A Complete Functional Characterization of Patients with Severe Knee Osteoarthritis in Need of Total Knee Replacement by Vinicius Taboni Lisboa, Bruno de Paula Leite Arruda, Rafael de Andrade Tambascia, Alessandro Rozin Zorzi, Alberto Cliquet, Gustavo Constantino de Campos

“…The objective of this study is to describe a complete set of functional characteristics to identify patients with end-stage knee osteoarthritis in need of a total knee replacement, correlating data from strength and performance tests with pain, function, and quality of life questionnaires. Methods: This was a cross-sectional study evaluating patients with end-stage knee osteoarthritis in a waiting list for total knee replacement at a University Hospital. …”
Get full text

Understanding Patient and Physiotherapist Requirements for a Personalized Automated Smartphone Telemonitored App for Posttotal Knee Arthroplasty Rehabilitation: Qualitative Study by Eleanor Shuxian Chew, Aileen Eugenia Scully, Samanth Shi-Man Koh, Ee-Lin Woon, Juanita Krysten Miao-Shi Low, Yu-Heng Kwan, John Wei-Ming Tan, Yong-Hao Pua, Celia Ia-Choo Tan, Luke Jonathan Haseler

“…To ensure uptake and long-term sustainability, this study adopted a person-based approach. MethodsA multistakeholder qualitative study of user needs was conducted. …”
Get full text

The relationship of tooth shade and skin tone and its influence on smile attractiveness in native South Indians: A web-based cross sectional survey by Hrudi Sundar Sahoo, Aishwarya Balasubramanian

“…The primary research question was whether there is a significant relationship between these variables and perceived smile attractiveness. Materials and methods: A web-based cross-sectional survey was conducted with approval from the Institutional Review Board of (Thai Moogambigai Dental College and Hospital, Chennai). …”
Get full text

Tracing inflammasomes in Alzheimer’s: insights from bibliometric analysis by Yingjun Chen, Yingjun Chen, Hui Pei, Hao Li, Wenjun Zeng, Zhitao Li

“…By identifying research hotspots and emerging topics, we aim to provide new insights and directions for researchers in this field.MethodsAll data related to inflammasomes in Alzheimer’s disease from 2000 to 2024 were collected from the Web of Science Core Collection (WoSCC), and annual publications, national publication trends, and proportion charts were analyzed and plotted using GraphPad price v8.0.2. …”
Get full text

Patient Experience with ABBV-444, a Proof-of-Concept Study for a Novel Artificial Tear with Trehalose and Sodium Hyaluronate for Dry Eye Symptoms by Hom MM, Ladhani O, Zhang Z, Liu H, Sonparote S, Dancey CC

“…We assessed symptom relief, tolerability, and patient experience of a novel carboxymethyl-cellulose–based artificial tear formulation with trehalose and sodium hyaluronate (ABBV-444) in patients with DED.Methods: This open-label, single-arm, single center study enrolled adult patients with baseline Ocular Surface Disease Index (OSDI) scores of ≥ 18 and ≤ 65. …”
Get full text

The burden of cough in idiopathic pulmonary fibrosis and other interstitial lung diseases: a systematic evidence synthesis by Rhiannon Green, Michael Baldwin, Nick Pooley, Kate Misso, Maureen PMH Rutten-van Mölken, Nina Patel, Marlies S. Wijsenbeek

“…To inform future research, treatment and care models, we conducted the first systematic synthesis of evidence on its associated burden. Methods A literature search was performed for articles published between January 2010 and October 2023 using databases including Embase, MEDLINE and the Cochrane Library. …”
Get full text

Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis by L. A. Knyazeva, N. Damjanov, L. I. Knyazeva, N. S. Meshcherina, I. I. Goryainov, M. A. Stepchenko, Ya. I. Bobyntsev, O. S. Rudakov

“…Objective: to evaluate the effect of golimumab (GLM) on endothelial vasomotor function and arterial stiffness in patients with ankylosing spondylitis (AS).Subjects and methods. A total of 42 patients with advanced-stage AS, who were older than 18 years and met the 1984 modified New York criteria with a disease duration of ≤5 years, were examined. …”
Get full text

Unravelling the pathogenic role and genotype-phenotype correlation of the USH2A p.(Cys759Phe) variant among Spanish families. by Raquel Pérez-Carro, Fiona Blanco-Kelly, Lilián Galbis-Martínez, Gema García-García, Elena Aller, Blanca García-Sandoval, Pablo Mínguez, Marta Corton, Ignacio Mahíllo-Fernández, Inmaculada Martín-Mérida, Almudena Avila-Fernández, José M Millán, Carmen Ayuso

“…(Cys759Phe) allele.<h4>Materials and methods</h4>Diagnosis was set according to previously reported protocols. …”
Get full text

Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Co... by Feng Y, Jia JM, Cheng YX, Lin J, Zhang XY, Wang YZ, Zuo YB

“…Whether remimazolam and propofol combined with flumazenil reversal can accelerate the recovery and enhance hemodynamic stability remains controversial.Methods: Fifty patients aged 18– 70 years with American Society of Anesthesiologists (ASA) class I–III and Child-Pugh classification A or B undergoing elective laparoscopic partial hepatectomy were enrolled. …”
Get full text

Endoscopic signs of gastroesophageal reflux disease with different hiatal hernias types by A. O. Nykonenko, Ye. I. Haidarzhi, О. М. Kiosov

“…The aim of the research was to study the endoscopic signs of gastroesophageal reflux disease with the most common hiatal hernia type I and type III. Materials and methods. The examination results of 153 patients with GERD and the most common hiatal hernia type I and type III at the stage of preparation for antireflux surgical treatment were analyzed. …”
Get full text

