Silk Biowaste Protein Mediated Silver Nanoparticles Synthesis and Analysis of Anti-Inflammatory, Wound Healing, Antidiabetic, Antioxidant, Tyrosinase Inhibition, and Antibacterial... by Das G, Shin HS, Yang IJ, Nguyen LTH, Patra JK

“…Gitishree Das,1,2 Han-Seung Shin,2 In-Jun Yang,3 Ly Thi Huong Nguyen,3,4 Jayanta Kumar Patra1,2 1Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea; 2Department of Food Science & Biotechnology, College of Life Science and Biotechnology, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea; 3Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju, 38066, Republic of Korea; 4Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USACorrespondence: Jayanta Kumar Patra, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea, Email jkpatra@dongguk.eduBackground: Silk, a natural biowaste protein from silkworm cocoons called sericin, has promising properties as a biomaterial for several biomedical applications, owing to its excellent biocompatibility, biodegradability, hydrophilicity, and reactivity.Purpose: The synthesis of AgNPs using these biowaste protein materials is more efficient, environmentally friendly, and cost-effective.Methods: In this study, a novel approach was developed to synthesize silver nanoparticles (Scn-AgNPs) using sericin as a reducing agent and to study their anti-inflammatory, wound healing, antidiabetic, antioxidant, tyrosinase inhibitory, and antibacterial mechanisms of action.Results: The initial production of Scn-AgNPs was established by a visual color change to brown, followed by UV-visible spectroscopy, which showed a solid absorption band at 422 nm due to surface plasmon resonance. …”
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Effectiveness of Group and Individual Counselling Interventions on COVID-19 Vaccination Intention Among Industrial Employees in Romania by Dumitra GG, Camen AR, Nechita F, Pîrlog MC, Kamal C, Dogaru CA, Radu M, Gheorghe EC, Dumitrescu EM, Dinescu VC, Surugiu R, Oancea CN, Turcu-Stiolica A

“…This study aims to measure the level of vaccine hesitancy, identifying the factors contributing to it, and to evaluate the effectiveness of two targeted interventions—group and individual counseling—designed to address vaccine hesitancy among employees in seven industrial companies in Romania during the Coronavirus disease 2019 (COVID-19) pandemics.Methods: A total of 256 participants were included in the study, and interventions were delivered by family physicians and occupational medicine specialists trained in motivational interviewing (MI) techniques. …”
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Survival Prediction of Esophageal Cancer Using 3D CT Imaging: A Context-Aware Approach With Non-Local Feature Aggregation and Graph-Based Spatial Interaction by Fuce Guo, Chen Huang, Shengmei Lin, Yongmei Dai, Qianshun Chen, Shu Zhang, Xunyu XU

“…In the current study, we aimed to develop an effective EC survival risk prediction using only 3D computed tomography (CT) images.The proposed model consists of two essential components: 1) non-local feature aggregation module(NFAM) that integrates visual features from tumor and lymph nodes at both local and global scales, 2) graph-based spatial interaction module(GSIM) that explores the latent contextual interactions between tumors and lymph nodes.The experimental results demonstrate that our model achieves superior performance compared to state-of-the-art survival prediction methods, emphasizing its robust predictive capability. …”
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Vertebral Column Decancellation for Correcting Cervicothoracic Kyphotic Deformity in Patients With Ankylosing Spondylitis by Han Yu, Qi Wang, Yiming Fan, Dengbin Qi, Tianhao Wang, Bing Li, Yi Huang, Ze Wang, Chao Xue, Guoquan Zheng

“…The purpose of the present study was to retrospectively analyze and evaluate the effect of VCD on cervicothoracic kyphotic deformity in patients with AS. Methods Records of eight patients with cervicothoracic kyphotic deformity who underwent VCD at C7 in our institution were retrospectively reviewed. …”
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The clinical efficacy of auricular acupuncture in the treatment of frequent episodic tension-type headache: a single-blind randomized controlled trial by Xiaxia Jin, Ziwen Xu, Tao Gao, Gaofeng Wang, Wendi Dong, Junyi Jin, Yongmei Yan

“…Purpose This study aimed to compare the efficacy and safety of auricular acupuncture and sham acupuncture in treating FETTH. Methods This was a randomized controlled trial. Participants with FETTH were randomly assigned in a 1:1 ratio to receive auricular acupuncture or sham acupuncture for 4 weeks, with follow-up lasting for up to 24 weeks. …”
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Clinical and biochemical characteristics of patients with acromegaly and normal or increased prolactin levels by Yuliya A. Kukushkina, Irena A. Ilovayskaya

