Relationship between advanced lung cancer inflammation index and all-cause and cause-specific mortality among chronic inflammatory airway diseases patients: a population-based stud... by Zhuanbo Luo, Peixu Chen, Shiyu Chen, Xue Kong, Hongying Ma, Chao Cao

“…This study aimed to investigate this relationship.MethodsWe gathered data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. …”
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Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

“…Methods Seven of 89 sites using the SJCARES registry were selected, stratified by global region and stage of implementation. …”
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Local adaptation, genetic diversity and key environmental interactions in a collection of novel red clover germplasm by A. D. Heslop, A. D. Heslop, Sai K. Arojju, Rainer W. Hofmann, John L. Ford, M. Zulfi Z. Jahufer, Anna C. Larking, Rachael Ashby, Charles A. Hefer, Ken G. Dodds, A. Saei, Jessica O’Connor, Andrew G. Griffiths

“…Our study identifies the importance of diverse germplasm when adding genetic variation into breeding programs. It also identifies efficient evaluation methods and key climatic variables that should be considered when developing adaptive red clover cultivars.…”
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Predicting early complications in patients with spinal gunshot wounds: A multicenter study by Guillermo A. Ricciardi, Juan P. Cabrera, Oscar Martínez, Javier Matta, Hugo Vilchis, Jeasson Javier Perez Ríos, Charles A. Carazzo, Michael Dittmar, Ratko Yurac

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Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients by Ning Zheng, Hai-Long Yu, Bing-Jie Zhang, Dan Wang, Ya-Liang Ji, Lu-Lu Dai, Wen Li, Sheng-Hui Li, Zhi-Liang Hu, Zhi-Liang Hu, Yi-Shan Zheng

“…This study aims to characterize the virome in bronchoalveolar lavage fluid (BALF) and peripheral blood samples from patients with various clinical conditions using mNGS.MethodsA total of 338 clinical samples—including 240 BALF and 69 blood samples for DNA sequencing, and 18 BALF and 11 blood samples for RNA sequencing—underwent shotgun metagenomic sequencing. …”
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Genomic characterization and antibiotic susceptibility of biofilm-forming Borrelia afzelii and Borrelia garinii from patients with erythema migrans by Giorgia Fabrizio, Giorgia Fabrizio, Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Daniela Kovacs, Massimo Francalancia, Giovanna D’Agosto, Elisabetta Trento, Grazia Prignano, Arianna Mastrofrancesco, Eva Ruzič-Sabljič, Fulvia Pimpinelli, Enea Gino Di Domenico

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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. by Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale

“…<h4>Methods and findings</h4>Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5). …”
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Evaluating the long-term impact of a distance learning course on attitudes, skills, practices, and knowledge in gender-affirming healthcare among healthcare professionals in Italy by Matteo Marconi, Ughetta Maria Favazzi, Pietro Carbone, Debora Guerrera, Angela Ruocco, Martina Manoli, Martina Manoli, Cristiana Barbati, Francesca Molinaro, Federica Maria Regini, Andrea Vittozzi, Alfonso Mazzaccara, Marina Pierdominici

“…This study extends the findings of an earlier evaluation of a distance learning course on TGD healthcare, exploring the sustainability of its effects over time.ObjectivesTo assess changes in self-reported attitudes, skills, practices, and knowledge retention 6 months after course completion.MethodsA longitudinal design was used with assessments at baseline (T0), post-course (T1), and six-month follow-up (T2). …”
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Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and glioma by Hong Cheng, Jing Wang, Yingjie Zhao, Xiaoli Hou, Fang Ling, Yixia Wang, Yasen Cao

“…Understanding the differential expression and functional implications of HSPs in these conditions is crucial for identifying potential therapeutic targets and biomarkers for diagnosis and prognosis. Methods: We utilized combined datasets (GSE6613 and GSE72267) to identify and analyze the heat shock-related genes differentially expressed in PD. …”
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RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer by Jing Zhu, Chun Yu, Xin Xu, Chu Zou, Jiaqi Li, Rui Wang, Xinchao Li, Aijun Sun, Shiyan Wang, Chao Jiang

