RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer by Jing Zhu, Chun Yu, Xin Xu, Chu Zou, Jiaqi Li, Rui Wang, Xinchao Li, Aijun Sun, Shiyan Wang, Chao Jiang

“…Although studies have revealed the functional mechanisms of RAB5B in specific tumor types, its role in pan-cancer and the underlying molecular mechanisms still lack in-depth analysis.MethodsA comparative analysis of RAB5B gene expression was conducted using transcriptomic datasets from Cancer Genome Map (TCGA) and Genotype-Tissue Expression (GTEx), followed by tissue distribution profiling via Human Protein Atlas (HPA) and GeneMANIA to map its expression across human tissues. …”
Get full text

Increasing COVID-19 Testing and Vaccination Uptake in the Take Care Texas Community-Based Randomized Trial: Adaptive Geospatial Analysis by Kehe Zhang, Jocelyn V Hunyadi, Marcia C de Oliveira Otto, Miryoung Lee, Zitong Zhang, Ryan Ramphul, Jose-Miguel Yamal, Ashraf Yaseen, Alanna C Morrison, Shreela Sharma, Mohammad Hossein Rahbar, Xu Zhang, Stephen Linder, Dritana Marko, Rachel White Roy, Deborah Banerjee, Esmeralda Guajardo, Michelle Crum, Belinda Reininger, Maria E Fernandez, Cici Bauer

“…The project titled Take Care Texas ObjectiveWe aimed to develop a novel procedure for adaptive selections of census block groups (CBGs) to include in the community-based randomized trial for the Take Care Texas project. MethodsCBG selection was conducted across 3 Texas regions over a 17-month period (May 2021 to October 2022). …”
Get full text

Comparative genetic mapping and a consensus interspecific genetic map reveal strong synteny and collinearity within the Citrus genus by Patrick Ollitrault, Patrick Ollitrault, Barbara Hufnagel, Barbara Hufnagel, Franck Curk, Aude Perdereau, Pierre Mournet, Pierre Mournet, Maëva Miranda, Maëva Miranda, Gilles Costantino, Yann Froelicher, Yann Froelicher, Mônica Alves, Maria Angeles Forner Giner, Malcolm W. Smith, Pablo Aleza, François Luro, Nelson A. Wulff, Leandro Peña, Raphaël Morillon, Raphaël Morillon, Arnaud Lemainque

“…An improved knowledge on the synteny/collinearity between the genome of these different species, and on their recombination landscapes, is essential to optimize interspecific breeding schemes.MethodWe have performed a large comparative genetic mapping study including several main clades of the Citrus genus. …”
Get full text

Access to Primary Care Telemedicine and Visit Characterization in a Pediatric, Low-Income, Primarily Latino Population: Retrospective Study by Priya R Pathak, Melissa S Stockwell, Mariellen M Lane, Laura Robbins-Milne, Suzanne Friedman, Kalpana Pethe, Margaret C Krause, Karen Soren, Luz Adriana Matiz, Lauren B Solomon, Maria E Burke, Edith Bracho-Sanchez

“…ObjectiveWe aimed to assess the relationship between demographics, patient portal activation, and telemedicine visits, as well as characterize diagnoses addressed in telemedicine, in a low-income, primarily Latino population over time. MethodsA multidisciplinary team conducted outreach for telemedicine and patient portal activation with the adoption of a new electronic health record. …”
Get full text

Enhancing Food Safety: Adapting to Microbial Responses Under Diverse Environmental Stressors by Imran Mohammad, Mohammed Sarosh Khan, Mohammad Rizwan Ansari, Mohammad Azhar Kamal, Mohammad Nadeem Bari, Mohammad Anwar

“…Finally, the manuscript offers a discuss prospects for identifying stress-resistant mechanisms through systems biology and further engineering these elements using synthetic biology to enhance productivity. Methods: The literature review sought to cover the most important aspects of stress-resistant mechanisms in the adaptation processes of microorganisms and their role in food safety and sustainable production of valuable biochemicals. …”
Get full text

‘Every Touch Point Is an Opportunity’: Tobacco Control Experts' Views on How to Implement Smoking Cessation Interventions Within an Australian Lung Cancer Screening Program by Nathan J. Harrison, Diane Riddiford‐Harland, Sarah York, Henry M. Marshall, Joel J. Rhee, Emily Stone, Mei Ling Yap, Ashleigh R. Sharman, Marianne Weber, Susan A. McCullough, Terri Byrne, Christine L. Paul, Jacqueline A. Bowden, Billie Bonevski, Nicole M. Rankin

