Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach by Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris

“…These mutations may disrupt EPCR stability and impair its anticoagulant function, thereby increasing the risk of thrombosis.MethodsWe employed a multi-layered computational approach to analyze 217 nsSNPs in the PROCR gene. …”
Get full text

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese by Hongmei Lai, Hongmei Lai, Jinhang Zhu, Jing Tao, Jing Tao, Zitong Guo, Zitong Guo, Xiaolin Yu, Xiaolin Yu, Xin Shen, Ting Wang, Ying Wang, Ying Wang, Huan Cai, Huan Cai, Xiao Cai, Zhenbang Wei, Yining Yang, Yining Yang

“…This study explores the genetic variation associated with ACS subtypes in the Han and Uyghur Chinese populations to support the development of precision medicine approaches tailored to ethnic-specific genetic backgrounds.MethodsA total of 985 ACS patients (668 Han and 317 Uyghur Chinese) representing different ACS subtypes were enrolled. …”
Get full text

Unravelling Metazoan and Fish Community Patterns in Yujiang River, China: Insights from Beta Diversity Partitioning and Co-Occurrence Network by Yusen Li, Dapeng Wang, Yuying Huang, Jun Shi, Weijun Wu, Chang Yuan, Shiqiong Nong, Chuanbo Guo, Wenjian Chen, Lei Zhou

“…However, traditional survey methods often fail to comprehensively capture species diversity, particularly for low-abundance taxa. …”
Get full text

Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies by Kelsey Fehr, Kelsey Fehr, Andrew Mertens, Chi-Hung Shu, Trenton Dailey-Chwalibóg, Trenton Dailey-Chwalibóg, Liat Shenhav, Liat Shenhav, Liat Shenhav, Lindsay H. Allen, Lindsay H. Allen, Megan R. Beggs, Megan R. Beggs, Lars Bode, Lars Bode, Rishma Chooniedass, Mark D. DeBoer, Lishi Deng, Camilo Espinosa, Camilo Espinosa, Camilo Espinosa, Daniela Hampel, Daniela Hampel, April Jahual, April Jahual, Fyezah Jehan, Mohit Jain, Patrick Kolsteren, Puja Kawle, Kim A. Lagerborg, Melissa B. Manus, Melissa B. Manus, Melissa B. Manus, Samson Mataraso, Samson Mataraso, Samson Mataraso, Joann M. McDermid, Ameer Muhammad, Payam Peymani, Payam Peymani, Martin Pham, Martin Pham, Setareh Shahab-Ferdows, Yasir Shafiq, Yasir Shafiq, Yasir Shafiq, Vishak Subramoney, Daniel Sunko, Daniel Sunko, Laeticia Celine Toe, Laeticia Celine Toe, Stuart E. Turvey, Lei Xue, Natalie Rodriguez, Natalie Rodriguez, Alan Hubbard, Nima Aghaeepour, Nima Aghaeepour, Nima Aghaeepour, Meghan B. Azad, Meghan B. Azad

“…Multi-modal machine learning methods (extreme gradient boosting with late fusion and two-layered cross-validation) will be applied to predict infant growth and identify determinants of HM variation. …”
Get full text

GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…Methods We utilized the 850k methylation array to measure DNA methylation levels in blood samples from 47 healthy controls and 93 patients with CHD. …”
Get full text

Mindfulness-Based Intervention Effects on EEG and Executive Functions: A Systematic Review by Gilberto Galindo-Aldana, Luis Arturo Montoya-Rivera, Jose Jaime Esqueda-Elizondo, Everardo Inzunza-Gonzalez, Enrique Efren Garcia-Guerrero, Alfredo Padilla-Lopez, Tara G. Bautista, Cynthia Torres-González

“…</b> This study concludes that the research integrating the analysis of the electrophysiological and executive function effects of MBI shows important methodological variations and clinical conditions, which explains the significant results reported individually. …”
Get full text

Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency by Yingzhen Gao, Siyu He, Xiaoyan Meng, Kun Zheng, Heyang Cui, Yikun Cheng, Xinyuan Shen, Yuanfang Zhai, Binbin Zou, Fang Wang, Hongyi Li, Pengzhou Kong, Yanqiang Wang, Xuefei Feng, Bin Yang, Ruifang Sun, Yongsheng Meng, Enwei Xu, Yanlin Guo, Ning Ding, Weimin Zhang, Xiaolong Cheng, Lunzhi Dai, Yongping Cui, Ling Zhang

