Low-coverage whole genome sequencing of cell-free DNA to predict and track immunotherapy response in advanced non-small cell lung cancer by Florian Janke, Mateo Gasser, Arlou K. Angeles, Anja L. Riediger, Magdalena Görtz, Louise Appenheimer, Astrid K. Laut, Simon Ogrodnik, Sabrina Gerhardt, Albrecht Stenzinger, Marc A. Schneider, Michael Thomas, Petros Christopoulos, Holger Sültmann

“…Targeted next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) has demonstrated potential clinical utility to support clinical decisions, but requires prior tumor genetic profiling for proper interpretation, and wide adoption remains limited due to high costs. Methods Tumor-agnostic low-coverage ctDNA whole genome sequencing (lcWGS) was used to longitudinally track genome-wide copy number variations (CNVs) and fragmentation features in advanced NSCLC patients (n = 118 samples from 49 patients) and healthy controls (n = 57). …”
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Theoretical model of homogenized piezoelectric materials with small non-collinear periodic cracks by Jean M. Nianga, D. Marhabi

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Multiscale Dissection of Spatial Heterogeneity by Integrating Multi‐Slice Spatial and Single‐Cell Transcriptomics by Yuqi Chen, Caiwei Zhen, Yuanyuan Mo, Juan Liu, Lihua Zhang

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A hybrid model for short-term offshore wind power prediction combining Kepler optimization algorithm with variational mode decomposition and stochastic configuration networks by Bingbing Yu, Yonggang Wang, Jun Wang, Yuanchu Ma, Wenpeng Li, Weigang Zheng

“…To enhance the stability and accuracy of wind power forecasting, a hybrid model integrating Kepler optimization algorithm (KOA), variational mode decomposition (VMD), and stochastic configuration network (SCN) is proposed. …”
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Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms by Lu X, Ji L, Chen D, Lian X, Yuan M

“…Future research that integrates multi-ancestry GWAS, functional validation, and multi-omics approaches may further enhance the utility of Mendelian randomization. …”
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Application of schmidt hammer and ultrasonic pulse velocity for structural integrity assessment in water dams by Wilson M. Kairu, Siphila W. Mumenya, Kenneth D. Njoroge, Ian M. Kaniu

“…The findings demonstrate that while Schmidt Hammer provides reliable surface strength estimations, UPV offers deeper insight into material heterogeneity and internal variability. Integrating both methods with core-derived calibration enhances the accuracy of field strength estimations, bridging the gap between laboratory-controlled conditions and real-world applications. …”
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Enhancing User-Centered Feature Development: Integrating Design Thinking into Feature-Driven Development by Anum Khalid, Safa Tariq, Rohina Akram, Dr. Maryam Kausar

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Artificial Intelligence Assistive Tool for Radiotherapy Plan Evaluation Based on Analysis of Integral Dose by Shriram Rajurkar, Teerthraj Verma, MLB Bhatt, S P Mishra, P Deshmukh, D Sargar

“…Results: In this study, variation of ID between nine-beam and seven-beam plans was calculated. …”
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ED-Swin Transformer: A Cassava Disease Classification Model Integrated with UAV Images by Jing Zhang, Hao Zhou, Kunyu Liu, Yuguang Xu

“…Traditional manual monitoring methods are limited by efficiency bottlenecks and insufficient spatial coverage. …”
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DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles by Giorgia Adamo, Sabrina Picciotto, Paola Gargano, Angela Paterna, Samuele Raccosta, Estella Rao, Daniele Paolo Romancino, Giulio Ghersi, Mauro Manno, Monica Salamone, Antonella Bongiovanni

“…Utilizing microalgae‐derived EVs, known as nanoalgosomes, as model systems, we optimised the assay parameters and validated its sensitivity and specificity in quantifying the enzymatic activity of esterases within the EV lumen while also evaluating EV membrane integrity. Compared to conventional methods that assess physicochemical features of EVs, our single‐step analysis efficiently detects batch‐to‐batch variations by evaluating changes in luminal cargo bioactivity and integrity across various EV samples, including differences under distinct storage conditions and following diverse isolation and exogenous loading methods, all using small sample sizes. …”
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A technical review on characterization methods for structures and properties of emulsion by Xuncheng Shi, Dawei Qi, Caihong Lin, Jianwei Li

