Identification of core noncoding RNA-associated competing endogenous RNA networks in renal fibrosis via whole-transcriptome sequencing by Yizhen Chen, Meng Cheng, Rong Dai, Weili Wang, Yonghao Sang, Liuting Wei, Yilin Gao, Wei Zhang, Yiping Wang, Lei Zhang

“…Objective This study aimed to investigate noncoding RNA (ncRNA) expression changes in renal fibrosis (RF) models induced by three distinct etiologies using whole-transcriptome RNA sequencing, identify overlapping differentially expressed (DE) ncRNAs, construct core competing endogenous RNA (ceRNA) networks, and explore their role in RF.Methods Three RF rat models, 5/6 nephrectomy, adenine, and unilateral ureteral obstruction, were established. …”
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Unilateral Biportal Endoscopic Decompression for Degenerative Lumbar Spinal Stenosis Under Local Anesthesia in Elderly Patients with Medical Comorbidities by Haining Tan, Yuquan Liu, Guangpeng Li, Lingjia Yu, Haibo Sun, Bin Zhu, Qi Fei, Yong Yang, Yuan‐Shun Lo, Xiang Li

“…This article explores the use of UBE decompression under local anesthesia (LA) in elderly patients with severe medical comorbidities treated at our institution, providing valuable clinical insights for the application of this technique. Methods A retrospective analysis was conducted on patients clinically diagnosed with lumbar spinal stenosis (LSS) at our center between November 2021 and March 2024, who underwent UBE decompression surgery under local LA. …”
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The use of drone-delivered Automated External Defibrillators in the emergency response for out-of-hospital cardiac arrest. A simulation study by Christopher M. Smith, Carl Powell, Celia J. Bernstein, Harry Howe, Mark Holt, Mary O’Sullivan, Keith Couper, Nigel Rees

“…The emergency call-handler may have an important role in helping bystanders retrieve and use an AED. Methods: Following an emergency (999) call for simulated out-of-hospital cardiac arrests, a remote drone was activated and made autonomous Beyond Visual Line of Sight flights to the scene. …”
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Translocation of black carbon particles to human intestinal tissueResearch in context by Thessa Van Pee, Kenneth Vanbrabant, Leen Rasking, Peter Van Eyken, Janneke Hogervorst, Philip Caenepeel, Marcel Ameloot, Michelle Plusquin, Tim S. Nawrot

“…One of the hypothesized underlying mechanisms is the absorption of air pollution-related particles from the gastrointestinal tract. Methods: We visualized and quantified black carbon particles via white light generation under femtosecond-pulsed laser illumination in ileum and colon biopsies of five human patients. …”
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Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial by Cheng He, Jianhua Li, Wei Hu, Bo Xiao, Tuoying Fan, Jiangjun Zhou, Feng Shuang, Hao Li

“…This study aimed to determine the efficacy of combining dexamethasone with vitamin B12 (VB12) via epidural injection in improving the symptoms of low back and leg pain after PEID, and the underlying mechanism of action. Methods Patients who underwent PEID for lumbar disc herniation (LDH) were enrolled and randomly assigned to the single surgery (SS) group, where disc removal was performed via PEID alone, or the combined treatment (CT) group, which received epidural injections of dexamethasone and VB12 alongside surgery. …”
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Retrospective analysis of clinical and radiological outcomes of thoracolumbar vertebral fractures treated with monoplanar pedicle screws compared with fixed-axis and polyaxial scre... by Wei Duan, Xin Zhao, Le Chang, Le Chang, Zhen Sun, Kangwei Lai, Kangwei Lai, Jingchun Zhang, Jingchun Zhang, Buqi Tian, Buqi Tian, Zhengxu Ye

“…This study compares clinical and radiological outcomes of these screws.MethodsSeventy-five patients (2020–2024) with thoracolumbar fractures were divided into three groups: Group A (fixed-axis screws, n = 31), Group B (polyaxial screws, n = 19), and Group C (monoplanar screws, n = 25). …”
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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…This study aimed to clarify the correlation with nasal anatomical variation detected by CT and RCPH treatment outcomes. <b>Methods:</b> A prospective cohort study was conducted on 90 RCPH patients undergoing surgery or medical therapy. …”
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Leukocyte-Rich Platelet-Rich Plasma’s Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials by Peiyuan Tang, Meihui Huang, Wenfeng Xiao, Ting Wen, Pavel Volotovsky, Mikhail Gerasimenko, Shiyao Chu, Shuguang Liu, Kai Zhang, Yusheng Li