“…This study aimed to provide novel insights into the molecular landscape of ESCC and identify clinically actionable targets associated with immunosuppression driven by metabolic changes. Methods We performed metabolomic and proteomic analyses combined with previous genomic and transcriptomic data, identified multi-omics-linked molecular features, and constructed metabolic-immune interaction-based ESCC classifiers in a discovery cohort and an independent validation cohort. …”
Get full text

Eddy-covariance fluxes of CO₂, CH₄ and N₂O in a drained peatland forest after clear-cutting by O.-P. Tikkasalo, O. Peltola, P. Alekseychik, J. Heikkinen, S. Launiainen, A. Lehtonen, Q. Li, E. Martínez-García, M. Peltoniemi, P. Salovaara, V. Tuominen, R. Mäkipää

“…</sub></span> ha<span class="inline-formula">⁻¹</span> yr<span class="inline-formula">⁻¹</span>, depending on the EC gap-filling method; 82.0 % of the total), while the role of N<span class="inline-formula">₂</span>O emissions (5.0 t <span class="inline-formula">CO<sub>2 eq.…”
Get full text

Monsoon Forcing on Precipitation Stable Isotopes in the Yarlung Tsangpo Grand Canyon: Evidence from Indian Summer Monsoon Dynamics by WANG Zhongyu, QI Jihong, XU Mo, LI Xiao, YI Lei, LIANG Jingyan, TAN Yao

“…This expanded investigation proves pivotal for advancing comprehension of the nuanced interactions between topography and meteorological phenomena, shedding light on the complex mechanisms influencing isotopic variations in precipitation and refining insights into broader climatic processes in the studied area.MethodsThe data source for this study included atmospheric precipitation and surface water samples collected through field surveys. …”
Get full text

Bifidobacterium, Spirulina, and Yeast extracts in low-energy diets for rabbits: effects on performance, hematology, lipid metabolism, hepatorenal function, immunity and hormones by Mohamed S. Shaheen, Ahmed A. Allam, Usama M. Abdel Monem, Sabry M. Bassiony, Bakry A. Khalil, Ayman S. Salah, Abdullah S. Alawam, Hassan A. Rudayni, Ahmed A. Elolimy, Kasim Sakran Abass

Get full text

Mapping the Global distribution, risk factors, and temporal trends of COPD incidence and mortality (1990–2021): ecological analysis by Shafaq Naeem, Fang Wang, Rabia Mubarak, Hui Shen, Xuechun Li, Irene Mommers, Syeda Rija Hussain, Saima Shakil Malik, Chuanhua Yu, Eelko Hak, Xiaolin Xu, Muhammad Fawad, Sumaira Mubarik

“…Methods Utilizing data from the Global Burden of Disease (GBD) study, this research conducted a comprehensive ecological analysis of COPD epidemiology from 1990 to 2021. …”
Get full text

Effect of liver biopsy size on MASLD fibrosis assessment by second-harmonic generation/two-photon excitation fluorescence microscopy by Daniel T. Field, Yayun Ren, Kutbuddin Akbary, Elaine Chng, Dean Tai, Nikolai V. Naoumov, David E. Kleiner, Jonathan A. Fallowfield, Timothy J. Kendall, Arun J. Sanyal

“…The impact of biopsy size and location on the accuracy of these approaches has not been assessed in MASLD, leaving quality assurance procedures undefined. Methods: One unstained section each from 100 hepatectomy/explant MASLD cases, 20 of each pathologist-assigned Non-alcoholic Steatohepatitis Clinical Research Network (NASH-CRN) fibrosis stage (F0–F4), were used to create virtual core biopsies by cropping regions from within the whole parent section. …”
Get full text

Identification and validation of reference genes for qPCR of Pseudomonas aeruginosa L10 under varying n-hexadecane concentrations by Huan Wang, Xiaobing Wang, Juntao Chen, Yumiao Zhang, Junhua Liu, Fangliang Xia, Jian Li, Tao Wu, Longxiang Liu

“…RefFinder provides a comprehensive assessment of reference gene stability by integrating four methods. The results indicated that among the reference genes of P. aeruginosa L10 cultured under various concentrations of n-hexadecane stress, anr had the highest Ct value and expression abundance, while tipA had the lowest. …”
Get full text