“…We sought perspectives from tobacco control/smoking cessation experts on optimally implementing smoking cessation interventions in an Australian LCS program. Methods Recruitment was via maximum variation and snowball sampling in 2022. …”
Get full text

Application of fourier transform infrared vibrational spectroscopy in identifying early biochemical changes in lipid profiles of individuals undergoing Roux-en-y gastric bypass by Amanda Motta de Bortoli, Márcia Helena Cassago Nascimento, Blanca Elena Guerrero Daboin, Beatriz Bobbio de Brito, Luiza Recla Pessotti, Paulo Roberto Filgueiras, Andressa Bolsoni Lopes, Valerio Garrone Barauna, Fabiano Kenji Haraguchi

Get full text

The impact of social and commercial determinants on the unequal increase of oral disorder disease burdens across global, regional, and national contexts by Yongqiang Lai, Ye Li, Xinwei Liu, Yuanxiang Shi, Fangqi Qu, Xiyu Zhang, Baoguo Shi, Xiaohe Wang, Tao Sun, Xianhong Huang, Dingyun You

“…The Global Oral Health Action Plan and the Bangkok Declaration underscore the importance of addressing commercial determinants as key drivers of oral health inequities. Methods We utilized data from the Global Burden of Disease 2021 (GBD 2021) study to analyze the burden of oral disorders—including incidence, prevalence, and disability-adjusted life years (DALYs)—across 204 countries and territories, stratified by Socio-demographic Index (SDI). …”
Get full text

Investigation of a chest radiograph-based deep learning model to identify an imaging biomarker for malnutrition in older adults by Ryo Sasaki, Yasuhiko Nakao, Fumihiro Mawatari, Takahito Nishihara, Masafumi Haraguchi, Masanori Fukushima, Ryu Sasaki, Satoshi Miuma, Hisamitsu Miyaaki, Kazuhiko Nakao

“…It is anticipated that AI will be integrated into the NST workflow in the future.…”
Get full text

Dietary Variability Among Mountain Gorilla Groups Across Volcanoes National Park, Rwanda by H. Ihimbazwe, J. D. Tuyizere, L. Kayitete, D. Abavandimwe, A. K. Kamanzi Shimwa, M. L. Power, C. C. Grueter, M. Flint, J. D. Nsanzineza, A. Jonas, G. Kwibuka, D. Ishimwe, F. Ndagijimana, J. D. Hakizimana, P. Uwingeli, S. C. McFarlin, M. M. Robbins, T. S. Stoinski, W. Eckardt

“…To compare diet quality, we combined nutritional values from newly collected food plants and previously collected and assessed food plant samples using comparable field and laboratory methods. We recorded 57 new foods for the study population. …”
Get full text

Stigma toward mental illness: A comparative analysis among medical and nursing students in two centers in Telangana, India by Md. Adil Faizan, V. Murali Krishna, Tialam Gautham, Govindappagari Venkata Jithendra

“…Materials and Methods: A cross-sectional study was conducted with 827 students from private medical college (Khammam) and government medical college (Warangal). …”
Get full text

Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015–2021 by Juan Domínguez González, Juan Castillo Mewa, Prudencio González, Pedro Del Cid, Jacinto Ariel Pérez Ruíz, Samantha Eunice Rosas Hermosilla

“…The resistance patterns detected by the GenoType MTBDRplus assay highlight the genetic variability of drug resistance in the country and emphasize the need to implement epidemiological surveillance methodologies. Integrating patient clinical data with genetic variation information is essential for improving disease control and understanding transmission dynamics and drug resistance acquisition. …”
Get full text

Effectiveness and safety of light therapy for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials by Lin Ang, Eunhye Song, Sunmi Choi, Jihye Kim

“…This systematic review aimed to assess the effectiveness and safety of light therapy in individuals with primary dysmenorrhea. Methods: For this systematic review and meta-analysis, we searched twelve electronic databases, including PubMed, Cochrane Library, Embase, Allied and Complementary Medicine Database (AMED), APA PsycINFO, CINAHL Complete, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), WanFang Data, Research Information Sharing Service (RISS), and Oriental Medicine Advanced Searching Integrated System (OASIS) to identify randomized controlled trials (RCTs) evaluating the effectiveness of light therapy for primary dysmenorrhea. …”
Get full text