“…Although studies have revealed the functional mechanisms of RAB5B in specific tumor types, its role in pan-cancer and the underlying molecular mechanisms still lack in-depth analysis.MethodsA comparative analysis of RAB5B gene expression was conducted using transcriptomic datasets from Cancer Genome Map (TCGA) and Genotype-Tissue Expression (GTEx), followed by tissue distribution profiling via Human Protein Atlas (HPA) and GeneMANIA to map its expression across human tissues. …”
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‘Every Touch Point Is an Opportunity’: Tobacco Control Experts' Views on How to Implement Smoking Cessation Interventions Within an Australian Lung Cancer Screening Program by Nathan J. Harrison, Diane Riddiford‐Harland, Sarah York, Henry M. Marshall, Joel J. Rhee, Emily Stone, Mei Ling Yap, Ashleigh R. Sharman, Marianne Weber, Susan A. McCullough, Terri Byrne, Christine L. Paul, Jacqueline A. Bowden, Billie Bonevski, Nicole M. Rankin

“…We sought perspectives from tobacco control/smoking cessation experts on optimally implementing smoking cessation interventions in an Australian LCS program. Methods Recruitment was via maximum variation and snowball sampling in 2022. …”
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The impact of social and commercial determinants on the unequal increase of oral disorder disease burdens across global, regional, and national contexts by Yongqiang Lai, Ye Li, Xinwei Liu, Yuanxiang Shi, Fangqi Qu, Xiyu Zhang, Baoguo Shi, Xiaohe Wang, Tao Sun, Xianhong Huang, Dingyun You

“…The Global Oral Health Action Plan and the Bangkok Declaration underscore the importance of addressing commercial determinants as key drivers of oral health inequities. Methods We utilized data from the Global Burden of Disease 2021 (GBD 2021) study to analyze the burden of oral disorders—including incidence, prevalence, and disability-adjusted life years (DALYs)—across 204 countries and territories, stratified by Socio-demographic Index (SDI). …”
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Investigation of a chest radiograph-based deep learning model to identify an imaging biomarker for malnutrition in older adults by Ryo Sasaki, Yasuhiko Nakao, Fumihiro Mawatari, Takahito Nishihara, Masafumi Haraguchi, Masanori Fukushima, Ryu Sasaki, Satoshi Miuma, Hisamitsu Miyaaki, Kazuhiko Nakao

“…It is anticipated that AI will be integrated into the NST workflow in the future.…”
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Dietary Variability Among Mountain Gorilla Groups Across Volcanoes National Park, Rwanda by H. Ihimbazwe, J. D. Tuyizere, L. Kayitete, D. Abavandimwe, A. K. Kamanzi Shimwa, M. L. Power, C. C. Grueter, M. Flint, J. D. Nsanzineza, A. Jonas, G. Kwibuka, D. Ishimwe, F. Ndagijimana, J. D. Hakizimana, P. Uwingeli, S. C. McFarlin, M. M. Robbins, T. S. Stoinski, W. Eckardt

“…To compare diet quality, we combined nutritional values from newly collected food plants and previously collected and assessed food plant samples using comparable field and laboratory methods. We recorded 57 new foods for the study population. …”
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Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015–2021 by Juan Domínguez González, Juan Castillo Mewa, Prudencio González, Pedro Del Cid, Jacinto Ariel Pérez Ruíz, Samantha Eunice Rosas Hermosilla

“…The resistance patterns detected by the GenoType MTBDRplus assay highlight the genetic variability of drug resistance in the country and emphasize the need to implement epidemiological surveillance methodologies. Integrating patient clinical data with genetic variation information is essential for improving disease control and understanding transmission dynamics and drug resistance acquisition. …”
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Spatial distribution of paediatric tuberculosis and factors associated with adverse treatment outcomes in Ashanti Region, Ghana: a retrospective analysis by Maxwell Afranie Appiah, Mawuli Gohoho, Ebenezer Enam Adzaklo, Geoffrey Delali Komla Gone, Joshua Kwabena Aniaku, Perfect Edinam Asamoah, John Owusu Gyapong, Emmanuel Kyeremateng, Emmanuel Tinkorang

