Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy by QU Na，ZHAO Xiaohong，NI Qiang

“…Objective To compare the effects of oxycodone and fentanyl on postoperative pain relief，immune balance of T-helper cells（Th），and adverse reactions in radical mastectomy. Methods A total of 120 female patients whounderwent elective radical mastectomy at Shanghai Public Health Clinical Center between December 2021 and January2024 were selected for this study. …”
Get full text

Effects of PRP injection combined with intersecting femoral head decompression versus combined with multiple core decompression in the treatment of avascular necrosis of femoral he... by Lei Sun, Ziyao Xu, Zhongyuan Zhang, Jinwei Zhao, Mengshuai Sun, Guangling Gao, Fang Gao, Hongjiang Jiang, Changjun Ju

“…The objective of this study is to evaluate the effect of PRP injection combined with intersecting femoral head decompression versus combined with multiple core decompression (MCD) in the treatment of ANFH. Methods A retrospective cohort analysis comparing two surgical interventions was conducted between January 2020 and December 2020. …”
Get full text

Qualitative and quantitative ultrasound parameters of carotid atherosclerotic plaques in patients with moderate cardiovascular risk according to the SCORE scale: 7-year prospective... by O. A. Pogorelova, M. I. Tripoten, I. S. Melnikov, L. Sh. Khamchieva, B. M. Tamaeva, S. G. Kozlov, T. V. Balakhonova

“…To assess asymptomatic carotid atherosclerosis in patients with moderate cardiovascular risk over a 7-year prospective follow-up using non-invasive ultrasound markers.Material and methods. Eighty patients (47 men and 33 women) aged 53,1±5,9 years with moderate Systematic Coronary Risk Evaluation (SCORE) level, low-density lipoprotein cholesterol (LDL-C) of 2,7-4,8 mmol/l and asymptomatic hemodynamically insignificant (stenosis <50%) carotid atherosclerosis (CA). …”
Get full text

Comparison of Milligan-Morgan Haemorrhoidectomy versus Laser Haemorrhoidoplasty in Patients with Grade II and III Haemorrhoids: A Prospective Observational Study by Asfar Ahamed Nawabjan, Sathish Rajkumar, Chudar Arumugam, Mohamed Marzook, Jasmine Sharmila, Lalith Kumar

“…Aim: To compare the clinical outcomes of Milligan-Morgan haemorrhoidectomy and laser haemorrhoidoplasty in patients with grade II and III haemorrhoids, focusing on postoperative pain, hospital stay, complications, and recovery time. Materials and Methods: A prospective observational study was conducted in the Department of General Surgery at Sri Lalithambigai Medical College and Hospital, Chennai, Tamil Nadu, India, from January 2022 to June 2023 (including three months of follow-up). …”
Get full text

Anatomical hemorrhoidectomy and semi-shutting suture combined with mucosal ligation for mixed hemorrhoids by Yuan Ke, Lei Yinfu, Chen Lina, Yu Lelai, Liu Huan, Shen Qingbo, Huang Qi, Pei Xi

“…[Objectives] To investigate the effect of anatomical hemorrhoidectomy and semi-shutting suture combined with mucosal ligation for mixed hemorrhoids. [Methods] Eighty patients with mixed hemorrhoids treated at our hospital between May 2019 and May 2020 were recruited and randomly assigned to the treatment and control group using the random number table. …”
Get full text

Safety and efficacy of robot-assisted percutaneous kyphoplasty under local anesthesia in a day-surgery setting for osteoporotic vertebral compression fractures by Yaming Wu, Yang Yuan, Yi Yin, Yaqin Gong, Yaowei Ye, Li Wu, Lizhen Qian

“…This retrospective study evaluates the safety and efficacy of robot-assisted percutaneous kyphoplasty (PKP) performed under local anesthesia within a day-surgery framework.MethodsClinical data from 127 patients with OVCFs who underwent robot-assisted PKP under local anesthesia in a day-surgery setting at the First People's Hospital of Kunshan between May 2022 and April 2024 were retrospectively analyzed. …”
Get full text

Knowledge of telemedicine and its associated factors among health professional in Ethiopia: A systematic review and meta-analysis. by Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Agmasie Damtew Walle, Addisalem Workie Demsash, Geleta Nenko Dube, Abiy Tasew Dubale, Sisay Yitayh Kassie, Gemeda Wakgari Kitil, Mesafint Zewold Jember, Chernet Desalegn Gebeyehu, Aster Temesgen Ariger, Eshetie Andargie Dires

“…This review evaluates Ethiopian-specific telemedicine knowledge and associated factors.<h4>Methods</h4>This systematic review was conducted using a search of several online databases in addition to the main databases, like Medline, PubMed, Scopus, and Science Direct. …”
Get full text