“…Aim: To identify hallmarks of clinical and biochemical parameters in patients with acromegaly and normal or increased prolactin level. Methods: We performed a single center, single sample retrospective, observational cohort uncontrolled non-interventional study in 306 patients (70 men and 236 women) with acromegaly examined from July 2021 to June 2024, 50 of them with a pituitary microadenomas and 256 with macroadenomas. …”
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Influence of Irrigant Activation Techniques on External Root Temperature Rise and Irrigation Penetration Depth in 3D-Printed Tooth Model: An In Vitro Study by Ali Addokhi, Ahmed Rahoma, Neveen M. A. Hanna, Faisal Alonaizan, Faraz Farooqi, Shimaa Rifaat

“…Thus, this study aimed to investigate the temperature rise during different irrigation activation techniques at various time intervals and evaluate the efficacy of these techniques in removing biofilm-mimicking hydrogel BMH of a simulated root canal system in 3D-printed tooth models. <b>Methods:</b> Ten extracted human mandibular premolars, prepared to size 40/0.04 taper, and a hundred 3D-printed resin premolars with simulated main (0.25 mm) and lateral canals (0.15 mm at 3, 7, 11 mm from apex) were used; 50 of them were filled with biofilm-mimicking hydrogel (BMH). …”
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Induction heating combined with antibiotics or SAAP-148 effectively reduces biofilm-embedded Staphylococcus aureus on a fracture-related implant mimic by Marielle Verheul, Anne A. Wagenmakers, Rob G. H. H. Nelissen, Peter H. Nibbering, Bart G. Pijls

“…In addition, we assessed the ability of antibiotics, the antimicrobial peptide SAAP-148, and bacteriophage (phage) ISP to enhance the efficacy of NCIH, thereby allowing the use of lower temperatures during NCIH. Methods: Clinical isolates of methicillin-resistant and methicillin-sensitive S. aureus (methicillin-resistant S. aureus (MRSA), methicillin-sensitive S. aureus (MSSA)) were cultured for seven days on Ti-6Al-7Nb (mimicking fracture plates) discs to obtain mature biofilms. …”
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Evaluating the MPM III and SAPS III prognostic models in a war-affected, resource-limited setting: a prospective study from the Gaza Strip by Belal Aldabbour, Ahmed J. H. Elhissi, Hamza Abudaqqa, Jaser Alqrinawi, Mohammed Badran, Mohammed Sulaiman, Yousef Alsoos, Yousef Altartour, Mohammed Abulebda, Mohammed Muhaisen, Omar Alsafadi, Zuhair Assaf

“…The intense conflict in the Gaza Strip presents an opportunity to evaluate the performance of local ICUs and validate the performance of the MPM and SAPS models within a resource-limited and highly stressed healthcare system. Methods A prospective study conducted from October to December 2024 included all patients admitted to ICUs in three of the four critical care units operating in the Gaza Strip. …”
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Oral health status, oral hygiene behaviors, and caries risk assessment of individuals with special needs: a comparative study of Pakistan and Saudi Arabia by Osama Khattak, Farooq Ahmad Chaudhary, Shahzad Ahmad, Muhammad Amber Fareed, Shazia Iqbal, Asma Shakoor, Mohammed Nadeem Baig, Haifa Ali Almutairi, Rakhi Issrani, Azhar Iqbal

“…This study aims to: (1) assess the oral health status of disabled individuals in Pakistan and Saudi Arabia, (2) evaluate their oral hygiene knowledge and behaviors, and (3) determine their caries risk using the Caries Management by Risk Assessment (CAMBRA) protocol. Methods A cross-sectional study was conducted on 189 participants aged 13 years and older, including both young people and adults with hearing, visual, or intellectual disabilities from Pakistan and Saudi Arabia between September 2023 and April 2024. …”
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Prognostic analysis of sepsis-induced myocardial injury patients using propensity score matching and doubly robust analysis with machine learning-based risk prediction model develo... by Pan Guo, Pan Guo, Li Xue, Fang Tao, Kuan Yang, YuXia Gao, Chongzhe Pei

“…This study aimed to evaluate the prognostic impact of SIMI and develop validated predictive models using advanced machine learning (ML) algorithms for identifying SIMI in critically ill sepsis patients.MethodsData were sourced from the Medical Information Mart for Intensive Care IV (MIMIC-IV, v3.0) database. …”
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Susceptibility-weighted MR imaging (SWI) of basal ganglia iron deposition in the early and advanced stages of Parkinson's disease by A. G. Trufanov, A. A. Yurin, A. B. Buriak, S. A. Sandalov, M. M. Odinak, I. V. Litvinenko

“…The accumulation of iron is visualized as an area of reduced signal intensity on SWI, and its estimation in accordance with the SPIN program has accordingly a smaller value. …”
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Effectiveness of AI-Driven Conversational Agents in Improving Mental Health Among Young People: Systematic Review and Meta-Analysis by Yi Feng, Yaming Hang, Wenzhi Wu, Xiaohang Song, Xiyao Xiao, Fangbai Dong, Zhihong Qiao

