Differential dynamic functional network connectivity in different motor subtypes of Parkinson's disease by Yu Pan, Hang Qu, Yi Zhao, Zhaoxia Qin, Jiangbing Liu, Wei Wang

“…Therefore, this study aimed to explore brain networks’ dynamic functional connectivity characteristics in patients with TD and ARD PD and their correlation with clinical symptoms. Methods: This study included 37 patients with TD PD, 33 with ARD PD, and 30 healthy controls (HCs). …”
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Feasibility of an at-home telerehabilitation programme for upper limb impairment post-stroke by Louise van Wyk, Maatje Kloppers, Lee-Ann J. Jacobs-Nzuzi Khuabi

“…Setting: Bishop Lavis, South Africa, a low-income area. Methods: A single-site parallel randomised feasibility study was conducted. …”
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Transcriptomic and metabolomic analyses reveal phenolic metabolism regulated by melatonin in pear peel by Shuai Yan, Liangliang Zhao, Deying Zhao, Gongxun Xu, Yufei Wang, Zhiqin Zhou, Cungang Cheng

“…However, the mechanisms by which pre-harvest application of melatonin regulates the metabolism of phenolic compounds in pear pericarp remain poorly understood. Methods In this study, the effect of pre-harvest spraying of melatonin on the synthesis of phenolics in pear peel and the regulatory mechanism were investigated using a multi-disciplinary approach, integrating physiological and biochemical, transcriptomic, and metabolic analyses, and the “Yuluxiang” pear as the test material. …”
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Breast cancer burden (1990–2040) in individuals aged 55 and above: a GBD 2021 analysis of global trends, sex-specific risk factors, and intervention impact by Shimao Jian, Wanmei Lin, Yuewen Tang, Guangyu Yao

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A Study on the Effects of Gluteal Muscle Activation on the Electromyography of Lower Limb Muscles in Young Male Patients With Patellofemoral Pain Syndrome by Wu Yue, Ren Shuang, Huang Hongshi, Ao Yingfang, Gou Bo

“…This study aims to investigate the impact of gluteal muscle activation exercises on the muscle involvement and movement patterns of young male patients with PFPS. Methods Our study was a randomized controlled clinical trial study from June 2020 to December 2021, included 18 young male patients with PFPS, randomly divided into two groups: the gluteus activation group (GAG) and control group (CON), with nine cases in each group. …”
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Evaluation of the impact of a course of therapy with an injectable form of chondroitin sulfate on the duration of remission and quality of life in patients with osteoarthritis by P. S. Kovalenko, I. S. Dydykina, O. G. Alekseeva, E. L. Shakhramanova, A. S. Potapova, S. I. Glukhova, E. G. Zotkin

“…Parenteral forms of chondroitin sulfate (CS) used for the background therapy of OA are characterized by proven efficacy and safety and, compared to oral forms, have greater bioavailability, faster onset of symptom-modifying effect and maintenance of more stable remission, which can significantly improve patients' quality of life.Objective: to evaluate the clinical efficacy and safety of two-month therapy with injectable CS and the duration of positive dynamics after the end of treatment in patients with knee OA (KOA).Material and methods. The open prospective observational study involved 35 patients (mainly women) aged 50–75 years with stage II–III KOA. …”
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Effectiveness of Intravitreal Dexamethasone Implant Treatment for Diabetic Macular Edema in Vitrectomized Eyes by Hüseyin Baran Özdemir, Murat Hasanreisoğlu, Murat Yüksel, Mestan Ertop, Gökhan Gürelik, Şengül Özdek

“…Objectives:To report the effectiveness and long-term outcomes of intravitreal dexamethasone implantation for diabetic macular edema (DME) in vitrectomized eyesMaterials and Methods:Medical records of patients were retrospectively reviewed. …”
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The Impact of Obesity on Pain Perception During and After Subcutaneous Injections: A Cross-Sectional Analysis by Candelaria de la Merced Díaz-González, Josefa María Ramal-López, Milagros de la Rosa-Hormiga

“…Previous studies have found higher levels of pain in people with obesity receiving SC insulin, and this study thus aimed to measure pain levels <i>during</i> and <i>after</i> an SC injection of low-molecular-weight heparin (LMWH) and identify how age, gender, and obesity may modulate the level of pain <i>during</i> and <i>after</i> the procedure. (2) Methods: This was a cross-sectional study, and the variables included age, gender, body mass index (BMI), BMI quartile, abdominal skin folds (ASFs), ASF quartile, and pain level <i>during</i> and <i>after</i> injection. …”
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A Nomogram Based on S100A7 and Clinicopathological Characteristics to Predict the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study by Zhang T, Yu X, Yang X, Li Y, Li X, Ma L

“…In this study, we investigated whether S100A7 can be used to predict the efficacy of neoadjuvant chemotherapy (NAC) and assessed its relationship with clinicopathological characteristics in BC.Methods: We retrospectively analyzed the clinicopathological data of patients with BC who underwent NAC at the Fourth Hospital of Hebei Medical University between January 2021 and December 2021. …”
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Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

“…The instructions were to meditate on the connection to a Universal Soul linked to a sense of expansion and universal connectedness (“one with everything”), which was prompted by a video of the galactic nebula that also controlled for the visual stimuli of the two other conditions.MethodsNine healthy adults (mean age = 29; range = 19–42; 5 women) underwent a block design fMRI scan using a Siemens 3T Prisma scanner. …”
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Omega-3 Polyunsaturated Fatty Acids Effect on Neuropathy of the Peripheral Nervous System in Dietary Obese Rats: Is the Source of These Fatty Acids Important for Outcome? by Davidson E, Obrosov O, Coppey L, Yorek M

