Case report: Discovery of novel CTNNB1 mutations and comparison of clinical characteristics in two patients with NEDSDV by Eojin Lee, Ja Young Choi, Shin-Seung Yang

“…Mutations in this gene can lead to neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV). This study aimed to identify CTNNB1 mutations in two patients presenting with global developmental delay and compare their distinct phenotypes. …”
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A Novel Artificial Bee Colony Algorithm Based on Internal-Feedback Strategy for Image Template Matching by Bai Li, Li-Gang Gong, Ya Li

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Predicting Compressive Strength of Concrete Containing Industrial Waste Materials: Novel and Hybrid Machine Learning Model by Mohammed Majeed Hameed, Mustafa Abbas Abed, Nadhir Al-Ansari, Mohamed Khalid Alomar

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Exploring the subtle and novel renal pathological changes in diabetic nephropathy using clustering analysis with deep learning by Tomohisa Yabe, Yuko Tsuruyama, Kazutoshi Nomura, Ai Fujii, Yuto Matsuda, Keiichiro Okada, Shogo Yamakoshi, Yuya Hamabe, Shogo Omote, Akihiro Shioya, Norifumi Hayashi, Keiji Fujimoto, Yuki Todo, Tatsuro Tanaka, Sohsuke Yamada, Akira Shimizu, Katsuhito Miyazawa, Hitoshi Yokoyama, Kengo Furuichi

“…We performed invariant information clustering (IIC)-based clustering on glomerular images obtained from nephrectomized kidneys of patients with and without diabetes. We also used visualizing techniques (gradient-weighted class activation mapping (Grad-CAM) and generative adversarial networks (GAN)) to identify the novel and early pathological changes on light microscopy in diabetic nephropathy. …”
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Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…Importantly, the ICT indirectly informs on the amount of FH that is complexed with FHAAs, thus assessing the significance of the FHAA in disrupting the regulatory function of FH. Overall, this novel assay offers a simple, fast, cost-effective, and, likely, more clinically relevant alternative for diagnosing FHAAs in at-risk populations.…”
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Anthropology and the City. Street Art in Medellín’s Comuna 13: A City-Making Practice and an Ethnographic Tool by Claudio Riga

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Kinetics and Kinematics of Shape Tracing in Children with Probable Developmental Coordination Disorder (pDCD) by Michal Hochhauser, Yfat Ben Refael, Esther Adi-Japha, Rachel Bartov

“…Background: Children with developmental coordination disorder (DCD) exhibit visual–motor deficits affecting handwriting. Shape tracing, a key prerequisite for handwriting, supports motor and cognitive development but remains underexplored in research, particularly in objectively studying its role in children with DCD. …”
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Rapid Detection of microRNA-122 in Serum and Finger Blood Using a Lateral Flow Nucleic Acid Biosensor by Min Zhang, Meijing Ma, Jiahui Wang, Yurui Zhou, Xueji Zhang, Guodong Liu

“…In this paper, we present a novel rapid testing method utilizing a lateral flow nucleic acid biosensor (LFNAB) for the sensitive and time-efficient detection of miR-122. …”
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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…Contemporary research focal points primarily concentrate on the activation and inhibition pathways of the NLRP3 inflammasome, the exploration of novel HF targets, and the association between HF and mitochondrial function. …”
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A Rare Tick Tale: A Novel Case of the Australian Paralysis Tick Causing Multiple Cranial Neuropathies by Sujan A. Surendran, Philomena McNamara, Jonathan N. Hyer, Charles S. Su

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Improving Crack Detection Precision of Concrete Structures Using U-Net Architecture and Novel DBCE Loss Function by Andrew Prasetyo, I Ketut Eddy Purnama, Eko Mulyanto Yuniarno, Priyo Suprobo

“…Conventional crack detection methods that rely on visual inspection and image processing often produce inconsistent results. …”
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A Novel Approach to Optimize Key Limitations of Azure Kinect DK for Efficient and Precise Leaf Area Measurement by Ziang Niu, Ting Huang, Chengjia Xu, Xinyue Sun, Mohamed Farag Taha, Yong He, Zhengjun Qiu

“…This study proposed a novel approach to address and optimize the limitations of the Azure Kinect DK through the multimodal coupling of RGB-D data for enhanced organ-level crop phenotyping. …”
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A Novel CRYBB2 Stopgain Mutation Causing Congenital Autosomal Dominant Cataract in a Chinese Family by Yu Zhou, Yaru Zhai, Lulin Huang, Bo Gong, Jie Li, Fang Hao, Zhengzheng Wu, Yi Shi, Yin Yang

“…Congenital cataract is the most common cause of the visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital cataract (ADCC) in a Chinese family using next-generation sequencing technology. …”
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Benzo[1,2-b:6,5-b’]dithiophene-4,5-diamine: A New Fluorescent Probe for the High-Sensitivity and Real-Time Visual Monitoring of Phosgene by Yingzhen Zhang, Jun Xiao, Ruiying Peng, Xueliang Feng, Haimei Mao, Kunming Liu, Zhenzhong Liu, Chunxin Ma

“…This work is the first to report a novel fluorescent system based on the Intramolecular Charge Transfer (ICT) effect, which can rapidly detect phosgene in both solution and gas phases with high sensitivity by integrating a benzo[1,2-b:6,5-b’]dithiophene-4,5-diamine (BDTA) probe. …”
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Tunnel Vision: A Novel Approach for Blood Clot Retrieval Using Cryotherapy through a Flexible Bronchoscope by Fernando Figueroa Rodriguez, Parminder Minhas, Houssein A. Youness

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Some novel exact solutions for the generalized time-space fractional coupled Hirota-Satsuma KdV equation by Yueling Cheng, Siyuan Hong, Shujun Yang, Xu Chi, Jinghao Yang

“…In this paper, two efficient methods, namely the modified G′/G,1/G-expansion method and the G′/bG′+G+a-expansion method, are employed to obtain novel exact wave solutions for the generalized time-space fractional coupled Hirota-Satsuma KdV equation. …”
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In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme by Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde

“…Docking studies employing gold software facilitated the visualization of ligand-protein interactions, utilizing the crystal structure of the COX-2 protein (PDB ID: 4m11). …”
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A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes by Rubén Grillo-Risco, Marta R. Hidalgo, Beatriz Martínez-Rojas, Victoria Moreno-Manzano, Francisco García-García

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Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals by Yuanqing Wang, Yuanqing Wang, Xiaojie Jiang, Yuan Xi, Siqi Wei, Songyi Ning, Wen Zhang, Wen Zhang

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Concurrent Renorrhaphy During Renal Mass Excision in Laparoscopic Nephron-Sparing Surgery: A Novel Surgical Technique by Nurullah Hamidi, Tuncel Uzel

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