Efficacy and safety of dexamethasone or triamcinolone in combination with anti-vascular endothelial growth factor therapy for diabetic macular edema: A systematic review and meta-a... by Bo Zhou, Hua Liu, Feng Xiong

“…The overall analysis revealed that combined treatment of dexamethasone or triamcinolone with anti-VEGF agents did not demonstrate superiority over anti-VEGF monotherapy in improving best-corrected visual acuity (BCVA) (Dexamethasone: SMD -0.266, 95% CI -1.001 to 0.468, 95% PI -2.878 to 2.346; Triamcinolone: SMD -0.340, 95% CI -1.230 to 0.550, 95% PI -3.554 to 2.874) and reducing central macular thickness (CMT) (Dexamethasone: SMD -1.255, 95% CI -2.861 to 0.350; Triamcinolone: SMD -0.207, 95% CI -0.895 to 0.481, 95% PI -2.629 to 2.215). …”
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Efficacy and Safety of Cataract Surgery Combined with Ab Interno Canaloplasty and Micro-Trabecular Bypass Stent Surgery in Open-Angle Glaucoma by Porter MS, Flowers A, Wood BP, Gallardo MJ

“…Matthew S Porter,1 Addie Flowers,1 Brandon P Wood,1 Mark J Gallardo2 1Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, USA; 2El Paso Eye Surgeons, El Paso, TX, USACorrespondence: Matthew S Porter, Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences School of Medicine, 3601 4th St, Lubbock, TX, 79430, USA, Tel +1-806-742-2011, Email matt.porter@ttuhsc.eduPurpose: To evaluate the effectiveness of canaloplasty via an ab-interno technique using the iTrack (Nova Eye Medical, Fremont, USA) combined with microtrabecular bypass stent surgery with the Hydrus microstent (Ivantis, Inc, Irvine, CA) following cataract surgery (CE) in patients with primary open-angle glaucoma (POAG).Methods: A retrospective, two-center, case series of 51 POAG eyes that underwent phacoemulsification followed by canaloplasty combined with microtrabecular bypass stent surgery. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Additional in vivo and in vitro experiments, including CCK-8 assays, colony formation and mouse xenograft models, were conducted to explore the biological role of NAT10-mediated ac4C modifications. …”
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Toxic Effects of Hydroxyl- and Amine-functionalized Silica Nanoparticles (SiO2 and NH2-SiO2 NPs) on Caenorhabditis elegans by Danielle E. Que, Wen-Che Hou, Micah Belle Marie Yap Ang, Chih-Chung Lin

“…The chronic lethality and lifespan assays revealed a significant decrease in survival rate and lifespan at 2.5 and 5 mg mL−1 for nematodes exposed to bare SiO2 NPs (89% and 88%; 22 days, p < 0.05 and 14 days, p < 0.05) and at 5 mg mL−1 for the NH2-SiO2 NPs-exposed group (86%; 20 days, p < 0.001). …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…This paper aimed to explore the long-acting erythropoiesis stimulating molecular mechanism of Pegmolesatide. Methods In vitro assays were utilized to assess Pegmolesatide erythropoietin receptor (EPOR) affinity, competitive binding, cell proliferation/survival, apoptosis, cell surface receptor expression, and signal transduction. …”
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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…Enzyme-linked immunosorbent assays (ELISA) were used to assess the levels of pro-inflammatory cytokines, Fe2+, and associated oxidative stress indicators in the serum and cell supernatant. …”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“…A functional splicing assay using a GAA hybrid minigene carrying different variants known to affect GAA exon 2 splicing was used to test the effect of engineered U1 snRNAs on exon 2 inclusion. …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…Results Feature selection via Lasso led to a final LR model incorporating high-density lipoprotein, smoking status, basal width, and Rad_Signature. This model, derived from machine learning frameworks including Support Vector Machine (SVM), Logistic Regression (LR), Multilayer Perceptron (MLP), k-Nearest Neighbors (KNN), and eXtreme Gradient Boosting (XGBoost) with fivefold cross-validation, showed AUCs of 0.95 (95% CI: 0.90–0.99) and 0.87 (95% CI: 0.72–1.0) in internal validation. …”
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Correlación entre eosinófilos y aminotransferasas en pacientes diabéticos y no diabéticos de un policlínico ubicado en el distrito de Villa El Salvador, Lima, Perú by Alberto Guevara Tirado