Noninferiority of 0.25% versus 0.375% Ropivacaine in Popliteal Sciatic and Saphenous Nerve Blocks for Analgesia After Foot and Ankle Surgery: A Randomized Self-Paired Noninferiorit... by Wu L, Xi C, Lei G, Li H, Yin Y, Wan M, Wu H, Wang Y, Hu C, Wang G

“…Hence, we hypothesized that the analgesic effect of 0.25% ropivacaine would be noninferior to that of 0.375% ropivacaine at the same volume and would reduce the degree of weakness.Patients and Methods: In this randomized, double-blind, self-paired, noninferiority trial, 31 patients who were scheduled for similar, elective, bilateral foot and ankle surgeries under general anesthesia combined with popliteal sciatic and saphenous nerve blocks were enrolled. …”
Get full text

Cognitive Disorders In Acquired Sensorineural Hearing Loss, At The Ent Department Of The &ldquo;Village Bondeko&rdquo; Center, In Kinshasa by Masamba GR, Sokolo Gedikondele J, Longo-Mbenza B, Nganga Nkanga MS, Matanda Nzanza R, Matonda-ma-Nzuzi T, Ikanga J, Nge Okwe A, Lema Mabwaka G, Mawalala Malengele H, Nangi Mampuya C, Lumbu Malundama D

“…Thus, the objective of the present study was to investigate the relationship between sensorineural hearing loss and cognitive disorders in a correlational approach.Methods: This is a cross-sectional and analytical study conducted in the ENT department of the Center for the Disabled (visual, auditory, and mental) “Village Bondeko”, from June to September 2023, involving 150 adults (≥ 20 years) with acquired sensorineural hearing loss; without a history of neuropsychic disorders. …”
Get full text

Assessment of publication time in Campbell Systematic Reviews: A cross‐sectional survey by Bei Pan, Long Ge, Xiaoman Wang, Ning Ma, Zhipeng Wei, Lai Honghao, Liangying Hou, Kehu Yang

“…There was no significant difference between Campbell coordinating groups' median publication times and time gap from searches of databases to full review publication existed. However, the methods group only published one full review with almost a 3‐year time gap from searches of databases to review publication. …”
Get full text

Analysis of clinical knowledge, absenteeism and availability of resources for maternal and child health: a cross-sectional quality of care study in 10 African countries by Laura Di Giorgio, David K Evans, Magnus Lindelow, Son Nam Nguyen, Jakob Svensson, Waly Wane, Anna Welander Tärneberg

“…Objective Assess the quality of healthcare across African countries based on health providers’ clinical knowledge, their clinic attendance and drug availability, with a focus on seven conditions accounting for a large share of child and maternal mortality in sub-Saharan Africa: malaria, tuberculosis, diarrhoea, pneumonia, diabetes, neonatal asphyxia and postpartum haemorrhage.Methods With nationally representative, cross-sectional data from ten countries in sub-Saharan Africa, collected using clinical vignettes (to assess provider knowledge), unannounced visits (to assess provider absenteeism) and visual inspections of facilities (to assess availability of drugs and equipment), we assess whether health providers are available and have sufficient knowledge and means to diagnose and treat patients suffering from common conditions amenable to primary healthcare. …”
Get full text

Effectiveness of telerehabilitation in non-operatively managed shoulder conditions: a systematic review and meta-analysis by Ting-wan Lin, Yang Yang, Hai-yan Hong, Xiao-bo Zhou, Tao-Hsin Tung, Bin-bin Zheng, Jian-min Zhang

“…However, its overall efficacy remains uncertain due to inconsistent findings in prior studies. Methods This systematic review and meta-analysis assessed the effectiveness of telerehabilitation for non-operatively managed shoulder conditions, concentrating on randomized controlled trials (RCTs). …”
Get full text

Resting-state functional magnetic resonance imaging findings in patients with acoustic neuroma and tinnitus by ZHAN Xiaolin, REN Yi, LI Yongpeng, HUANG Qiao, YIN Shihua

“…Objective To investigate the neural network mechanism of tinnitus in patients with acoustic neuroma by observing the imaging findings of resting-state functional magnetic resonance imaging (rs-fMRI). Methods A total of 18 patients with acoustic neuroma who were hospitalized in the Department of Otolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Guangxi Medical University from November 2022 to December 2023 for concurrent surgical treatment were divided into a tinnitus group (group A) and a non-tinnitus group (group B) based on the presence or absence of tinnitus. …”
Get full text

U-shaped association between serum chloride and hypertension risk with nadir around 103 mmol/L: insights from regression and interpretable machine learning (XGBoost/SHAP) using NHA... by Shancheng He, Xuemei Zhong, Guangming Chen, Long Li

“…This research attempted to explicate the link between serum levels of chloride and the risk of hypertension occurrence, as well as to identify the threshold level at which the risk undergoes changes across the general population and various demographic segments.MethodsEmploying materials from the to 2017–2018 National Health and Nutrition Examination Survey (NHANES; n = 4,591), we employed multivariate regression analysis to gauge the connection between adult serum chloride concentrations and the risk of hypertension occurring. …”
Get full text

