Long-term use of nonsteroidal anti-inflammatory drugs for pain control in patients with osteoarthritis: results of the 12-month observational study AELITA (Analgesia: Effective Tre... by A. E. Karateev, E. Yu. Polishchuk, E. S. Filatova, A. S. Potapova, V. A. Nesterenko, V. N. Amirdzhanova

“…Objective: to evaluate the efficacy and safety of long-term use of NSAIDs for pain control in patients with OA in real clinical practice.Patients and methods. To assess the results of long-term use of NSAIDs in OA, a 12-month observational non-interventional study was conducted. …”
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Posterior corneal elevation after small incision lenticule extraction (SMILE) in eyes of different myopia severity by Li Jiang, Changting Tang, Bao Shu, Ying Liu, Qingyan Zeng, Xiaohua Lei, Zhengwei Shen, Yijun Hu

“…Purpose: To investigate the changes in posterior corneal elevation after small incision lenticule extraction (SMILE) surgery in eyes of different myopia severity. Methods: A total of 141 eyes of 86 patients were recruited and followed at 1 month, 3 months, 6 months, and 12 months after SMILE surgery. …”
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Micropulse cyclophotocoagulation in combined treatments of neovascular glaucoma by I.V. Shiryaev, S.V. Sosnovskii, M.M. Pravosudova, I.E. Panova

“…To evulate the efficiency of micropulse cyclophotocoagulation (MP-CPC) in the combined treatment of patients with secondary refractory neovascular glaucoma with object vision. Material and methods. The study involved 30 patients (30 eyes) with neovascular glaucoma (NVG) in the stage of partial or complete blockade of the iridocorneal angle with decompensated intraocular pressure (IOP) resistant to drug therapy, who had object vision. …”
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Epidemiological analysis of emergency ophthalmic cases in a specialist hospital in Tianjin by LI Xin, YU Feiping

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Influence of Premedication and Dental Anxiety on Anesthetic Efficacy in Patients Undergoing Root Canal for Symptomatic Irreversible Pulpitis in Upper and Lower Molars: A Comparativ... by Luis Manteca-Fernández, Cristina Meniz-García, Fernando Fernández-Cáliz, Cristina Barona-Dorado, Juan Santos-Marino, Natalia Martínez-Rodríguez

“…The null hypothesis (H0) of this study was that articaine and bupivacaine would have a similar anesthetic efficacy when used during the treatment of symptomatic irreversible pulpitis of the posterior mandibular and maxillary teeth, independent of non-steroidal anti-inflammatory drugs (NSAIDs) premedication or the patient’s anxiety levels. <b>Methods:</b> A total of 140 patients presenting with pulpitis in the upper and lower molars were randomly assigned to one of two anesthetics: articaine or bupivacaine. …”
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Knowledge among patients with Hepatitis C initiating on direct-acting antiviral treatment in rural Rwanda: A prospective cohort study by Dale A Barnhart, Innocent Kamali, Francoise Nyirahabihirwe, Carol Mugabo, Jean de la Paix Gakuru, Mariam Uwase, Esdras Nizeyumuremyi, Tumusime Musafiri, Jean de Dieu Gatete, Jean Damascene Makuza, Fredrick Kateera, Bethany Hedt-Gauthier, Jean d’Amour Ndahimana

“…Objective We assessed knowledge on hepatitis C among rural Rwandans initiating DAA treatment for hepatitis C in a prospective cohort. Methods We administered 15 true-false statements before treatment initiation and during one follow-up visit occurring either 1 or 2 months after treatment initiation. …”
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High-load strength training compared with standard care treatment in young adults with joint hypermobility and knee pain: study protocol for a randomised controlled trial (the HIPE... by Birgit Juul-Kristensen, Jonas Bloch Thorlund, Peter Henriksen, Behnam Liaghat, Jens Bojsen-Møller, Afsaneh Mohammadnejad, Bibi Dige Heiberg

“…So far, no randomised controlled trials (RCTs) have compared high-load strength training with traditional treatment strategies (standard care) for this patient group.Methods and analysis In this RCT, we aim to recruit patients with GJHk and knee pain from primary care physiotherapy clinics in the Region of Southern Denmark and via social media. …”
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Advantages of alginate and PPI combination in relief of heartburn and regurgitation during the first days of treatment of gastroesophageal reflux disease by D. S. Bordin, O. B. Yanova, O. I. Berezina, Ye. V. Treyman

“…To estimate advantages of combined intake of proton pump inhibitor (PPI) and alginate in comparison to monotherapy by PPI in terms of symptom relief in the first days of gastroesophageal reflux disease (GERD) treatment.Material and methods. Overall 96 patients with GERD were investigated. …”
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Extreme Lateral Interbody Fusion: An Observational Study of Functional and Radiological Outcome by Dana Abdel Hafeez, Hosam Abdel Hafeez, Omar A. Al-Mohrej, Mohammed A. Al-Rabiah, Hamzah M. F. Magableh, Ibrahim Bin Ahmed, Nazir Khan, Anwar M. Al-Rabiah

“…This prospective observational study seeks to address this gap by reporting these outcomes in patients treated at the King Faisal Specialist Hospital & Research Centre (KFSHRC) over a mean follow-up period of 5 years. Methods This case series amassed baseline patient data, encompassing gender, age, body mass index (BMI), American Society of Anesthesiology (ASA) classification, operated level, and posterior fixation type. …”
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Clinical and social aspects of dysmenorrhea development by L. V. Pakharenko