“…Las variables fueron edad, sexo, glucemia basal, recuento de eosinófilos, niveles de aspartato aminotransferasa y niveles de alanina aminotransferasa. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…The effect of phage vB_Kpn_HF0522 on biofilms was assessed using crystal violet staining assay. The Galleria mellonella (G. mellonella) infection model and mouse infection models were established to evaluate the practical application potential of the phage and the fitness cost of phage-resistant bacteria.Results: Phage was isolated from hospital sewage for experimental studies. …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…The estrous cycle was observed, and HE staining was performed for pathological changes in the ovary and uterus. Immunofluorescence assay was employed to measure the expression of p-eIF2α, ATF4 and CHOP in the ovarian tissue. …”
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A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery by Jin-Can Huang, Shao-Cheng Lyu, Bing Pan, Han-Xuan Wang, You-Wei Ma, Tao Jiang, Qiang He, Ren Lang

“…The logistic regression model was established and evaluated for accuracy through the above variables in the training set and the validation set, respectively, and was visualized by Nomograms. Meanwhile, the model was further verified and compared for accuracy, the area under the curve (AUC) of the receiver operating characteristic curves (ROC), and calibration analysis. …”
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Sistem Identifikasi Penyakit Paru Obstruktif Kronik (PPOK) Berdasarkan Suara Paru-Paru Menggunakan Jaringan Saraf Tiruan Berbasis Raspberry Pi by Lindhu Parang Kusuma, Barlian Henryranu Prasetio, Eko Setiawan

“…The output of this system is a visualization of the sound of the lungs captured by the stethoscope and the diagnosis of the lung condition displayed in real-time. …”
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Aldehyde Dehydrogenase 2 rs671 Polymorphism is Associated with Susceptibility of Coronary Atherosclerosis in Patients with Hypertension by Hou H, Huang S, Huang W, Huang L, Zhang Z, Liang L

“…Atherosclerosis is a chronic inflammatory disease caused by lipid deposition in the blood vessels, and aldehyde dehydrogenase 2 (ALDH2) is involved in this process. …”
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Perancangan dan Implementasi Game Edukasi Kesehatan Gigi “Tooth and Fairy” berbasis Android Menggunakan Unity Engine by Sussi Sussi, Sri Astuti, Nurwulan Fitriyanti, Nyoman Bogi Aditya Karna, Nizar Rizky Awany, Muhammad Fajar Firdiansyah, Rafli Noveri Alfariji, Dhea Dearly Herman, Muhammad Risqi Risfianda, Muh Nurkhaliz

“…Conventional methods are less attractive, have minimal visualization, and less challenging, so that children get bored easily in understanding the information provided. …”
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Hymecromone Administration in Real Clinical Practice: Results of the Prospective Multicentre Observational Study in the Republic of Kazakhstan by A. V. Nersesov, D. A. Kaybullaeva, V. S. Rakhmetova, I. A. Lozinskaya, A. K. Kurmangalieva, V. S. Ayupova, A. B. Orazbaeva, A. K. Kanabaeva, Yu. O. Shulpekova

“…The study included 2 patient visits and an intermediate telephone contact. A visual analogue scale and RAPID questionnaire were used to characterise biliary pain; severity of associated symptoms, bowel habit and a quality of life according the SF-12 were also assessed. …”
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Teknologi Opinion Mining untuk Mendukung Strategic Planning by Dwi Rolliawati, Khalid Khalid, Indri Sudanawati Rozas

“…Based on sentiment analysis by Vader and Liu’s approach which was visualized by K-Means graphs, the finding was that 97,54% of public opinion toward Sunan Ampel Islamic State University Surabaya led to a 'neutral' sentiment, while positive = 2,16% and negative=0,34%. …”
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Dual Role of &alpha;-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…This study aims to investigate the alterations in the HPA and its potential roles during IBD development.Methods: We utilized a dextran sodium sulfate (DSS)-induced colitis model in mice and employed immunofluorescence, real-time quantitative PCR (RT-qPCR), enzyme-linked immunosorbent assay (ELISA), among other techniques, to evaluate the impact of colitis on the HPA. …”
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The Role of Mature Brain-Derived Neurotrophic Factor and Its Precursor in Predicting Early-Onset Insomnia in Stroke Patients Experiencing Early Neurological Deterioration by Shi G, Yu P, Wang Z, Xu M, Guo M, Wang X, Zhou R

“…Serum levels of mBDNF and proBDNF were quantified using enzyme-linked immunosorbent assays. EOI was diagnosed according to the International Classification of Sleep Disorders, Third Edition (ICSD-3). …”
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Anatomy, histology, and morphology of fish gills in relation to feeding habits: a comparative review of marine and freshwater species by Mohamed A. M. Alsafy, Hanan H. Abd-Elhafeez, Ahmed M. Rashwan, Atef Erasha, Safwat Ali, Samir A. A. El-Gendy

“…Histological findings revealed various types of cells, such as superficial pavement cells, large chloride cells, mucous goblet cells, and basal epithelial cells. The lymph space is situated within the gill arch epithelia and is encompassed by cells that resemble tenocytes. …”
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