; pilot study. Methods Fifty-three adult female migraine patients were classified into three groups: episodic migraine without aura (MO, n = 31), episodic migraine with aura (MA, n = 15), and chronic migraine (CM, n = 7). …”
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Dark Adaptometry Kinetics Differentiates Age-Related Macular Degeneration from Central Serous Chorioretinopathy by Ashwin P. Verghese, BE, Claudia C. Lasalle, BA, David J. Ramsey, MD, PhD

“…Participants: Consecutive patients with a clinical diagnosis of AMD or CSCR who were ≥50 years of age. Methods: The study included patients who had completed a DA study in ≥1 eye measured at 5° superior to the fovea on the retina. …”
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Quercetin inhibits ferroptosis to alleviate intestinal ischemia-reperfusion injury by MA Xiaojie, LENG Yufang, LENG Yufang, MU Jialu

“…Objective‍　‍To investigate the role of quercetin （QUE） in ferroptosis during intestinal ischemia-reperfusion （IR） injury and elucidate its underlying mechanisms. Methods ① Potential target genes of QUE were predicted using the TCMSP， PharmMapper， and SwissTargetPredictive databases. …”
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Effect of diode laser cyclophotocoagulation in treatment of patients with refractory glaucoma by Čanadanović Vladimir, Tušek-Lješević Ljiljana, Miljković Aleksandar, Barišić Sava, Bedov Tatjana, Babić Nikola

“…Patient's symptoms, bests corrected visual acuity and IOP were recorded 7 days, and 1, 3 and 6 months after the DCPC treatment. …”
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Identification and validation of NEIL2 as a prognostic biomarker and potential therapeutic target in cervical cancer by Yan Li, Jiayuan Du, Lingjia Wei, Tianmeng Tan, Liyi Bao, Jinqiu Su, He Wang

“…Therefore, the aim of this study was to explore the potential mechanisms of NEIL2 as a novel prognostic biomarker for CC patients. Methods Firstly, the Cancer Genome Atlas (TCGA)—Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) dataset was acquired from the University of California Santa Cruz Xena database. …”
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End-stage Ankle Arthritis: Variations in the Current State of Practice of Asia-Pacific Foot and Ankle Surgeons by Chin Yik Tan, Joshua Balogun-Lynch, Gowreeson Thevendran

“…Background: This study is aimed to assess differences in the pattern of practice and choice of management of end-stage ankle arthritis among established Asia-Pacific foot and ankle surgeons. Materials and methods: A survey was presented to fellowship trained foot and ankle surgeons registered with their respective national orthopedic professional societies practicing in the Asia-Pacific region. …”
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Chronic Isolated Fracture of the Metatarsal Head in Lesser Toes Treated with Open Reduction and Internal Fixation by Wenjing Li MD, Ying Li MD

“…This study aims to report the clinical and imaging characteristics, as well as treatment results, of these fractures. Methods: A retrospective consecutive case-series study was performed on 5 patients with symptomatic chronic isolated shear fracture of a metatarsal head in the lesser toes from January 2018 to April 2021. …”
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Impact of Sagittal Spinal Balance on Functional Recovery After PLIF of L5‐S1 Isthmic Spondylolisthesis With Lumbar Spinal Stenosis by Jiaheng Lv, Quan Zhou, Wei He, Tianci Fang, Yujie Shen, Yulin Chen, Hao Liu, Huilin Yang, Yifei Zheng, Tao Liu

“…This study analyzes the influence of residual sagittal imbalanceon health‐related quality of life (HRQOL) after PLIF for L5‐S1 IS with LSS, aiming to optimize surgical correction and prognostic accuracy. Methods This study analyzed 103 consecutive patients with L5‐S1 IS and LSS undergoing PLIF from 2020 to 2022, followed at 3 days, 3 months, and ≥ 1 year postoperatively, using SPSS 26.0 for statistical analysis. …”
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Human congenital cataract mutation in MYH9 alters F-actin organization and cell functions by Hao Yuan, Zhen-Yu Wang, Jia-Rui Yang, Chen Huang, Liang Zhu, Xue-Min Li

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Evaluation of a Novel eHealth Tool for Pulmonary Rehabilitation in People With Chronic Obstructive Pulmonary Disease: Randomized Controlled Pilot and Feasibility Trial by Åsa Karlsson, Pernilla Sönnerfors, Sara Lundell, Annika Toots, Karin Wadell

“…Moreover, this study aims to evaluate clinical outcome measures to prepare for a future larger trial. MethodsA multicenter, parallel-group randomized controlled pilot and feasibility trial was conducted in 6 primary health care centers. …”
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Association between clinical and MRI‐detected imaging findings for people with midfoot pain, a cross‐sectional study by Jill Halstead, Carmen Martín‐Hervás, Elizabeth M. A. Hensor, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, John B. Arnold, Jennifer Jones, Anthony C. Redmond

“…This study aimed to describe bone, joint and soft tissue changes and to explore associations between MRI‐detected abnormalities and clinical symptoms (pain and disability) in a group of adults with midfoot pain, but who were radiographically negative for osteoarthritis. Methods Community‐based participants with midfoot pain underwent an MRI scan of one foot and scored semi‐quantitatively using the Foot OsteoArthritis MRI Score (FOAMRIS). …”
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Bahir Dar Child Development Cross-Sectional Study, Ethiopia: study protocol by Alemayehu Worku, Yemane Berhane, Lian V Folger, Anne CC Lee, Krysten North, Nebiyou Fasil, Kalkidan Yibeltal, Fred Van Dyk, Firehiwot Workneh, Theresa I Chin, Sarah K G Jensen, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Moriah E Thomason, Terrie Inder, Patricia Ellen Grant

“…This study aims to characterise the typical development of healthy children and factors that influence child development in Bahir Dar, Ethiopia.Methods and analysis The Bahir Dar Child Development Study is a cross-sectional study implemented in two health centres, Shimbit and Abaymado and in Felege Hiwot Comprehensive Specialized Hospital (FHCSH) in Bahir Dar, Amhara, Ethiopia. …”
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Retinal biomarkers for the risk of Alzheimer’s disease and frontotemporal dementia by Ruihan Wang, Jiajie Cai, Yuzhu Gao, Yingying Tang, Hui Gao, Linyuan Qin, Hanlin Cai, Feng Yang, Yimeng Ren, Caimei Luo, Shiyu Feng, Hongbo Yin, Ming Zhang, Chunyan Luo, Qiyong Gong, Xiong Xiao, Qin Chen

“…Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.MethodsWe included a total of 3,0573 UK Biobank participants without dementia, ocular disorders, and diabetes who underwent baseline retinal optical coherence tomography (OCT) imaging. …”
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Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families by Yang Cao, Xiaolong Zhang, Lan Lan, Danyang Li, Jin Li, Linyi Xie, Fen Xiong, Lan Yu, Xiaonan Wu, Hongyang Wang, Qiuju Wang

“…This study focuses on two mitochondrial function-related genes which result in non-isolated AN, FDXR and TWNK, providing a summary and enrichment analysis of genes associated with non-isolated AN to elucidate the genotype-phenotype correlation and underlying mechanisms. Methods Seven independent Chinese Han patients with mutations in FDXR and TWNK underwent comprehensive clinical evaluations, genetic testing, and bioinformatics analyses. …”
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