Efficacy and prognostic factors of anti-VEGF treatment for neovascular age-related macular degeneration: An OCTA imaging-based deep learning analysis by Shengnan Liu, Yuanyuan Liu, Xiaohan Wu, Haochen Wang, Ziqi Jin, Peiru Wang, Jinyu Feng, Song Chen, Wei Zhou

“…Background: Anti-VEGF therapies improve visual acuity and reduce central macular thickness (CMT) in neovascular age-related macular degeneration(nAMD) patients. …”
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EFFICACY OF A FIXED COMBINATION OF LOSARTAN AND AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION: SEASONAL FEATURES by M. D. Smirnova, T. V. Fofanova, Z. N. Blankova, M. V. Vitsenya, T. V. Tsybulskaya, Yu. F. Dianova, F. T. Ageev

“…The goal is to evaluate the efficacy and security of treatment of patients with arterial hypertension (AH) during the heat wave of a fixed combination of ARBS+ACC (losartan+amlodipine).Materials and methods. Included 26 patients with hypertension 1 and 2 degrees from 42 to 81 years. …”
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Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma by Lin Fu, Jiang-Tao Lou, Yue Guo, Pei-Juan Wang, Rong-Rong Le, Shu-Xia Xu, Guo-Xing Li, Yuan-Bo Liang

“…AIM: To report the one-year surgical outcome Kahook Dual Blade goniotomy combined with phacoemulsification (KDB-Phaco) in Chinese patients with primary open angle glaucoma (POAG). METHODS: This is a retrospective study included 43 eyes of 28 Chinese POAG patients with cataract who accepted KDB-Phaco and followed-up for 12mo. …”
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Efficacy of manipulation under anesthesia with ultrasound-guided platelet-rich plasma injection in shoulder stiffness concomitant with rotator cuff injury by Shiyi Yao, PhD, Gen Li, PhD, Qiulun Zhou, MPH, Renhao Yang, PhD, Renxuan Li, MSc, Yang Xu, MSc, Yin Zhang, PhD, MD, Lei Wang, PhD, MD

“…Little has been reported on the efficacy of MUA with ultrasound-guided platelet-rich plasma injection for shoulder stiffness concomitant with RCI. Methods: Beginning from August 2023, 30 patients with shoulder stiffness accompanied by RCI were enrolled in the study. …”
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The clinical features and perfusion density in paracentral acute middle maculopathy by optical coherence tomography angiography study by Zhengfeng Liu, Xuemei Pan, Dan Wang, Yingying Zou, Peipei Liu, Ying Wang, Hongsheng Bi, Xiaofeng Xie

“…Purpose: To observe the clinical features of the paracentral acute middle maculopathy (PAMM) and to investigate the changes in perfusion density of superficial capillary plexus (SCP) and deep capillary plexus (DCP) in PAMM by optical coherence tomography angiography (OCTA). Methods: Twelve patients (12 eyes) diagnosed with PAMM and 13 healthy participants (13 eyes) were enrolled. …”
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The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses by Dustyn Barnette, Amy L. Inselman, Pravin Kaldhone, Grace S. Lee, Kelly Davis, Sumit Sarkar, Pritpal Malhi, J. Edward Fisher, Joseph P. Hanig, Richard D. Beger, E. Ellen Jones

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a dynamic approach capable of generating 2D ion images to visualize the distribution of an analyte of interest across a tissue section.MethodsGiven the importance of lipid metabolism and neurotransmitters in the developing central nervous system, this study incorporates MALDI MSI to assess lipid distributions across mouse gestational day (GD) 18 fetuses, with and without observable NTDs following maternal exposure on GD 8 to morphine (400 mg/kg BW) or the NTD positive control valproic acid (VPA) (500 mg/kg BW).ResultsAnalysis of whole-body mouse fetuses revealed differential lipid distributions localized mainly in the brain and spinal cord, which included several phosphatidylcholine (PC) species such as PCs 34:1, 34:0, and 36:2 localized to the cortex or hippocampus and lyso PC 16:0 across all brain regions. …”
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Efficacy and safety of ozone injection into the intervertebral foramen for treating patients with chronic, intractable postherpetic neuralgia: a one-year follow-up study by Jiang-Lin Wang, Jiang-Lin Wang, Hai-Li Li, Xiang-Bo Liu, Jia-Gui Zhao, Dong Huang, Cheng Wu, Jia-Shuang Wang, Jia-Shuang Wang, Jun Chen, Jun Chen

