Species Diversity, Biomass Production and Carbon Sequestration Potential in the Protected Area of Uttarakhand, India by Geetanjali Upadhyay, Lalit M. Tewari, Ashish Tewari, Naveen Chandra Pandey, Sheetal Koranga, Zishan Ahmad Wani, Geeta Tewari, Ravi K. Chaturvedi

Get full text

The clinical aspects ot the sulphonylurea compounds from the position of the cardioprotective approach at patient with type 2 diabetes, using glucocardiomonitoring by N. A. Chernikova, L. L. Kamynina, A. S. Аmetov, D. A. Sychov

“…Meanwhile the synchronized glucocardiomonitoring allowed to providing the accurate information about the cardiometabolic status of patients with T2DM.AIMS: Using the professional glucocardiomonitoring for T2DM-SU patients to investigate the relation between the glycemic variability, integral glycemic parameters and proarrhythmogenic cardiovascular events and the long-term cardiovascular outcomes.MATERIALS AND METHODS: In the observational (randomised for inclusion of patients) controlled trial the SU-patients with the T2DM duration 9,8±6,6 years were included, whom the professional glucocardiomonitoring had been made during 5 days and then the fatal and non-fatal cardiovascular events had been investigated during 5 years. …”
Get full text

Malignant epithelial cell marker–driven risk signature enables precise stratification in esophageal cancer by Hao Zhang, Hao Zhang, Shizhao Cheng, Shizhao Cheng, Yijun Xu, Yijun Xu

“…Single-cell RNA sequencing (scRNA-seq) provides new perspectives on the cellular makeup and conditions in tumor tissues, with promising implications for functional classification and personalized therapeutic strategies in esophageal cancer.MethodsIn this study, we integrated scRNA-seq data with bulk RNA-seq profiles from esophageal cancer tissues to construct a comprehensive cellular atlas, focusing on the transcriptional characteristics of epithelial cells. …”
Get full text

Feasibility study of a domestic fully automated NAT system for blood screening in blood donors by YAO Fenglan, WANG Rui, HU Jinghui, GE Hongwei, LENG Chan, ZHA Yi, ZHAO Zifu, LIU Zhengmin

“…[Objective] To validate the analytical performance, operational performance, and process control measures of a domestic fully automatic nucleic acid testing (NAT) system, thereby ensuring an efficient and orderly blood screening workflow. [Methods] The concordance rate and sensitivity of WanTag-Vortex Plus system were verified using WHO standard reference panels of HIV-1, HCV and HBV, while precision was assessed using weak positive samples of HIV-1, HCV and HBV. …”
Get full text

Assessing Dynamic Cognitive Function in the Daily Lives of Youths With and Without Type 1 Diabetes: Usability Study by Mary Katherine Ray, Jorie Fleming, Andrew Aschenbrenner, Jason Hassenstab, Brooke Redwine, Carissa Burns, Ana Maria Arbelaez, Mary Ellen Vajravelu, Tamara Hershey

“…ObjectiveBefore we can assess this relationship, we need to determine the feasibility of measuring cognition in youths in daily life and determine the plausibility of obtaining glucose variation with CGM to be integrated with real-time cognition measures. …”
Get full text

Entomological Surveillance of Aedes mosquitoes, vectors of arboviruses in a peri-urban area of Yaounde, Centre, Cameroon by Ms Bertille Djapoum, Ms Gisele Aurelie FOKO DADJI, Ms Borel DIAPPI-TCHAMEN, Ms Abraham FOMENA, Ms Joseph Lebel TAMESSE, Ms Christophe ANTONIO-NKONDJIO

“…In this line, a large-scale surveillance was undertaken in a peri-urban area of Yaounde, Cameroon to study the spatio-temporal distribution of Aedes population. Methods: The study was conducted in Nkolbisson, a peri-urban district of Yaounde over one year. …”
Get full text

Modeling healthcare resource dynamics and its application based on interregional population mobility by Jiaming Guo, Beibei Yan, Yanli Yang, Yifei Ning, Yan Zhou, Rui Zhang, Yifei Ma, Jiantao Li, Hongmei Yu, Hongmei Yu, Hongmei Yu, Hongmei Yu, Jun Xie, Jun Xie, Jun Xie

