New insights into markers for distinguishing neuroendocrine prostate cancer: evidence from single-cell analysis by Hailang Luo, Hailang Luo, Hailang Luo, Boyang Li, Boyang Li, Boyang Li, Meng Zhang, Meng Zhang, Meng Zhang, Hongqun Wang, Zongyao Hao, Zongyao Hao, Zongyao Hao, Qintao Ge, Qintao Ge, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…The identification of reliable biomarkers for NEPC is essential for early detection and intervention.MethodsWe combined single-cell and bulk transcriptome analysis to identify novel markers of NEPC. …”
Get full text

Physiochemical and functional properties of gelatin obtained from frigate mackerel (Auxis thazard), skipjack tuna (Katsuwonus pelamis), Longtail tuna (Thunnus tonggol) and yellowfi... by Qinghe Yin, Haohao Shi, Yongqiang Zhao, Gang Yu, Haohao Wu, Guanghua Xia, Tao Yang

“…This study conducted a systematic investigation into the physicochemical and functional properties of gelatin extracted through alkaline methods from the skins of four commercially significant tuna species: frigate mackerel (Auxis thazard), skipjack tuna (Katsuwonus pelamis), longtail tuna (Thunnus tonggol), and yellowfin tuna (Thunnus albacares). …”
Get full text

Sensitivity analysis of the INRA 2018 feeding system for ruminants by hybrid local and global approaches: Comparing the contribution of dietary input variables to multiple response... by Seoyoung Jeon, Tristan Senga Kiessé, Sophie Lemosquet, Pierre Nozière

“…Hence, hybridizing the SA methods can help to interpret the system and facilitate a more precise evaluation thereof, especially GSA, which is amenable to nonmonotonic models such as those characterizing complex feeding systems integrating multiple nutritional and animal factors.…”
Get full text

Syndemic geographic patterns of cancer risk in a health-deprived area of England by Catherine Jones, Thomas Keegan, Andy Knox, Alison Birtle, Jessica A. Mendes, Kelly Heys, Peter M. Atkinson, Luigi Sedda

Get full text

Analysis of costs in implementing the HEARTS hypertension program in Nigerian primary care by Emmanuel Ndenor Sambo, Muhammad Jami Husain, Soumava Basu, Malau Mangai Toma, Sunday Victor Eze, Kufor Osi, Nanlop Ogbureke, Okeoma Erojikwe, Bolanle Banigbe, Andrew E. Moran, Deliana Kostova

“…Objective To assess the costs of scaling up the HEARTS hypertension control package and compare these costs with those of usual care. Methods Data on the costs of implementing the HEARTS program were collected from 15 purposively sampled primary health facilities in Kano, Ogun, and FCT Abuja between February and April 2024. …”
Get full text

Incorporating gene expression and environment for genomic prediction in wheat by Jia Liu, Jia Liu, Andrew Gock, Kerrie Ramm, Sandra Stops, Tanya Phongkham, Adam Norman, Russell Eastwood, Eric Stone, Shannon Dillon

“…Here we explored the role transcriptome data could play in enhancing GS in wheat.MethodsAcross 286 wheat lines, we integrated phenotype and multi-omic data from controlled environment and field experiments including ca. 40K single nucleotide polymorphisms (SNP), abundance data for ca. 50K transcripts as well as meta-data (e.g. categorical environments) to predict individual genetic merit for two agronomic traits, flowering time and height. …”
Get full text

Neuroprotective effects of creatine supplementation in mild TBI management among contact sport athletes: A scoping review by John E. Giraldo, Diego A. Bonilla, Luis F. Bedoya, Katherine F. Hoyos, Santiago G. Velasquéz, Mayra M. Márquez, Jorge L. Petro

“…In studies involving contact sport athletes, creatine was integrated into nutritional protocols to aid concussion recovery, with observed variations in the N-acetylaspartate/creatine ratio highlighting a potential role in restoring cerebral metabolism.Conclusion Although the evidence is limited, findings from animal models and contact sports athletes suggest that creatine supplementation may help mitigate the metabolic disturbances associated with concussions. …”
Get full text

Public attitudes and values regarding a semi‐urban feral ungulate by Danhe Yang, Debottam Bhattacharjee, Kate J. Flay, Yifu Wang, Hannah S. Mumby, Alan G. McElligott

“…Studying public attitudes and values, such as appreciation and preservation for semi‐urban feral buffalo, points to methods for successful strategies using buffalo as ‘agents’ of conservation. …”
Get full text

Understanding Gender-Specific Daily Care Preferences: Topic Modeling Study by Kyungmi Woo, Se Hee Min, Aeri Kim, Subin Choi, Gregory L Alexander, Terrence O’Malley, Maria D Moen, Maxim Topaz

“…ObjectiveThis study aims to identify and analyze the key themes and daily care preferences from unstructured adult text narratives with a focus on uncovering gender-specific variations. MethodsThis study used 4350 deidentified, unstructured textual data from MyDirectives (MyDirectives, Inc), an interactive online platform. …”
Get full text

Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA by Che-Mai Chang, Chang-Jiun Wu, Maxim Shkurnikov, Chin-Lin Guo, Wan-Chen Huang, Alexander Tonevitsky, Wei-Chiao Chang

“…Understanding these interactions is crucial for elucidating differences in immune responses and disease severity among diverse populations. Methods We updated the T-CoV portal to incorporate and analyze EG.5 and XBB.1.16 variants. …”
Get full text