“…ObjectiveThis study aims to examine the effectiveness of AI-driven CAs for mental health among young people, and explore the potential moderators of efficacy. MethodsA total of 5 main databases (PubMed, PsycINFO, Embase, Cochrane Library, and Web of Science) were searched systematically dated from the establishment of the database to August 6, 2024. …”
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Development of a Serious Game to Simulate Neonatal Intensive Care Unit Experiences: Collaborative Quasi-Experimental Study by Yukihide Miyosawa, Koichi Hirabayashi, Kodai Yamada, Fumiya Kobayashi, Nanami Ogihara, Noa Takeda, Eri Okamura, Shogo Matsumura

“…Structured as a 6-chapter visual novel, the game follows a high school student observing the NICU during a hospital internship. …”
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Enhanced Teleoperation of Robotic Arms Through Master-Slave Configuration With Multithreading by Ahmad Faiz Fawzan Ahmad Zainudin, Mohd Hairi Mohd Zaman, Mohd Faisal Ibrahim, Mohd Asyraf Zulkifley, M. Marzuki Mustafa

“…Low-pass filtering techniques were applied to suppress signal noise and improve trajectory smoothness, while multithreading methods were used to separate sensor polling and data transmission processes. …”
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Reliability and Validity Study of the <italic>International Classification of Functioning</italic>，<italic>Disability and Health Rehabilitation Set</italic> in Rehabilitation of Kn... by LEI Lei, PENG Zhizhou, GAO Mingyue, LI Fei, MAO Ningning, WU Xi, XIAO Chengcheng, XUN Yajing, ZHAO Suchen, FAN Xiaojun

“…ObjectiveTo explore the reliability and validity of the <italic>International Classification of Functioning, Disability and Health Rehabilitation Set</italic> (ICF-RS) in assessing the body function, activities and social participation of patients with knee osteoarthritis (KOA).MethodsA total of 60 KOA patients in the Outpatient Department of Orthopedic Rehabilitation in the Fifth Hospital of Xiamen and the Xiangyang Central Hospital from October to December 2022 were recruited. …”
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A 360° Approach to Personalize Lifestyle Treatment in Primary Care for People With Type 2 Diabetes: Feasibility Study by Zeena Harakeh, Iris de Hoogh, Anne-Margreeth Krijger-Dijkema, Susanne Berbée, Gino Kalkman, Pepijn van Empelen, Wilma Otten

“…ObjectiveThis work examines the acceptability, implementation, and potential effects of the 360° diagnostic tool and subsequent tailored treatment (360° approach) in a 6-month intervention and feasibility study conducted in standard primary health care settings in the Netherlands. MethodsA single-group design with baseline, 3-month, and 6-month follow-ups was used. …”
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CLEC3B as a Prognostic and Immunological Biomarker in Pan-Cancer: Multi-Omics Profiling and Validation in Pancreatic Cancer and Exosomes by Nan K, Zhang L, Peng Y, Huang J, Yin S, Zou Y, He K, Zhang M

“…In this study, we explored the potential roles of CLEC3B as a tumor suppressor and in immune function across multiple cancer types.Methods: We visualized outcomes derived from Gene Expression Omnibus (GEO) and diverse online databases. …”
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T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing by Xiong Y, Zhang Z, Liu S, Shen L, Zheng L, Ding L, Liu L, Wu L, Hu Z, Li L, Hu Z, Zhang Z, Zhou L, Xu M, Yao Y

“…Herein, we fabricated an innovative immune cell membrane-coated zeolitic imidazolate framework-8 (ZIF-8) nano-delivery platform and explored its effects on myocarditis.Methods: ZIF-8 nanoparticles loaded with siRNA targeting IRF1 (siIRF1) were coated with a T lymphocyte-macrophage hybrid membrane (siIRF1@ZIF@HM NPs) via sonication and extrusion. …”
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The clinical efficacy of hybrid surgery based on the Waveflex semi-rigid dynamic internal fixation system for the treatment of lumbar degenerative diseases: over three-year follow-... by Zhiwu Zhang, Jiashen Shao, Nan Su, Xiang Li, Qi Fei, Yong Yang, Hai Meng

“…Abstract Objective To investigate the efficacy and safety of hybrid surgery based on the Waveflex internal fixation system for the treatment of lumbar degenerative disease. Methods A retrospective analysis was conducted on 31 consecutive patients who underwent hybrid surgery (fusion combined with non-fusion surgery) using the Waveflex internal fixation system for lumbar degenerative diseases between December 2019 and May 2021. …”
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