Identification of hypoxia-related diagnostic biomarkers and immune signatures in diminished ovarian reserve by Minxue Song, Lili Ni, Zebing Ma, Xin Zhong, Yibing Liu, Jilin Kuang, Ping Li

“…This study investigated the genetic links between hypoxia and DOR.MethodsThe GSE87201 dataset for DOR was sourced from Gene Expression Omnibus database, normalized for common differentially expressed genes (Co-DEGs), and identified Hypoxia-related differentially expressed genes (HRDEGs) via GeneCards; Receiver Operating Characteristic (ROC) curves evaluated HRDEGs’ diagnostic value, and protein-protein interaction networks were visualized with STRING and Cytoscape. …”
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Feasibility of home initiation of an airway clearance device (SIMEOX) by telecare in people with non-cystic fibrosis bronchiectasis: a pilot study by Jean-Christian Borel, Nathalie Arnol, Sylvie Leroy, Marlène Murris-Espin, Rebecca Hamidfar, Marie Mahot, Raphael Abouly, Hughes Gauchez, Sophie Jacques, Eloise Joffray, Laurent Morin

“…We hypothesised that telecare would be an effective means to train people with NCFB in the handling of device and to monitor and promote device adherence.Objectives (1) To evaluate frequency of use of the SIMEOX for 10 weeks after telecare training. (2) To assess user satisfaction and clinical efficacy of the SIMEOX+telecare.Methods Multicentre, prospective, pilot study in adults with NCFB. …”
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Ocular manifestations in pediatric tumor suppressor gene mutations: a case series and literature review of RB1, NF1, NF2, VHL, and TSC by Aoxiang Wang, Chanyuan Wang, Wen Li, Jing Qiao, Yulin Luo, Yu Tian

“…We have summarized the ocular presentations of these common tumor suppressor gene mutations in pediatric patients. Methods We reviewed 11 representative case reports, documenting in detail the ocular manifestations and progression of each case. …”
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Risk prediction of stroke-associated pneumonia in acute ischemic stroke with atrial fibrillation using machine learning models by Tai Su, Peng Zhang, Peng Zhang, Bingyin Zhang, Zihao Liu, Zexing Xie, Xiaomei Li, Jixiang Ma, Tao Xin

“…Univariate analysis and LASSO regression analysis methods were used to screen predictors. The patients with AIS and AF were randomly divided into a training set, validation set, and test set. …”
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18F-FDG PET/CT-based deep learning models and a clinical-metabolic nomogram for predicting high-grade patterns in lung adenocarcinoma by Yue Guo, Xibin Jia, Chuanxu Yang, Chao Fan, Hui Zhu, Xu Chen, Fugeng Liu

“…Abstract Background To develop and validate deep learning (DL) and traditional clinical-metabolic (CM) models based on 18 F-FDG PET/CT images for noninvasively predicting high-grade patterns (HGPs) of invasive lung adenocarcinoma (LUAD). Methods A total of 303 patients with invasive LUAD were enrolled in this retrospective study; these patients were randomly divided into training, validation and test sets at a ratio of 7:1:2. …”
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Symptom variability in outpatients with COPD and validation of the Colombian COPD Symptom Variability Instrument (EPOC-CoVaSy) by Eidelman Antonio González-Mejía, Olga Constanza Uñate-Suárez, Carlos José Bula- Gutiérrez, Yojana Patricia Patiño-Jiménez

“…Objectives: To describe symptom variability in patients with COPD throughout the day and night for four weeks using a patient diary, and to validate a questionnaire created for such purpose (Colombian Self-Administered Instrument of Symptom Variability in COPD - EPOC-CoVaSy). Materials and methods: Cohort study conducted in 96 patients with COPD treated between June and December 2016 at the Centro de Atención Pulmonar – CAP in Barranquilla, Colombia, who filled out a patient diary for four weeks and, after this period, the self-administered EPOC-CoVaSy instrument. …”
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Exploring the influences of myopia in primary and secondary school students in Xinjiang using propensity score matching by Xiaopeng Hu, Xianyan Yuan, Hua Li, Haoxuan Gong, Zhicong Fu, Yuting Xie, Lin Zhu, Haina Chen, Yingli Yang, Dongsheng Rui