“…However, other sources exist that could be a better environmental, safety, and/or economic choice.Methods: Male Sprague Dawley rats 12 weeks of age were fed a 45% kcal diet to induce obesity and model pre-diabetes. …”
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OTX2 expression contributes progression of gastric cancer in young adults by Jingming Zhai, Ting Lyu, Yimin Guo, Yanhui An, Yali Xiang, Linying Xie, Chao Zeng

“…However, there are few reports regarding the genetic alteration in gastric cancer of young adults. Bioinformatics methods were used to screen the key genes and signaling pathways of gastric cancer in young adults, and molecular biology techniques were used to verify the key proteins involved in the occurrence and development of gastric cancer in young adults. …”
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Pre‐Percutaneous Coronary Intervention C‐Reactive Protein Levels and In‐Stent Restenosis: A Systematic Review and Meta‐Analysis by Himanshu Rai, Renitha Reddi, J. J. Coughlan, Rory Durand, Daniel O'Callaghan, Roisin Colleran, Robert A. Byrne

“…Against this background, we performed a systematic review and meta‐analysis, investigating the association between baseline CRP levels and the incidence of ISR after PCI. Methods Relevant published studies were identified following a PubMed, EMBASE, MEDLINE, Scopus and Web of Knowledge databases search until April 30, 2024. …”
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Role of Sesamoid Position and Recurrence of Hallux Valgus Deformity by Thomas L. Lewis BSc (Hons) MBChB (Hons) FRCS (TrMFSTEdOrth), Robbie Ray MBChB, ChM(TFRCSed(TrO) FEBOTOrth), Evelyn Murphy MBBCh BAO MCh FRCS (TrOrth), Min Jia Chua MB BS FRCSEd, Clare Watt BNurs, Peter Robinson BSc(Hons), MBChB, FRCS(TrOrth), Peter Lam MBBS (Hons), FRACS, FAOA

“…The aim of this study was to investigate the role of sesamoid position and impact on recurrence of hallux valgus deformity following percutaneous minimally invasive hallux valgus surgery. Methods: A prospectively maintained research registry of fourth-generation percutaneous metatarsal extra-capsular transverse osteotomy (META) for hallux valgus between 2017-2023 was retrospectively analysed to identify feet that had recurrence of hallux valgus deformity (defined as HVA>20°). …”
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Safety profile of ramelteon from the perspective of physicians and pharmacists: a 20-year real-world pharmacovigilance analysis based on the FAERS database by Jianhong Wu, Yujie Zhou, Linghe Qiu, Liang Liu, Fei Wang, Lili Zhen, Na Li

“…This study analyzes adverse events associated with ramelteon based on data from the FDA Adverse Event Reporting System (FAERS) database. Methods Case reports submitted by physicians and pharmacists were extracted from the FAERS database from the first quarter of 2005 to the third quarter of 2024. …”
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Unilateral Biportal Endoscopic Debridement and Drainage for Lumbar Infectious Spondylodiscitis: A Retrospective Study and Preliminary Results by Chu R, Cui W, Chen W, Zhuang Y, Yin G, Peng W, Zhang S

“…This study aims to evaluate the clinical efficacy of unilateral biportal endoscopic (UBE) debridement and drainage for treating lumbar infectious spondylodiscitis.Methods: We retrospectively analysed sixteen patients diagnosed with lumbar infectious spondylodiscitis who underwent UBE debridement and drainage between April 2022 and July 2023. …”
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Public self-reported adverse experience and knowledge about use of herbal and dietary supplements by Kamonphat Wongtaweepkij, Satchawit Srinonghang, Wiriya Youngpattana, Krittin Summa, Sonthiya Papenkort, Anthony R. Cox, Narumol Jarernsiripornkul

“…This study aims to explore use, adverse experiences, self-assessed knowledge and perspectives on HDS among the general public in Thailand. Methods A cross-sectional self-administered survey in the general public conducted in 6 public areas in a large city of northeastern Thailand, over 5-month period. …”
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Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000&amp;ndash;May 2024). Trends, Collaborations, and Emerging Insights by Wang Z, Bi H, Li D, Zhang W, Wang C, Yang J, Shen X, Yan R, He F, Duan H

“…The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.Patients and Methods: Publications on exosomes in SCI were identified from the Web of Science Core Collection using specific search criteria. …”
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Small-dose esketamine combined with sufentanil reduces perioperative inflammation in elderly patients with total hip replacement by YANG Wen, LI Yong, YANG Zhuoxuan

“…Objective To analyze the impact of low-dose esketamine combined with sufentanil on peri-operative inflammation and immune function of elderly patients undergoing total hip arthroplasty (THA). Methods From January 2019 to January 2022, 120 elderly patients who underwent THA under combined spinal-epidural anesthesia and received patient-controlled intravenous analgesia (PCIA) were included. …”
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Open and arthroscopic debridement for lateral epicondylitis: a systematic review and meta-analysis based on comparative studies by Bo Tang, Cheng Fan, Yuan He

“…Abstract Objective To systematically compare and meta-analyse the clinical efficacy of open and arthroscopic debridement for patients with lateral epicondylitis. Methods A retrieval and systematic review of comparative studies of lateral epicondylitis treated with open versus arthroscopic debridement was conducted, and further pooled analysis was performed to compare the overall differences in clinical outcomes, including pain and elbow function scores, surgical time, complications and revision surgery rate. …”
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