RESULTS OF AN OBSERVATIONAL PROSPECTIVE STUDY OF THE EFFICACY AND SAFETY OF BELIMUMAB (BENLYSTA®) IN SYSTEMIC LUPUS ERYTHEMATOSUS IN REAL CLINICAL PRACTICE by E. A. Aseeva, S. K. Soloviev, A. A. Mesnyankina, T. M. Reshetnyak, N. E. Lopatina, S. I. Glukhova, E. L. Nasonov

“…To evaluate the efficacy of belimumab (BLM), a biological agent, that blocks B-lymphocyte-stimulating factor registered for the treatment of active SLE, is an important task of the practice of rheumatology.Objective: to evaluate the efficacy and safety of BLM in patients with high and moderate SLE activity.Subjects and methods. The investigation enrolled 16 patients with a Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) score of 6 to 19, who were positive for antinuclear factor (100%) and had low complement levels and high anti-native DNA antibodies (81%). …”
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Graph theory-based analysis of functional connectivity changes in brain networks underlying cognitive fatigue: An EEG study. by Yabing Lou, Rui Pi, Ruifeng Sun, Jilin Wu, Wei Wang, Ziman Zhu, Tengteng Dai, Weijun Gong

“…Through the application of both global and local graph-theoretical metrics to characterize the topology of brain networks, this study establishes a conceptual framework supporting enhanced detection of cognitive fatigue manifestations while facilitating examination of its neurophysiological substrates.<h4>Methods</h4>The study cohort comprised neurologically intact individuals aged 20-35 years, recruited from Beijing Rehabilitation Hospital, Capital Medical University between February 6 and September 30, 2024 for participation in a cognitive fatigue induction task. …”
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Machine Learning-Based Mortality Risk Prediction Model in Patients with Sepsis by Zhang Y, Li C, Ji Y, Wei B, Guo S, Mei X, Wang J

“…By integrating traditional biomarkers, novel biomarkers, clinical data, and established scoring systems, the model seeks to enhance predictive accuracy and thereby improve clinical outcomes in high-risk patient population.Methods: Conducted at Beijing Chao-Yang Hospital from August 2021 to August 2023, our study included 180 emergency department patients meeting Sepsis 3.0 diagnostic criteria. …”
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The effects of short-term preoperative physical therapy and education on early functional recovery of patients younger than 70 undergoing total hip arthroplasty by Vukomanović Aleksandra, Popović Zoran, Đurović Aleksandar, Krstić Ljiljana

“…The aim of this paper was to investigate the effect of short-term preoperative program of education and physical therapy on patients' early functional recovery immediately after total hip arthroplasty (THA). Methods. This prospective study included 45 patients with hip osteoarthritis scheduled to undergo primary THA and admitted to the Department of Orthopedics of Military Medical Academy. …”
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Global, regional, and national differences in the burden of refraction disorders among children, adolescents, and older adults: current trends and future projections by Qiheng Yuan, Longji Wang, Bianjin Sun, Siwen Chen, Yutong Kang, Yongliang Lou, Meiqin Zheng

“…This study used data from the 2021 Global Burden of Disease (GBD) report to analyze regional differences and trends in the burden of RD among children, adolescents, and the elderly at the national level. Methods GBD 2021 data were used to examine RD burden in these groups, exploring associations with the Socio-demographic Index (SDI) and analyzing inequality trends. …”
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Bibliometric analysis of immunogenic cell death in hepatocellular carcinoma by Jianming Sun, Chun Liu, Dongdong Liu, Xinlian Hu, Shirong Ren, Guoying Jiang, Daizhong Zhang, Shuai Hu, Xiaojing Yuan, Jun Tao

“…Using VOSviewer network visualisation and R-bibliometrix quantitative metrics, we sought to show how scientific output has evolved and to pinpoint research gaps that may guide future investigations. Methods We retrieved 568 publications from the Web of Science Core Collection (2000–2024) using a tailored keyword strategy encompassing “Hepatocellular carcinoma” and “Immunogenic cell death.” …”
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Efficacy of Intraoperative Paracetamol and Nefopam Infusions in Addition to Transversus Abdominis Plane Block in Kidney Transplant Recipients by Jaesik Park, Sun Cheol Park, Min Suk Chae, Sang Hyun Hong, Jung-Woo Shim

