Relationship between advanced lung cancer inflammation index and all-cause and cause-specific mortality among chronic inflammatory airway diseases patients: a population-based stud... by Zhuanbo Luo, Peixu Chen, Shiyu Chen, Xue Kong, Hongying Ma, Chao Cao

“…This study aimed to investigate this relationship.MethodsWe gathered data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. …”
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Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

“…Methods Seven of 89 sites using the SJCARES registry were selected, stratified by global region and stage of implementation. …”
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Local adaptation, genetic diversity and key environmental interactions in a collection of novel red clover germplasm by A. D. Heslop, A. D. Heslop, Sai K. Arojju, Rainer W. Hofmann, John L. Ford, M. Zulfi Z. Jahufer, Anna C. Larking, Rachael Ashby, Charles A. Hefer, Ken G. Dodds, A. Saei, Jessica O’Connor, Andrew G. Griffiths

“…Our study identifies the importance of diverse germplasm when adding genetic variation into breeding programs. It also identifies efficient evaluation methods and key climatic variables that should be considered when developing adaptive red clover cultivars.…”
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Predicting early complications in patients with spinal gunshot wounds: A multicenter study by Guillermo A. Ricciardi, Juan P. Cabrera, Oscar Martínez, Javier Matta, Hugo Vilchis, Jeasson Javier Perez Ríos, Charles A. Carazzo, Michael Dittmar, Ratko Yurac

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Detecting Changes in Soil Fertility Properties Using Multispectral UAV Images and Machine Learning in Central Peru by Lucia Enriquez, Kevin Ortega, Dennis Ccopi, Claudia Rios, Julio Urquizo, Solanch Patricio, Lidiana Alejandro, Manuel Oliva-Cruz, Elgar Barboza, Samuel Pizarro

“…This approach, tailored to the Peruvian Andes, integrates spectral indices and field-collected data, offering innovative tools to optimize fertilization practices, address soil management challenges, and merge modern technology with traditional methods for sustainable agricultural practices.…”
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Systematizing peer recovery support services for substance use disorder: a taxonomy for measuring recovery milestones by Kimberly Horn, Ryan E. Flinn, Angela Marie Hagaman, Kristyn Zajac, Lauren A. Hoffman, Melissa N. Poulsen, Camille C. Cioffi, Ducel Jean-Berluche, Ethan Spana, Patrick F. Hibbard, Tess K. Drazdowski, Aaron Hogue

“…However, variability in PRSS roles, training, and settings creates challenges for consistent evaluation and measurement of effectiveness.ObjectiveIntroduce a systematic taxonomy to clarify the roles, functions, and activities within PRSS, providing a structured framework for evaluating their impact on key SUD recovery milestones.MethodsThe taxonomy was developed through a rapid narrative literature review, expert consultation, and an iterative consensus process informed by a Delphi-like approach. …”
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Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients by Huilin Xu, Mingming Li, Houshan Yao, Guoliang Chen, Jiani Chen, Xinyun Hou, Hong Yang, Chenghang Yu, Zeshuai Lin, Jiawei Zhu, Rong Wang, Shi Qiu, Xuan Liu, Zhipeng Wang, Xia Tao, Lei Liu

“…Identifying predictive factors for CIH is crucial for clinical management.Patients and MethodsThis study analyzed colorectal tissue (CRT), plasma, and urine samples from CRC patients. …”
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Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines by David Hodgson, Yi Liu, Yi Liu, Louise Carolan, Siddhartha Mahanty, Kanta Subbarao, Kanta Subbarao, Sheena G. Sullivan, Sheena G. Sullivan, Sheena G. Sullivan, Annette Fox, Annette Fox, Adam Kucharski

“…Notably, mRNA vaccines have exhibited superior effectiveness compared to Adenovirus (AdV) vaccines, especially with extended dosing intervals. MethodsUsing in-host mechanistic modelling, this study elucidates these variations and unravels the biological mechanisms shaping the immune responses at the cellular level. …”
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Ultra-broadband coherent open-path spectroscopy for multi-gas monitoring in wastewater treatment by Roderik Krebbers, Kees van Kempen, Yueyu Lin, Joris Meurs, Lisanne Hendriks, Ralf Aben, José R. Paranaiba, Christian Fritz, Annelies J. Veraart, Amir Khodabakhsh, Simona M. Cristescu

“…Wastewater treatment plants significantly contribute to greenhouse gas emissions, including nitrous oxide (N2O), carbon dioxide (CO2), and methane (CH4). Current methods to measure these emissions typically target specific molecular compounds, providing limited scope and potentially incomplete emissions profiles. …”
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Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients by Ning Zheng, Hai-Long Yu, Bing-Jie Zhang, Dan Wang, Ya-Liang Ji, Lu-Lu Dai, Wen Li, Sheng-Hui Li, Zhi-Liang Hu, Zhi-Liang Hu, Yi-Shan Zheng

“…This study aims to characterize the virome in bronchoalveolar lavage fluid (BALF) and peripheral blood samples from patients with various clinical conditions using mNGS.MethodsA total of 338 clinical samples—including 240 BALF and 69 blood samples for DNA sequencing, and 18 BALF and 11 blood samples for RNA sequencing—underwent shotgun metagenomic sequencing. …”
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Genomic characterization and antibiotic susceptibility of biofilm-forming Borrelia afzelii and Borrelia garinii from patients with erythema migrans by Giorgia Fabrizio, Giorgia Fabrizio, Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Daniela Kovacs, Massimo Francalancia, Giovanna D’Agosto, Elisabetta Trento, Grazia Prignano, Arianna Mastrofrancesco, Eva Ruzič-Sabljič, Fulvia Pimpinelli, Enea Gino Di Domenico