“…Consequently, there is a critical need for a comprehensive review that integrates various characterization methods. This review addresses this gap by systematically evaluating key techniques, including scattering methods (dynamic light scattering, small-angle x-ray scattering), spectroscopic techniques (Fourier transform infrared and nuclear magnetic resonance spectroscopy), microscopy methods (scanning electron microscopy, confocal laser scanning microscopy), and rheometry. …”
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Integrated irrigation of water and fertilizer with superior self-correcting fuzzy PID control system. by Wanjun Zhang, Jingsheng Tong, Feng Zhang, Wanliang Zhang, Jingxuan Zhang, Jingyi Zhang, Jingyan Zhang, Honghong Sun, Derek O Northwood, Kristian E Waters, Hao Ma

“…., excessive overshoot, prolonged settling time, poor adaptability to nonlinearities) and the insufficient real-time adjustment capability of conventional fuzzy PID control, which relies on empirically predefined rule bases, this study proposes a self-correcting fuzzy PID control strategy for agricultural water-fertilizer integrated systems. Traditional PID control, due to its static parameters, suffers from reduced stability and error accumulation under dynamic variations (e.g., irrigation flow fluctuations, environmental disturbances) or nonlinear interactions (e.g., coupling effects of fertilizer concentration and pH). …”
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Urban ecological environment quality evaluation using deep autoencoder integration of multisource remote sensing data by Shengtang Wang, Weizhen Wang, Feinan Xu

“…The results indicated that Beijing's UEEQ exhibited overall stability with localized variations, with 85.7 % of the area remaining unchanged. …”
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Integrated DNA Barcoding and Morphometric Characterization of Palm Weevils (Rhynchophorus spp.) in North Sulawesi by Endrile Golmen Balansa, Christina Leta Salaki, Dantje Tarore, Juliet Merry Eva Mamahit, Beivy Jonathan Kolondam, Trina Ekawati Tallei

“…This study concludes that integrating morphometric and genetic analyses reveals geographic structuring within R. vulneratus, highlighting the effectiveness of combined methods for accurate identification and population differentiation. …”
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Integrating Physical Unclonable Functions with Machine Learning for the Authentication of Edge Devices in IoT Networks by Abdul Manan Sheikh, Md. Rafiqul Islam, Mohamed Hadi Habaebi, Suriza Ahmad Zabidi, Athaur Rahman Bin Najeeb, Adnan Kabbani

“…PUFs produce output responses against challenge inputs based on the physical structure and intrinsic manufacturing variations of an integrated circuit (IC). These challenge-response pairs (CRPs) enable secure and reliable device authentication. …”
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A Two-Stage Deep Fusion Integration Framework Based on Feature Fusion and Residual Correction for Gold Price Forecasting by Cihai Qiu, Yitian Zhang, Xunrui Qian, Chuhang Wu, Jiacheng Lou, Yang Chen, Yansong Xi, Weijie Zhang, Zhenxi Gong

“…Given the far-reaching impact of the gold price on global financial markets, accurately predicting the gold price has become essential, with machine learning methods emerging as a prominent tool to tackle this challenge. …”
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Centroid Jamming Strategy for Reconnaissance and Strike Integrated UAV Based on Chaff Cartridge Protection by Qing Chaojin, He Linsi, Wei Maogang, Wang Zilong

“…The simulation results demonstrate that under the given initial distance and escape time conditions, the closest distance between the missile and the RSUAV increases to more than 127 times of the missile explosion range, and prolongs the survival time of the RSUAV by about 62.5%. The proposed method can help to improve the survival probability of RSUAV, and it presents the effectiveness and robustness with the parameters variations of missile, chaff cartridge, and environmental conditions.…”
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Effects of Crop Rotation Diversification and Livestock Integration on Above‐Ground Arthropod Dynamics Under Conservation Agriculture by Amandrie Louw, Johann Strauss, Pia Addison

“…ABSTRACT Diversification through integrating diverse crop species and livestock is key to enhancing above‐ground arthropod diversity and promoting the sustainability of cropping systems within conservation agriculture (CA) in South Africa. …”
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Enhancing Traffic Flow in Heterogeneous Freeways: Integration of Multivariable Extremum Seeking and Filtered Feedback Linearization Control by Pouria Karimi Shahri, Arash Rahmanidehkordi, Azad Ghaffari, Amir H. Ghasemi

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GNSS integrated displacement and attitude determination for structural health monitoring of long-span bridges by Xiangdong An, Xiaolin Meng, Liangliang Hu, Yilin Xie, Fan Zhang, Shuguo Pan

“…This paper presents an integrated displacement and attitude determination approach for bridge health monitoring, leveraging Global Navigation Satellite System (GNSS) technology to simultaneously capture displacement and attitude variations, such as pitch and heading angles. …”
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