“…ObjectiveDue to the high prevalence of myopia among primary and secondary school students in Shihezi City in recent years, this study was conducted to understand the prevalence and the factors influencing it and to provide a scientific basis for future interventions to improve, protect, and promote the visual health of these students.MethodsThe study population consisted of primary and secondary school students in Shihezi City. …”
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Treatment of Hallux Rigidus: Comparison of Hemiarthroplasty with Cartiva Implant, Allograft Interpositional Arthroplasty, and Arthrodesis by Ryan Sanii MD, MPH, Kevin Phan MD, Drew Krumm MD, Daniel J. Patton MD, Tyler Madden MD, John G. Anderson MD, John D. Maskill MD, Donald R. Bohay MD, FACS, Michelle A. Padley PhD, Cameron G. Patthanacharoenphon MD

“…Methods: A retrospective cohort study of 99 patients was performed. …”
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Safety and efficacy of mycophenolate mofetil in treating neuromyelitis optica spectrum disorders: a protocol for systematic review and meta-analysis by Yang Chen, Ming Jin, Mengyu Han, Luqi Nong, Ziqiang Liu, You Chen, Huan Meng, Yali Qin, Zhijun Wang

“…This research aims to perform a direct and comprehensive systematic review and meta-analysis to evaluate MMF’s effectiveness and safety in treating NMOSD.Methods and analysis This systematic review will cover all comparative researches, from randomised controlled trials to cohort studies, and case–control study. …”
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Comparison of percutaneous endoscopic lumbar discectomy (PELD) and unilateral biportal endoscopic (UBE) discectomy in the treatment of far lateral lumbar disc herniation (FLLDH): a... by Liang Li, Jilong An, Lei Guo, Xiuqi Shan, Yapeng Sun, Jiaqi Li, Fei Zhang, Wei Zhang

“…Abstract Purpose This study aimed to compare the clinical efficacy of percutaneous endoscopic lumbar discectomy (PELD) and unilateral biportal endoscopic (UBE) discectomy in treating patients with far lateral lumbar disc herniation (FLLDH). Methods From January 2020 to January 2022, 65 patients with FLLDH underwent either PELD or UBE discectomy. …”
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Gut Microbial Signatures in Long COVID: Potential Biomarkers and Therapeutic Targets by Soyoung Oh, Sujin An, Kihyun Park, Soohyung Lee, Yoo Min Han, Seong-Joon Koh, Joowon Lee, Hyerin Gim, Donghyun Kim, Haesook Seo

“…Here, we aimed to investigate connections between the gut microbiota and long COVID severity. Methods Fecal samples were collected from 31 patients with long COVID, 14 with COVID-19 but not long COVID, and 23 healthy controls. …”
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Deep learning-based cough classification using application-recorded sounds: a transfer learning approach with VGGish by Sanghoon Han, Yu-rim Lee, Ji-ho Lee, JinHee Jeon, Choongki Min, Kyungnam Kim, Donghoon Kim, Myung Pyo Kim, Young Mi Park, Uiri An, Kyoung Min Moon

“…Additionally, we examined how clinical expertise and diagnostic input influence the model’s generalization performance. Methods This study introduces a deep learning framework utilizing VGGish as a transfer learning model, enhanced with additional detection and classification networks. …”
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UK Medical Cannabis Registry: An Analysis of Outcomes of Medical Cannabis Therapy for Hypermobility‐Associated Chronic Pain by Mary Dickinson, Simon Erridge, John Warner‐Levy, Evonne Clarke, Katy McLachlan, Ross Coomber, Wendy Holden, James J. Rucker, Michael W. Platt, Mikael H. Sodergren

“…Objective The study aims to evaluate the clinical outcomes in patients with hypermobility spectrum disorder (HSD) and hypermobile Ehlers–Danlos syndrome (hEDS) with chronic pain following treatment with cannabis‐based medicinal products (CBMPs). Methods This was a case series conducted with the UK Medical Cannabis Registry. …”
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Evaluation of lateral flow devices for rabies diagnosis in decomposed animal brain samples by Ryota Todoroki, Joely T. Ongtangco, Kazunori Kimitsuki, Nobuo Saito, Milagros R. Mananggit, Cornelio R. Velasco, Jaira D. Mauhay, Alyssa M. Garcia, Catalino S. Demetria, Yamada Kentaro, Akira Nishizono