Investigation of the antioxidant status and the number of double-stranded DNA breaks in models of brain tumor lesion by metastases of non-small cell lung cancer in vivo by E. V. Zaikina, I. A. Alliluev, Yu. N. Lazutin, Yu. V. Przhedetskiy, Yu. S. Shatova, M. A. Engibaryan, E. F. Komarova, D. A. Kharagezov, A. V. Galina, A. A. Kiblitskaya, M. V. Mindar, L. Z. Kurbanova

“…Evaluation of the antioxidant status and DNA damage in tissues of subcutaneous xenografts of non-small cell lung cancer and in peritumoral tissues created using the A549 and H1299 cell cultures.Materials and methods. The study included 35 intact male Balb/c Nude immunodeficient mice. …”
Get full text

Relationship between latent left ventricular contractile dysfunction and signs of immune inflammation in patients with COVID-19 pneumonia by N. E. Shirokov, E. I. Yaroslavskaya, D. V. Krinochkin, N. A. Musikhina, T. I. Petelina, N. A. Osokina

“…To investigate the relationship between echocardiographic parameters and laboratory immune inflammation signs in patients after coronavirus disease 2019 (COVID-19) pneumonia depending on the left ventricular (LV) involvement according to speckle tracking echocardiography (STE).Material and methods. The study included 216 patients (men, 51,1%, mean age, 50,1±11,1 years). …”
Get full text

Psychometric validation of the Chronic Ocular Pain Questionnaire (COP-Q) by Amy Findley, Brigitte J. Sloesen, Nicola Hodson, Agkreta Leventi, Ben Pascoe, Rob Arbuckle, Paul O’Brien, Christel Naujoks, Michela Montecchi-Palmer, Diana Plaza, Paul M. Karpecki, Pedram Hamrah

“…This study assessed the psychometric properties of the COP-Q to determine the adequacy of the COP-Q as a ‘fit-for-purpose’ instrument to derive trial endpoints for future clinical studies in COSP. Methods Patients with COSP completed the COP-Q daily for four weeks on an electronic, touch-screen, tablet device as part of a longitudinal, observational study in the United States (N = 124). …”
Get full text

A High-Throughput, Three-Dimensional Multiple Myeloma Model Recapitulating Tumor-Stroma Interactions for CAR-Immune Cell-Mediated Cytotoxicity Assay by Luanpitpong S, Janan M, Poohadsuan J, Rodboon N, Samart P, Rungarunlert S, Issaragrisil S

“…Components in BM niche contribute to the immunosuppressive tumor microenvironment (TME), but three-dimensional (3D) MM models that recreate the complex TME and enable high-throughput cytotoxicity assay of chimeric antigen receptor (CAR)-engineered immune cells are still lacking.Methods: Stable, luciferase (Luc)-labeled target MM cells were generated using Luc/RFP dual reporter system to track MM growth. 3D spheroids were formed in a 96-well plate in the presence or absence of cancer-associated fibroblast (CAF)-like stromal cells activated by MM-derived conditioned medium and the cytotoxicity of CAR-immune cells, which were represented by third-generation anti-CD138 CAR-NK-92 cells, was evaluated by luciferase assay using a multimode microplate reader. …”
Get full text

Isolated Transpupillary Photodynamic Therapy in Local Treatment of Choroidal Melanoma by I. E. Panova, E. V. Boiko, E. V. Samkovich, V. G. Gvazav

“…Objective: To evaluate the long-term results of local application of transpupillary photodynamic therapy (PDT) with chlorine photosensitizer in isolated organ-preserving treatment of uveal melanoma (UM) and to determine predictors of its effectiveness.Patients and methods. Retrospective analysis of transpupillary PDT efficacy in 38 patients (38 eyes) diagnosed with choroidal melanoma (CM) treated between 2016 and 2024. …”
Get full text

Changes in the Relationship Between Gray Matter, Functional Parameters, and Quality of Life in Patients with a Post-Stroke Spastic Upper Limb After Single-Event Multilevel Surgery:... by Patricia Hurtado-Olmo, Pedro Hernández-Cortés, Ángela González-Santos, Lourdes Zuñiga-Gómez, Laura Del Olmo-Iruela, Andrés Catena

“…<b>Objective</b>: To compare structural MRI-evaluated gray matter volume changes in patients with post-stroke upper limb spasticity for >1 year between those undergoing surgery and those treated with botulinum toxin A (BoNT-A) and to relate these findings to upper limb function and quality of life outcomes. <b>Materials and Methods</b>: <i>Design.</i> A two-arm controlled and randomized clinical trial in patients with post-stroke upper limb spasticity. …”
Get full text