AN OPEN-LABEL MULTICENTER OBSERVATIONAL STUDY OF THE EFFICACY, TOLERABILITY, AND SAFETY OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG AMTOLMETIN GUACIL IN PATIENTS WITH KNEE OSTEOARTH... by E. S. Tsvetkova, L. N. Denisov, A. N. Otteva, A. L. Dubikov, S. P. Yakupova, O. N. Ivanova, N. I. Korshunov, A. R. Vaisberg, R. A. Abyshev, A. V. Tartynov, E. L. Nasonov

“…Reddy's Laboratories Ltd, India) versus previous therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with knee osteoarthritis (OA) and signs of dyspepsia.Subjects and methods. The open-label observational study included 220 patients aged 30–65 years who suffered from knee OA and intense pain during NSAID intake and had symptoms of dyspepsia in the absence of contraindications to the use of AMG. …”
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Association of cervical artery stenosis with common cerebral microvascular lesions and coronary artery calcifications by Chiheb Louizi, Eya Khadhraoui, Eya Khadhraoui, Joachim Lotz, Joachim Lotz, Joachim Lotz, Daniel Behme, Daniel Behme, Erelle Fuchs, Johannes T. Kowallick, Johannes T. Kowallick, Sebastian J. Müller, Sebastian J. Müller

“…While white matter hyperintensities are often associated with small vessel disease, atherosclerosis is the primary cause of coronary artery disease.MethodsWe evaluated staging CT scans of the body and staging brain MRIs from patients with newly diagnosed malignant melanoma (without metastasis) between 01/01/2015 and 06/30/2023. …”
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Hybrid Deep Learning for Survival Prediction in Brain Metastases Using Multimodal MRI and Clinical Data by Cristian Constantin Volovăț, Călin Gheorghe Buzea, Diana-Ioana Boboc, Mădălina-Raluca Ostafe, Maricel Agop, Lăcrămioara Ochiuz, Ștefan Lucian Burlea, Dragoș Ioan Rusu, Laurențiu Bujor, Dragoș Teodor Iancu, Simona Ruxandra Volovăț

“…<b>Background:</b> Survival prediction in patients with brain metastases remains a major clinical challenge, where timely and individualized prognostic estimates are critical for guiding treatment strategies and patient counseling. <b>Methods:</b> We propose a novel hybrid deep learning framework that integrates volumetric MRI-derived imaging biomarkers with structured clinical and demographic data to predict overall survival time. …”
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Icarisid Ⅱ modulates mitochondrial dynamics for anti-HBV activity by Zhengyun Liu, Haiyan Yang, Juan Wen, Dongyan Xiao, Dongyan Xiao, Wan Yu, Guo Luo, Qihai Gong, Huan Wang

“…IntroductionTo investigate the potential anti-hepatitis B virus (HBV) activity of Icariside Ⅱ (ICS Ⅱ), and elucidate its underlying mitochondrial dynamics mechanisms.MethodsThe study employed in vivo and in vitro assays to evaluate anti-HBV effects of ICS Ⅱ. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…BackgroundAlthough finger joint capsulitis has been described among the most frequent injuries in climbers, no clinical studies on treatment strategies and outcomes are available.Study designProspective case series study.MethodsBetween 2015 and 2018 we prospectively treated 50 patients (38 male, 12 female) with a total number of 69 independent finger joint capsulitis according to a clinic specific treatment regimen and evaluated the outcome retrospectively. …”
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Comparative study of the vascular structures of the retina and choroid in Chinese Han and Uygur populations with proliferative diabetic retinopathy: An OCTA study by Yunxian Gao, Zhumahan Tuokedaerhan, Jie Zhang, Lei Yang, Yani Zhang, Wanying Cheng, Yong Zhao, Jiawei Wang