Defining Reablement in the Dutch Context: A Modified Delphi Study by Buma LE, Mouchaers I, Zwakhalen SM, Vluggen S, Satink T, Metzelthin SF

“…This study extends the original conceptual definition by integrating these elements, offering clearer, more practical guidance for real-world application.Materials and methods: A modified Delphi study was performed to develop a definition of reablement that fits the Dutch health and social care system, extending beyond conceptual understanding. …”
Get full text

Empowering excellence: transforming GIRFT accessibility through a centralised Trust intranet portal: Northern Care Alliance Experience by Ayesha Lala, Robert Nipah, Alistair Craig, Molly Gollop, Shirley Naylor, William Keith Gray, Janet Cox, Katrein Savage, Paul Mcmullen, Alshymaa Eltahan

“…Objective: The primary goal was to establish a centralised GIRFT intranet webpage to enhance communication, promote engagement and facilitate structured access to GIRFT resources among clinical and managerial staff. Methods: A QIP drivers diagram was employed to identify six key drivers and corresponding interventions essential for developing the webpage (Fig 1). …”
Get full text

Adaptation and validation of the Washington group/unicef child functioning module in a nationally representative sample of Canadian children and youth by Emma Nolan, Katherine Cost, Ryan Miller, Li Wang, Chen Yun-Ju, Jordan Edwards, Eric Duku, Stelios Georgiades, Peter Szatmari, Harriet MacMillian, Charlotte Waddell, Katholiki Georgiades

“…Findings highlight the value of a dimensional approach to functional difficulties, offering a more comprehensive understanding of population-level variations in functioning. Integrating this measure into large-scale surveys can facilitate trend monitoring, improve data-driven policy interventions, and support strategic planning for education, healthcare, and social services. …”
Get full text

Unraveling Cefiderocol Resistance Strategies in Klebsiella pneumoniae Strains from the United Arab Emirates by Dr. Farah Al Marzooq, Ms Lana Daoud

“…This study aims to examine the genetic makeup of CFDC-susceptible (S) and non-susceptible (NS) Klebsiella pneumoniae (KPN) isolates to uncover the causes of CFDC resistance. Methods: A total of 241 KPN strains isolated from various infection sites were included in this study. …”
Get full text

Neoadjuvant chemoradiotherapy with or without PD-1/PD-L1 inhibitors in locally advanced rectal cancer: a systematic review and meta-analysis by Muhammad Ansab, Sepideh Razi, Farwa Nisa, Eiman Araib, Shree Rath, Iqra Khan, Noor Ul Huda Ramzan, Esha Dilawar, Anwaar Saeed

“…Methods A systematic search of PubMed, Embase, ClinicalTrials.gov, and Cochrane Central Library was conducted up to October 11, 2024. …”
Get full text

Hydrogeological and electrostratigraphic modeling of coastal aquifers: Investigating systemic vulnerability, hydraulic yield potential, and corrosivity pathways by Jewel E. Thomas, Ndifreke I. Udosen, Aniekan M. Ekanem, Nyakno J. George

“…Results indicate that 86 % of the study area is non-corrosive, making it suitable for long-term pipeline installation, a factor rarely integrated into groundwater assessments. The study alsoadvances understanding of the Benin Formation by linking resistivity variations to arenaceous-argillitic intercalations, and this significantly influences groundwater movement and contaminant transport. …”
Get full text

Risk Factors for Gout in Taiwan Biobank: A Machine Learning Approach by Liu YR, Nfor ON, Zhong JH, Lin CY, Liaw YP

“…The study aimed to identify crucial risk factors and evaluate the performance of different models in gout prediction.Patients and Methods: This study analyzed data from 88,210 individuals in the Taiwan Biobank, identifying 19,338 cases of gout and 68,872 controls. …”
Get full text

Effects of Pomegranate Seed Oil on Lower Extremity Ischemia-Reperfusion Damage: Insights into Oxidative Stress, Inflammation, and Cell Death by Ümmü Gülşen Bozok, Aydan İremnur Ergörün, Ayşegül Küçük, Zeynep Yığman, Ali Doğan Dursun, Mustafa Arslan

“…<i>Aim</i>: This study sought to clarify the therapeutic benefits and mechanisms of action of pomegranate seed oil (PSO) in instances of ischemia–reperfusion (IR) damage in the lower extremities. <i>Materials and Methods</i>: The sample size was determined, then 32 rats were randomly allocated to four groups: Control (C), ischemia–reperfusion (IR), low-dose PSO (IR + LD, 0.15 mL/kg), and high-dose PSO (IR + HD, 0.30 mL/kg). …”
Get full text

Saturation Oxygenation Pressure Index: A Novel Non-invasive Approach for Evaluating Pulmonary Disease Severity in Neonates on Non Invasive Ventilation by Swetha Naikodi, AS Jagadish, R Premalatha, B Ravichander

“…Changes in distending pressure requirements, Fraction of Inspired Oxygen (FiO2), or both, indicate variations in disease severity. An integrated tool that incorporates these parameters would facilitate an objective evaluation of disease severity. …”
Get full text

The Impact of Various Pretreatment Agents on Shear Bond Strength between Self-adhesive Resin Cement and Dentin: An <italic>In Vitro</italic> Study by Ruhi Bajaj, Salil Pawah, Amit Gupta, Arpit Sikri, Prateek Madan

“…These agents have been studied for their effects on improving the self-adhesive resin cement’s bond strength in different dental procedures. Materials and methods: A total of 24 recently extracted maxillary premolar teeth were carefully chosen for the present study. …”
Get full text