“…Here, we reported the efficacy and safety of a standardized therapeutic approach with CT-guided intervertebral foramen injection of ozone (IVFO) in patients with chronic intractable thoracic and lumbar (PHN) (n = 56) who had been tolerant or insensitive to first-line drugs, such as gabapentin (GBP) or pregabalin.MethodsVisual analogue scale (VAS), quantitative sensory testing (von Frey filaments only), and infrared thermography were used to identify and quantify the pain intensity, area of mechanical hyperalgesia, and skin temperature in the included patients with PHN before and after IVFO treatment. …”
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The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation: protocol for a randomised controlled trial at a quaterna... by Ryan Paul, Atefeh Noori, Christian Veillette, Darius Luke Lameire, Aazad Abbas, Jonathan Persitz, Heather Baltzer, Emily Collett, Andrea Chan

“…This study aims to evaluate the effect of topical TXA administration during isolated distal radius ORIF on early postoperative pain.Methods and analysis The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation (TRADR) study is a randomised controlled double-blinded trial that will enrol 90 patients, 18 years of age or older, undergoing volar open reduction internal fixation. …”
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Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice by Yulia Dwi Setia, Yulia Dwi Setia, Mio Kokubo-Tanaka, Ryusei Tanaka, Akemi Yoshida, Eiji Nagayasu, Parnian Ahmadi, Parnian Ahmadi, Parnian Ahmadi, Ayako Yoshida, Ayako Yoshida, Haruhiko Maruyama

“…In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cell down-regulation in the early phase of infection.MethodsMale C57BL/6 mice were orally infected with 300 oocysts. …”
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Real-time augmented feedback for gait training: are gait responses affected by the choice of target parameter? by Mathilde Legrand, Mathilde Legrand, Mathilde Legrand, Florette Grenet, Olivia Hochstrasser, Olivia Hochstrasser, Andreas Luft, Andreas Luft, Roger Gassert, Roger Gassert, Roger Gassert, Olivier Lambercy, Olivier Lambercy, Chris Easthope Awai

“…BackgroundAugmented visual feedback (AVF) is a promising approach for gait rehabilitation after stroke. …”
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Novel minimally invasive carpal tunnel release using a specialized surgical kit: a prospective multi-center case series by Hsuan-Fu Chen, Shun-Min Chang, Chih-Ming Kao, Yu-Lin Chen, Li-Ting Kao, Ya-Chuan Hsu, Yin-Chih Fu, Yan-Hsiung Wang, Wen-Chih Liu, Tien-Ching Lee

“…This study evaluates a novel minimally invasive surgical technique using a specialized instrument for carpal tunnel release. Methods In this prospective multi-center case series, 41 patients underwent minimally invasive carpal tunnel release using a novel surgical kit. …”
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Global trends in the use of artificial intelligence for urological tumor histopathology: A 20-year bibliometric analysis by Fazhong Dai, Yifeng He, Juan Duan, Kangjian Lin, Qian Lv, Zhongxiang Zhao, Yesong Zou, Jianhong Jiang, Zongtai Zheng, Xiaofu Qiu

“…This study conducted a 20-year bibliometric analysis to map global research trends and innovations in AI-driven urological pathology. Methods For this bibliometric analysis, literature from 2004 to 2024 was retrieved from the Web of Science Core Collection. …”
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Key Decision‐Making in Post‐Failed Internal Fixation of Intertrochanteric Fractures Hip Arthroplasty: A Multicenter Retrospective Study on Fracture Healing's Impact on Femoral Comp... by Jiexin Huang, Jiagu Huang, Haiqi Ding, Jianhua Lyu, Changyu Huang, Yang Chen, Qijin Wang, Hongyan Li, Baijian Wu, Ying Huang, Minghui Yang, Xinyu Fang, Wenming Zhang

“…This study aimed to explore how the healing status of fractures after FIF‐ITF failure affects the choice of femoral stem and clinical outcomes. Methods Our retrospective cohort study reviewed 105 cases of patients with FIF‐ITF who underwent hip arthroplasty at three tertiary Grade A hospitals between December 2012 and December 2022. …”
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18F-NaF PET/CT in Presumed Aseptic Pseudarthrosis after Spinal Fusion: Correlation with Findings at Revision Surgery and Intraoperative Cultures by Yacine El Yaagoubi, Jean-Edouard Loret, Eric Lioret, Clément Thomas, Adrien Simonneau, Laurent Vinikoff, Caroline Prunier-Aesch, Alain Chetanneau, Laurent Philippe, Maja Ogielska, Louis Bernard