18F−Prostate−Specific Membrane Antigen PET/CT imaging for potentially resectable pancreatic cancer (PANSCAN−2): a phase I/II study by Jisce R. Puik, Thomas T. Poels, Gerrit K. J. Hooijer, Matthijs C. F. Cysouw, Joanne Verheij, Johanna W. Wilmink, Elisa Giovannetti, Geert Kazemier, Arantza Farina Sarasqueta, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg

“…This phase I/II study aimed to assess the feasibility of 18F-PSMA PET/CT to detect PDAC. Methods Seventeen patients with clinically resectable PDAC underwent 18F-PSMA PET/CT prior to surgical resection. …”
Get full text

An explainable AI-driven deep neural network for accurate breast cancer detection from histopathological and ultrasound images by Md. Romzan Alom, Fahmid Al Farid, Muhammad Aminur Rahaman, Anichur Rahman, Tanoy Debnath, Abu Saleh Musa Miah, Sarina Mansor

“…This research introduces the Deep Neural Breast Cancer Detection (DNBCD) model, an explainable AI-based framework that utilizes deep learning methods for classifying breast cancer using histopathological and ultrasound images. …”
Get full text

Immediate Analgesic Efficacy of Acupuncture in Acute Postoperative Pain Following Internal Fixation of Intertrochanteric Femoral Fractures: Protocol for a Randomized Controlled Tri... by Wang H, Wang T, Tang X, Tang X, Li C, Deng Y, Li Q, Liang F, Liao J, Guo T

“…The primary outcome will be pain intensity measured by the Visual Analogue Scale (VAS) at 10 minutes post-treatment. …”
Get full text

A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study by Shilin Li, Mingfeng Lu, Lilian Zhao, Lilei He, Weifeng Fan, Jie Zhou, Sumin Yan

“…Abstract Objective To introduce a novel infrapatellar fat pad (IPFP) preservation technique for anterior cruciate ligament reconstruction (ACLR) and evaluate its efficacy in reducing postoperative pain and enhancing functional recovery of the knee, assessing its impact on postoperative IPFP fibrosis, intra-articular inflammation, and cartilage degeneration progression. Methods This study included 86 anterior cruciate ligament (ACL) tear patients treated at Foshan Hospital of Traditional Chinese Medicine between May 2019 and June 2022. …”
Get full text

Additive Therapeutic Effects of Topical Sirolimus Following Oral Propranolol Therapy for Kaposiform Hemangioendothelioma by Xiu B, Xu Z, Xu Z, Zhang B, Wei L, Ma L

“…Sequential topical sirolimus may enhance outcomes while minimizing systemic toxicity.Objective: To evaluate the additive therapeutic effect and safety of topical sirolimus in KHE patients with suboptimal response after oral propranolol.Methods: This retrospective study included five pediatric patients with cutaneous KHE treated at Beijing Children’s Hospital from October 2018 to October 2022. …”
Get full text

A bibliometric analysis of studies related to the nuclear factor kappa B signaling pathway in knee osteoarthritis between 2004 and 2023 by Yafeng Mo, Jiahao Chu, Tiewu Chen, Wenbing Liu, Jing Tang

“…ObjectiveThis study aimed to identify the principal research areas and trends in the nuclear factor kappa B (NF-κB) signaling pathway in knee osteoarthritis (KOA).MethodsThe Web of Science core collection (WoSCC) database was searched for studies related to the NF-κB signaling pathway in KOA published between 2004 and 2023. …”
Get full text

Holiday Weight Change in a US College Student Sample: A Prospective Observational Cohort Study by Hannah B. Yoo, Casen Bigham, Tanisha Basu, Sharmin Akter, Tiffany Tsai, Alexis Brown, Sara Kiros, Shruthi Durai, Claire Brown, Martin Binks

Get full text

An Analysis of the Vocational-Educational Problematics for Substantiating Production Specialist Competencies by V. E. Steinberg, L. V. Vakhidova, E. M. Gabitova

“…The methodology was designed for the differentiation, specification and justification of relevant specialised competencies, which complement universal and general professional competencies documented in educational standards.Methodology and research methods. As a research methodology, a causal approach was used, specifically implemented in the form of a multi-dimensional matrix informing a stage-by-stage analysis, which links the need for qualified personnel (experts, who have necessary competencies) with the pedagogical conditions for their preparation (formation of necessary competencies in students).Results and scientific novelty. …”
Get full text

DISSECTING AORTIC ANEURYSM IN REAL–LIFE CLINICAL PRACTICE: DIAGNOSTICS, TREATMENT AND PROGNOSIS by S. V. Seleznev, I. A. Baranova, E. P. Krivonosova, N. V. Kuvychlina, K. G. Pereverzeva, L. P. Kalinina

“…Objective: analysis of clinical features of the dissecting aortic aneurysm (DAA) and factors affecting prognosis in a group of 40 patients, hospitalized in Ryazan Regional Cardiology Dispensary during 2008–2012.Material and methods. We have analyzed clinical data of 40 patients with DAA, assessed their survival and identified factors affecting prognosis.Results. …”
Get full text

Efficacy of platelet-rich plasma in meniscal repair surgery: a systematic review of randomized controlled trials by Giovanni Sergio Utrilla, Irene Roman Degano, Riccardo D’Ambrosi

“…The secondary objective was to identify potential bias-inducing elements in the analyzed studies. Methods In December 2023, a systematic search was conducted in PubMed, Cochrane, Embase, and Scopus for randomized controlled trials. …”
Get full text