“…This study evaluates the diagnostic accuracy of the ADTEC lateral flow device (LFD) for rabies post-mortem diagnosis using decomposed brain samples. Methods We used 34 animal heads submitted with a cold chain to an animal diagnostic laboratory located in central Philippines including 26 DFAT-positive and eight DFAT-negative samples. …”
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Association between circulating plasma CTRP3 levels and acute ischemic stroke: a systematic review and meta-analysis by Qingsheng Niu, Qingsheng Niu, Qingsheng Niu, Ziyi Zhu, Yaowen Jiang, Yaowen Jiang, Zhi Wan, Zhi Wan

“…This meta-analysis aims to investigate the association between circulating CTRP3 levels and acute ischemic stroke.ObjectiveThe objective of this meta-analysis is to re-evaluate the relationship between circulating CTRP3 levels and acute ischemic stroke.MethodsWe conducted a comprehensive search across PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang Data, and CBM to identify relevant studies up to February 2025 and 110 articles were found. …”
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A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer by Shogen Boku, Hironaga Satake, Seiichiro Mitani, Kiyoshi Maeda, Toshihiro Kudo, Toshifumi Yamaguchi, Tatsuya Takagi, Hisato Kawakami, Hisato Kawakami

“…We evaluated the efficacy and safety as well as the optimal dosage of L.E.M. extract for OIPN in patients with colorectal cancer (CRC).MethodsAfter curative resection, we used a 1:1:1 ratio to randomly assign patients with CRC with persistent OIPN (defined by a visual analogue scale [VAS] numbness score ≥40 mm) to the low-dose (L.E.M. 300 mg twice daily [bid]), high-dose (L.E.M. 900 mg bid), and placebo groups. …”
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Percutaneous unilateral biportal endoscopy versus uniportal endoscopy for lumbar spinal stenosis: a single-centre, prospective, non-randomised cohort trial protocol by Xiang Li, Yong Yang, Lingjia Yu, Haining Tan, Yuquan Liu, Guangpeng Li, Yuanshun Lo, Zhu Bin

“…Therefore, the present prospective study aimed to compare the efficacy and safety of UBE and UE for treating patients with LSS.Methods and analysis This single-centre, prospective, non-randomised cohort trial is designed to compare the efficacy and safety of UBE and UE in treating patients with LSS. …”
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Analgesia and sedative effects of a fixed nitrous oxide/oxygen mixture on supragingival scaling patients: a study protocol for a randomised controlled trial by Lu Tang, Yuchen Wang, Fan Sun, Chenxi Sun, Xiaochen Jiang, Weifeng Wang, Xueling Qiu, Xiaona Sui, Lingjun Zhou

“…The purpose of this study is to explore the safety and effectiveness of a fixed inhaled nitrous oxide/oxygen mixture analgesia technology in the process of supragingival scaling and to provide empirical evidence for patients to reduce pain and reduce anxiety during supragingival scaling.Methods and analysis This is a randomised, double-blind, placebo-controlled trial that is expected to enrol 120 patients. …”
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Modifying quantitative sensory testing to investigate tactile sensory function and behavioral reactivity in children with intellectual and developmental disabilities: establishing... by Jaclyn Gunderson, Emma Worthley, Breanne Byiers, Alyssa Merbler, Andrea Huebner, Deanna Hofschulte, Jasmine Lee, Catherine Riodique, Frank Symons

“…The current study aimed to (a) replicate the feasibility of a modified quantitative sensory test (mQST) with a sample of children with NDDs, (b) assess validity evidence based on behavioral reactivity during mQST application and the corresponding behavioral measurement coding system, and (c) explore group differences in behavioral reactivity to mQST stimuli by demographic (sex), clinical (autism status), and behavioral pathology (self-injury) variables. Methods The mQST protocol was implemented and blindly coded across 47 participants aged 2–12 years (M age = 6.7 years, SD = 2.6; 70% male) with NDDs. …”
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A Comparative Study between Transcutaneous Electrical Nerve Stimulation and Fentanyl to Relieve Shoulder Pain during Laparoscopic Gynecologic Surgery under Spinal Anesthesia: A Ran... by Zahra Asgari, Zahra Tavoli, Reihaneh Hosseini, Masoomeh Nataj, Fatemeh Tabatabaei, Fatemeh Dehghanizadeh, Hosein Haji-Amoo-Assar, Mahdi Sepidarkish, Ali Montazeri

“…This study aimed to compare the effect of transcutaneous electrical nerve stimulation (TENS) with fentanyl on pain relief in patients who underwent gynecologic laparoscopy under spinal anesthesia. Methods. We conducted a prospective randomized clinical trial from May 2016 to March 2017. …”
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