Spatial distribution of paediatric tuberculosis and factors associated with adverse treatment outcomes in Ashanti Region, Ghana: a retrospective analysis by Maxwell Afranie Appiah, Mawuli Gohoho, Ebenezer Enam Adzaklo, Geoffrey Delali Komla Gone, Joshua Kwabena Aniaku, Perfect Edinam Asamoah, John Owusu Gyapong, Emmanuel Kyeremateng, Emmanuel Tinkorang

“…This study thus examined the spatial distribution of paediatric TB cases, treatment outcomes, and factors influencing adverse treatment outcomes in the Ashanti Region of Ghana. Methods This was a retrospective cross-sectional study of paediatric TB cases registered from 2016 to 2020 in 11 randomly selected districts in the Ashanti Region of Ghana. …”
Get full text

Computational Investigation of Long Free-Span Submarine Pipelines with Buoyancy Modules Using an Automated Python–Abaqus Framework by Ty Phuor, Pavel A. Trapper, Alon Urlainis, Avshalom Ganz

“…The developed approach advances existing methods by significantly reducing the computational complexity and enabling extensive parametric analyses, making it a valuable tool for designing stable, cost-effective offshore pipeline systems.…”
Get full text

STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…We systematically investigated the expression patterns and prognostic relevance of STAT1 isoform-specific transcripts across pan-cancer tissues, with a particular focus on ovarian cancer (OV), and elucidated their potential mechanisms in modulating the tumor immune microenvironment (TIME) to influence patient prognosis. Methods Integrated analysis of the GTEx and TCGA databases was conducted to systematically evaluate the transcript expression profiles of STAT1 isoforms across 32 cancer types and 29 normal tissues. …”
Get full text

Forecasting motion trajectories of elbow and knee joints during infant crawling based on long–short-term memory (LSTM) networks by Jieyi Mo, Qiliang Xiong, Ying Chen, Yuan Liu, Xiaoying Wu, Nong Xiao, Wensheng Hou

“…Therefore, this paper aims to explore the feasibility of using LSTM networks to predict crawling trajectories, thereby advancing our understanding of how to actively control crawling rehabilitation training robots. Methods We collected joint trajectory data from 20 healthy infants (11 males and 9 females, aged 8–15 months) as they crawled on hands and knees. …”
Get full text

CATHODOLUMINESCENCE AND RAMAN SPECTROSCOPY AS A BASIS FOR THE SELECTION OF REFERENCE SAMPLES FOR LA-ICP-MS ANALYSIS OF ZIRCON by S. L. Votyakov, M. V. Chervyakovskaya, Yu. V. Shchapova, E. A. Pankrushina, G. B. Mikhalevsky, V. S. Chervyakovsky

“…In order to develop express methods for the quantitative assessment of properties and the selection of reference samples close to investigated sample, to ensure similar conditions for the evaporation of substances and parameters of fractionation of trace elements in LA-ICP-MS, a comparative analysis of the U-Pb isotopic composition, Raman and cathodoluminescent spectra of zircon GJ-1, Plesovice, 91500, Temora-2, Mud Tank reference samples has been performed. …”
Get full text

Evaluation of Free-Living Motor Symptoms in Patients With Parkinson Disease Through Smartwatches: Protocol for Defining Digital Biomarkers by Carlos Polvorinos-Fernández, Luis Sigcha, María Centeno-Cerrato, Guillermo de Arcas, Miriam Grande, Mayca Marín, Isabel Pareés, Juan Carlos Martínez-Castrillo, Ignacio Pavón

“…The goal is to identify reliable digital biomarkers that can effectively distinguish patients with PD from healthy controls and classify disease severity in both supervised and unsupervised free-living environments. MethodsThis paper outlines a protocol for an observational case-control study aimed at assessing motor symptoms in patients with PD using a smartwatch. …”
Get full text

Deep learning radiomics based on contrast enhanced MRI for preoperatively predicting early recurrence in hepatocellular carcinoma after curative resection by Ying Zhao, Sen Wang, Sen Wang, Yue Wang, Jun Li, Jinghong Liu, Yuhui Liu, Haitong Ji, Wenhan Su, Qinhe Zhang, Qingwei Song, Yu Yao, Yu Yao, Ailian Liu, Ailian Liu

“…PurposeTo explore the role of deep learning (DL) and radiomics-based integrated approach based on contrast enhanced magnetic resonance imaging (CEMRI) for predicting early recurrence (ER) in hepatocellular carcinoma (HCC) patients after curative resection.MethodsTotal 165 HCC patients (ER, n = 96 vs. non-early recurrence (NER), n = 69) were retrospectively collected and divided into a training cohort (n = 132) and a validation cohort (n = 33). …”
Get full text