“…Because alterations of bone metabolism may precede structural anatomical changes on computed tomography (CT), we aimed to investigate the ability of fluorine 18 sodium fluoride positron emission tomography/computed tomography (18F-NaF PET/CT) to identify pseudarthrosis after spinal fusion using surgical revision as the reference standard. Methods We retrospectively reviewed 18F-NaF PET/CT scans performed between February 2019 and September 2020 in patients experiencing pain after spinal fusion. …”
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The Golden Year? Early Intervention Yields Superior Outcomes in Chronic Pelvic Pain with Pudendal Neuralgia: A Comparative Analysis of Early vs. Delayed Treatment by Alexandru Ciudin, Albert Carrion, Rosa Regue, Alfredo Rodriguez, Eduardo Garcia-Cruz, Diana Finkelstein, Claudia Mercader, Cristian Toma, Razvan Popescu, Cristian Persu, Sergi Colom, Narcis Camps, Ramon Serrate, María José Ribal

“…Pudendal nerve infiltration is a recognized treatment, but the optimal timing of intervention remains unclear. Methods: This prospective study included 81 patients diagnosed with PN and treated with pudendal nerve infiltrations. …”
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Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction by Satoshi Yasuda, Christopher B Granger, David B Brieger, Shaun G Goodman, Karolina Andersson Sundell, Tabassome Simon, Dirk Westermann, Anthony P Carnicelli, Ruth Owen, Mauricio G Cohen, Katarina Hedman, Stuart J Pocock, Jose Carlos Nicolau

“…We compared characteristics, quality of life and clinical outcomes in stable patients post-MI with/without AF.Methods/results The prospective, international, observational TIGRIS (long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease) registry included 8406 patients aged ≥50 years with ≥1 atherothrombotic risk factor who were 1–3 years post-MI. …”
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Charting progress in learning health systems: A systematic review of 5 years of definitions, models, and frameworks by Louise A. Ellis, Georgia Fisher, Maree Saba, Genevieve Dammery, Kate Churruca, Samantha Spanos, Carolynn L. Smith, Bianca Forrester, Yvonne Zurynski, Jeffrey Braithwaite

“…This review of the LHS literature consolidates current understanding of LHS definitions, models, frameworks, and underlying theory, relative to their initial conceptualization by the IoM. Methods Three academic databases (PubMed, Embase, and Scopus) were searched for peer‐reviewed literature between 2018 and 2023. …”
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Research trends and hotspots of acupuncture therapy for obesity from 2004 to 2023: A bibliometric analysis by Jinkun Wang, Kangdi Cao, Zhaoyi Chen, Tianli Lyu, Qiuyu Xia, Lu Liu, Bin Li

“…Objectives: To investigate the characteristics, hotspots, and frontiers of global scientific output in acupuncture research for obesity over the past two decades. Methods: We retrieved publications on acupuncture for obesity published from 2004 to 2023 from the Web of Science Core Collection. …”
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Association of <i>OPRM1</i> and <i>OPRD1</i> Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer by Carolina Gutiérrez-Cáceres, Nikolas Ávila, Leslie C. Cerpa, Matías F. Martínez, Carlos E. Irarrazabal, Benjamín Torres, Olga Barajas, Nelson M. Varela, Luis A. Quiñones

“…This study evaluated the association of <i>OPRM1</i> (rs1799971 and rs510769) and <i>OPRD1</i> (rs2236861) polymorphisms with pain severity, opioid efficacy, and ADRs in Chilean colorectal cancer patients. <b>Methods</b>: The genotypes of <i>OPRM1</i> and <i>OPRD1</i> polymorphisms and clinical data from 69 colorectal cancer patients were analyzed. …”
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Investigating the impact of teleworking during the COVID-19 pandemic on work-related musculoskeletal disorders (WMSDs) and psychosocial factors of employees: a review article by Neda Ghasemi, Hosein Fallah, Mohamadhosein Nabian, Morteza Ghasemi, gholamhosein Halvani, Amirmohamad Najafipour

“…The purpose of this study is to investigate the impact of teleworking on musculoskeletal disorders and psychosocial factors in the days of Corona. Materials and Methods: This research was done by a review method. …”
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