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Impacts of Ecological Restoration Projects on Ecosystem Carbon Storage of Tongluo Mountain Mining Area, Chongqing, in Southwest China by Lei Ma, Manyi Li, Chen Wang, Hongtao Si, Mingze Xu, Dongxue Zhu, Cheng Li, Chao Jiang, Peng Xu, Yuhe Hu

“…This hybrid approach overcame the limitations of traditional plot-based methods by providing spatially explicit, cost-effective monitoring solutions for mining ecosystems. …”
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Hyperspectral imaging-driven deep learning approach: Asymptomatic stage detection and severity grading of tomato yellow leaf curl disease by Junzhi Chen, Wenshan Zhong, Xuejun Yue, Ziyu Ding, Mengdan Du, Xuantian Li, Biao Chen, Haifeng Li, ZiFu He, Xiaoman She, Yafei Tang

“…The prolonged asymptomatic infection period and non-distinct early symptoms of TYLCD impose limitations on traditional detection methods, whereas hyperspectral imaging technology, capable of capturing rich spectral and spatial features, provides a technical foundation for early lesion identification and dynamic disease progression monitoring. …”
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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. by Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale

“…<h4>Methods and findings</h4>Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5). …”
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Comprehensive Analysis of Congenital Aniridia and Differential Diagnoses: Genetic Insights and Clinical Manifestations by Jonathan Hall, Marta Corton, Fabian Norbert Fries, Jessica Obst, Clara Grünauer-Kloevekorn, Berthold Seitz, Maria della Volpe Waizel, Eszter Jávorszky, Kálmán Tory, Erika Maka, Maryam Amini, Shweta Suiwal, Tanja Stachon, Nóra Szentmáry

“…Additionally, it proposes a diagnostic framework to distinguish CA from other conditions that present with similar iris abnormalities. Methods We conducted a comprehensive literature review to compile and analyze clinical and genetic data related to CA and its differential diagnoses. …”
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Beyond dietary therapy: addressing weight stigma awareness in medical students by Giuseppe Annunziata, Giordano Bruno Zonzini, Evelyn Frias-Toral, Raynier Zambrano-Villacres, Alexander Bertuccioli, Davide Sisti, Ludovica Verde, Daniele Di Pauli, Annamaria Colao, Giovanna Muscogiuri, Daniel Simancas-Racines, Alessandro Gennaro, Luigi Barrea

“…This research aimed to examine weight-related stigma among university students enrolled in healthcare-related academic programs. Methods To measure weight stigma, researchers administered the Italian version of the Attitude Toward Obese Persons (I-ATOP) questionnaire to 201 students from the University of Urbino (Italy) and the University of Malaga (Spain). …”
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Insights into high-altitude adaptation and meat quality regulation by gastrointestinal metabolites in Tibetan and black pigs by Xue Bai, Xue Bai, Zhiying Huang, Helin Tan, Yiren Gu, Xun Wang, Long Jin, Peng Shang, Keren Long, Diyan Li, Mingzhou Li

“…Our goal was to correlate omic variations with meat quality traits and identify potential biomarkers predictive of superior meat quality, elucidate the regulatory effects of digestive tract microbial metabolites on Tibetan pig muscle characteristics, and reveal the genetic and nutritional mechanisms that promote adaptation to extreme environmental conditions.MethodsThis analysis encompassed metabolomic profiling of the entire digestive tract-including the stomach, jejunum, cecum, colon, and rectum-as well as histological, amino acid, fatty acid composition, and transcriptomic assessments of the longissimus dorsi muscle tissues to investigate how digestive tract microbial metabolites influence muscle adaptation to high altitudes.ResultsAnalyses revealed that Tibetan pig muscles contain smaller, more oxidative fibers enriched with flavor-enhancing amino acids. …”
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Evaluating the long-term impact of a distance learning course on attitudes, skills, practices, and knowledge in gender-affirming healthcare among healthcare professionals in Italy by Matteo Marconi, Ughetta Maria Favazzi, Pietro Carbone, Debora Guerrera, Angela Ruocco, Martina Manoli, Martina Manoli, Cristiana Barbati, Francesca Molinaro, Federica Maria Regini, Andrea Vittozzi, Alfonso Mazzaccara, Marina Pierdominici

“…This study extends the findings of an earlier evaluation of a distance learning course on TGD healthcare, exploring the sustainability of its effects over time.ObjectivesTo assess changes in self-reported attitudes, skills, practices, and knowledge retention 6 months after course completion.MethodsA longitudinal design was used with assessments at baseline (T0), post-course (T1), and six-month follow-up (T2). …”
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Association of <i>OPRM1</i> and <i>OPRD1</i> Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer by Carolina Gutiérrez-Cáceres, Nikolas Ávila, Leslie C. Cerpa, Matías F. Martínez, Carlos E. Irarrazabal, Benjamín Torres, Olga Barajas, Nelson M. Varela, Luis A. Quiñones

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Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and glioma by Hong Cheng, Jing Wang, Yingjie Zhao, Xiaoli Hou, Fang Ling, Yixia Wang, Yasen Cao

“…Understanding the differential expression and functional implications of HSPs in these conditions is crucial for identifying potential therapeutic targets and biomarkers for diagnosis and prognosis. Methods: We utilized combined datasets (GSE6613 and GSE72267) to identify and analyze the heat shock-related genes differentially expressed in PD. …”
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