Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment by Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon

“…Responses to E2 were associated with loss of E2 expression in at least one tumor, indicating the functional capacity of these E2-recognizing T cells and many of these interactions validated in a functional assay. Conversely, cellular responses to E6 and E7 were limited in quantity and cytotoxic capacity, and tumor E6 and E7 expression persisted.Conclusions These data highlight antigenicity beyond HPV16 E6 and E7 and nominate candidates for antigen-directed therapies.…”
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O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury by Zhichao Zeng, Xuqiang Liao, Xinjian Zhao

“…Co-immunoprecipitation (Co-IP) assays were employed to investigate the interaction between NLRP3 and OGT. …”
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Over-the-counter carrageenan-based sprays may interfere with PCR testing of nasopharyngeal swabs to detect SARS-CoV-2. by Taylor Corocher, Kira Edwards, Yvonne Hersusianto, Donald Campbell, Hui Yin Lim, Paul Monagle, Prahlad Ho

“…Carrageenan-containing nasal sprays, available over-the-counter (OTC), are often marketed as having anti-viral effects. …”
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The Cytotoxicity Assessment of Grapefruit Peel Essential Oil and Its Effect on Frying Stability of Sunflower Oil by Ghania Kaanin-Boudraa, Fatiha Brahmi, Linda Grimaud, Mohamed Lamine Freidja, Ourdia-Nouara Kernou, Daniel Henrion, Samir Hadjal, Khodir Madani, Lila Boulekbache-Makhlouf

“…Methods: Cell viability was evaluated using the MTT-based cytotoxicity assay. Various EO concentrations (0.01-0.5 mg/ml) were added to cultured cells Human Umbilical Vein Endothelial Cells (HUVECs) and Human Stellar Hepatic Cell lines LX-2 (SCC064) and incubated for 24 and 48 h. …”
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Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

“…This comprehensive study used multiple assays in tandem in order to explore the most potent GSK-3β inhibitor. …”
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GWSF-EuSWAP70 gene expression to enhance gray mold resistance in Arabidopsis thaliana by Zhenchi Huang, Xiaoming Li, Fenglian Cai, Lichun Li, Zhihua Wu

“…Results The results showed that the EuSWAP70 gene was successfully transformed into A. thaliana, and the PCR assay confirmed the presence of the EuSWAP70 gene in transgenic Arabidopsis plants. …”
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FRONTEIRAS EM SAÚDE E ECOLOGIA DE ABERES: acupuntura numa perspectiva pós-colonial by Leila Massiére Carneiro

“…Neste contexto, a acupuntura passa a ser incorporada como técnica alijada de seus métodos próprios de diagnose e propedêutica, uma estratégia que implica na redução drástica de suas possibilidades de cura, mas garante sua submissão à Medicina Biomecânica, restringindo sua atuação apenas aos casos em que esta não oferece bons resultados. …”
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Hemorrhagic syndrome at liver cirrhosis by I. A. Kurkina, O. S. Volkova, M. V. Mayevskaya, V. T. Ivashkin

“…Bleeding developing at invasive procedures in LC patients, bleeding from varicose esophageal veins, hematomas, hemorrhagic purpura, nasal bleeding, odontorrhagia, menorrhagias are actual clinical problems. …”
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Comparison of effectiveness in smoking cessation using nicotine replacement therapy and electronic cigarettes by Adrianna Kopaczyńska, Katarzyna Szafrańska, Szymon Niemirka, Aleksandra Janiak, Kinga Dominiczak, Łukasz Grądalski, Filip Dębicki

“…Nicotine replacement therapy has been shown to enhance cessation success rates significantly, with various forms available, including skin patches, chewing gum, nasal and oral sprays, inhalers, lozenges, and tablets. …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…This project involved screening of ST invasion inhibitors through a gentamicin protection assay and identified purpurin (PPR) as capable of inhibiting the ST invasion of HeLa cells. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules. …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Methods: sPLA2 inhibitory activity of different fractions of the plant was evaluated by a commercially available sPLA2 assay kit compared to the inhibition caused by the commercially available sPLA2 inhibitor CAY 10590. …”
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A systematic review of neurological symptoms and brain abnormalities in SARS-CoV-2 infections by Daniel Montoya, Jacobo Albert, Sarah Lopez-Martin

“…The most affected brain area was the corpus callosum, followed by the lateral ventricles and surrounding areas, the midbrain, the basal ganglia, the internal capsule, the olfactory bulb, the thalamus, the insular cortex, and the amygdala. …”
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Electrodiagnostic assessment of autonomic nervous system in diabetic autonomic neuropathy: Case series in 72 diabetes patients by Suchitra Dube, Sandip M. Hulke, Santosh L. Wakode, Sagar Khadanga

“…Severe involvement was observed in 24% of the patients in present study. Involvement of the vagal parasympathetic component of ANS was obvious evidenced by increase in resting heart rate, decrease in Valsalva ratio, E/I index, and standing ratio. …”
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Taurine Prevented Biochemical Alterations in Chronic Restraint-Stressed Wistar Rats by Iliya, Ezekiel, Agnes Igimi, Odey, Stephen Olawale, Ajayi, Ejike, Daniel Eze, Obioha, Mary

“…Other biochemical parameters assayed in the serum were the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). …”
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Analisis Sentimen Kebijakan Penerapan Kurikulum Merdeka Sekolah Dasar dan Sekolah Menengah pada Media Sosial Twitter dengan Menggunakan Metode Word Embedding dan Long Short Term Me... by Alif Rizal Maulana, Satrio Hadi Wijoyo, Yusi Tyroni Mursityo

“…Dashboard visualization is also used by schools and the Batu City Education Office as a measure of the benefits and reflections of implementing the Independent Curriculum and also conducting evaluations to make it better in the future. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…However, for obesity, there are changes in airway anatomy structure such as short neck, round chin, and large tongue, which makes them prone to airway obstruction after sleep or anesthesia, blocking the passage of oxygen in and out, which will cause hypoxemia over time and further cause damage to the body. …”
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Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán

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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

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Outcome of Different Preemptive Analgesia Modalities in Patients Undergoing Total Knee Replacement Surgeries: A Prospective Randomized Study by Narendra Vaidya, Gourav S. Pawar, Anup P Gadekar, Nilesh A. Patil, Pravin Rameshrao Kutemate, Mohit Kolhapure

“…Results: The average Visual Analog Scale score was the least in Group 2, followed by Group 1 and Group 3 (P < 0.001). …”
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