“…Background: To compare the vascular structures of the retina and choroid in Chinese Han and Uygur populations with proliferative diabetic retinopathy (PDR) using swept-source OCTA (SS-OCTA). Methods: Fifty-three eyes of 53 healthy volunteers (25 from Hans and 28 from Uygurs) and 40 eyes of 40 PDR patients (20 from Hans and 20 from Uygurs) were included. …”
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Influence of L-tryptophan use on the dynamics of cognitive functions in the complex therapy of delayed psycho-speech development in children by V. M. Polyakov, L. V. Rychkova, T. A. Belogorova, V. I. Mikhnovich, O. V. Bugun, O. N. Berdina, Zh. V. Prokhorova, T. A. Teterina, L. N. Lebedeva, L. I. Lebedeva

“…The purpose of this study is to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3–7 years with delayed psycho-speech development (DPSD). …”
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Resting-State Functional MRI in Dyslexia: A Systematic Review by Bruce Martins, Isabel A. B. Verrone, Mariana M. I. Sakamoto, Mariana Y. Baba, Melissa E. Yvata, Katerina Lukasova, Mariana P. Nucci

“…By synthesizing extant evidence, this work aims to clarify dyslexic connectivity profiles and provide a foundation for future research and clinical translation. <b>Methods:</b> This systematic review analyzed publications from the last 10 years in two scientific databases, focusing on individuals with dyslexia, without previous injuries, who underwent resting-state functional magnetic resonance imaging (rs-fMRI) assessments, comparing them with typical readers. …”
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Dual Attention-Based Global-Local Feature Extraction Network for Unsupervised Change Detection in PolSAR Images by Dazhi Xu, Ming Li, Yan Wu, Peng Zhang, Xinyue Xin

“…Numerical experiments on five real spaceborne PolSAR datasets demonstrate that our DA-GLN is more competitive than other state-of-the-art methods.…”
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Hydrodissection technique for pain relief during peri-microwave ablation in patients with subpleural non-small cell lung cancers by Nan Wang, Tianyu Xue, Peng Liu, Pikun Cao, Jingwen Xu, Zhigang Wei, Xin Ye

“…Purpose This study aimed to assess the application value of the hydrodissection technique (HT) for pain relief during peri-microwave ablation (MWA) in patients with subpleural non-small cell lung cancers (NSCLCs).Methods This retrospective study comprised 218 patients with subpleural NSCLCs who underwent computed tomography (CT)-guided percutaneous MWA. …”
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Assessing the cataract surgical rate and gender equity in cataract services in south-east Nigeria by Clare Gilbert, Onyinye Onyia, Ada Ejealor Aghaji, Christiana Ubaka, Eberechukwu Ogbeanu Achigbu, Ifeoma Lilian Ejiakor, Adaku I Mbatuegwu, Chiamaka J P Okeke, Barbara C Okoli, Emmanuel U Ogborogu, Kenneth C Dike, Florence U Nkwogu

“…The aim of this study was to assess the CSR in men and women in Imo state, Nigeria.Methods A retrospective review of cataract surgery undertaken in all eye health facilities in Imo State in 2019. …”
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Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial by Cyrus Cooper, J-Y Reginster, R Chapurlat, C Christiansen, H Genant, N Bellamy, W Bensen, F Navarro, J Badurski, E Nasonov, X Chevalier, P N Sambrook

“…We describethe rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis.Research design, methods, and results: This double-blind, placebo-controlled trial (98 centres, 18 countries) includes ambulatory Caucasian men and women aged ≥50 years with primary knee osteoarthritis of the medial tibiofemoralcompartment (Kellgren and Lawrence grade 2 or 3), joint space width (JSW) 2.5 to 5 mm, and knee pain on most days in the previous month (intensity ≥40 mm on a visual analogue scale). …”
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Clinical Features of Patients with Exfoliation Glaucoma Requiring Surgical Intervention by Hideyuki Nakano, Tetsuya Togano, Yuta Sakaue, Aki Suetaka, Ryu Iikawa, Rieko Nakano, Takeo Fukuchi

“…Retrospective study. Methods. The study included 46 eyes from 36 XFG patients, 85 eyes from 53 primary open-angle glaucoma (POAG) patients, and 54 eyes from 35 normal-tension glaucoma (NTG) patients. …”
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In what context and by which mechanisms can creative arts interventions improve wellbeing in older people? A realist review protocol [version 2; peer review: 2 approved] by Geoff Wong, Anne Ferrey, Alexandra Caulfield, Jeremy Leslie-Spinks, Nia Roberts, Trish Greenhalgh, Helle Mölsted Alvesson

