Acute pharmacological effects of α-PVP in humans: a naturalistic observational study by Georgina De la Rosa, Georgina De la Rosa, Esther Papaseit, Esther Papaseit, Olga Hladun, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Dolly Andrea Caicedo, Martha Catalina Argote, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magí Farré, Magí Farré, Clara Pérez-Mañá, Clara Pérez-Mañá

“…Since the pharmacology of α-PVP remains scarcely studied, we aimed to evaluate the acute pharmacological effects and its abuse potential in humans after intranasal administration.MethodsWe carried out a non-controlled observational study in a naturalistic environment in nine participants (3 women and six men) with a previous history of psychostimulant use. …”
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Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors by Lauren A Dalvin, James Chodosh, Andrew G Lee, Clare L Fraser, Marc Dinkin, Michael Levy, Douglas B Johnson, Meghan Berkenstock, Edmund Tsui, John J Chen, Kerry L Reynolds, Prem S Subramanian, Lynn K Gordon, H Nida Sen, Michael K Yoon, Fiona Costello, Ninani Kombo, Amanda C Guidon, Bart K Chwalisz, Krista M Rubin, Sapna Gangaputra, Lucia Sobrin, Jon McDunn, Julia Pimkina, Johnathan Rine, Afreen Shariff, Suzanne K Freitag, Eileen L Chang, Renee Liu, Kiandokht Keyhanian, Katie Huynh, M Tariq Bhatti, Lindsey B DeLott, Robert A Egan, Michal Kramer, Anne-Marie Lobo-Chan, Dimosthenis Mantopoulos, George Papaliodis, Misha Pless

“…Ophthalmic immune-related adverse events (Eye-irAEs) from immune checkpoint inhibitors can cause visual morbidity. The absence of standardized definitions for Eye-irAEs not only impedes the development of evidence-based treatments but also progress in translational research. …”
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High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes by Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang, Kun Liu

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Intravitreal Dexamethasone Implant for Postoperative Macular Oedema Secondary to Vitrectomy for Epiretinal Membrane and Retinal Detachment: A Systematic Review and Meta-Analysis by Guglielmo Parisi, Matteo Fallico, Teresio Avitabile, Antonio Longo, Elina Ortisi, Andrea Russo, Francesco Petrillo, Andrea Maugeri, Martina Barchitta, Vincenza Bonfiglio, Claudio Furino, Gilda Cennamo, Paolo Caselgrandi, Paola Marolo, Luca Ventre, Michele Reibaldi

“…To evaluate the efficacy of intravitreal dexamethasone implant (DEX) for the treatment of macular oedema secondary to vitrectomy for epiretinal membrane (ERM) and retinal detachment (RD) by conducting a systematic review with meta-analysis of published studies. Methods. Studies reporting clinical outcomes of DEX use for the treatment of macular oedema secondary to ERM and RD vitrectomy were searched on PubMed and Embase databases. …”
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Development of a predictive model for long-term care and support eligibility certification associated with dementia-related functional impairments: the IRIDE cohort study by Daichi Yamashiro, Hiroyuki Suzuki, Susumu Ogawa, Mari Yamashita, Hiroki Moriya, Hiroyuki Sasai, Shuichi P. Obuchi, Takumi Abe, Hiroshi Murayama, Takumi Hirata, Yoshinori Fujiwara, Shuichi Awata, Masahiro Akishita, Kenji Toba, IRIDE Cohort Study Investigators

“…This study aimed to develop and validate risk prediction models for dementia-related functional impairments using data from the Integrated Research Initiative for Living Well with Dementia Cohort Study (IRIDE-CS), integrating multiple cohort studies conducted in urban Japan. Methods Data, including participant characteristics and dementia-related functional impairments, were collected from 3678 participants in the IRIDE-CS aged 65 and older. …”
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Effects of proprioceptive exercise for knee osteoarthritis: a systematic review and meta-analysis by Yaoyu Lin, Debiao Yu, Debiao Yu, Debiao Yu, Xiaoting Chen, Peng Chen, Nan Chen, Bin Shao, Bin Shao, Bin Shao, Bin Shao, Qiuxiang Lin, Qiuxiang Lin, Fuchun Wu, Fuchun Wu, Fuchun Wu, Fuchun Wu

“…The present study sought to systematically evaluate the effects of proprioceptive exercise on symptoms and functional outcomes in patients with KOA, with a particular focus on balance performance.MethodsFollowing PRISMA guidelines, a comprehensive search was conducted across six electronic databases from the establishment of the database to January 21, 2025. …”
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Short-Term Effects of a Snack Including Fruit Juice Enriched with Vitamin D3, n-3 Fatty Acids, and Probiotics on Energy Intake and Satiety in Normal-Weight and Overweight Individua... by Christina Athanasaki, Nikolaos Zacharodimos, Sofia Tsitsou, Dionysia-Lydia Bothou, Stamatia Vitsou-Anastasiou, Olga S. Papadopoulou, Emilia Papakonstantinou

