Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Radiation oncologists and immunologists convened a virtual consensus discussion to identify current deficiencies, challenges, pitfalls and critical gaps when combining radiotherapy with immunotherapy and making recommendations to the field and advise National Cancer Institute on new directions and initiatives that will help further development of these two fields.This commentary aims to raise the awareness of this complexity so that the need to study radiation dose, fractionation, type and volume is understood and valued by the immuno-oncology research community. …”
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Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth by Rui Zhou, Ziqian Liu, Tongtong Wu, Xianwei Pan, Tongtong Li, Kaiting Miao, Yuru Li, Xiaohui Hu, Haigang Wu, Andrew M. Hemmings, Beier Jiang, Zhenzhen Zhang, Ning Liu

“…Identification of new selective EGFR-T790M inhibitors has proven challenging through traditional screening platforms. …”
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Anatomy Education and Training Methods in Oral Surgery and Dental Implantology: A Narrative Review by Carlo Barausse, Pietro Felice, Roberto Pistilli, Gerardo Pellegrino, Lorenzo Bonifazi, Subhi Tayeb, Irene Neri, Foteini-Dionysia Koufi, Antonietta Fazio, Maria Vittoria Marvi, Lucia Manzoli, Stefano Ratti

“…Starting from a total of 1319 studies, 47 were included to be carefully evaluated, and 20 studies were finally selected for this narrative review. The studies utilize methodologies such as randomized controlled trials (RCTs), cross-sectional surveys, case–control studies, and systematic reviews. …”
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Evaluating the Binding Potential and Stability of Drug-like Compounds with the Monkeypox Virus VP39 Protein Using Molecular Dynamics Simulations and Free Energy Analysis by Ahmed M. Hassan, Hattan S. Gattan, Arwa A. Faizo, Mohammed H. Alruhaili, Azzah S. Alharbi, Leena H. Bajrai, Ibrahim A. AL-Zahrani, Vivek Dhar Dwivedi, Esam I. Azhar

“…<b>Conclusions:</b> Notably, all the selected compounds, especially compounds <b>1</b> and <b>2</b>, demonstrate high binding affinity. …”
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Connecting patients with clinical trials using patient navigation: a scoping review protocol by Caroline Hamm, Megan Delisle, Nicole Askin, Olla Hilal, Pratham Gupta, Nasong Anthony Luginaah, Leena Moshref, Carla Epp, Renee Nassar, Roaa Hirmiz, Milica Paunic, Mahmoud Hossami, Rhonda Abdel-Nabi, Kayla Touma, Depen Sharma, Rija Fatima, Emmanuel Akingbade

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Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment by Nasimudeen R. Jabir, Md. Tabish Rehman, Khadeejah Alsolami, Shazi Shakil, Torki A. Zughaibi, Raed F. Alserihi, Mohd. Shahnawaz Khan, Mohamed F. AlAjmi, Shams Tabrez

“…The MD simulation study confirmed the stability of BACE-6Z5 and γ-secretase-6Z5 complexes and highlighted the formation of a stable complex between 6Z5 and target enzymes.Conclusion The virtual screening, molecular docking, and molecular dynamics simulation studies revealed the potential of these multi-enzyme targeted ligands. …”
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Standardising the administration of joint injections across the Wolverhampton NHS Trust: a service improvement project in rheumatology through the lens of medical education by Hirushi Jayasekera, Tamaraudubamo Agunbiade, S. Venkat Chalam

“…Fourteen applicants were selected at random. Pre-course surveys collected quantitative and qualitative data on performance challenges, confidence, and baseline knowledge. …”
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Application of Chatbots to Help Patients Self-Manage Diabetes: Systematic Review and Meta-Analysis by Yibo Wu, Jinzi Zhang, Pu Ge, Tingyu Duan, Junyu Zhou, Yiwei Wu, Yuening Zhang, Siyu Liu, Xinyi Liu, Erya Wan, Xinying Sun

“…PubMed and Web of Science databases were searched using keywords around diabetes, chatbots, conversational agents, virtual assistants, and more. The search period was from the date of creation of the databases to January 1, 2023. …”
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Transformative applications in biology education: A case study on the efficacy of adaptive learning with numerical insights by Shin I. Aleksandrovich, Tyan Ramazan, Raissa Utegaliyeva, Balzat Sarimbayeva, Gaukhar Keubassova, Rakhima Bissalyyeva, Kuanysh Syman, Gaukhar Abdikarimova

“…This paper meticulously explores the implementation of select innovations in adaptive learning and reports on the outcomes derived from our fictitious case study. …”
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A practice and exploration of blended learning in medical morphology during the post-COVID-19 pandemic era by Qinlai Liu, Na Yuan, Yongan Wang, Beibei Sun, Leiying Yang, Zhaopeng Wang, Chen Fang, Wenping Sun, Baihua Luo, Yaling Liu, Xin Liu, Li Ge

“…In the experimental class, a virtual digital platform with flipped classroom learning was integrated. …”
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Energy Consumption in Microservices Architectures: A Systematic Literature Review by Gabriel Araujo, Vandirleya Barbosa, Luiz Nelson Lima, Arthur Sabino, Carlos Brito, Iure Fe, Paulo Rego, Eunmi Choi, Dugki Min, Tuan Anh Nguyen, Francisco Airton Silva