Examining the social distributions in neighbourhood black carbon and ultrafine particles in Montreal and Toronto, Canada by Emmanuelle Batisse, Marshall Lloyd, Alicia Cavanaugh, Arman Ganji, Junshi Xu, Marianne Hatzopoulou, Jill Baumgartner, Scott Weichenthal

“…Background: Socioeconomic inequities in outdoor ultrafine particles (UFP) and black carbon (BC) are understudied in Canada, where metropoles like Montreal and Toronto feature distinct sociodemographic diversity and urban characteristics compared to U.S. cities. Methods: We collected vulnerability indicators, including social, economic, household composition, and immigration status, at the dissemination area level for Montreal and Toronto using data from the 2006 and 2021 Canadian Census of Population. …”
Get full text

Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort by Tahzeeb Fatima, Yuan Zhang, Georgios K. Vasileiadis, Araz Rawshani, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Gröndal, Kim Hørslev-Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Mikkel Østergaard, Till Uhlig, Tuulikki Sokka-Isler, Anna Rudin, Cristina Maglio

“…Metabolomics may help to identify such biomarkers as it allows for a comprehensive exploration of disease-related variations that extends beyond the genome and proteome. …”
Get full text

Factors associated with clinical antimicrobial resistance in China: a nationwide analysis by Wenyong Zhou, Zexuan Wen, Wenlong Zhu, Jiali Gu, Jing Wei, Haiyan Xiong, Weibing Wang

“…We used a "One Health" perspective to evaluate the association of human and veterinary antibiotic usage, environmental factors, socio-economic factors, and health care factors with clinical AMR in China. Methods We analyzed data from 31 provincial-level administrative divisions in China, encompassing 20,762,383 bacterial isolates sourced from the China Antimicrobial Resistance Surveillance System dataset between 2014 and 2022. …”
Get full text

Global, regional, and national burden of osteoarthritis from 1990 to 2021 and projections to 2035: A cross-sectional study for the Global Burden of Disease Study 2021. by Xiaoming Xie, Kuayue Zhang, Yuan Li, Yulong Li, Xinyi Li, Yi Lin, Liangqing Huang, Guihua Tian

“…<h4>Objective</h4>This study aims to report the trends and cross-national disparities in the burden of osteoarthritis (OA) by region, age, gender, and time from 1990 to 2021, and to further project changes through 2035.<h4>Methods</h4>In this systematic analysis based on the Global Burden of Disease (GBD) study, population survey data on osteoarthritis from 21 countries/regions and U.S. insurance claims data were used to estimate the prevalence and incidence of OA in 204 countries and regions from 1990 to 2021. …”
Get full text

A Prior Knowledge-Enhanced Deep Learning Framework for Improved Thermospheric Mass Density Prediction by Ling Li, Changyong He, Dunyong Zheng, Shaoning Li, Dong Zhao

“…This work underscores the value of merging data-driven methods with domain-specific prior knowledge, offering a promising pathway for advancing TMD modeling in space weather and atmospheric research.…”
Get full text

Alterations of static and dynamic changes in intrinsic brain activity and its relation to behavioral outcomes in subcortical ischemic stroke after one-month intervention by Yongxin Li, Jianping Wang, Maohua Yao, Yun Ran

“…In combination, this study demonstrates that a comprehensive understanding of abnormal activity and its longitudinal changes in ischemic stroke can be achieved by integrating static and dynamic imaging methods. Regions showing significant overlap among different brain activity indicators and exhibiting consistent image-behavior relationships may have some potential values for predicting clinical outcomes.…”
Get full text

Trend of thyroid cancer incidence in China, 1992-2021: a Joinpoint regression and age-period-cohort analysis by XIONG Dan, SU Xiaojun, FANG Yanmei

“… ‍Objective‍　‍To analyze the temporal trend of thyroid cancer incidence in China from 1992 to 2021 and evaluate the impact of age, period and cohort on the incidence. Methods‍　‍Based on the Global Burden of Disease 2021, the trend changes of age-standardized incidence rate (ASIR) of thyroid cancer in China from the period were analyzed, and the obtained data were further analyzed with Joinpoint regression and age-period-cohort analysis. …”
Get full text