“…This retrospective study explored the additional analgesic efficacy of paracetamol and nefopam infusions in living-donor KT recipients who received a transversus abdominis plane (TAP) block. <i>Materials and Methods</i>: Consecutive living-donor KT recipients at our institute between January 2020 and March 2022 were divided into groups that received a TAP block with paracetamol and nefopam infusions (Group TA) or a TAP block without analgesics (Group T) during surgery. …”
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Efficacy and safety of acupuncture in the treatment of Meniere’s disease: a systematic review and meta-analysis by Mingjie Tang, Mingjie Tang, Yinghong Li, Man Lu, Tianchen Zhang, Yanhao Ge, Jie Han, Jiqin Tang, Zhaoming Chen

“…This review aimed to evaluate the efficacy of acupuncture treatment for MD.MethodsEight databases were systematically searched from their inception to June 1, 2024, to identify randomized clinical trials on acupuncture treatment for MD. …”
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Geospatial Trends in Insurance Payor Reimbursements Based on Area Deprivation Index for Total Ankle Arthroplasty across Southwestern Pennsylvania by Garcia Findlay BS, Marfred Umanes Munoz BS, MS, Kenzo M. Cotton BS, Devon Scott, Richard Michael Smith MD, Jarrett D. Cain DPM MSc, Lauren Lewis MD MPH, Macalus V. Hogan MD, MBA

“…Our study analyzes the geospatial trends in medical reimbursement types and TAA utilization across Southwestern Pennsylvania whether a significant association between neighborhood socioeconomic conditions, as measured by the ADI, and reimbursement type exists. Methods: Institutional review board approval was obtained (IRB 20020136). …”
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Quantitative ultra-widefield fluorescein angiography biomarkers in diabetic retinopathy and association with treatment and progression by Iyengar RS, Fleifil S, Aaberg MT, Yu G, Patel TP, Powell C, Tran AK, Paulus YM

“…Wolfe St, Baltimore, MD, 21287, USA, Tel +1 410 955-3518, Email ypaulus1@jh.eduPurpose: To determine if demographic factors and calculated areas of nonperfusion (NP) and neovascularization (NV) on ultra-widefield (UWF) fluorescein angiography (FA) in the eyes of patients with diabetes are associated with treatment with intravitreal injections (IVIs), panretinal photocoagulation (PRP), and diabetic retinopathy (DR) progression.Patients and Methods: This retrospective, cross-sectional study included 363 patients (651 eyes) treated at the University of Michigan Kellogg Eye Center between January 2009 and May 2018. …”
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Apoptosis-Inducing Factor (AIF) content in tumor cell mitochondria from colorectal cancer patients by O. I. Kit, E. M. Frantsiyants, S. A. Ilchenko, V. A. Bandovkina, I. V. Neskubina, A. I. Shikhlyarova, Yu. A. Petrova, A. A. Vereskunova, A. O. Adamyan, E. N. Kolesnikov, G. G. Beloshapkina, A. Yu. Arakelova, U. M. Gaziev, S. V. Sanamyants

“…To investigate the level of protein AIF in the mitochondria of tumor cells and visually unchanged tissues of the colon in male and female patients with colorectal cancer.Materials and methods. …”
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Microvascular flow imaging of fibroids: A prospective pilot study by Marissa Frijlingh, Barbara Stoelinga, Robert A. deLeeuw, Wouter J. K. Hehenkamp, Jos W. R. Twisk, Thierry van denBosch, Lynda J. M. Juffermans, Judith A. F. Huirne

“…The purpose of our study was to determine the reproducibility of MV‐flow imaging and to explore this technique for clinical practice for assessing blood flow in fibroids. Material and Methods Thirty patients with one or multiple fibroids (diameter 1.5–12.0 cm) were prospectively included. …”
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Immediate effects of high-intensity laser therapy for nonspecific neck pain: a double-blind randomized controlled trial by Yuhua Xie, Yuhua Xie, Yingxiu Diao, Dongyu Wu, Manxia Liao, Linrong Liao, Linrong Liao, Linrong Liao

“…ObjectivesThe objective of this research was to assess the immediate effects of high-intensity laser therapy (HILT) on nonspecific neck pain (NNP) by evaluating outcome measures such as pain intensity, cervical active range of motion (ROM), stiffness of neck muscles, and functional disability.MethodsThis clinical trial, which was conducted in a double-blind and randomized manner, involved patients diagnosed with NNP who were allocated either to either a HILT group (HILT + exercise) or a placebo group (placebo-laser therapy + exercise). …”
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Does music counteract mental fatigue? A systematic review. by Cong Ding, Soh Kim Geok, He Sun, Samsilah Roslan, Shudian Cao, Yue Zhao