“…Cloud computing emerges as a paradigm that facilitates on-demand access to technological resources through the mechanism of service virtualization. This virtualization enables the partitioning of hardware resources among applications that are organized into distinct independent modules. …”
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Targeting USP47 enhances the efficacy of KRAS inhibitor in KRASG12C mutated non-small cell lung cancer by controlling deubiquitination of c-Myc by Hyungkyung Shin, SuA Hwang, Jeong Hyun Jeong, Sang Chul Shin, Yeonji Oh, Jinhyeok Kim, Inah Hwang, Eunice EunKyeong Kim, Hyunah Choo, Eun Joo Song

“…Additionally, the compound K-552, a USP47 inhibitor identified through virtual screening, effectively destabilizes c-Myc and inhibits KRASG12C-mutated NSCLC cell proliferation. …”
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DistB-Condo: Distributed Blockchain-Based IoT-SDN Model for Smart Condominium by Anichur Rahman, Md. Jahidul Islam, Ziaur Rahman, Md. Mahfuz Reza, Adnan Anwar, M. A. Parvez Mahmud, Mostofa Kamal Nasir, Rafidah Md. Noor

“…It also presents an optimized Cluster Head Selection (CHS) algorithm for selecting a Cluster Head (CH) among the clusters that efficiently saves energy. …”
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Activity tracking devices in pregnancy: Understanding the participant experience in a longitudinal birth cohort by Ashley Redding, Dionne Coates, Andrea E. Cassidy-Bushrow, Jennifer K. Straughen, Sara Santarossa

“…Two groups of six participants participated virtually, which included conversations about the overall participant experience, compliance with protocols, and opportunities for knowledge dissemination about PA. …”
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World Health Organization Evidence-Based Self-Help Plus Intervention for Stress Management via Chatbot: Protocol for Adaptation to a Tech-Enabled Model by Valentina Fietta, Silvia Rizzi, Lorenzo Gios, Maria Chiara Pavesi, Chiara De Luca, Silvia Gabrielli, Merylin Monaro, Nicolò Navarin, Erik Gadotti, Oscar Mayora-Ibarra, Marianna Purgato, Corrado Barbui, Stefano Forti

“…ConclusionsThe digital adaptation of the SH+ intervention into the ALBA platform could represent a significant step forward in expanding the accessibility and personalization of mental health interventions in potentially different settings and target groups. The use of virtual coaching applications can play a central role in improving the availability and ease of access of psychological support, even in different and mHealth formats. …”
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Introducing Novel Methods to Identify Fraudulent Responses (Sampling With Sisyphus): Web-Based LGBTQ2S+ Mixed-Methods Study by Kinnon Ross MacKinnon, Naail Khan, Katherine M Newman, Wren Ariel Gould, Gin Marshall, Travis Salway, Annie Pullen Sansfaçon, Hannah Kia, June SH Lam

“…A systematic protocol was developed to identify scam, nonsense, and ineligible responses and to conduct web-based Zoom video platform screening with select participants. ResultsOf the 1377 completed survey responses, 957 (69.5%) were deemed eligible and included in the analytic dataset after applying the exclusion protocol and conducting 113 virtual screenings. …”
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Impact of Mobile Health (mHealth) Use by Community Health Workers on the Utilization of Maternity Care in Rural Malawi: A Time Series Analysis by Kachimanga C, Ng’ambi WF, Kazinga D, Ndarama E, Amulele MA, Munyaneza F, Abejirinde IOO, van den Akker T, Kulinkina AV

“…This study evaluates the impact of this app on the uptake of antenatal care (ANC), facility-based births, and postnatal care (PNC), compared to a reference period where CHWs provided the same services without mHealth, using the interrupted time series analysis.Patients and Methods: Using aggregated monthly data and segmented quasi-Poisson regression models, we compared the effects of mHealth on selected maternal health outcomes. The models were adjusted for the COVID-19 pandemic, the occurrence of cyclones, and a cholera epidemic. …”
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Optimized Sampling Strategies for Isoniazid in East Asian Pediatric Populations Using Population Pharmacokinetics-Informed Approaches by Ju G, Liu X, Peng Y, Yang W, Xu N, He Q, Zhang C, Chen L, Yang N, Zhang G, Li C, Su P, Zhu X, Ouyang D

“…Virtual patients with varying NAT2 phenotypes were created, and real-world pediatric scenarios were evaluated using questionnaire data, sampling windows, and stochastic simulations.Results: From eight analyzed models (four for East Asian adults and four for non-East Asian pediatrics), we simplified two over-parameterized models using lumping without loss of performance. …”
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Enhancing 3D A* path planning of intelligent bridge crane based on energy efficiency criteria by Heng YANG, Yue LI, Min LIU, Qing DONG

“…The optimal operation scheme is selected by introducing the evaluation values of time, energy, and inflection points. …”
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‘We’re not there yet!’: a qualitative study exploring the commissioning of adult Community Health Services in England to support the avoidance of hospital admissions by Rachel Meacock, Kath Checkland, Pauline Allen, Donna Bramwell, Mhorag Goff

“…Semi-structured interviews were conducted virtually and transcripts analysed using a reflexive thematic approach.Setting Adult CHS, which included two sites with CHS providers embedded in acute hospital Trusts, one standalone CHS Trust and a CHS provider collaborative. …”
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