“…Methods: Forty-six healthy individuals (normal weight: <i>n</i> = 24, 25 ± 1 years, BMI: 21 ± 1 kg/m²; overweight: <i>n</i> = 22, 28 ± 2 years, BMI: 27 ± 1 kg/m²) participated in this randomized, double-blind, within-subject crossover study. …”
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Balancing accuracy and user satisfaction: the role of prompt engineering in AI-driven healthcare solutions by Mini Han Wang, Mini Han Wang, Mini Han Wang, Mini Han Wang, Mini Han Wang, Xudong Jiang, Xudong Jiang, Xudong Jiang, Xudong Jiang, Peijin Zeng, Peijin Zeng, Peijin Zeng, Xinyue Li, Kelvin Kam-Lung Chong, Guanghui Hou, Xiaoxiao Fang, Yang Yu, Xiangrong Yu, Junbin Fang, Yi Pan

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STABLE trial of spectacle provision and driving safety among myopic motorcycle users in Vietnam: study protocol for a stepped-wedge, cluster randomised trial by Vinh Chi Le, Kien Gia To, Van Dat Le, Le Nguyen, Graeme MacKenzie, Lovemore Nyasha Sigwadhi, Prabhath Piyasena, Mai Tran, Ving Fai Chan, Rohit C. Khanna, Mike Clarke, Lynne Lohfeld, Heather Dickey, Augusto Azuara-Blanco, Asha Latha Mettla, Sridevi Rayasam, Han Thi Ngoc Doan, Dung Van Do, Phuoc Hong Le, Charlie Klauer, Richard Hanowski, Zeb Bowden, Lynn Murphy, Joanne Thompson, Susan McMullan, Cliona McDowell, Raja Narayanan, Julie-Anne Little, Huong Thu Ha, Sangchul Yoon, Rahul Goel, Lan Luong, Xuan Nguyen, Nathan Congdon

“…Secondary outcomes include visual function, cost-effectiveness and self-reported crash events. …”
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Assessment of sub-maximal aerobic capacity in North African patients with chronic hepatitis B: a pilot case-control study [version 2; peer review: 2 approved] by Houda Chaouch, Imed Latiri, Jihene Bergaoui, Sawssen MRAD, Helmi Ben Saad, Samia Ernez Hajri, Jihene Ben Abdallah, Salma Amous

“…This study aimed to evaluate sub-maximal aerobic capacity in CHB patients compared to apparently healthy participants (control-group (CG)). Methods A 6-min walk test (6MWT) was performed. The 6-min walk distance (6MWD) was recorded, along with heart-rate (HR), oxy-hemoglobin saturation (SpO2), blood-pressure, and dyspnea ( ie ; visual analogue scale) at rest (Rest) and at the end (End) of the 6MWT. …”
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Scope of practice of primary care nurses: a protocol for an umbrella review of international literature by Kris Aubrey-Bassler, Marie-Ève Poitras, Shabnam Asghari, Michelle Swab, Lindsay Hedden, Maria Mathews, Ruth Martin-Misener, Elizabeth J Halcomb, Julia Lukewich, Leslie Meredith, Dana Ryan, Suzanne Braithwaite, Danielle Macdonald, Kathleen Leslie, Anaelle Morin, Monica McGraw, Patrick Chiu, Émilie Dufour, Sophia Myles, Annie Rioux-Dubois, Deanne Curnew, Jen Calver, Jill Bruneau

“…., roles and activities) of PCNs in primary care.Methods and analysis We will conduct the umbrella review according to the Joanna Briggs Institute methodology, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) guidelines, and using the Nursing Care Organization Framework as guidance. …”
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N-Glycoside of Indolo[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking S... by Nikolay Kalitin, Natalia Koroleva, Anna Lushnikova, Maria Babaeva, Nadezhda Samoylenkova, Ekaterina Savchenko, Galina Smirnova, Yulia Borisova, Alexander Kostarev, Aida Karamysheva, Galina Pavlova

“…In this study, we investigated the anti-glioblastoma therapeutic potential of glycosylated indolocarbazole analog LCS1269 utilizing in vitro, in vivo, and in silico approaches. <b>Methods:</b> Cell viability was estimated by an MTT assay. …”
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Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway by Ning Wang, Chengyang Sun, Yijie Yang, Dandan Zhang, Lulu Huang, Chenrui Xu, Minghan Wang, Mengmeng Xu, Tongtong Yan, Yue Wu, Li Xu, Yahan Ju, Hao Sun, Wenyi Guo