“…Additionally, the mechanisms by which music counteracts mental fatigue will be discussed.<h4>Methods</h4>A comprehensive search was conducted across five databases-Web of Science, PubMed, SCOPUS, SPORTDiscus via EBSCOhost, and the Psychological and Behavioral Sciences Collection via EBSCOhost-up to November 18, 2023. …”
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Concentrations of DDT metabolites in different food items and public health risk in Africa regions: systematic review and metal analysis by Dechasa Adare Mengistu, Abraham Geremew, Roba Argaw Tessema, Tara Wolfing

“…Therefore, this review was designed to assess the concentration of DDT metabolites (p,p'-DDT, p,p'-DDD, and p,p'-DDE) in various food items and evaluate the health risk to consumers in the African.MethodsThe preferred reporting item for systematic reviews and meta-analysis (PRISMA) protocol was used to conduct this work. …”
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Costs and acceptability of simplified monitoring in HIV-suppressed patients switching to dual therapy: the SIMPL’HIV open-label, factorial randomised controlled trial by Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J. Metzner, Laurent Decosterd, Huldrych F. Günthard, Patrick Schmid, Andreas Limacher, Mattia Branca, Alexandra Calmy

“…However, different monitoring and treatment strategies carry different costs and health consequences. MATERIALS AND METHODS: The SIMPL’HIV study was a randomised trial that assessed the non-inferiority of dual maintenance therapy. …”
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Cartilage lesions are not the main factor influencing pain and functional impairment in early knee osteoarthritis: a multivariate analysis on intra- and extra-articular factors aff... by Luca Bianco Prevot, Alessandro Bensa, Pietro S Randelli, Giuseppe Filardo

“…Aims: To investigate the correlation between symptoms, in terms of pain and functional scores, and the extent of cartilage damage as well as other intra- and extra-articular factors in patients suffering from early knee osteoarthritis (OA). Methods: The subjects were selected from the Osteoarthritis Initiative database according to the following inclusion criteria: Kellgren-Lawrence (KL) grade 0-1-2, MRI at baseline, and availability of cartilage-denuded subchondral bone values. …”
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Comparative study of the efficacy and safety of Chondroguard® during its combined (intra-articular and intramuscular) and intramuscular injection in patients with knee osteoarthrit... by L. I. Alekseeva, E. P. Sharapova, N. G. Kashevarova, E. A. Taskina, A. M. Lila, A. N. Bogdanov, S. A. Bozhkova, A. A. Bagretsova, S. M. Noskov, E. A. Grunina

“…Objective: to evaluate the efficacy and safety of Chondroguard® in the combined (intra-articular (IA) + intramuscular (IM)) and IM injection in patients with knee osteoarthritis (OA).Patients and methods. The study enrolled 150 patients with knee OA who were divided into two groups with 75 patients in each group. …”
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Adipose tissue-derived versus bone marrow-derived cell concentrates for the injective treatment of knee osteoarthritis: protocol of a prospective randomised controlled trial by Paolo Spinnato, Stefano Zaffagnini, Giuseppe Filardo, Marco Miceli, Luca Andriolo, Lorenzo Zanasi, Francesca Veronesi, Viviana Costa, Marco Franceschini, Gianluca Giavaresi

“…The aim of this randomised controlled trial is to compare the safety and clinical outcomes of a single intra-articular injection of BMAC versus a single intra-articular injection of MFAT in patients with knee OA.Methods and analysis 204 patients aged 40–75 years and affected by knee OA are randomised to receive a single injection of BMAC or MFAT in a 1:1 ratio. …”
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Efficacy of Tulsi-Turmeric Oil Pulling versus Sesame Oil Pulling on Temporomandibular Joint Movement in Oral Submucous Fibrosis (Vata Pitta dominant Tridosaja Sarvasara Mukharoga):... by Anshika Kishor Singh, Gaurav Rajendra Sawarkar, Punam Gaurav Sawarkar

“…Other assessments will include IID scoring, cheek flexibility, and Visual Analog Scale (VAS) scores before and after the intervention. …”
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