“…Aim of the research was to determine clinical and social aspects of women with dysmenorrhea. Materials and methods. The study involved 155 women with diagnosis dysmenorrhea who formed the basic group. 55 persons had primary form of disease (the I group), 100 patients – secondary one (the II group). …”
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Effects of single femoral nerve block and continuous femoral nerve block on perioperative analgesia and muscle strength in elderly patients undergoing total knee arthroplasty, a ra... by Yan Tao, Nan Cai, Juxia Zhang, Yan Zhou, Pengfei Liu

“…ObjectiveTo investigate the effect of single femoral nerve block (SFNB) with 0.2% ropivacaine 50 ml on postoperative pain and muscle strength in elderly patients undergoing knee replacement.MethodsNinety-four patients scheduled for primary total knee arthroplasty (TKA) were randomized into two groups. …”
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Gamma camera imaging characteristics of 203/212Pb as a theragnostic pair for targeted alpha therapy: a feasibility study by David Kästner, Holger Hartmann, Robert Freudenberg, Marc Pretze, Claudia Brogsitter, Michael K. Schultz, Jörg Kotzerke, Enrico Michler

“…The aim of this study was to investigate suitable imaging protocols and to characterize the scintigraphic imaging properties and their implications for the clinical feasibility as theragnostic isotopes. Methods Planar and SPECT/CT images were obtained with medium- and high-energy collimators on a Siemens Symbia Intevo 6 using a NEMA image quality phantom in various phantom setups and another body-shaped phantom with several inserts. …”
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Efficacy of Diclofenac and Ketoprofen Transdermal Patches for Postoperative Analgesia and their Effect on Renal Functions in Patients Undergoing Percutaneous Nephrolithotomy: A Ran... by Sandip Baheti, Vaibhavi Singh

“…Pain was assessed using the Visual Analog Scale (VAS) at 0, 4, 8, 12, 16, 24 and 48 hours. …”
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Contextual factors related to aging determine force-based manipulation dosage: a prospective cross-sectional study by Michele J. Maiers, Alexander R. Sundin, Ryan J. Oster, Steven Kreul, Quinn Malone, Steven R. Passmore

“…This study aimed to determine whether contextual factors pertaining to aging result in the modulation of kinetic and kinematic parameters used by experienced clinicians when delivering SMT. Methods Participants were randomly presented with a series of 12 AI-generated patient vignettes, featuring both visual and auditory content and representing varying age-related contextual factors. …”
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The influence of socioeconomic position on patient-reported outcome measures following hip fractures – a register-based observational study on 35,206 patients from the Norwegian hi... by Cato Kjaervik, Jan-Erik Gjertsen, Eva Stensland, Jan Abel Olsen, Christer Kjaervik, Odd Soereide

“…Methods This was a nationwide retrospective cohort study using linked data from the Norwegian Hip Fracture Register and Statistics Norway. …”
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Conservative Treatment of Sesamoiditis: A Systematic Literature Review with Individual-Level Pooled Data Analysis by Carlo Biz, Maria Chiara Maccarone, Valentina Bonso, Elisa Belluzzi, Stefano Masiero, Nicola Luigi Bragazzi, Pietro Ruggieri

“…This systematic review aims to evaluate the effectiveness of conservative treatments for sesamoiditis by summarising individual-level data from published studies. <i>Materials and Methods</i>: A comprehensive literature search was conducted in PubMed/MEDLINE, Scopus, ISI/Web of Science, and PEDro (Physiotherapy Evidence Database) up to December 2024 in accordance with PRISMA 2020 guidelines and following a protocol specifically devised for rare or underrepresented medical conditions. …”
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Breast Cancer Vlogs on YouTube: Descriptive and Content Analyses by Nina Morena, Elly Dimya Htite, Yitzchok Ahisar, Victoria Hayman, Carrie A Rentschler, Ari N Meguerditchian

“…ObjectiveThis study aimed to determine (1) the forms of content about breast cancer that tend to be discussed in vlogs, (2) the reasons why women choose to vlog their breast cancer experiences, and (3) the potential for breast cancer vlogs to serve as an alternative or complement to peer-to-peer support as well as a site of digital community overall. MethodsYouTube was searched in incognito mode in November 2023 using the search terms “breast cancer vlog.” …”
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Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism by Xin Shang, Xin Shang, Yu Fu, Ying Wang, Shuxun Yan

“…ObjectiveThe objective of this study is to investigate the ability of Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) to ameliorate obesity and lipid metabolism disorders in rats subjected to a high-fat diet (HFD) through metagenomics, untargeted lipidomics, targeted metabolism of bile acid (BA), and BA pathways, providing a novel perspective on the management of metabolic disorders.MethodsIn this research, HFD-fed rats were concurrently administered SZ-A orally. …”
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Nasal Symptoms Among Allergic Rhinitis Patients Could Contribute to Sexual Dysfunction by Zhang H, Zhang H, Jin P, Yu K, Zi X, Liang X, Zhang H, Zhao L

“…This study aimed to explore the relationship between the severity of nasal symptoms and sexual function in AR patients.Methods:  A case-control study involving 1034 AR patients and 422 healthy controls was conducted. …”
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A multimodal nomogram for benign-malignant discrimination of lung-RADS ≥4A nodules: integration of oxygen enhanced zero echo time MRI, CT radiomics, and clinical factors by Tiancai Yan, Ling Liu, Yuxin Li, Chunhui Qin, Haonan Guan, Tong Zhang

“…This study aimed to develop a preoperative prediction model integrating OE-ZTE-MRI/CT radiomics and clinical factors for benign-malignant discrimination of Lung-RADS ≥4A nodules and compare its performance against single-modality models.Methods99 nodules from 84 prospectively enrolled patients undergoing both LDCT and OE-ZTE-MRI were included. …”
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