“…This study thus examined the spatial distribution of paediatric TB cases, treatment outcomes, and factors influencing adverse treatment outcomes in the Ashanti Region of Ghana. Methods This was a retrospective cross-sectional study of paediatric TB cases registered from 2016 to 2020 in 11 randomly selected districts in the Ashanti Region of Ghana. …”
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Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach by Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris

“…These mutations may disrupt EPCR stability and impair its anticoagulant function, thereby increasing the risk of thrombosis.MethodsWe employed a multi-layered computational approach to analyze 217 nsSNPs in the PROCR gene. …”
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Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese by Hongmei Lai, Hongmei Lai, Jinhang Zhu, Jing Tao, Jing Tao, Zitong Guo, Zitong Guo, Xiaolin Yu, Xiaolin Yu, Xin Shen, Ting Wang, Ying Wang, Ying Wang, Huan Cai, Huan Cai, Xiao Cai, Zhenbang Wei, Yining Yang, Yining Yang

“…This study explores the genetic variation associated with ACS subtypes in the Han and Uyghur Chinese populations to support the development of precision medicine approaches tailored to ethnic-specific genetic backgrounds.MethodsA total of 985 ACS patients (668 Han and 317 Uyghur Chinese) representing different ACS subtypes were enrolled. …”
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Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies by Kelsey Fehr, Kelsey Fehr, Andrew Mertens, Chi-Hung Shu, Trenton Dailey-Chwalibóg, Trenton Dailey-Chwalibóg, Liat Shenhav, Liat Shenhav, Liat Shenhav, Lindsay H. Allen, Lindsay H. Allen, Megan R. Beggs, Megan R. Beggs, Lars Bode, Lars Bode, Rishma Chooniedass, Mark D. DeBoer, Lishi Deng, Camilo Espinosa, Camilo Espinosa, Camilo Espinosa, Daniela Hampel, Daniela Hampel, April Jahual, April Jahual, Fyezah Jehan, Mohit Jain, Patrick Kolsteren, Puja Kawle, Kim A. Lagerborg, Melissa B. Manus, Melissa B. Manus, Melissa B. Manus, Samson Mataraso, Samson Mataraso, Samson Mataraso, Joann M. McDermid, Ameer Muhammad, Payam Peymani, Payam Peymani, Martin Pham, Martin Pham, Setareh Shahab-Ferdows, Yasir Shafiq, Yasir Shafiq, Yasir Shafiq, Vishak Subramoney, Daniel Sunko, Daniel Sunko, Laeticia Celine Toe, Laeticia Celine Toe, Stuart E. Turvey, Lei Xue, Natalie Rodriguez, Natalie Rodriguez, Alan Hubbard, Nima Aghaeepour, Nima Aghaeepour, Nima Aghaeepour, Meghan B. Azad, Meghan B. Azad

“…Multi-modal machine learning methods (extreme gradient boosting with late fusion and two-layered cross-validation) will be applied to predict infant growth and identify determinants of HM variation. …”
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Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency by Yingzhen Gao, Siyu He, Xiaoyan Meng, Kun Zheng, Heyang Cui, Yikun Cheng, Xinyuan Shen, Yuanfang Zhai, Binbin Zou, Fang Wang, Hongyi Li, Pengzhou Kong, Yanqiang Wang, Xuefei Feng, Bin Yang, Ruifang Sun, Yongsheng Meng, Enwei Xu, Yanlin Guo, Ning Ding, Weimin Zhang, Xiaolong Cheng, Lunzhi Dai, Yongping Cui, Ling Zhang

“…This study aimed to provide novel insights into the molecular landscape of ESCC and identify clinically actionable targets associated with immunosuppression driven by metabolic changes. Methods We performed metabolomic and proteomic analyses combined with previous genomic and transcriptomic data, identified multi-omics-linked molecular features, and constructed metabolic-immune interaction-based ESCC classifiers in a discovery cohort and an independent validation cohort. …”
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