“…This study elucidates the neuroprotective role of gut microbiota derived tryptophan metabolites in glaucoma through gut-eye communication and inhibition of microglia-mediated neuroinflammation. Methods Gut microbiota profiling (16 S rRNA sequencing) and serum indoleacetic acid (IAA) quantification were performed in glaucoma patients versus controls. …”
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Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard by I. Yu. Torshin, A. M. Lila, A. V. Naumov, A. Yu. Kochish, L. I. Alekseeva, E. A. Taskina, I. V. Sarvilina, A. N. Galustyan, A. N. Gromov, A. K. Khadzhidis, L. V. Vasilieva, E. F. Yevstratova, M. I. Udovika, O. A. Gromova

“…., EOD, course 20-30 injections) in the complex therapy of osteoarthritis (OA).Materials and Methods. Tie meta-analysis according to tie fixed-effects model included all published clinical studies on tie efficacy and safety of the CG drug in OA). …”
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Tailoring Chronic Disease Interventions to Meet Specific Needs of Women: A Case Example of a Hypertension Program by Caroline A. Dancu, Julie Schexnayder, Hayden B. Bosworth, Allison Lewinski, Abigail Shapiro, Tiera Lanford, Courtney White Clark, Bevanne Bean-Mayberry, Leah L. Zullig, Jennifer M. Gierisch, Karen M. Goldstein

“…This study describes a process for tailoring existing evidence-based interventions to the biological and sociocultural determinants of health for women. Methods: This study adapted the Team-supported, Electronic Health Record (EHR)-leveraged, Active Management (TEAM) CVD preventative care intervention designed for telehealth-based remote hypertension (HTN) care in rural Veterans. …”
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Performance on the Rey-Osterrieth complex figure test and the correlation with the magnetic resonance imaging brain lesion volume in multi-infract versus small vessel disease demen... by Semnić Marija D., Semnić Robert, Nikolašević Željka, Bugarski-Ignjatović Vojislava V., Vujanić-Stankov Tijana Ž., Kostić Smiljana, Ocić Gordana, Kozić Duško

“…This paper aimed to identify the differences between the performances on the Rey-Osterrieth Complex Figure (ROCF) test in MID and SSVD and correlate the ROCF scores in both groups with magnetic resonance imaging (MRI) ischemic lesion load. Methods. Sixty VaD patients with matching severity of dementia, age, and education were included in this study: 32 with SSVD and 28 with MID ac-cording to the NINDS-AIREN (National Institute of Neuro-logical Disorders and Stroke and Association Internationale pour la Recherché et l'Enseignement en Neurosciences) neuroradiological criteria. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Dalia Ali, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. Methods. Stem cell signaling small molecule library functional screen was performed employing human bone marrow skeletal (mesenchymal) stem cells (hBMSCs). …”
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Artificial intelligence-produced radiographic enhancements in dental clinical care: provider and patient perspectives by Lyubov D. Slashcheva, Lyubov D. Slashcheva, Kelly Schroeder, Lisa J. Heaton, Hannah J. Cheung, Brenda Prosa, Nicole Ferrian, Jesse Grantz, Jesse Grantz, Deborah Jacobi, John J. O’Malley, Michael Helgeson, Eric P. Tranby

“…The goal of this study was to survey dental providers and patients about the use of AI-enhanced radiographs in the diagnostic and patient education processes.MethodsWithin their Community Collaborative Practice model, Apple Tree Dental in Minnesota implemented the use of an AI software platform that annotates carious lesions and periodontal measurements on dental radiographs. …”
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The critical role of diet, exercise, and sleep in shaping the gut microbiota of children with idiopathic short stature: a Retrospective study by Qin Zeng, Qin Zeng, Jun Zhu, Jun Zhu, Yanling Hu, Yanling Hu, Shaoyu Su, Shaoyu Su, Jing Chen, Jing Chen

“…ObjectivesTo investigate the gut microbiota in children with varying degrees of idiopathic short stature (ISS) and to examine the relationship between their intestinal microbiota and lifestyle factors, including diet, exercise, medication, sleep, and psychological state.MethodsA retrospective study involving 58 ISS children was conducted from May to October 2022. …”
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Enhancing safety with an AI-empowered assessment and monitoring system for BSL-3 facilities by Yi-Ling Fan, Ching-Han Hsu, Ju-Yu Wu, Ying-Ying Tsai, Wei J. Chen, Min-Shi Lee, Fang-Rong Hsu, Lun-De Liao

“…Laboratory management failures can pose significant hazards. Methods: An external system captured images of personnel entering a laboratory, which were then analyzed by an AI-based system to verify their compliance with personal protective equipment (PPE) regulations, thereby introducing an additional layer of protection. …”
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