“…<b>Background</b>: Arthroscopic rotator cuff repair faces high retear risks in multi-tendon injuries due to insufficient biological healing; leukocyte-rich PRP may enhance tendon–bone integration through inflammatory modulation and growth factor release. <b>Methods</b>: Four databases including PubMed, Embase, Cochrane Library, and Web of Science were searched until March 2025. …”
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Deep learning based on multiparametric MRI predicts early recurrence in hepatocellular carcinoma patients with solitary tumors ≤5 cm by Tingting Mu, Xinde Zheng, Danjun Song, Jiejun Chen, Xuewang Yue, Wentao Wang, Shengxiang Rao

“…Purpose: To evaluate the effectiveness of a constructed deep learning model in predicting early recurrence after surgery in hepatocellular carcinoma (HCC) patients with solitary tumors ≤5 cm. Materials and methods: Our study included a total of 331 HCC patients who underwent curative resection, with all patients having preoperative dynamic contrast-enhanced MRI (DCE-MRI). …”
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Reconceptualizing Pediatric Strabismus as a Condition Rooted in Sensory Processing Disorder: A Novel Case-Based Hypothesis by Mirjana Bjeloš, Ana Ćurić, Mladen Bušić, Katja Rončević, Adrian Elabjer

“…This report presents a proof-of-concept case suggesting strabismus may represent a neurobehavioral manifestation of sensory processing imbalance, rooted within the broader framework of SPD. <b>Methods:</b> We report a pediatric case marked by episodic monocular eye closure triggered by environmental stimuli, without identifiable ophthalmologic or neurologic pathology. …”
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Short-term clinical and functional outcomes of distal biceps tendon fixation: all-suture vs. titanium anchors by Felix Hochberger, MD, Julian Hess, MD, Christian Konrads, MD, Tizian Heinz, MD, Ella Segatz, Maximilian Rudert, MD, Kilian List, MD

“…Background: The objective of this study was to evaluate the preliminary clinical and functional outcomes of patients with distal biceps tendon ruptures undergoing surgical fixation using 2 intramedullary all-suture anchors (ASAs) and to compare these outcomes with a control group treated with 2 intramedullary titanium anchors (TAs). Methods: A retrospective case series was conducted on patients who underwent distal biceps tendon fixation using either TAs (Mitek Sports Medicine, Raynham, MA, USA) or ASAs (Arthrex, Naples, FL, USA). …”
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Comparative analysis of stentless aortic root and composite valve grafts for aortic root replacement: a retrospective single-centre study by Maria Comanici, Mohammad Yousuf Salmasi, Fabio De Robertis, Toufan Bahrami, Sunil K. Bhudia, Jullien A. Gaer, Shahzad G. Raja

“…This study aims to analyze the in-hospital outcomes and long-term survival of these two surgical approaches. Methods: A retrospective analysis was conducted on 594 patients who underwent ARR between July 2003 and December 2023. …”
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Modified minimally invasive surgical technique plus Bio-Oss Collagen for regenerative therapy of isolated interdental intrabony defects: study protocol for a randomised controlled... by Ye Han, Churen Zhang, Haidong Zhang, Zhaoguo Yue, Lili Miao, Kaining Liu, Jianxia Hou

“…This study will search for differences between M-MIST combined with Bio-Oss Collagen, and M-MIST alone in regeneration therapy for intrabony defects.Methods and analysis The present research is designed as a two-group parallel randomised controlled trial. …”
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Transanal Irrigation in Patients with Low Anterior Resection Syndrome After Rectal-Sphincter-Preserving Surgery for Oncological and Non-Oncological Disease: A Systematic Review by Andrea Morini, Massimiliano Fabozzi, Magda Zanelli, Francesca Sanguedolce, Andrea Palicelli, Alfredo Annicchiarico, Candida Bonelli, Maurizio Zizzo