“…ObjectiveThis study aims to assess the impact of inter-regional population mobility on epidemic progression and healthcare resource congestion during acute infectious disease outbreaks, providing a scientific basis for population control and healthcare resource allocation during pandemics.MethodsUsing the SARS-CoV-2 pandemic as a case study, we selected two city pairs—“Taiyuan–Jinzhong” and “Linfen–Yuncheng” as research subjects. …”
Get full text

Effect of Zinc Nano Oxide on the Quality of Turkey Sperm in Liquid State by Vahid Lotfi vafa, Khalil Mirzadeh, Saleh Tabatabaei Vakili, Amin Kazemizadeh

“…Zinc oxide nanoparticles improve acrosomal membrane integrity, preserve membrane health, enhance acrosomal function, and positively affect mitochondrial performance and its functional integrity  Methods: Semen samples were collected twice weekly for five weeks from 18 Bronze turkeys. …”
Get full text

Diagnostic Predictors of Recovery Outcomes Following Open Reduction and Internal Fixation for Tibial Plateau Fractures: A Retrospective Study Based on the Schatzker Classification by Carlo Biz, Carla Stecco, Samuele Perissinotto, Xiaoxiao Zhao, Raffaele Ierardi, Luca Puce, Filippo Migliorini, Nicola Luigi Bragazzi, Pietro Ruggieri

“…This study examines the role of diagnostic predictors in differentiating recovery trajectories in two groups of patients treated for closed TPFs by open reduction and internal fixation (ORIF), comparing patients with less severe fractures and patients with more severe fractures (BCFs). <b>Methods</b>: A consecutive series of patients with a diagnosis of TPFs treated by ORIF at our institution between 2009 and 2016 were analyzed in this retrospective study. …”
Get full text

The alteration of IL-17 signaling pathway in bipolar disorder: a preliminary study with transcriptomic perspective by Xiaobo Wang, Xiaobo Wang, Su Yu, Zhen Gao, Fangming Xu, Yumei Wang, Yumei Wang, Yumei Wang, Tianle Zhang, Tingting Xie, Xihua Jia

“…This study aims to explore global mRNA expression in Peripheral blood white cells (PBMC) of BD patients.MethodsWe analyzed whole-genome gene expression profiles from PBMC of 12 BD states-manic (BD-M), 12 BD states-depressive (BD-D), and 12 matched healthy controls (HC) using microarrays. …”
Get full text

Mapping near-real-time soil moisture dynamics over Tasmania with transfer learning by M. T. Widyastuti, J. Padarian, B. Minasny, M. Webb, M. Taufik, D. Kidd

“…Deep learning (DL) techniques have recently been employed to produce high-resolution maps of various soil properties; however, these methods require substantial training data. This study sought to map daily soil moisture across Tasmania, Australia, at an 80 m resolution using a limited set of training data. …”
Get full text

Small Target Detection Algorithm for UAV Aerial Images Based on Improved YOLOv7-tiny by ZHANG Guanghua, LI Congfa, LI Gangying, LU Weidang

“…This study proposes a small target detection algorithm for UAV aerial images using a ConvMixer detection head based on the improved YOLOv7-tiny to address the problems of missed detection and false detection caused by significant variations in target scale, densely distributed small-sized targets and complex backgrounds in UAV aerial images.MethodsFirst, the activation function LeakyReLU is replaced with SiLU to compensate for the limited nonlinear expression of LeakyReLU and to enhance convergence speed and model generalization during training. …”
Get full text

The joint role of the immune microenvironment and N7-methylguanosine for prognosis prediction and targeted therapy in acute myeloid leukemia by Zhixiang Chen, Zhixiang Chen, Zhimei Chen, Xiaobo Huang, Xiaobo Huang, Xiaobo Huang, Xiongbin Yan, Xiongbin Yan, Xiaolin Lai, Xiaolin Lai, Shaoyuan Wang, Shaoyuan Wang

“…Biological pathway disparities between risk subgroups were analyzed via Gene Set Enrichment Analysis, Gene Set Variation Analysis, and ssGSEA. A clinical nomogram integrating the signature with prognostic indicators was developed. …”
Get full text

Next-Generation Sequencing–Based Molecular Profiling of Conjunctival Squamous Cell Carcinoma and Its Potential Application for Therapy by Hakan Demirci, MD, Josh N. Vo, PhD, Yi-Mi Wu, PhD, Victor Elner, MD, Arul M. Chinnaiyan, MD, PhD, Dan Robinson, PhD, F. Yesim Demirci, MD