“…Creative arts encompass a wide range of activities, including performing arts, visual arts, design and craft, literature, culture and digital and electronic arts. …”
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Integration of Intraoperative Neurophysiological Monitoring into Laparoscopic Pelvic Nerve Decompression Surgery: A Novel Technique for Protecting Pelvic Nerves by Elif Cansu Gundogdu, Ahmet Kale, Metin Mercan, Vildan Yayla, Ugur Efe Ozcan, Taner Usta, Esra Keles

“…Background: This study aims to present a novel technique that integrates intraoperative neurophysiological monitoring (IONM) into laparoscopy for continuous monitoring of pelvic nerves at risk during surgery to ensure their protection. Methods: This is a prospective analysis of 10 consecutive patients receiving surgical treatment for proven diagnosis of lumbosacral plexus nerve entrapment. …”
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POLYMORPHISMS OF EXTRACELLULAR CONNECTIVE TISSUE REMODELING PROTEINASES AND <i>MMP2, MMP3, MMP9</i> GENES, AND NEOANGIGENESIS <i>VEGF</i> GENE IN RETINAL MICROANGIOPATHY IN THE PAT... by A. V. Shevchenko, V. F. Prokofiev, V. I. Konenkov, V. V. Klimontov, N. V. Tyan, D. V. Chernykh, A. N. Trunov, V. V. Chernykh

“…The genetic typing was carried out by restriction fragment length polymorphism and TaqMan methods.The analysis of complex genotypes at the five polymorphic positions has revealed some significant findings in positive and negatively incorporated complexes. …”
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Enhancing Pain Management and Psychological Recovery in Earthquake Victims: The Role of Continuous Regional Analgesic Techniques Assessed by QoR-15 by Ergun Mendes, Ozal Adiyeke, Onur Sarban, Melih Civan, Okyar Altas, Alperen Korucu, Funda Gumus Ozcan, Gozen Oksuz

“…The aim of this study was to observe the pain and psychological changes in earthquake victims in light of the QoR-15 score. Methods: After approval by the local ethics committee (Decision No. 2023-194), earthquake victims with catheters in trauma and reconstructive surgery were retrospectively evaluated. …”
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Biportal endoscopic lumbar discectomy surgery in patients with cauda equina syndrome caused by lumbar herniated intervertebral disc: a retrospective multi-center cohort study by Sang-Min Park, Ho-Jin Lee, Hyun-Jin Park, Ki-Han You, Jong-Hun Jung, Samuel K. Cho, Ho-Joong Kim, Jin S. Yeom

“…This study evaluates the efficacy of biportal endoscopic (BE) lumbar discectomy in treating CES caused by lumbar herniated intervertebral discs. Methods This retrospective case series includes 32 CES patients treated with BE lumbar discectomy from March 2017 to July 2022. …”
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Using spaceborne SAR and ground-based measurements to identify spatial patterns in soil moisture and seasonal thaw timing in permafrost environments of Alaska by W. Brad Baxter, Zachary Hoppinen, Kristofer Lasko, Tate Meehan, David Brodylo, Taylor D. Sullivan, Amanda J. Barker, Thomas A. Douglas

“…We integrate ground-based and spaceborne microwave methods to investigate patterns and controls on surface soil moisture (SSM) in boreal and arctic permafrost environments of Alaska. …”
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Pediatric medication management barriers faced by providers serving underserved populations and proposed solutions by Tiranun Rungvivatjarus, Tiranun Rungvivatjarus, Maria Z. Huang, Maria Z. Huang, Britanny Winckler, Britanny Winckler, Erin S. Fisher, Erin S. Fisher, Kyung E. Rhee, Kyung E. Rhee

“…This study explores provider-reported barriers and proposed solutions to improving medication management.MethodsFocus group discussions were selected to obtain data as they can provide rich insight into participants’ perspectives. …”
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