“…The aim of the present systematic review was to evaluate the feasibility and effectiveness of TAI in patients with significant LARS symptoms. Methods: We performed a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and guidelines in addition to the <i>Cochrane Handbook for Systematic Reviews of Interventions</i>. …”
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Resting-State Brain Network Characteristics Related to Mild Cognitive Impairment: A Preliminary fNIRS Proof-of-Concept Study by Guohui Yang, Chenyu Fan, Haozheng Li, Yu Tong, Shuang Lin, Yashuo Feng, Fengzhi Liu, Chunrong Bao, Hongyu Xie, Yi Wu

“…Background: This study investigates the reliability of functional near-infrared spectroscopy (fNIRS) in detecting resting-state brain network characteristics in patients with mild cognitive impairment (MCI), focusing on static resting-state functional connectivity (sRSFC) and dynamic resting-state functional connectivity (dRSFC) patterns in MCI patients and healthy controls (HCs) without cognitive impairment. Methods: A total of 89 MCI patients and 83 HCs were characterized using neuropsychological scales. …”
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The Impact of Prostate-Specific Antigen and Gleason Scores on Cardiovascular Death in Prostate Cancer Patients after Radiotherapy or Chemotherapy: A Population-Based Study by Huijuan He, Liyu Guo, Peipei Wang, Yuting Yang, Zhenxing Lu, Xiaoping Peng, Tianwang Guan

“…This study explored the association between PC tumor characteristics and CVD risk in PC patients who had received RT or CT. Methods: Fine-gray competitive risk analysis was employed to identify CVD risk factors. …”
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Alflutop Russian longitudinal multicenter observational study: use in patients with chronic back pain (message 3) by A. M. Lila, A. E. Karateev, L. I. Alexeeva, E. A. Taskina, An. B. Danilov, S. A. Zhivolupov, I. N. Samartsev, E. R. Barantsevich, A. P. Rachin

“…The use of slow-acting disease-modifying symptomatic drugs, such as bioactive concentrate from small marine fish (BCSMF, Alflutop), is considered a potential element of complex therapy for chronic non-specific back pain (CNBP).Objective: to evaluate the efficacy of the BCSMF in patients with CNBP in real-life clinical practice.Material and methods. An open observational study included 10,047 patients with CNBP (age – 58.3±14.9 years, 58.4% women) with moderate or severe pain – 60 [50; 70] mm on the visual analogue scale (VAS). …”
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Observation of the clinical effectiveness of transanal opening of the intersphincteric space in the treatment of high intersphincteric anal fistula and suprasphincteric anal fistul... by Huang Luqiao, Li Shanshan, Yang Yong, Meng Qingliang, Liang Chunhui, Pan Dong, Sun Shangying, Xie Guangwei, Zhang Zhengguo

“…[Objectives] To investigate the clinical effectiveness of transanal opening of the intersphincteric space (TROPIS) in the treatment of high intersphincteric anal fistula and suprasphincteric anal fistula. [Methods] A total of 124 patients with high intersphincteric anal fistula and suprasphincteric anal fistula who underwent surgical treatment at the Department of Anorectal Surgery, Xuzhou Central Hospital from September 2021 to June 2023 were selected as the study subjects. …”
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PHARMACOEPIDEMIOLOGY OF ORIGINAL DROTAVERINE USE IN DYSMENORRHEA: RESULTS OF AN INTERNATIONAL MULTICENTER STUDY by A. L. Unanyan, V. A. Alimov, S. E. Arakelov, M. S. Afanasyev, D. V. Baburin, D. V. Blinov, T. D. Guriyev, U. V. Zimovina, A. E. Kadyrova, Yu. M. Kossovich, L. S. Polonskaya

“…Objective: To evaluate the effectiveness of drotaverine in the daily practice management of spasmodic abdominal pain due to gastrointestinal, biliary, urological tract conditions and dysmenorrhea. Material and Methods: a multicenter, prospective, cross-sectional and longitudinal product registry (3 visits), non-interventional on the therapeutic strategy was conducted in Mexico, Kazakhstan, and Russia. …”
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Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy by Yan Li, Lei Wang, Bojun Xu, Liangbin Zhao, Li Li, Keyang Xu, Anqi Tang, Shasha Zhou, Lu Song, Xiao Zhang, Huakui Zhan

“…This study is aimed at revealing the therapeutic mechanisms of Cordyceps in DN by undertaking a network pharmacology analysis. Materials and Methods. In this study, active ingredients and associated target proteins of Cordyceps sinensis were obtained via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Swiss Target Prediction platform, then reconfirmed by using PubChem databases. …”
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