Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Finally, Ibrutinib, combined with doxil, prolonged median survival in rodent glioma models (27 vs. 16 days, p < 0.0001) with brain imaging showing a − 53% versus − 75% volume change with doxil alone versus combination therapy (p < 0.05). …”
Get full text

Individual Differences in Placebo Analgesia: Functional Connectivity and Neural Mechanisms [Letter] by Cao H, Zhang Y, Bai L, Ma X

Get full text

African Journal of Governance and Public Leadership (AJoGPL)  by Benon C, Basheka, Dominique E, Uwizeyimana

Get full text

Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…In the respectful 96-well plate QLISA format, two different analyte concentrations can be hardly distinguishable, but the transfer to micro-volumetric detection on the glass slide highly increased the signal strength according to green and red FL intensity of QDs.Conclusion: Our method significantly enhances detection sensitivity, as compared to measured in parallel QLISAs in a 96 well plate format, enables multiplexing and may prove very valuable for samples of limited volumes.Keywords: quantum dots, biomarker, microvolume, FL spectroscopy, immunoassay, QLISA…”
Get full text

EDITORIAL EXPLOSION by Gabriela COCA

“…The Professor Ede Terényi, offers the interested specialists the result of his researches of more then twenty-five years in the area of the harmony of the modern music of the first half of the past century. The volume, The Harmony of the Modern Music (1900 – 1950) treats The Gravitational Harmonic System, the Non-Gravitational Harmonic System (The Geometric One), and The Synthesis of the Two Harmonically Systems. …”
Get full text

Management of eight cases of subarachnoid hemorrhage using transpulmonary thermodilution during clazosentan therapy by Hiroto Iyota, Yasumasa Kawano, Hironori Fukumoto, Takato Tajiri, Mitsutoshi Iwaasa, Sinichi Morimoto, Yoshito Izutani, Shintaro Yamasaki, Kazuya Yamauchi, Hiroki Hatomoto, Hiroshi Abe, Yoshihiko Nakamura

“…During clazosentan treatment, the median global end-diastolic volume index based on transpulmonary thermodilution remained at 715.5 ml/m2 (interquartile range: 643–788). …”
Get full text

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine sett... by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

“…Moreover, administration of the sulfonamide inhibitor to rats subjected to transient middle cerebral artery occlusion decreased infarct volumes and improved neurological deficits. Our results support the involvement of carbonic anhydrase IX in postischemic damage and pave the way for possible pharmacological interventions with selective inhibitors in the management of brain ischemia.…”
Get full text

ANTi-JAM solutions for smart roads: Ant-inspired traffic flow rules under CAVs environment by Marco Guerrieri, Nicola Pugno

“…Emerging technologies, including smart roads, communication systems, and Cooperative and Automated Vehicles (CAVs), allow us to speculate on the use of traffic control systems inspired by ant behaviour to avoid the risk of congestion even at high traffic volumes, as demonstrated by the preliminary results of this research.…”
Get full text

Optimization of mechanical and water barrier properties of avocado seed starch based film and its application as smart pH indicator by adding blue butterfly pea flower extract by Ayse Gul Asikkutlu, Meral Yildirim-Yalcin

“…An application study was conducted with blue butterfly pea flower (Clitoria ternatea) extract added at 10 % by volume of the film solution to test its use as a spoilage indicator in packaging chicken breast meat. …”
Get full text

A Reflection on the Current State of Active Learning Research by Amedee Marchand Martella, Darryl Schneider

“…Interest in active learning continues to grow worldwide. Although the large volume of active learning research has provided a myriad of ways to implement active learning in the classroom, the construct remains underdeveloped and difficult to operationalize because of three main issues in the research literature: (a) the variation in active learning activities in research and in practice; (b) the dichotomy between active learning and lecture; and (c) whether “active” in active learning refers to behavioral activity, cognitive activity, or both. …”
Get full text

A multimodal multidomain multilingual medical foundation model for zero shot clinical diagnosis by Fenglin Liu, Zheng Li, Qingyu Yin, Jinfa Huang, Jiebo Luo, Anshul Thakur, Kim Branson, Patrick Schwab, Bing Yin, Xian Wu, Yefeng Zheng, David A. Clifton

“…Existing approaches are mainly supervised, the quality of which heavily depends on the volume and quality of available labeled data. However, for rarer or more novel diseases, enrolling patients to collect data is both time-consuming and expensive. …”
Get full text

Comparative review of transcortical and trans-Sylvian approaches for surgical resection of giant insular gliomas: outcomes and challenges by Maman Roufai Hamissou Moussa, Rafeq Agila

“…It is often encountered with a large volume, extending to the surrounding areas, functional pathway, and vascular structure, making its surgical resection very challenging for a neurosurgeon. …”
Get full text

On quantifying dynamic behavior of architected metal/polymer TPMS/lattices-based interpenetrating phase composites by K. B. Shingare, Andreas Schiffer, Kin Liao

“…Our results reveal that the effective properties of IPCs increase with respect to the volume fraction of respective architectures in conjunction with enhanced natural frequency and less deformation. …”
Get full text

Investigating the Use of Waste Vehicle Tyres as Partial Replacement of Coarse Aggregates in Structural Concrete. by Nkwasibwe, Kraph

“…The specimens were prepared by replacing coarse aggregate with 5, 10, 15, and 20% of the volume of Rubber aggregate. A total of 30 cube specimens were cast. …”
Get full text