“…Participants: Twenty patients with invasive cSCC consecutively managed at an academic ocular oncology setting. Methods: Integrative exome and transcriptome analysis of fresh-frozen tumor and matching normal samples. …”
Get full text

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes by Wenxu Wang, Wenxu Wang, Jincheng Lu, Jincheng Lu, Ningyun Pan, Ningyun Pan, Huiying Zhang, Jingcen Dai, Jie Li, Cheng Chi, Liumei Zhang, Liang Wang, Mengying Zhang, Mengying Zhang

“…This study aims to identify different molecular subtypes of AD and potential drugs for treating AD based on PANoptosis.MethodsDifferentially expressed PANoptosis genes associated with AD were identified via Gene Expression Omnibus (GEO) dataset GSE48350, GSE5281, and GSE122063. …”
Get full text

The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese... by Wang J, Chen Z, Guan M, Ma Z, Peng L, Chen J, Fiori PL, Carru C, Capobianco G, Coradduzza D, Zhou L

“…We aimed to comprehensively evaluate the genetic association between inflammation and cervical cancer, and construct an accurate prognosis model based on circulating inflammatory parameters and indexes with machine learning (ML) algorithms.Patients and Methods: We tested the genome-wide association of circulating inflammatory molecules (CIMs) (91 circulating inflammatory cytokines and 10 inflammatory cells) and summary data retrieved from the UK biobank (cases = 1659 and controls =381,902) with two-sample Mendelian randomization (MR) and colocalization analyses. …”
Get full text

Deep Learning–Based Precision Cropping of Eye Regions in Strabismus Photographs: Algorithm Development and Validation Study for Workflow Optimization by Dawen Wu, Yanfei Li, Zeyi Yang, Teng Yin, Xiaohang Chen, Jingyu Liu, Wenyi Shang, Bin Xie, Guoyuan Yang, Haixian Zhang, Longqian Liu

“…ObjectiveThis study aimed to address these challenges using an advanced preprocessing algorithm to enhance the accuracy, efficiency, and standardization of eye region cropping for clinical workflows and AI data preprocessing. MethodsThis retrospective and prospective cross-sectional study utilized 5832 images from 648 inpatients and outpatients, capturing 3 gaze positions under diverse conditions, including obstructions and varying distances. …”
Get full text

The light-harvesting chlorophyll a/b-binding proteins of photosystem II family members are responsible for temperature sensitivity and leaf color phenotype in albino tea plant by Jing-Jing Ye, Xin-Yi Lin, Zi-Xian Yang, Ying-Qi Wang, Yue-Rong Liang, Kai-Rong Wang, Jian-Liang Lu, Peng Lu, Xin-Qiang Zheng

“…Introduction: Light-harvesting chlorophyll a/b-binding (LHCB) protein complexes of photosystem II are integral to the formation of thylakoid structure and the photosynthetic process. …”
Get full text

Dynamic Migration Pattern of Groundwater and Deformation Mechanism in Cataclastic Bedding Rock Landslides: A Case Study of Muyubao Landslide in Three Gorges Reservoir Area by DENG Mao-lin, LIANG Zhi-kang, WANG Guo-fa, WANG Biao, ZHOU Lu-lu, WAN Hang, PENG Xu, SU Peng-min, ZHU Xiao-han

“…This paper attempts to establish an interaction model linking rainfall, reservoir water, and groundwater with groundwater as the main triggering factor of landslide deformation, and to further reveal the dynamic migration patterns of groundwater under the coupled effects of reservoir water level fluctuations and rainfall. [Methods] The study took the Muyubao Landslide, a cataclastic bedding landslide in the Three Gorges Reservoir area, as a case study. …”
Get full text

Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse c... by Farah Al-Marzooq, Akela Ghazawi, Maitha Alshamsi, Abdulrahman Alzaabi, Omar Aleissaee, Hamad Almansoori, Abdullah Alsaadi, Rauda Aldhaheri, Hafsa Ahli, Lana Daoud, Amna Ahmad, Timothy Collyns, Seema Oommen

“…We aimed to correlate their antibacterial efficacy with the genomic characteristics of the strains. Methods: This study investigated 73 E. coli strains and tested them for susceptibility to different antibiotics, including DBOs. …”
Get full text