Core outcomes for the evaluation of new healthcare programmes – a modified Delphi study by Benjamin P. Harvey, Emmelie Barenfeld, Joakim Öhlén, Jana Bergholtz, Carl Johan Orre, Tomas Lindroth, Hanna Gyllensten

“…The outcomes underwent a two-round modified Delphi method with representative groups including managerial decision-makers, researchers, health workers, and patients/patient representatives. …”
Get full text

Construction of an evaluation indicator system for the emergency management capability of major infectious diseases in urban communities by Xiuying Guan, Wentao Li, Nan Cui, Jiacen Yu, Libin An

“…The modified Delphi method was applied to refine the third-level indicators for the evaluation system. …”
Get full text

Relationship between advanced lung cancer inflammation index and all-cause and cause-specific mortality among chronic inflammatory airway diseases patients: a population-based stud... by Zhuanbo Luo, Peixu Chen, Shiyu Chen, Xue Kong, Hongying Ma, Chao Cao

“…This study aimed to investigate this relationship.MethodsWe gathered data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. …”
Get full text

New insights into Wiskott-Aldrich syndrome: ten novel WAS mutations and their clinical impact in a Brazilian cohort by Lucas W. Santos, Samuel S. Medina, Jéssica O. Frade-Guanaes, Lúcia H. Siqueira, Luiz Gustavo R. de Lima, Luiz Gustavo R. de Lima, Bruna Chati, Bruna Chati, Marcos T. Nolasco da Silva, Marcos T. Nolasco da Silva, Adriana G. L. Riccetto, Adriana G. L. Riccetto, Paula Lyra, Ana Carla A. M. Falcão, Pedro P. A. Santos, Regina S. W. Di Gesu, Bianca Stefanello, Bianca Stefanello, Gabriela G. Yamaguti-Hayakawa, Carmem M. S. Bonfim, Maria M. S. Vilela, Maria M. S. Vilela, Margareth C. Ozelo, Margareth C. Ozelo

Get full text

Predicting early complications in patients with spinal gunshot wounds: A multicenter study by Guillermo A. Ricciardi, Juan P. Cabrera, Oscar Martínez, Javier Matta, Hugo Vilchis, Jeasson Javier Perez Ríos, Charles A. Carazzo, Michael Dittmar, Ratko Yurac

Get full text

Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

“…Methods Seven of 89 sites using the SJCARES registry were selected, stratified by global region and stage of implementation. …”
Get full text

Local adaptation, genetic diversity and key environmental interactions in a collection of novel red clover germplasm by A. D. Heslop, A. D. Heslop, Sai K. Arojju, Rainer W. Hofmann, John L. Ford, M. Zulfi Z. Jahufer, Anna C. Larking, Rachael Ashby, Charles A. Hefer, Ken G. Dodds, A. Saei, Jessica O’Connor, Andrew G. Griffiths

“…Our study identifies the importance of diverse germplasm when adding genetic variation into breeding programs. It also identifies efficient evaluation methods and key climatic variables that should be considered when developing adaptive red clover cultivars.…”
Get full text

Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients by Ning Zheng, Hai-Long Yu, Bing-Jie Zhang, Dan Wang, Ya-Liang Ji, Lu-Lu Dai, Wen Li, Sheng-Hui Li, Zhi-Liang Hu, Zhi-Liang Hu, Yi-Shan Zheng

“…The observed virus–bacteria networks provide novel insights into pulmonary microbial ecology and underscore the importance of integrating host and disease context in virome studies.…”
Get full text

Cognition and experience of surgical incisions in patients undergoing laparoscopic surgery with enhanced recovery after surgery protocol: A qualitative study by Hongxia Xu, Yihong Xu, Gongjie Shi, Jiaqi Lu, Liping Zhu, Guibing He, Xiao Liang

“…The data were analyzed via the framework method to identify themes related to incision experiences. …”
Get full text

Genomic characterization and antibiotic susceptibility of biofilm-forming Borrelia afzelii and Borrelia garinii from patients with erythema migrans by Giorgia Fabrizio, Giorgia Fabrizio, Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Daniela Kovacs, Massimo Francalancia, Giovanna D’Agosto, Elisabetta Trento, Grazia Prignano, Arianna Mastrofrancesco, Eva Ruzič-Sabljič, Fulvia Pimpinelli, Enea Gino Di Domenico

Get full text

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. by Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale

“…Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction.…”
Get full text

Evaluating the long-term impact of a distance learning course on attitudes, skills, practices, and knowledge in gender-affirming healthcare among healthcare professionals in Italy by Matteo Marconi, Ughetta Maria Favazzi, Pietro Carbone, Debora Guerrera, Angela Ruocco, Martina Manoli, Martina Manoli, Cristiana Barbati, Francesca Molinaro, Federica Maria Regini, Andrea Vittozzi, Alfonso Mazzaccara, Marina Pierdominici

“…The findings underscore the need for structural support and integrated reinforcement to embed gender-affirming care into routine practice.…”
Get full text

RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer by Jing Zhu, Chun Yu, Xin Xu, Chu Zou, Jiaqi Li, Rui Wang, Xinchao Li, Aijun Sun, Shiyan Wang, Chao Jiang

“…In most malignancies, RAB5B expression correlated positively with Copy Number Variation (CNV) and methylation. It also correlated significantly with immunotherapy biomarkers and responses. …”
Get full text

Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and glioma by Hong Cheng, Jing Wang, Yingjie Zhao, Xiaoli Hou, Fang Ling, Yixia Wang, Yasen Cao

“…Gene Set Variation Analysis (GSVA) was performed to explore functional profiles, while LASSO regression was employed to screen potential PD biomarkers. …”
Get full text

Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach by Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris

“…These mutations may disrupt EPCR stability and impair its anticoagulant function, thereby increasing the risk of thrombosis.MethodsWe employed a multi-layered computational approach to analyze 217 nsSNPs in the PROCR gene. …”
Get full text

The impact of social and commercial determinants on the unequal increase of oral disorder disease burdens across global, regional, and national contexts by Yongqiang Lai, Ye Li, Xinwei Liu, Yuanxiang Shi, Fangqi Qu, Xiyu Zhang, Baoguo Shi, Xiaohe Wang, Tao Sun, Xianhong Huang, Dingyun You

“…Policy efforts should prioritize intersectoral actions to regulate harmful commercial practices, strengthen primary oral health care in underserved regions, and integrate oral health into universal health coverage frameworks. …”
Get full text

Investigation of a chest radiograph-based deep learning model to identify an imaging biomarker for malnutrition in older adults by Ryo Sasaki, Yasuhiko Nakao, Fumihiro Mawatari, Takahito Nishihara, Masafumi Haraguchi, Masanori Fukushima, Ryu Sasaki, Satoshi Miuma, Hisamitsu Miyaaki, Kazuhiko Nakao

“…It is anticipated that AI will be integrated into the NST workflow in the future.…”
Get full text

Dietary Variability Among Mountain Gorilla Groups Across Volcanoes National Park, Rwanda by H. Ihimbazwe, J. D. Tuyizere, L. Kayitete, D. Abavandimwe, A. K. Kamanzi Shimwa, M. L. Power, C. C. Grueter, M. Flint, J. D. Nsanzineza, A. Jonas, G. Kwibuka, D. Ishimwe, F. Ndagijimana, J. D. Hakizimana, P. Uwingeli, S. C. McFarlin, M. M. Robbins, T. S. Stoinski, W. Eckardt

“…Building on previous efforts, we describe dietary variability among VNP mountain gorilla groups by integrating data from groups ranging in the northeast VNP. …”
Get full text

Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015–2021 by Juan Domínguez González, Juan Castillo Mewa, Prudencio González, Pedro Del Cid, Jacinto Ariel Pérez Ruíz, Samantha Eunice Rosas Hermosilla

“…The resistance patterns detected by the GenoType MTBDRplus assay highlight the genetic variability of drug resistance in the country and emphasize the need to implement epidemiological surveillance methodologies. Integrating patient clinical data with genetic variation information is essential for improving disease control and understanding transmission dynamics and drug resistance acquisition. …”
Get full text

Spatial distribution of paediatric tuberculosis and factors associated with adverse treatment outcomes in Ashanti Region, Ghana: a retrospective analysis by Maxwell Afranie Appiah, Mawuli Gohoho, Ebenezer Enam Adzaklo, Geoffrey Delali Komla Gone, Joshua Kwabena Aniaku, Perfect Edinam Asamoah, John Owusu Gyapong, Emmanuel Kyeremateng, Emmanuel Tinkorang

“…Additionally, the NTP should train community health workers to conduct stigma-sensitive integrated home visits for TB/HIV co-infected children to mitigate potential adverse treatment outcomes.…”
Get full text